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All Journal Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Jurnal Kedokteran Diponegoro Mutiara Medika: Jurnal Kedokteran dan Kesehatan JURNAL NASIONAL TEKNIK ELEKTRO The Indonesian Biomedical Journal Biomedical Journal of Indonesia Bioma : Jurnal Biologi Indonesia AgriHealth: Journal of Agri-food, Nutrition and Public Health Jurnal Kesehatan Tambusai Jurnal Kedokteran Raflesia Indonesian Journal of Multidisciplinary Science Dikdimas : Jurnal Pengabdian Kepada Masyarakat Bencoolen Journal of Pharmacy
Nikki Aldi Massardi
Universitas Bengkulu
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences

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PENGARUH USIA DAN JENIS KELAMIN TERHADAP KADAR IGG DAN KEJADIAN COVID-19 PASCAVAKSINASI PADA TENAGAESEHATAN KOTA BENGKULU Putri Syifa Nabilah; Utari Hartati Suryani; Nikki Aldi Massardi; Debie Rizqoh; Riry Ambarsarie
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.24902

Abstract

Variabilitas respons antibodi terhadap vaksinasi COVID-19 dipengaruhi oleh faktor-faktor seperti usia dan jenis kelamin. Penelitian ini bertujuan untuk mengkaji dampak usia dan jenis kelamin terhadap kadar IgG serta kejadian COVID-19 pascavaksinasi. Dengan memperoleh pemahaman mendalam tentang hubungan ini, diharapkan dapat ditingkatkan strategi vaksinasi yang lebih efektif dan efisien bagi berbagai kelompok populasi. Penelitian ini adalah penelitian cross-sectional yang dilakukan selama periode Juli hingga Desember 2021, melibatkan partisipasi 60 tenaga kesehatan dari Rumah Sakit Harapan dan Doa (RSHD) di Kota Bengkulu. Data primer dikumpulkan dari responden ini dalam rangka mengidentifikasi hubungan antara usia, jenis kelamin, dan respons antibodi terhadap vaksinasi COVID-19. Pengambilan data kadar antibodi IgG dilakukan dengan teknik CMIA, sementara data usia, jenis kelamin, dan kejadian COVID-19 pascavaksinasi melalui kuesioner. Metode statistik yang diterapkan dalam penelitian ini mencakup serangkaian uji, seperti uji Kruskal-Wallis, uji Mann-Whitney, dan uji Chi-Square. Temuan penelitian menegaskan bahwa kelompok usia 40-55 tahun dan perempuan memiliki kadar IgG yang lebih tinggi, sedangkan proporsi kejadian COVID-19 pascavaksinasi lebih tinggi pada kelompok usia 20-29 tahun dan laki-laki. Hal ini menunjukkan pengaruh signifikan dari usia dan jenis kelamin terhadap respons antibodi dan kejadian COVID-19 pascavaksinasi. Kesimpulan ini memberikan wawasan penting bagi strategi vaksinasi yang lebih efektif dan cermat bagi berbagai kelompok populasi.
Spatial Distribution of COVID-19 Related to the Potential for Spreading Outbreaks and Vulnerability of a Region in Bengkulu Province on 2020 Naurah Shafa Putri Cahyangi; Dessy Triana; Liya Agustin Umar; Nikki Aldi Massardi; Utari Hartati Suryani; Riry Ambarsari
BENCOOLEN JOURNAL OF PHARMACY Vol. 2 No. 2 (2022): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v2i2.24359

Abstract

Coronavirus disease 2019 (COVID-19) was declared a pandemic on March 11, 2020, by the World Health Organization (WHO). The spread of COVID-19 increases with different conditions and situations in each region. Spatial distribution plays a role in identifying the vulnerability of an area. This study aimed to determine the differences in COVID-19 cases from one area to another in 10 regions in Bengkulu Province in 2020. This study is a descriptive study with an observational study through a cross-sectional approach using an epidemiological investigation form as a data source. Sampling was carried out from July to December 2020 and obtained from 3044 respondents who met the inclusion criteria. The total sampling technique did sampling. The relationship between the population density of an area and the severity of COVID-19 cases was statistically analyzed using the Spearman rank test. The results showed that areas with higher density levels, such as Bengkulu City, caused a wider spread of cases, causing the number of COVID-19 cases to increase compared to other areas with lower population densities in Bengkulu Province. There is no significant relationship between population density and the severity of COVID-19
The Correlation Between Adult Age Factors toward The Clinical Manifestation and The Severity Level of COVID-19 in Bengkulu Province in 2020 Begumratu VOCA; Dia Triyani Putri; Dessy Triana; Riry Ambarsari; Nikki Aldi Massardi; Utari Hartati Suryani
BENCOOLEN JOURNAL OF PHARMACY Vol. 2 No. 2 (2022): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v2i2.24362

Abstract

Coronavirus Disease-19 (COVID-19) is an acute respiratory disease in Wuhan, China, and was discovered discovered in 2019. The things that need to be considered in COVID-19 patients include their clinical manifestation and the severity level of COVID-19. The severity level of COVID-19 patients is associated with age. Each age has a different proportion of severity. The study aimed to determine the correlations among adult age with clinical manifestation and severity of COVID-19 in Bengkulu Province 2020. This study used an observational analytic study. The sample was 108 patients 19 - ≥65 years old and confirmed positive for COVID-19 in 2020. The assessment used the epidemiological investigation form and medical record from Dr. M.Yunus Hospital. At the same time, the severity level of COVID-19 was obtained from the measurement based on the COVID-19 Prevention and Control Guidelines by the Indonesian Ministry of Health. The results showed that the subjects in 19 – 23 years old mostly have asymptomatic severity, 24 – 64 years old mostly have mild severity, and ≥65 years old have moderate severity. It was concluded that there was a significant correlation between the severity of COVID-19 in Bengkulu Province in 2020.
Pengaruh pemberian teh hitam (camellia sinensis) terhadap gambaran histopatologi gaster tikus putih (Rattus norvegicus) jantan Sprague dawley yang diinduksi minyak jelantah Akbar, Novrian; Sari, Kartika; Massardi, Nikki Aldi
JURNAL KEDOKTERAN RAFLESIA Vol. 7 No. 2 (2021)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v7i2.19031

Abstract

Latar Belakang: Minyak jelantah atau minyak goreng bekas adalah minyak yang digunakan secara berulang tanpa penambahan minyak goreng baru. Pemakaian minyak berulang kali dapat merusak struktur kimia dan menghasilkan radikal bebas. Hasil dari proses tersebut adalah senyawa toksik seperti hidroperoksida. Teh mengandung enam kelompok bioflavanoid catechins, theaflavins, the arubigins, oxyaromatic acids, flavonols, flavones, dan derivac gallic acid yang dapat menghambat radikal bebas, melindungi organ dari stress oksidatif. Teh hitam selain mengandung katekin juga mengandung theaflavin dan thearubigin sebagai hasil dari proses oksidasi enzimatik yang lebih tinggi dibandingkan dengan teh hijau. Metode: Penelitian ini menggunakan metode penelitian eksperimental post test only control grup design dengan menggunakan 24 tikus Sprague dawley jantan dibagi dalam 6 kelompok secara acak dan diberi perlakuan selama 7  minggu. K0 (control) (diberi aquadest), K1 (diberi  minyak jelantah 12 kali penggorengan  1,5 ml/hari, 1 jam kemudian diberi aquadest), K2 (diberi infusa teh hitam dengan dosis 0,50 gr/200grBB), K3 ( diberi infusa teh hitam dengan dosis 0,75 gr/200grBB), K4(diberi minyak jelantah 12 kali penggorengan  1,5 ml 1 jam kemudian diberi infusa teh hitam dengan dosis 0,50 gr/200grBB) K5 (diberi minyak jelantah 12 kali penggorengan  1,5 ml 1 jam kemudian diberi infusa teh hitam dengan dosis 0,75 gr/200grBB), setiap hari selama 6 minggu. Pada akhir penelitian tikus dilakukan terminasi dan diambil lambungnya untuk pembuatan preparat histopatologi dengan pewarnaan Hematoksilin Eosin. Data dianalisis dengan uji Kruskal-Wallis dan uji Post Hoc Mann-Whitney. Hasil: Hasil uji Kruskal-Wallis diperoleh nilai p=0,063, yang artinya tidak terdapat perbedaan bermakna dari skor histopatologi antar kelompok. Hasil uji Post Hoc Mann-Whitney menunjukkan tidak terdapat perbedaan bermakna K0 terhadap K1 yang berarti pemberian minyak jelantah 12 kali pemanasan tidak merusak  gambaran histopatologi lambung ditinjau secara statistik. Perbandingan antara K0 dengan K2 dan K3 tidak terdapat perbedaan bermakna yang artinya dosis yan diberikan tidak merusak gambaran histopatologi lambung. Perbandingan antara K0 dengan K4 dan K5 menunjukkan tidak terdapat perbedaan bermakna yang artinya pemberian infusa teh hitam (Camellia sinensis) dosis 0,50 gr/200 grBB dan dosis 0,75 gr/200 grBB tidak terjadi perbaikan terhadap kerusakan gaster tikus putih. Kesimpulan: Penelitian membuktikan bahwa Induksi minyak jelantah dengan 12x pemanasan berulang tidak menyebabkan kerusakan pada gaster tikus Rattus norvegicus dan pemberian infusa teh hitam (Camellia sinensis) dosis 0,50 gr/200 grBB dan dosis 0,75 gr/200 grBB tidak terjadi perbaikan terhadap kerusakan gaster tikus putih.
HUBUNGAN EKSPRESI miRNA-21 DENGAN TARGET PDCD4 DAN miRNA-143 DENGAN TARGET BLC-2 PADA KASUS KANKER SERVIKS Nikki Aldi Massardi; Soemanadi; Beti Ernawati Dewi; Dewi Wulandari; Eduardus Gilang Putra
Bioma Vol. 19 No. 1 (2023): Bioma
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/Bioma19(1).6

Abstract

A study has been carried out to compare the expression of miRNA-21 and miRNA-143 with target mRNA PDCD4 and BCL-2 in cases of early-stage cervical cancer compared to advanced stages. These data can be used as information for the development of non-invasive cervical cancer prognostic methods. The study was conducted by taking serum samples and exfoliativecell samples from normal subjects and subjects with cervical cancer detection and then analyzed using qRT-PCR. Samples of cervical cancer patients consisting of 15 subjects and 4 normal subjects were used to obtain relative quantity values for the expression of miRNA-21, miRNA-143, mRNA PDCD4 and BCL-2. In the study of miRNA-21, there was no significant difference in determining cervical cancer with p>0.05 using the t-test (0.594) and a significant relationship was found between miRNA 21 and PDCD4 with a strong correlation (p<0.05, r = -0.563; Pearson). The relationship between miRNA-143 and the Bcl-2 target gene in this study showed a weak and insignificant correlation (r = -0.101; p > 0.05; Pearson). There was a significant relationship between miRNA-21 and PDCD4 in early-stage and advanced-stage samples, while the relationship between miRNA-143 and the Bcl-2 mRNA target gene showed no significant correlation.
Differences in Before and After Temephos Intervention in Bengkulu City: Larvae Free Rate of Aedes spp. Gunasari, Lala Foresta Valentine; Destilyana, Rizqita; Massardi, Nikki Aldi; Triana, Dessy
Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Vol 22, No 1 (2025): March 2025
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/presipitasi.v22i1.157-167

Abstract

One of the strategies to reduce dengue transmission is to control the population of vectors, such as larval eradication. The use of temephos larvicide (Abate®) is the most widely carried out in the community. An indicator of the success of the larval eradication program is the Larvae Free Rate (LFR) assessment. This study aimed to determine the difference between LFR of Aedes spp. before and after temephos intervention in Bengkulu City. This study is experimental research with one group pre-test and post-test design. The population of this study was all houses in Bengkulu City with a total sample of 670 houses. Sampling was carried out using cluster random sampling techniques in 67 urban villages in Bengkulu City. This research was carried out by conducting a survey of larvae before and after temephos intervention in containers. Sixty-seven urban-villages, in 44 (65,67%) urban-villages was found an increase of LFR after temephos intervention. The average LFR before temephos intervention was 67.61%, while after temephos intervention increased to 82.98%, there was a significant difference between LFR of Aedes spp. before and after temephos intervention in Bengkulu City (p=0.001). Temephos intervention is effective to increase LFR of Aedes spp. in Bengkulu City.
Co-Authors Afriyastuti Herawati Agustian, Indra Ahmad Azmi Nasution Akbar, Novrian Albbi, M. Alvi Jalilul Hakim Azella Chika Fauzia Begumratu Voca Begumratu VOCA Beti Ernawati Dewi Debie Rizqoh Dessy Triana Dessy Triana Dessy Triana Dessy Triana Destilyana, Rizqita Dewi Wulandari Dewi Wulandari Dia Triyani Putri Dia Triyani Putri Eduardus Gilang Putra Ellen Maidia Djatmiko Elvira Yunita Enny Nugrahaeni Enny Nugrahaeni Fitrilina Fitrilina Fitrilina, Fitrilina Gunasari, Lala Foresta Valentine Herawati, Afriyastuti Indra Agustian Jayawarsa, A.A. Ketut Jusup Endang Kartika Sari Liya Agustin Umar M. Albbi Mardhatillah Sariyanti Mardhatillah Sariyanti Mardhatillah Sariyanti Mulya Sundari Mulya Sundari Nabila Putri Firdalina Naurah Shafa Putri Cahyangi Noor Diah Erlinawati Novita Arifani Putra, Eduardus Gilang Putri Syifa Nabilah Riry Ambarsari Riry Ambarsarie Riry Ambarsarie Soemanadi Soemanadi Sylvia Rianissa Putri Tiara Ayoe Andita Utari Hartati Suryani Zayadi Zainuddin