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All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Health Notions Journal of Dentomaxillofacial Science Indonesian Journal of Life Sciences Denta: Jurnal Kedokteran Gigi Odonto dental journal
Erna Sulistyani
Fakultas Kedokteran Gigi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health

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Journal : Health Notions

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The Effect of Sodium Fluoride Administration on IL-1β and TNF-α Expression on Orthodontic Teeth Movement Rina Sutjiati; Erna Sulistyani; Leliana Sandra Deviade Putri; Rudy Joelijanto; Herniyati Herniyati; Dwi Prijatmoko; Adik Wulandari; Dani Agam Rahmadianto
Health Notions Vol 6, No 3 (2022): March
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn60304

Abstract

Relapse in post orthodontic treatment is common in the community because resorption in the pressure side occurs excessively due to teeth being moved with an orthodontic device. Excessive resorption can be inhibited by using NaF which has been shown to inhibit osteoclast activity, thereby reducing osteoclast numbers. The purpose of this study was to analyze the effect of NaF administration on IL-1β and TNF-α expression of osteoclast in orthodontic teeth movement. The research used experimental-quantitative research type applying Randomized Posttest Only Control Group Design, by selecting the experimental group and the control group randomly. Animal model using 16 male Wistar rats given orthodontic force using NiTi closed coil spring adjusted to give 10 grams/cm2 of mechanical strength, were applied to the palatal in the maxillary incisors of the Wistar rat teeth. Rats were divided into two groups, the control group (C group) and treatment group (T group) given topical NaF application (11.75 ppm). Immunohistochemical examination was performed to calculate IL-1β and TNF-α expression on osteoclasts on the 7th day and 14th day. The administration of NaF reduces IL-1β and TNF-α osteoclast’s expression both on the 7th day (p <0.05) and 14th day (p <0.05). Data were tested by the Kolmogorov-Smirnov test, Levene test and the difference tested Annova followed by LSD (p <0.05). Topical administration of NaF application to the gingival sulcus of male Wistar rats in orthodontic tooth movement can reduce the number of osteoclasts that express IL-1β in the alveolar bone in the pressure area. Topical administration of NaF application to the gingival sulcus of male Wistar rats in orthodontic tooth movement can reduce the number of osteoclasts that express TNF-α in the alveolar bone in the pressure region. Decreased number of osteoclasts expressing IL-1β and TNF-α significantly occurred on the 7th day and 14th day. Keywords: IL-1β; TNF-α; NaF; osteoclast; orthodontic teeth movement
Expression of IL-10 and Caspase-3 in Alveolar Bone after Topical Administration of Sodium Fluoride (Naf) Gel in Orthodontic Tooth Movement Rina Sutjiati; Sulistyani Sulistyani; Erna Sulistyani; Rudy Joelijanto; Annisa Syifa M.; Hasna&#039; Fakhriyah J.
Health Notions Vol 6, No 2 (2022): February
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn60206

Abstract

The success of orthodontic treatment can be achieved through tissue, cellular and molecular mechanisms due to mechanical stimuli formed by the pressure side and the tension side. Sodium Fluoride (NaF) is known to increase the bone formation process in the area of attraction in vitro and in vivo. The study aimed to determine sodium fluoride (NaF) against Caspase-3 by osteoblasts and IL-10 by osteoclasts in alveolar bone remodeling on orthodontic tooth movement. The research applied laboratory experiment using 16 male Wistar rats. Rats were divided into two groups; group C: given orthodontic strength without NaF; and group T: given orthodontic strength with NaF. Variable measurements were carried out after the 7th and 14th day. The data was statistically tested using One-Way Anova test analysis (p ≤0.05) to compare the mean number of expressions of both groups C and T. The number of osteoclasts expressing IL-10 was significantly higher in group T when compared to that of group C while the number of osteoblasts expressing Caspase-3 was smaller in group T when compared to that of group C. NaF can increase IL-10 expression in osteoclasts and decrease Caspase-3 expression by osteoblasts on orthodontic tooth movement. Keywords: Caspase-3; IL-10; sodium fluoride (NaF); immunohistichemistry
Co-Authors Adik Wulandari Agustin, Merry Ayu Ayu Ainunnusak Ayuningtyas Andriani, Hilma Annisa Syifa M. Atik Kurniawati, Atik Bilqis P. Safitri Budi Yuwono Dani Agam Rahmadianto Dewi, Leni Rokhma Dwi Prijatmoko Enti Isnarni Enti Isnarni, Enti Futaihana, Hasna' Garaniva Gayuh Setyawan Gayuh Setyawan, Gayuh Hafizh, Cinantya Handayani, Ari T.W. Happy Harmono Hasna&#039; Fakhriyah J. Herniyati Herniyati Herniyati Hesty Kumala Sari Iin Eliana Triwahyuni Khairunnisa, Luthfitah Zahra Leliana S. Devi Leliana Sandra Devi Ade Putri Lisa Miftakhul Janna Lutfi Lailia Sofidiana Mayangsari, Zahra Muchamad Ziyad Afif Nihla Fitriyani Nur Lely Yaumil Qodriyati Perwitasuci, Brigitta Damai Prameswari, Syefira Putri Prihanti, Ayu Mahartini PUDJI ASTUTI Pujiana Endah Lestari Riclas Yusuf Punta Wibisono Rina Sutjiati Rina Sutjiatu Roedy Budirahardjo Rudi Joelijanto Rudy Joealijanto Saikha Adila Azzah Sholehah, Almaratus Sulistyani Sulistyani Swandari, Rindang Syahrani, Nafila Wulandari, Widya Nurfitriastuti Zahreni Hamzah