Juferdy Kurniawan
Divisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta

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Journal : The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

COVID-19 Related to Liver Impairment and Its Impact on Chronic Liver Disease Andri Sanityoso Sulaiman; Juferdy Kurniawan; Chyntia Olivia Maurine Jasirwan; Saut HH Nababan; Kemal F Calista; Cosmas Rinaldi A Lesmana; Irsan Hasan; Rino Alvani Gani; Baiq Kirana DN Mandasari
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 3 (2020): VOLUME 21, NUMBER 3, December 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.477 KB) | DOI: 10.24871/2132020220-225

Abstract

By late December 2019, a novel beta-coronavirus, named as COVID-19 (2019-nCoV), was discovered in Wuhan, Hubei Province, China which epidemiologically linked to a Huanan seafood market in Wuhan. Coronavirus Disease 2019 or COVID-19 cases are growing rapidly from Wuhan to many countries, finding the health care system unprepared to face this threat. No effective drugs are clinically approved to manage the disease and strategies to protect the most vulnerable from developing severe illness and infection is still unclear. Information on how COVID-19 virus infection may affects many organs, especially the liver and the relevance of pre-existing liver disease in patients as a risk factor for the infection or disease severity are still scarce and inconclusive. Besides, the recommendation and consideration in liver transplant patients, hepatocellular carcinoma, or patient on immunosuppressive therapy still need further analysis Therefore, the information on the mechanism and treatment of COVID-19 related liver injury in patients with or without pre-existing liver disease should be considered.
Spleen and Liver Stiffness as Noninvasive Predictors of Varices in HBV Cirrhosis Siahaan, Billy Stinggo; Kurniawan, Juferdy; Simadibrata, Marcellus; Rizka, Aulia; Sanityoso, Andri; Rumende, Cleopas Martin; Rachman, Andhika; Shatri, Hamzah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023137-142

Abstract

Background: Esophageal varices (EV) are the most frequent complication of portal hypertension in patients with liver cirrhosis. Due to many reasons, esophagogastroduodenoscopy remains impractical for routine surveillance in everyday practice. Hence, ongoing studies into reliable non-invasive test for predicting EV are still important.Methods: A total of 71 patients with liver cirrhosis due to hepatitis B who underwent endoscopy, spleen stiffness measurement (SSM), and liver stiffness measurement (LSM) between January and April 2023 were enrolled in this study. Diagnostic applicability was assessed using the area under the receiver-operator curve (AUC) to measure and compare the performance of each measurement and combination for predicting EV, as well as to obtain the corresponding optimal prediction value.Results: This study included 71 patients with liver cirrhosis. Among them, 74.6% (53 patients) were classified as Child-Pugh A, 22.5% (16 patients) as Child-Pugh B, and 2.8% (2 patients) as Child-Pugh C. The prevalence of esophageal varices (EV) within the cohort was 71.8%. This study showed that SSM with a cut-off of 38.8 kPa had AUC 0.867 (95% CI: 0.774–0.960) (sensitivity 78.4%, specificity 80%), and LSM with a cut-off of 10.55 kPa had AUC 0.822 (95% CI: 0.701–0.943) (sensitivity 88.2%, specificity 65%).Conclusion: Spleen and liver stiffness measurements demonstrate good performance in predicting EV in patients with liver cirrhosis caused by hepatitis B.
Liver Disease Associated with Inflammatory Bowel Disease Kurniawan, Juferdy; Budiman, Refael Alfa
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 1 (2024): VOLUME 25, NUMBER 1, April, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/251202471-75

Abstract

Inflammatory Bowel Disease (IBD) is a chronic condition characterized by persistent inflammation of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn’s disease (CD). While the current global incidence of IBD exceeds 0.3% in Western nations, Indonesia reports a comparatively lower prevalence however with projections indicate a potential rise in incidence from 2020 to 2050. Hepatobiliary manifestation is one of the most common extraintestinal manifestations of IBD. Some of the liver disease associated with IBD had similar background immune response, inflammatory reaction, similar risk factor, or due to the treatment of IBD. Primary sclerosing cholangitis (PSC) has close association with IBD and both affect the prognostic and disease progression of each other. Non-alcoholic fatty liver disease (NAFLD) shares common metabolic risk factors. Several drugs used as the treatment of IBD might cause hepatic injury especially due to the long treatment duration of IBD. Hepatitis B reactivation is another concerning event found after prolonged used of immunosuppressive drugs of IBD. Therefore, close monitoring of liver function test periodically is a mandatory test to screen liver disease in IBD patients.  Keyword: Inflammatory bowel disease, liver disease, autoimmune hepatitis, drug-induced liver injury
EUS-Guided Portal Pressure Gradient Measurement in Patients with Portal Hypertension: Evidence-Based Case Report Hidayat, Putra Nur; Kurniawan, Juferdy
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 3 (2022): VOLUME 23, NUMBER 3, December 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2332022253-257

Abstract

Aim: This evidence-based case report aims to assess the accuracy of EUS-PPG measurement in patients with portal hypertension.Method: A literature search was performed using PubMed, Cochrane, ProQuest, and EBSCO. A total of 2 articles were selected after meeting the inclusion and exclusion criteria. Critical study assessment was conducted to assess the validity, importance, and applicability of the study.Results: As a result, the first study found higher EUS-PPG measurement values in patients with clinical parameters of portal hypertension and the second study found a good correlation between EUS-PPG measurement values with hepatic vein pressure gradient (HVPG) and transjugular intrahepatic portosystemic shunt (TIPS) portal pressure gradient (PPG).Conclusion: From these two studies, it can be concluded that EUS-PPG measurement is a safe, effective, and feasible method to be performed on patients.
Co-Authors -, Gunawan - -, Gunawan - A, GM Yudi Prasetia Agnes Elsha Maria Simbolon Amin, Bany Faris Andhika Rachman Andri Sanityoso Andri Sanityoso Sulaiman Anggi Anggelina Permatasari Aprilicia, Gita Aravinda Pravita Ario Perbowo Putra Ario Perbowo Putra, Ario Perbowo Aulia Rizka, Aulia Baiq Kirana DN Mandasari Bany Faris Amin Budiman, Refael Alfa C Rinaldi A Lesmana Chairunisa, Shafira Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Cleopas Martin Rumende Dadang Makmun Dela Ryana Swaraghani Dewi ANGGRAENI Dewi Martalena Diana Sunardi E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Esthika Dewiasty, Esthika Felix Firyanto Widjaja Gita Aprilicia GM Yudi Prasetia A Gunawan - - Hanif, Muhammad Yusuf Hasan Maulahela, Hasan Ikhwan Rinaldi Imanuel Setiawan, Stefanus Irfan Kresnadi Irfan Kresnadi Irsan Hasan Jasirwan, Chyntia Olivia M Karenina, Vannessa Kemal F Calista Kemal Fariz Kalista Kemal Fariz Kalista Kemal Fariz Kalista, Kemal Fariz Kie Chen Kresna Adhiatma Kresnadi, Irfan Kuntjoro Harimurti Kurniyanto Kurniyanto Kurniyanto, Kurniyanto Leonard Nainggolan Lutfie Lutfie, Lutfie Marcellus Simadibrata Marcellus Simadibrata Muhammad Yusuf Hanif Nababan, Saut Horas H. Nadia Ayu Mulansari, Nadia Ayu Permatasari, Anggi Anggelina Prasetyadi, Yosafat Lambang Purwita Wijaya Laksmi Putra Nur Hidayat Putri, Trivani Rino Alvani Gani Rino Alvani Gani Rino Alvani Gani Rino Alvani Gani Rudy Hidayat Sakinah Rahma Sari Sari, Sakinah Rahma Saut HH Nababan Saut Horas Hatoguan Nababan Sepmeitutu, Iwandheny Shafira Chairunisa Siahaan, Billy Stinggo Simbolon, Agnes Elsha Maria Stefanus Imanuel Setiawan Swaraghani, Dela Ryana Syahrizal Syarif Tahir, Andi Cahaya Teguh Karyadi Teressa, Maria Trivani Putri Triyanta Yuli Pramana Vannessa Karenina Widayat Djoko Santoso Widayat Djoko Santoso, Widayat Djoko Yosafat Lambang Prasetyadi