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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Andri Sanityoso
Division of Gastroenterology, Department of Internal Medicine University of Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
Medicine & Pharmacology

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Spleen and Liver Stiffness as Noninvasive Predictors of Varices in HBV Cirrhosis Siahaan, Billy Stinggo; Kurniawan, Juferdy; Simadibrata, Marcellus; Rizka, Aulia; Sanityoso, Andri; Rumende, Cleopas Martin; Rachman, Andhika; Shatri, Hamzah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023137-142

Abstract

Background: Esophageal varices (EV) are the most frequent complication of portal hypertension in patients with liver cirrhosis. Due to many reasons, esophagogastroduodenoscopy remains impractical for routine surveillance in everyday practice. Hence, ongoing studies into reliable non-invasive test for predicting EV are still important.Methods: A total of 71 patients with liver cirrhosis due to hepatitis B who underwent endoscopy, spleen stiffness measurement (SSM), and liver stiffness measurement (LSM) between January and April 2023 were enrolled in this study. Diagnostic applicability was assessed using the area under the receiver-operator curve (AUC) to measure and compare the performance of each measurement and combination for predicting EV, as well as to obtain the corresponding optimal prediction value.Results: This study included 71 patients with liver cirrhosis. Among them, 74.6% (53 patients) were classified as Child-Pugh A, 22.5% (16 patients) as Child-Pugh B, and 2.8% (2 patients) as Child-Pugh C. The prevalence of esophageal varices (EV) within the cohort was 71.8%. This study showed that SSM with a cut-off of 38.8 kPa had AUC 0.867 (95% CI: 0.774–0.960) (sensitivity 78.4%, specificity 80%), and LSM with a cut-off of 10.55 kPa had AUC 0.822 (95% CI: 0.701–0.943) (sensitivity 88.2%, specificity 65%).Conclusion: Spleen and liver stiffness measurements demonstrate good performance in predicting EV in patients with liver cirrhosis caused by hepatitis B.
Co-Authors -, Darmadi Ali Sulaiman Andhika Rachman Ari Fahrial Syam Aulia Rizka, Aulia Bhanu S Kumar C Rinaldi A Lesmana Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Cleopas Martin Rumende Dadang Makmun Dwi Rahayu NL Praptiwi, Dwi Rahayu NL E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Eric Daniel Tenda FX Pridady Irsan Hasan Jeffry Beta Tenggara Juferdy Kurniawan Kemal Fariz Kalista, Kemal Fariz Laurentius Lesmana Lutfie Lutfie, Lutfie Marcellus Simadibrata Maulana Suryamin, Maulana Murdani Abdullah Nurul Akbar Ralph Girson Rino A Gani Rino Alvani Gani Siahaan, Billy Stinggo Siti Setiati Sjaifoellah Noer Soemarno Soemarno Velma Herwanto Wardhana, Agasjtya Wisjnu Wirasmi Marwoto