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All Journal Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Jurnal Kedokteran Diponegoro Mutiara Medika: Jurnal Kedokteran dan Kesehatan JURNAL NASIONAL TEKNIK ELEKTRO The Indonesian Biomedical Journal Biomedical Journal of Indonesia Bioma : Jurnal Biologi Indonesia SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL AgriHealth: Journal of Agri-food, Nutrition and Public Health Jurnal Kesehatan Tambusai Indonesian Journal of Multidisciplinary Science Dikdimas : Jurnal Pengabdian Kepada Masyarakat Bencoolen Journal of Pharmacy
Nikki Aldi Massardi
Universitas Bengkulu
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences

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The Correlation Between Adult Age Factors toward The Clinical Manifestation and The Severity Level of COVID-19 in Bengkulu Province in 2020 Begumratu VOCA; Dia Triyani Putri; Dessy Triana; Riry Ambarsari; Nikki Aldi Massardi; Utari Hartati Suryani
BENCOOLEN JOURNAL OF PHARMACY Vol. 2 No. 2 (2022): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v2i2.24362

Abstract

Coronavirus Disease-19 (COVID-19) is an acute respiratory disease in Wuhan, China, and was discovered discovered in 2019. The things that need to be considered in COVID-19 patients include their clinical manifestation and the severity level of COVID-19. The severity level of COVID-19 patients is associated with age. Each age has a different proportion of severity. The study aimed to determine the correlations among adult age with clinical manifestation and severity of COVID-19 in Bengkulu Province 2020. This study used an observational analytic study. The sample was 108 patients 19 - ≥65 years old and confirmed positive for COVID-19 in 2020. The assessment used the epidemiological investigation form and medical record from Dr. M.Yunus Hospital. At the same time, the severity level of COVID-19 was obtained from the measurement based on the COVID-19 Prevention and Control Guidelines by the Indonesian Ministry of Health. The results showed that the subjects in 19 – 23 years old mostly have asymptomatic severity, 24 – 64 years old mostly have mild severity, and ≥65 years old have moderate severity. It was concluded that there was a significant correlation between the severity of COVID-19 in Bengkulu Province in 2020.
Differences in Before and After Temephos Intervention in Bengkulu City: Larvae Free Rate of Aedes spp. Gunasari, Lala Foresta Valentine; Destilyana, Rizqita; Massardi, Nikki Aldi; Triana, Dessy
Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Vol 22, No 1 (2025): March 2025
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/presipitasi.v22i1.157-167

Abstract

One of the strategies to reduce dengue transmission is to control the population of vectors, such as larval eradication. The use of temephos larvicide (Abate®) is the most widely carried out in the community. An indicator of the success of the larval eradication program is the Larvae Free Rate (LFR) assessment. This study aimed to determine the difference between LFR of Aedes spp. before and after temephos intervention in Bengkulu City. This study is experimental research with one group pre-test and post-test design. The population of this study was all houses in Bengkulu City with a total sample of 670 houses. Sampling was carried out using cluster random sampling techniques in 67 urban villages in Bengkulu City. This research was carried out by conducting a survey of larvae before and after temephos intervention in containers. Sixty-seven urban-villages, in 44 (65,67%) urban-villages was found an increase of LFR after temephos intervention. The average LFR before temephos intervention was 67.61%, while after temephos intervention increased to 82.98%, there was a significant difference between LFR of Aedes spp. before and after temephos intervention in Bengkulu City (p=0.001). Temephos intervention is effective to increase LFR of Aedes spp. in Bengkulu City.
PENGARUH USIA DAN JENIS KELAMIN TERHADAP KADAR IGG DAN KEJADIAN COVID-19 PASCAVAKSINASI PADA TENAGAESEHATAN KOTA BENGKULU Nabilah, Putri Syifa; Suryani, Utari Hartati; Massardi, Nikki Aldi; Rizqoh, Debie; Ambarsarie, Riry
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.24902

Abstract

Variabilitas respons antibodi terhadap vaksinasi COVID-19 dipengaruhi oleh faktor-faktor seperti usia dan jenis kelamin. Penelitian ini bertujuan untuk mengkaji dampak usia dan jenis kelamin terhadap kadar IgG serta kejadian COVID-19 pascavaksinasi. Dengan memperoleh pemahaman mendalam tentang hubungan ini, diharapkan dapat ditingkatkan strategi vaksinasi yang lebih efektif dan efisien bagi berbagai kelompok populasi. Penelitian ini adalah penelitian cross-sectional yang dilakukan selama periode Juli hingga Desember 2021, melibatkan partisipasi 60 tenaga kesehatan dari Rumah Sakit Harapan dan Doa (RSHD) di Kota Bengkulu. Data primer dikumpulkan dari responden ini dalam rangka mengidentifikasi hubungan antara usia, jenis kelamin, dan respons antibodi terhadap vaksinasi COVID-19. Pengambilan data kadar antibodi IgG dilakukan dengan teknik CMIA, sementara data usia, jenis kelamin, dan kejadian COVID-19 pascavaksinasi melalui kuesioner. Metode statistik yang diterapkan dalam penelitian ini mencakup serangkaian uji, seperti uji Kruskal-Wallis, uji Mann-Whitney, dan uji Chi-Square. Temuan penelitian menegaskan bahwa kelompok usia 40-55 tahun dan perempuan memiliki kadar IgG yang lebih tinggi, sedangkan proporsi kejadian COVID-19 pascavaksinasi lebih tinggi pada kelompok usia 20-29 tahun dan laki-laki. Hal ini menunjukkan pengaruh signifikan dari usia dan jenis kelamin terhadap respons antibodi dan kejadian COVID-19 pascavaksinasi. Kesimpulan ini memberikan wawasan penting bagi strategi vaksinasi yang lebih efektif dan cermat bagi berbagai kelompok populasi.
The Relationship Between Age and Clinical Manifestations and COVID-19 Severity in Bengkulu in 2020 Suryani, Utari Hartati; Triana, Dessy; Ambarsarie, Riry; Zainuddin, Zayadi; Massardi, Nikki Aldi; Voca, Begumratu; Putri, Dia Triyani
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 12 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/ijoms.v2i12.643

Abstract

The infectious disease COVID-19 caused by the SARS-CoV-2 virus can infect all age groups. The symptoms that arise can vary from no symptoms to severe and critical symptoms. Differences in clinical symptoms can occur due to differences in the distribution, maturation and function of the SARS-CoV-2 virus receptors. These clinical symptoms will determine the severity of COVID-19. This study aims to analyze the relationship between age and clinical symptoms and the severity of COVID-19 in Bengkulu Province in 2020. This study used an observational analytic study with a cross-sectional design. Samples were taken using a consecutive sampling technique and a total of 109 subjects were obtained who were COVID-19 patients in Bengkulu Province from March to December 2020. Assessment of clinical symptoms used COVID-19 epidemiological investigations. The degree of severity is determined based on the Guidelines for the Prevention and Control of COVID-19 by the Ministry of Health of the Republic of Indonesia. The relationship between the two variables was analyzed using the Spearman Rank test. The results of this study indicate that there is a significant relationship between the age factor of COVID-19 patients in determining the severity of COVID-19 (p=0.000; p <0.05).
Health Education About Clean and Healthy Lifestyle Behavior (PHBS) in the Transition Period of the Covid-19 Pandemic for Students Rizqoh, Debie; Djatmiko, Ellen Maidia; Massardi, Nikki Aldi; Hakim, Alvi Jalilul; Arifani, Novita; Fauzia, Azella Chika
DIKDIMAS : Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 1 (2023): DIKDIMAS : JURNAL PENGABDIAN KEPADA MASYARAKAT  VOL 2 NO 1 APRIL 2023
Publisher : Asosiasi Profesi Multimedia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/dikdimas.v2i1.93

Abstract

After the COVID-19 pandemic is ongoing up to 3 years, finally Indonesia started experience transition from pandemic going to endemic, following decreasing of case positive for COVID-19. During the transition, a number of rule start relaxed, however government recommend public for still carry out health protocol. Besides, in field education, all school carry out 100 % offline learning. The students have to stay alert from COVID-19 infection or another infection. So that, clean and healthy lifestyle (PHBS) is necessary carried out at school. There are several indicators of PHBS in schools that are necessary known by students. This health education aims to give education to 97 students in schools especially at SMK Negeri 2 Bengkulu City about importance implementing PHBS in the transition period of COVID-19 pandemic. This activity took place on Thursday , 22 September 2022. The method used form give education and discussion regarding PHBS in schools. We evaluated student’s understanding by pre-test and post-test about PHBS. Participant generally already have own knowledge regarding PHBS and more understand PHBS after participated in this activity.
HUBUNGAN EKSPRESI miRNA-21 DENGAN TARGET PDCD4 DAN miRNA-143 DENGAN TARGET BLC-2 PADA KASUS KANKER SERVIKS Nikki Aldi Massardi; Soemanadi; Beti Ernawati Dewi; Dewi Wulandari; Eduardus Gilang Putra
Bioma Vol. 19 No. 1 (2023): Bioma
Publisher : LPPM Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/Bioma19(1).6

Abstract

A study has been carried out to compare the expression of miRNA-21 and miRNA-143 with target mRNA PDCD4 and BCL-2 in cases of early-stage cervical cancer compared to advanced stages. These data can be used as information for the development of non-invasive cervical cancer prognostic methods. The study was conducted by taking serum samples and exfoliativecell samples from normal subjects and subjects with cervical cancer detection and then analyzed using qRT-PCR. Samples of cervical cancer patients consisting of 15 subjects and 4 normal subjects were used to obtain relative quantity values for the expression of miRNA-21, miRNA-143, mRNA PDCD4 and BCL-2. In the study of miRNA-21, there was no significant difference in determining cervical cancer with p>0.05 using the t-test (0.594) and a significant relationship was found between miRNA 21 and PDCD4 with a strong correlation (p<0.05, r = -0.563; Pearson). The relationship between miRNA-143 and the Bcl-2 target gene in this study showed a weak and insignificant correlation (r = -0.101; p > 0.05; Pearson). There was a significant relationship between miRNA-21 and PDCD4 in early-stage and advanced-stage samples, while the relationship between miRNA-143 and the Bcl-2 mRNA target gene showed no significant correlation.
Effectiveness of AI-Based Chatbots as Additional Psychiatry Assistive Technology and Alternative to Mental Health Services for Adolescents Rahmat, Arya Dwi; Tauhid, Alfana Yudaru; Mulyadi, Faizah Azzahrah; Ellfazmy, Asyifa; Nikki Aldi Massardi; Elvira Yunita
Surabaya Physical Medicine and Rehabilitation Journal Vol. 8 No. 1 (2026): SPMRJ, FEBRUARY 2026
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/spmrj.v8i1.75554

Abstract

Background: Adolescents' lives have been profoundly impacted by the rapid development of artificial intelligence (AI), especially in mental health. AI provides easier access to learning and psychological support through chatbots. However, it also raises concerns like dependency, reduced critical thinking, risks of stress, and social isolation, especially due to social media algorithms that shape digital behavior. Data privacy and diagnostic accuracy are also key issues in mental health applications. Aim: The main objective of this review is to examine whether AI-based chatbots can serve as an additional psychiatry assistive technology to help adolescents. Scope: The review was carried out by examining research articles from databases including PubMed and Google Scholar, with a focus on papers published between 2020 and 2025. Findings: AI chatbots like Emohaa, Elomia, and SEJATI have proven effective in alleviating symptoms of depression, anxiety, and insomnia. They provide immediate support, promote emotional expression, and foster self-awareness. These chatbots have also shown promise in telerehabilitation contexts by aiding in monitoring, providing behavioral feedback, and facilitating early intervention. However, an overreliance on AI systems might hinder emotional sensitivity and social growth. Conclusion: AI chatbots hold significant promise as therapeutic resources in adolescent mental health, especially in under-resourced environments. However, their application must be carefully weighed against ethical considerations, data privacy safeguards, and continuous professional supervision. The responsible incorporation of AI into mental health care can enhance access and customization while reducing psychological and social risks.
Co-Authors Afriyastuti Herawati Agustian, Indra Ahmad Azmi Nasution Albbi, M. Alvi Jalilul Hakim Ambarsarie, Riry Arifani, Novita Azella Chika Fauzia Begumratu VOCA Beti Ernawati Dewi Debie Rizqoh Dessy Triana Dessy Triana Dessy Triana Dessy Triana Destilyana, Rizqita Dewi Wulandari Dewi Wulandari Dia Triyani Putri Djatmiko, Ellen Maidia Eduardus Gilang Putra Ellen Maidia Djatmiko Ellfazmy, Asyifa Elvira Yunita Elvira Yunita Enny Nugrahaeni Enny Nugrahaeni Fauzia, Azella Chika Fitrilina Fitrilina Fitrilina, Fitrilina Gunasari, Lala Foresta Valentine Hakim, Alvi Jalilul Herawati, Afriyastuti Indra Agustian Jusup Endang Kartika Sari Liya Agustin Umar M. Albbi Mardhatillah Sariyanti Mardhatillah Sariyanti Mardhatillah Sariyanti Mulya Sundari Mulya Sundari Mulyadi, Faizah Azzahrah Nabila Putri Firdalina Nabilah, Putri Syifa Naurah Shafa Putri Cahyangi Noor Diah Erlinawati Novita Arifani Putra, Eduardus Gilang Putri, Dia Triyani Rahmat, Arya Dwi Riry Ambarsari Riry Ambarsarie Soemanadi Soemanadi Suryani, Utari Hartati Sylvia Rianissa Putri Tauhid, Alfana Yudaru Tiara Ayoe Andita Utari Hartati Suryani Voca, Begumratu Zainuddin, Zayadi