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All Journal Medical Journal of Indonesia Jurnal Media Gizi Indonesia (MGI) The Indonesian Journal of Public Health The Indonesian Biomedical Journal Jurnal Health Sains JOURNAL LA MEDIHEALTICO Narra J Yuridika Asian Journal of Social and Humanities Folia Medica Indonesiana
Meity Ardiana
Departemen Kardiologi Dan Kedokteran Vaskuler Fakultas Kedokteran Universitas Airlangga/RSUD Dr. Soetomo, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Effects of digoxin in inhibiting ACE2 and SARS-CoV-2 binding for attenuating COVID-19 in human adipocytes Ardiana, Meity; Suryawan, I Gde Rurus; Hermawan, Hanestya Oky; Putri, Primasitha Maharani Harsoyo; Rahma, Safira
Medical Journal of Indonesia Vol. 33 No. 3 (2024): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247273

Abstract

BACKGROUND Angiotensin-converting enzyme 2 (ACE2) has a role in SARS-CoV-2 incidence, and digoxin is a competitive inhibitor of SARS-CoV-2-ACE2 binding. This study aimed to investigate the effects of digoxin on SARS-CoV-2-ACE2 binding, proinflammatory cytokines, and prothrombotic factors in adipocytes of patients with COVID-19. METHODS This in vitro study used adipocyte cultures, which were divided into negative control, positive control (SARS-CoV-2 S1 spike protein only), SARS-CoV-2 S1 spike protein with digoxin, and SARS-CoV-2 S1 spike protein with human recombinant soluble ACE2 (hrsACE2). Data were analyzed using one-way ANOVA and Pearson correlation. RESULTS SARS-CoV-2 significantly elevated ACE2 and increased interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), tissue factor (TF), and plasminogen activator inhibitor-1 (PAI-1) compared to the negative control group (p<0.001). No SARS-CoV-2-ACE2 binding was detected in SARS-CoV-2 with digoxin and hrsACE2 groups, compared to the positive control group (0 ng/ml versus 0 ng/ml versus 36.33 [1.58] ng/ml, p<0.001). Digoxin significantly decreased IL-6 (48.94 [1.80] ng/ml versus 90.93 [4.29] ng/ml; p<0.001), TNF-α (87.65 [6.88] ng/ml versus 307.95 [57.34] ng/ml; p<0.001), TF (5.33 [0.32] ng/ml versus 6.85 [0.22] ng/ml; p<0.001), and PAI-1 levels (2.92 [0.168] ng/ml versus 4.86 [0.11] ng/ml; p<0.001), compared to positive control group. ACE2 positively correlated with IL-6 (p = 0.004, r = 0.763) and TF (p = 0.004, r = 0.768) but was not correlated with IL-1β, TNF-α, and PAI-1 levels. CONCLUSIONS This study promoted digoxin therapy to prevent cytokine storm and thromboembolism by decreasing IL-6, TNF-α, TF, and PAI-1 in adipocyte cultured models at an early stage of COVID-19.
Relationship Between Central Obesity and The Risk of Hypertension in Obesity Adolescents Ardina Maharani, Putri; Widjaja, Nur Aisiyah; Ardiana, Meity; Hanindita, Meta Herdiana
Asian Journal of Social and Humanities Vol. 2 No. 03 (2023): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i03.199

Abstract

The increasing prevalence of central obesity in adolescents is accompanied by an increase in risk factors for cardiovascular disease. The study aims to analyze the relationship between central obesity and the risk of hypertension in obese adolescents, including both male and female subjects. This study was undertaken to provide opportunities for further exploration of the relationship between central obesity and hypertension in adolescents. The study was a retrospective observational study that utilized medical record data from a previous research project entitled "Polimorfisme Gen Adiponectin ADIPOQ +45 T>G, ADIPOQ – 11377 C>G dengan Kadar Adiponektin Pada Remaja Obesitas dan Resiko Sindrom Metabolik." This data was obtained from research conducted on obese adolescents aged 13-18 years in junior and senior high schools in Surabaya and Sidoarjo who met the criteria. The sample comprised 140 obese adolescents, who were then categorized into two groups: those without central obesity and those with central obesity. Statistical data were analyzed using SPSS with the Chi Square test. There is a very strong and significant relationship between central obesity and the risk of hypertension in obese adolescents (p = 0.000; r = 0.373); central obesity and the risk of hypertension in obese male adolescents (p = 0.001; r = 0.587); and central obesity and the risk of hypertension in obese female adolescents (p = 0.003; r = 0.300). The study found a significant relationship between central obesity and hypertension risk in obese adolescents. Adolescents with central obesity were 3.6 times more likely to develop hypertension than those without. Male adolescents with central obesity were 6.5 times more likely to develop hypertension than those without. Female adolescents with central obesity were 2.9 times more likely to develop hypertension
Dyslipidemia And Hypertension Among Indonesian Hajj Pilgrims: A Cross-Sectional Study Ardiana, Meity; Nirwana, Wira
Jurnal Health Sains Vol. 5 No. 8 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i8.1344

Abstract

There has been an increase in the preval_ence of cardiovascular disease in Indonesia due to an increased preval_ence of hypertension. Cardiovascular disease is the primary cause of morbidity and mortality among Indonesian Hajj pilgrims. Dyslipidemia and hypertension are positively correlated, with dyslipidemia potentially contributing to hypertension through the mechanism of atherosclerosis. The primary objective of this study is to identify the association between hypertension and dyslipidemia among Indonesian hajj pilgrims. A cross-sectional study involving 114,069 participants in total. The Indonesian Hajj pilgrims in 2023 were the research population. Pre-embarkation medical exams were performed by qualified healthcare professionals, and data were taken from Hajj medical service records. Using bivariate analysis and the Chi-Square (χ2) test, the proportions of age and gender were compared between the hypertension and non-hypertension groups. The relationship between triglyceride, HDL, and LDL levels and hypertension was determined through logistic regression analysis. Logistic regression analysis was used to provide a multivariate analysis of the relationship between dyslipidemia and hypertension. The hypertension group has an average age of 60.2 + 11.6 years old (p<0.0001). There was no difference in the effect of gender on hypertension (p=0.105). HDL, LDL, and Triglyceride serum levels significantly affected the preval_ence of hypertension (p<0.0001). Dyslipidemia was a risk factor for hypertension with an OR of 1.084 (1.057-1.112) (95% CI). Dyslipidemia is a risk factor for hypertension. Serum levels of HDL, LDL, and triglycerides affect blood pressure.
FACTORS ASSOCIATED WITH MEDICATION ADHERENCE AND SYSTOLIC AND DIASTOLIC BLOOD PRESSURE OF HYPERTENSIVE PATIENTS Ziddan, Hamka; Ardiana, Meity; Dewanti, Linda; Ratri, Anudya Kartika
Folia Medica Indonesiana Vol. 61, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Uncontrolled hypertension can cause complications such as heart disease, brain disease, kidney disease, and other diseases. Medication adherence is a primary factor in controlling blood pressure (BP) in hypertensive patients. This study aims to provide an overview of the factors associated with medication adherence of hypertensive patients treated at Taman Public Health Center in Sidoarjo, Indonesia. This study used a cross-sectional approach involving hypertensive patients. This study employed consecutive sampling, with the number of samples comprised of patients undergoing outpatient care from January 2, 2023, to February 25, 2023, totaling 103 respondents. The study employed the Morisky Medication Adherence Scale 8-item (MMAS-8) questionnaire to evaluate medication adherence. Fifty-nine (57.3%) patients had poor adherence, and 83 (80.6%) patients had poor BP control. The significant factors associated with medication adherence were employment status (p = 0.021), drug regimen and prescription refill time (p = 0.001), and experiencing forgetfulness/negligence related to their medication (p = 0.011). Significant factors associated with systolic and diastolic BP are having health insurance (p = 0.030 and p = 0.006) and drug regimen-prescription refill time (p = 0.029 and p = 0.041). These factors can be used as considerations during policymaking to improve medication adherence and BP control of hypertensive patients.
Mortality among Heart Failure Patients in the Presence of Cachexia , Andrianto; Karman, Ula Nur Pramesti; Mudjanarko, Sony Wibisono; Ardiana, Meity; Hermawan, Hanestya Oky
Folia Medica Indonesiana Vol. 59, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • Around 38.8% of heart failure patients with cachexia died during the 180-1,876-day follow-up period. • Cachexia increases the risk of mortality in heart failure patients. Abstract: Despite the fact that obesity has long been recognized as a risk factor for cardiovascular disease, the mortality rate of heart failure (HF) patients with cachexia is still high. Several studies have been conducted to investigate the association between cachexia and mortality in HF patients. However, the research results vary, as do the diagnostic criteria employed to assess cachexia. This meta-analysis aimed to conclusively summarize the association between cachexia and mortality in HF patients. The data were obtained from prospective or retrospective cohort studies with full texts in English or Indonesian and keywords related to "cachexia," "heart failure," and/ or "mortality". Studies that did not assess mortality in HF patients with cachexia and had no full text accessible were omitted. A literature search was conducted through four databases (PubMed, Web of Science, Scopus, and SAGE Journals) using keywords, reference searches, and/ or other methods on April 2022 in accordance with the Preferred Reported Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data from the selected studies were presented and analyzed using qualitative and quantitative synthesis methods. The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias in the selected cohort studies. The qualitative synthesis contained nine studies, whereas the quantitative synthesis (meta-analysis) included six studies. Cachexia was found in 16.0% of the 4,697 patients studied. During the 180-1,876-day follow-up period, 33.0% of the patients died, with a mortality rate of 38.8% among the patients with cachexia. The pooled analysis revealed cachexia to be a significant predictor of mortality in HF patients (hazard ratio (HR)=3.84; 95% CI=2.28-6.45; p<0.00001), but with significant heterogeneity (p<0.00001; I2=88%). In conclusion, cachexia worsens HF prognosis.
Association Between Body Mass Index, Visceral Fat, and the Risk of Metabolic Syndrome Among Obese Adolescents in Indonesia Indriati, Ataillah Azizah; Widjaja, Nur Aisiyah; Ardiana, Meity; Hanindita, Meta Herdiana
Journal La Medihealtico Vol. 6 No. 6 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i6.2831

Abstract

This study examined the association between Body Mass Index (BMI) and visceral fat with the risk of Metabolic Syndrome (MetS) among obese adolescents in Surabaya and Sidoarjo, Indonesia. The research addressed the increasing burden of cardiometabolic disorders in adolescents, focusing on the importance of early screening for central adiposity. A cross- sectional design was employed involving 72 obese adolescents from junior and senior high schools. BMI was measured using standard anthropometry, while visceral fat was assessed through Waist Circumference (WC)and Bioelectrical Impedance Analysis (BIA). MetS was identified based on established clinical criteria. The findings revealed that both BMI and visceral fat were significantly associated with MetS, with BIA-derived visceral fat demonstrating the strongest predictive value. Adolescents with high visceral fat exhibited substantially higher risks of dyslipidemia, hypertension, and overall metabolic abnormalities. These results highlight the limitations of BMI as a standalone indicator and reinforce the need for integrating visceral fat assessment in school-based screening programs. Early identification and targeted interventions are essential to mitigate the progression of MetS during adolescence.
Co-Authors , ANDRIANTO Adriano Anandita, Faizal A. Andrianto Anna Surgean Veterini Annis Catur Adi Ardina Maharani, Putri Enny Susanti Hanestya Oky Hermawan Hanestya Oky Hermawan Hanestya Oky Hermawan, Hanestya Oky Hanindita, Meta Herdiana Harits, Muhammad Harsono, Primasitha M. Harsoyo, Primasitha M. Heni Rachmawati Hermawan, Hanestya O. Indriati, Ataillah Azizah Karman, Ula Nur Pramesti Kurniadi Doni Linda Dewanti Muhammad Rafli Nirwana, Wira Nur Aisiyah Widjaja, Nur Aisiyah Primasitha Maharany Harsoyo Putri Ardina Maharani Putri, Primasitha Maharani Harsoyo Rahma, Safira Ratri, Anudya Kartika Rendi Aji Prihaningtyas Roedi Irawan Shafira, Aisya A. Sony Wibisono Suryawan, I Gde Rurus Suryawan, I GR. Ula Nur Pramesti Karman Yeni Purnamasari, Yeni Yulianto Yulianto Ziddan, Hamka