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All Journal Medula The Journal of The Indonesian Medical Students´ Association Jurnal Administrasi Bisnis Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Sains Farmasi dan Kesehatan JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Intan Kusumaningtyas
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Agriculture, Biological Sciences & Forestry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Review Article: Antibacterial Activity of Mangrove Lindur Extract (Bruguiera gymnorrhiza) Against Staphylococcus aureus Setyadi, Yudha Putra; Kurniawaty, Evi; Kusumaningtyas, Intan
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1300

Abstract

Infectious diseases remain prevalent in Indonesia, influenced by environmental factors such as poor sanitation, low public awareness of clean and healthy living behaviors, and a tropical climate. Infectious diseases are health issues caused by microorganisms, such as bacteria, viruses, or parasites, that enter the body. Staphylococcus aureus is one of the primary pathogens for humans and can cause various infections. The main treatment for Staphylococcus aureus infections is antibiotics. However, bacterial resistance to methicillin antibiotics (Methicillin-Resistant Staphylococcus aureus or MRSA) is increasingly common in Indonesia. Therefore, alternative antibiotic treatments based on plant-derived compounds are highly needed. One plant with potential antibacterial activity is Bruguiera gymnorrhiza. Commonly known as bakau lindur, various parts of Bruguiera gymnorrhiza, such as its bark, leaves, and roots, have antibacterial properties. This is attributed to the bioactive compounds present in its extracts, including flavonoids, saponins, alkaloids, phenols, steroids, terpenoids, and tannins.. This article aims to determine whether Bruguiera gymnorrhiza extract exhibits antibacterial activity against Staphylococcus aureus. Based on the literature review, Bruguiera gymnorrhiza extract has been proven to possess antibacterial activity against Staphylococcus aureus. The best antibacterial activity was observed in the 96% ethanol extract of Bruguiera gymnorrhiza bark at a concentration of 15,000 ppm, resulting in a 13.62 mm inhibition zone categorized as strong.
Potensi Daun Jambu Air (Syzygium aquem) sebagai Fitofarmaka : Literature Review Febrianti, Arlin; Susianti, Susianti; Kusumaningtyas, Intan; Mustofa, Syazili
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1456

Abstract

Traditional medicine widely utilizes plant extracts from various parts of plants due to their secondary metabolite content, which possesses therapeutic effects. One plant with high pharmacological potential is the water apple leaf (*Syzygium aqueum*), belonging to the Myrtaceae family and commonly found in tropical regions such as Indonesia, Malaysia, and India. Water apple leaves have been used as phytopharmaceuticals because they contain various bioactive compounds that can be extracted and utilized for treating different diseases. The active compounds commonly found in water apple leaves include alkaloids, flavonoids, steroids, triterpenoids, and coumarins. Studies have shown that water apple leaf extracts exhibit various pharmacological activities, including antibacterial, antioxidant, anti-inflammatory, anticancer, antimicrobial, and antidiabetic properties. Additionally, the bioactive compounds in water apple leaves have the potential to be further developed as natural therapeutic agents for treating degenerative diseases and infections. This pharmacological potential positions water apple leaves as a promising phytopharmaceutical candidate for development in the pharmaceutical and healthcare industries. However, further research is required to explore the mechanisms of action, efficacy, and potential toxicity of the active compounds in water apple leaves. A comprehensive study in this area will enable the optimization of water apple leaves as a safe and effective natural therapy for various diseases.
Co-Authors Andon Hestiantoro Ari Wahyuni Diana Mayasari Dyah Wulan Sumekar Rengganis Wardani Endah Setyaningrum, Endah Febrianti, Arlin Fitria Saftarina Happy, Terza Aflika Kurniawaty, Evi Maretta, Alvina Christy Maureen Angelica Moch Dzulkirom Muhammad Maulana Nadifa, Shallu Afdha Primasari Pertiwi Putri Rahma Azzahra Raharjo, Shafana Azzahra Rani Himayani Ruth Leria Noverika Salsabila, Karina Adra Septiani, Linda Setyadi, Yudha Putra Susianti, Susianti Sutarto Sutarto Syazili Mustofa TA Larasati Winda Trijayanthi Utama, Winda Trijayanthi Wiwi Febriani