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All Journal e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK Bali Journal of Anesthesiology Medical Scope Journal (MSJ) Jurnal Neuroanestesi Indonesia Journal of Comprehensive Science
Diana Lalenoh
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : JURNAL BIOMEDIK

 1 
MULA KERJA ROKURONIUM Tompodung, Sadrakh; Tambajong, Harold F.; Lalenoh, Diana
JURNAL BIOMEDIK : JBM Vol 5, No 1 (2013): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.5.1.2013.2636

Abstract

Abstract: Endotracheal intubation needs a muscle relaxant to permit the pipe to get easily into the trachea. Injury of the respiratory tract during this procedure can be avoided by being cognizant of the onsets of action of certain muscle relaxants. Rocuronium is a non-depolarization muscle relaxant with intermediate duration of action and fewer side effects. This study aimed to find out the onset of action of rocuronium. This was an observational study conducted in the operation rooms of Prof. Dr. R.D. Kandou Hospital from November 2012 to January 2013. Samples were patients with ASA 1-2, aged 18 40 years who had been selected by using simple random sampling methods. Midazolam 0,7 mg/kg BW and fentanyl 2 µg/kg BW were used as premedication agents; propofol 2 mg/kg BW as an anaesthetic induction agent; and rocuronium 0,6 mg/kg BW as the muscle relaxant. The rocuronium?s onset of action was measured by using TOF-Watch after the injection of rocuronium until the percentage of muscle relaxation was 0. The results showed that the onset of action in 17 samples (14 females and 3 males) was 151 seconds. The onset of action in females was 65 seconds shorter than in males. A correlation test (P = 0.857) and the chi-square test (P = 0.434) showed no significant correlation between age and the onset of action. There was a significant difference (P < 0.05) between the onset of action and sex showed by the t-test (P = 0.023) and the chi-square test (P = 0.035). Conclusion: The average onset of action of rocuronium was 2 minutes and 31 seconds, with  females having a shorter onset of action of rocuronium. Keywords: onset of action, rocuronium.     Abstrak: Pemasangan pipa trakea memerlukan obat pelumpuh otot untuk memudahkan pipa ini masuk ke saluran napas. Cedera saluran napas akibat pemasangan pipa trakea dapat dihindari dengan mengetahui mula kerja (onset of action) dari obat pelumpuh otot. Rokuronium merupakan obat pelumpuh otot jenis non-depolarisasi dengan lama kerja sedang tanpa efek samping bagi tubuh. Penelitian ini bertujuan untuk mengetahui mula kerja rokuronium dan dilakukan di ruang operasi Rumah Sakit Prof Dr. R.D. Kandou Manado sejak bulan Nopember 2012 hingga Januari 2013. Sampel ialah pasien dengan ASA 1-2, berusia 18-40 tahun, yang dipilih secara simple random sampling. Pasien dipremedikasi dengan midazolam 0,7 mg/kg BB dan fentanil 2 µg/kg BB, diinduksi dengan propofol 2 mg/kg BB dan kemudian diberikan rokuronium 0,6 mg/kg BB secara intra vena. Mula kerja rokuronium diukur antara selesai penyuntikan hingga persentase kelumpuhan otot pada TOF-watch mencapai 0. Hasil penelitian memperlihatkan pada 17 sampel (14 orang perempuan dan 3 orang laki-laki), rerata mula kerja rokuronium 151 detik. Mula kerja rokuronium pada perempuan 65 detik lebih singkat daripada laki-laki. Hasil uji korelasi (P = 0,857) dan uji chi-square (P = 0,434) memperlihatkan tidak terdapat korelasi bermakna antara usia dan mula kerja rokuronium. Terdapat perbedaan bermakna (P < 0,05) antara mula kerja rokuronium dan jenis kelamin yang ditunjukkan dengan uji t (P = 0,023) dan uji chi-square (P = 0,035). Simpulan: Rerata mula kerja rokuronium dengan dosis 0,6 mg/kg BB untuk kedua jenis kelamin 2 menit 31 detik. Perempuan mempunyai mula kerja rokuronium lebih singkat daripada laki-laki. Kata kunci: mula kerja, rokuronium.
PENANGANAN PERIOPERATIF PADA ASMA Suhartono, Christina; Tambajong, Harold F; Lalenoh, Diana Ch.
Jurnal Biomedik : JBM Vol 5, No 1 (2013): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.5.1.2013.2039

Abstract

Abstract: The management of a patient with asthma during surgery requires a special treatment based on thorough clinical and laboratory examinations to reduce complications during surgery and the post-operative state. Asthma is characterized by a difficulty in breathing due to spastic contractions of bronchiolar smooth muscles, which partially block the bronchioles’ airways. The evaluation of asthma patients before anesthesia and surgical procedures is essential to prevent or control the occurence of asthma attacks during intra-operation and post-operation. Patients with histories of chronic asthma or frequent exacerbations of asthma have to be treated to achieve an optimal condition or a condition in which asthma symptoms are minimal. Patients with frequent bronchospasms should be treated. The selection of drugs and anesthetic procedures should be considered meticulously to avoid a stimulation of  bronchospasm or an asthma attack. Keywords: asthma, perioperative management, patient.   Abstrak: Pengelolaan pasien dengan penyakit asma selama pembedahan membutuhkan penanganan khusus berdasarkan pemeriksaan klinis dan laboratorium yang saksama untuk mengurangi komplikasi selama dan pasca pembedahan. Asma adalah kesukaran bernapas yang ditandai dengan kontraksi spastik otot polos bronkiolus, yang menyumbat bronkiolus secara parsial. Evaluasi pasien asma sebelum tindakan anestesia dan pembedahan sangat penting untuk mencegah atau mengendalikan kejadian serangan asma, baik selama pembedahan maupun pasca pembedahan. Pasien dengan riwayat asma berulang atau kronis memerlukan pengobatan hingga tercapai kondisi yang optimal untuk dilakukan operasi atau kondisi dimana gejala-gejala asma sudah minimal. Pasien dengan  bronkospasme berulang harus diobati terlebih dahulu. Pemilihan obat-obatan dan tindakan anestesia perlu dipertimbangkan dengan cermat untuk menghindari terjadinya bronkospasme atau serangan asma. Kata kunci: asma, penanganan perioperatif, pasien.
Tatalaksana Acute Respiratory Distress Syndrome Pada Pasien Dewasa Dengan Steroid Masikome, Jessica N.; Laihad, Mordekhai L.; Lalenoh, Diana C.
JURNAL BIOMEDIK : JBM Vol 13, No 1 (2021): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.13.1.2021.31797

Abstract

Abstract: Acute Respiratory Distress Syndrome (ARDS) is a non-cardiogenic pulmonary edema caused by several risk factors and is an emergency case. ARDS characterized by acute intervals, alveolar edema, acute hypoxemia, decreased pulmonary compliance and multi-organ dysfunction or decreased organ function. ARDS often treated in an intensive care unit along with underlying factors. Although many medical treatments ineffective in treating ARDS, corticosteroids can reduce fluid in the alveolar capillaries and the attachment of neutrophils to endothelial capillaries. Aim of this study was to look at indicators of ARDS with steroids looking at the mortality rate, ventilator-free days, and length of stay for ARDS with steroids. Search data using three databases, namely Pubmed, Sciencedirect, Google Scholar. Ten literatures met the inclusion and exclusion criteria. Consisted of one retrospective observational study, one analytical retrospective study, three randomized control trials and five cohort studies. Total sample in 10 literatures was 1633 people for the steroid therapy group and 1303 for the control group. Result of a literature review study showed that steroids had less impact on reducing mortality in ARDS patients, steroids had an effect on increasing the number of ventilator-free days and steroids did not have an impact on increasing length of stay.Keywords: Acute Respiratory Distress Syndrome, Steroid Abstrak: Acute Respiratory Distress Syndrome (ARDS) merupakan edema pulmoner non-kardiogenik yang disebabkan beberapa faktor risiko dan merupakan kasus kegawatdaruratan. Karakteristik ARDS terjadi dalam selang waktu pendek atau akut, edema alveolar, hipoksemia akut, penurunan komplians paru serta multiple organ disfunction atau penurunan fungsi organ. ARDS sering dirawat dalam ruang rawat intensif beserta faktor-faktor yang mendasari. Meskipun banyak sekali pengobatan medikamentosa yang tidak efektif dalam pengobatan ARDS, namun kortikosteroid mampu mengurangi tembusnya cairan pada membran kapiler alveolar dan perlekatan neutrofil pada kapiler endotel. Tujuan dari studi ini adalah mengetahui tatalaksana ARDS dengan steroid dengan melihat angka mortalitas, ventilator free days, dan length of stay dari tatalaksana ARDS dengan steroid. Pencarian data menggunakan tiga database yaitu Pubmed, Sciencedirect, Google Scholar. Sepuluh literature yang memenuhi kriteria inklusi dan eksklusi. Terdiri dari satu penelitian retrospective observational, satu penelitian retrospective analysis, tiga penelitian randomized control trial dan lima penelitian cohort study. Jumlah sampel penelitian pada 10 literature tersebut adalah 1633 orang untuk grup terapi steroid dan 1303 untuk grup kontrol. Hasil penelitian literature review menunjukkan steroid kurang memberi dampak dalam mengurangi angka mortalitas pada pasien ARDS, steroid memberi dampak dalam peningkatan angka ventilator free days dan steroid tidak memiliki dampak yang bermakna pada peningkatan length of stay.Kata Kunci: Acute Respiratory Distress Syndrome, Steroid.
Co-Authors Bambang Suryono, Bambang Bongakaraeng, Tika Yudiyani Christina Suhartono Dewi Yulianti Bisri Fendiputra, Melvin Firdaus, Riyadh Firdaus, Riyadh Galuh R. Mufti, Galuh R. Harold F Tambajong Harold F. Tambajong Harold Tambajong Ibrahim, Rian Ida Bagus Krisna Jaya Sutawan Iddo Posangi Kambey, Barry I. Kiki Ekawati Kowel, Feysira C. E. P. Laihad, Mordekhai L. Lalenoh, Hermanus Laritmas, Sintikhe C. Y. Leopold Laihad, Mordekhai Louisandrina Saranti, Muifa Lucky Kumaat Lucky T. Kumaat Maria Estefina Siwi, Maria Estefina Marsela J. A. Berhimpong Masikome, Jessica N. Mordekhai L. Laihad Mordekhai Leopold Laihad Muhammad Gufran Ni Wayan Ira L. Dewi Nur Fadhliyah Asimin, Nur Fadhliyah Patty, Vania Nita Permatasari, Endah Poluan, Timothy M. Rawis, Daniel Rawis, Maria L. Raynaldo E. D. Togas Rehatta, Nancy Margareta Rheza N. Tambajong, Rheza N. Rosiana Lamerkabel Sadrakh Tompodung Saleh, Siti Chasnak Sri Rahardjo Subekti, Bambang Eko Subekti, Bambang Eko Sudjito, M. H Tanambel, Popi Tanio, Pratiwi N. Taroreh, Reinhard C. Tatang Bisri Thambas, Anastasia T. Tia, Herry Y. Tifany Tewuh Tori Sepriwan, Tori Triyatna R. A. Tampubolon Wonggo, Tesalonika Wuisan, Debby D.