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All Journal Naturalis : Jurnal Penelitian Pengelolaan Sumberdaya Alam dan Lingkungan The Indonesian Biomedical Journal Biomedical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Herb-Medicine Journal BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati ISM (Intisari Sains Medis) : Jurnal Kedokteran Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Journal of Telenursing (JOTING) Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS JAMAS: Jurnal Abdi Masyarakat

Elvira Yunita

Department Biochemistry And Molecular Biology, Faculty Of Medicine And Health Sciences, Universitas Bengkulu, Bengkulu, Indonesia

Author-ID : 3265212

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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AKTIVITAS ANTIOKSIDAN EKSTRAK JERUK KALAMANSI (CITRUS MICROCARPA), JERUK GERGA (CITRUS RETICULATE) DAN BUAH MANGROVE (SONNERATIA ALBA) DARI PROVINSI BENGKULU Elvira Yunita
Naturalis: Jurnal Penelitian Pengelolaan Sumber Daya Alam dan Lingkungan Vol. 10 No. 1 (2021)
Publisher : Badan Penerbitan Fakultas Pertanian (BPFP), Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31186/naturalis.10.1.14398

Stres oksidatif dapat berkaitan erat dengan beberapa penyakit seperti Parkinson, Alzheimer, arterosklerosis, hipertensi dan diabetes. Antioksidan menjadi komponen penting untuk mengatasi stress oksidatif yang terjadi di dalam tubuh. Sumber antioksidan alami asal Provinsi Bengkulu yang telah didukung sebagai komoditas unggulan Pemerintah Provinsi yaitu jeruk kalamansi (Citrus microcarpa), jeruk gerga (Citrus reticulata) dan buah mangrove (Sonneratia alba). Ketiga komponen tersebut telah dijual dalam bentuk olahan makanan dan dikonsumsi oleh masyarakat. Meskipun demikian, aktivitas antioksidan dari ekstrak komoditas tersebut belum banyak dilaporkan. Tujuan penelitian ini yaitu menganalisis aktivitas antioksidan ekstrak jeruk kalamansi, jeruk gerga dan buah mangrove. Penelitian ini diawali dengan proses pembuatan ekstrak etanol dari ketiga komoditas tersebut dengan teknik maserasi. Setelah itu, aktivitas antioksidan dari ketiga ekstrak tersebut akan diperiksa dengan teknik 2,2-difenil-1-pikrilhidrazil (DPPH). Hasil pengukuran dengan DPPH dari ekstrak jeruk kalamansi, jeruk gerga dan buah mangrove dengan standar asam galat menunjukkan bahwa ekstrak buah mangrove memiliki aktivitas antioksidan terbesar (IC50 = 36,473 ppm) jika dibandingkan dengan ekstrak jeruk gerga (IC50 = 1257,77 ppm) maupun jeruk kalamansi (IC50 = 1593,72). Ekstrak buah mangrove memiliki aktivitas antioksidan lebih besar jika dibandingakan dengan ekstrak jeruk gerga maupun jeruk kalamansi.Kata kunci: antioksidan, jeruk, gerga, kalamansi, mangrove

MEKANISME KERJA ANDROGRAFOLIDA DARI SAMBILOTO SEBAGAI SENYAWA ANTIOKSIDAN Elvira Yunita
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 1 (2021): Herb-Medicine Journal Januari 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i1.8825

Andrographolide is the main bioactive compound derived from sambiloto, Andrographis paniculata. Andrographolide compounds can potentially be used as phytopharmaca substances. Andrographolide has very broad pharmacological aspects, including anti-inflammatory, anticancer and anti-diabetic. The pharmacological aspects possessed by andrographolide are probably closely related to the chemical profile and the mechanism of action of andrographolide as an antioxidant in counteracting free radicals. Therefore, it is important to know the chemical profile and mechanism of action of andrographolide compounds as antioxidants to understand the mechanism of action of these compounds in dealing with various diseases. This study is based on a review of related literature. Based on the literature review, it was found that the mechanism of action of andrographolide as anti-cancer, anti-inflammatory and anti-dyslipidemia is closely related to the mechanism of action of this compound as an antioxidant. The unsaturated γ- lactone structure at C13 and C14 of andrographolide can neutralize superoxide anions. The double bond in this carbonyl ester group will affect the deprotonization of the H atone located at C15 so that the H atoms on C15 will be easily extracted by the highly reactive superoxide anion. Thus, andrographolide can stop the chain reaction of a radical molecule. This mechanism can cause andrographolide compounds to play a role in reducing the effects of free radicals in various diseases.

The Effect Of Black Tea (Camellia sinensis) Administration On Renal Histopathology Of Male White Rats (Rattus norvegicus) From Sprague Dawley Strain Induced By Used Cooking Oil Hilda Taurina; Jihan Vira Yuniar; Elvira Yunita
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i2.3432

Used cooking oil is cooking oil that has been heated repeatedly, so that it can cause the formation of free radical compounds. Free radicals are toxic kidneys that generate cell injury via lipid peroxidation, DNA damage, and protein peroxidation. Black tea (Camellia sinensis) infusion has a strong polyphenol group, namely epigallocatechin gallate, thearubigin, theaflavin, the amino acid L-theanine, flavonols, and catechins that can inhibit free radicals and protect organs from oxidative stress. This study was a post-only control group design experiment. The research subjects used were 24 Sprague Dawley male rats which were divided into six groups. The first group was the control group (K0). Treatment group 1 was given distilled water and used cooking oil after 12 times heating (K1), treatment group 2 was given black tea at a dose of 2.5g/ kg bw (body weight) and distilled water (K2), and treatment group 3 was given black tea at a dose of 3.75 g/kg bw and distilled water (K3). Treatment group 4 was given used cooking oil after 12 times heating and black tea with a dose of 0.50 gr/200 gr bw (K4), treatment group 5 was given used cooking oil after 12 times heating and black tea with a dose of 3.75 g/kg bw (K5). All groups were treated for 42 days. Then, the rats' kidney was collected, and data were analyzed by Kruskal Wallis and One Way ANOVA test. The results of the Kruskal Wallis and One Way ANOVA test showed a decrease in glomerular and tubular damage after the rats orally induced with black tea were given 12x heating used cooking oil (p<0.05). The mean histopathological score in the administration of black tea at a dose of 3.75 g/kg bw was lower than at a dose of 2.5 g/kg bw. This study shows that infusion of black tea (Camellia sinensis) can prevent glomerular and tubular damage induced by used cooking oil.

Histopatologi Testis pada Tikus Putih (Rattus norvegicus) yang Diberikan Minyak Jelantah dan Infusa Teh Hitam (Camellia sinensis) Gina Fendiati Putri; Liya Agustin Umar; Elvira Yunita
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol 4 No 1 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

This study aimed to analyze the effect of infusion of black tea (Camellia sinensis) on the histopathological features of the testes in white rats (Rattus norvegicus) that had been induced with used cooking oil. The design of this research is an experimental post-test only control group design. The research subjects used 24 rats which were divided into six groups with six weeks of treatment. The testicular condition was assessed using the Johnsen Score criteria. The results of this study indicate that there are differences in testicular damage scores between treatment groups. The results of the histopathological score analysis showed that the group that was given only used cooking oil had a higher level of damage than the group that was only given black tea. The group that was given cooking oil and black tea one hour later affected testicular damage in rats with p significance values â€‹â€‹of 0.018 and 0.018. In conclusion, giving black tea infusion at a dose of 0.50 g/200 gram BW and 0.75 gr/200 gram BW was able to prevent damage due to oil induction with 12x heating in the testes of Rattus norvegicus rats. Keywords: Camellia sinensis, Histopathology, Cooking Oil, Rat Testes

Uji In Vitro Aktivitas Imunomodulator Minyak Atsiri Serai Dapur (Cymbopogon citratus) terhadap Proliferasi Sel Limfosit Mencit Gustria Ernis; Doni Notriawan; Dyah Fitriani; Elvira Yunita; Inta Cantika
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 4 No 2 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

This study aims to determine the immunomodulatory activity of lemongrass essential oil on the proliferation of mouse lymphocyte cells in vitro. The method used is steam distillation to obtain citronella essential oil. Isolation of lymphocyte cells was obtained from the spleen organ of Swiss-Webster strain mice which was carried out aseptically. The lymphocyte cell proliferation test was carried out using the MTT Assay method and the absorbance was measured using an ELISA reader at 550 nm. The results showed that the lemongrass essential oil contained positive alkaloids, flavonoids, saponins, and steroids/triterpenoids with an essential oil yield of 0.043%. The higher the volatile oil concentration, the higher the Optical Density (OD) value obtained, but the OD increase at a 50 to 100 g/mL concentration was not significantly different. In conclusion, lemongrass essential oil has immunomodulatory activity against lymphocyte cell proliferation in mice tested in vitro. Keywords: Immunomodulator, Essential Oil, Lemongrass (Cymbopogon citratus), Immune System

Polimorfisme Gen VEGF-A (rs2010963) pada Turunan Pertama Penderita Penyakit Jantung Koroner (PJK) Aurora Fajria Anwari; Novriantika Lestari; Marisadonna Asteria; Sipriyadi Sipriyadi; Ismir Fahri; Elvira Yunita
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 4 No 2 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

This study aims to identify the VEGF-A gene polymorphism (rs2010963) in the first generation of patients with coronary heart disease (CHD) and non-CHD in Bengkulu City. The method used is molecular analysis of polymorphism through Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP). This type of research is descriptive observational with a cross-sectional research design. The results of this study indicate that the genotype frequency of the VEGF-A gene polymorphism (rs2010963) in the first generation of patients with CHD is genotype CC = 11 (52.4 %), GG = 7 (33.3%) and CG = 3 (14.3%). ). The distribution of the VEGF-A genotype (rs2010963) in the first non-CHD offspring, namely GG = 9 (42.9%), CC = 7 (33.3%) and GC = 5 (23.8%). The statistical analysis results showed that the p-value obtained was 0.460 for the VEGF-A gene polymorphism genotype (rs2010963) in the first CHD and Non-CHD derived samples. In conclusion, there was no significant difference in the VEGF-A gene polymorphism in the first generation of CHD and non-CHD groups in Bengkulu City. Keywords: PCR-RFLP, Coronary Heart Disease, Gene Polymorphism, VEGF-A

Ekstrak Labu Siam (Sechium edule) Dapat Menurunkan Kadar Serum Malondialdehid pada Tikus Putih (Rattus norvegicus) yang Diberikan Pakan Kolesterol Maria Eka Patri Yulianti; Elvira Yunita; Zhafran Hafizhki; Meiny Suzery; Neni Susilaningsih; Suhartono Suhartono
Journal of Telenursing (JOTING) Vol 4 No 1 (2022): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v4i1.3587

This study aimed to analyze the effect of chayote extract (Sechium edule) on malondialdehyde serum levels in white rats (Rattus norvegicus) fed a high-cholesterol diet and to prove the antioxidant content of chayote. The method used is experimental with a post-test-only control group design. This study used white rats, which were divided into five groups. The results of this study indicate that the administration of chayote extract at a dose of 0.25 g/kg BW and 0.5 g/kg BW can reduce the serum MDA concentration, although it is not statistically significant, while the administration of a chayote extract at a dose of 0.75 g/Kg BW can significantly reduce serum MDA levels in white rats induced by hypercholesterolemia. In conclusion, chayote extract at a dose of 0.75 g/kg BW can reduce blood MDA serum levels in white rats induced by hypercholesterolemia. Keywords: Chayote Extract, Hypercholesterolemia, Malondialdehyde

Telekonsultasi Dalam Rangka Pemutusan Rantai Penularan Covid-19 di Kota Bengkulu Dessy Triana, M. Biomed; Hardiansyah Hardiansyah; Sri Yunita; Miftahul Haniyah; Enny Nugraheni Sulistiyorini; Riry Ambarsarie; Rizkianti Anggraini; Elvira Yunita; Mardhatillah Sariyanti
DHARMA RAFLESIA Vol 19, No 2 (2021): DESEMBER (ACCREDITED SINTA 5)
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/dr.v19i2.18373

Coronavirus Disease-19 (Covid-19) is a disease that has become a global epidemic. The World Health Organization (WHO) has declared Covid-19 a pandemic. Indonesia declared the status of the Covid-19 disease to be an Emergency Response. Supporting the social distancing, the right strategy is needed to continue implementing health services amid the Covid-19 pandemic. This activity aimed to provide knowledge related to Covid-19 to the community and health consultations and medical advice through applications (teleconsultation) to minimize patients queuing at Health Service Facilities directly. The activity partners were the Indonesian Medical Association (IDI) Bengkulu City Branch, Bengkulu City Health Office, and the Indonesian Red Crescent (BSMI) Bengkulu City Region. The method of this activity was to provide socialization, health consultation and medical advice through applications (teleconsultation) regarding the spread, transmission and prevention of Covid-19 from May 1 to August 31 2020. The number of participants was 41 people from Bengkulu City. The highest number of diseases consulted were acute respiratory infections (38.7%.) and Covid-19 independent protocol consultation (31.58%.) Teleconsultation can be continued and developed into a patentable application. Application development is indispensable in responding to the challenges of the health world in the digital era.

Epigenetic Regulation of Breast Cancer Stem Cells Elvira Yunita
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.289

Breast cancer arises as a result of abnormal breast cells forming at an uncontrolled rate. Death in this case of breast cancer is due to the ability of cancer cells to adapt so that it can have an effect on metastasis and recurrence of cancer that was previously thought to have been resolved. The results showed, there is a stem cell population in breast cancer cases which will cause breast cancer to become increasingly difficult to treat. Such cells are known as breast cancer stem cells. Breast cancer cells have the ability to differentiate and contribute greatly to the breast cancer program, as well as to resistance to therapy. Therefore, epigenetic regulation of breast cancer cells is important to study in order to overcome cancer so that it can overcome progression and resistance to cancer therapy being carried out.Epigenetic regulation that has been known in cancer cases includes DNA methylation, histone acetylation, histone methylation and epigenetic regulation by miRNA. DNA methylation is the addition of a methyl group to the nitrogen base of DNA cytosine which will force the DNA transcription process. Acetylation of the addition of an acetyl group at the end of the histone causes reduced chromatin condensation so that it will activate the transcription process. Methylation histones will also suppress transcription so that genes cannot be expressed. In addition, there is also a small RNA molecule known as miRNA which can bind to the transcribed mRNA. This binding will cause the mRNA to degrade or inhibit its translation.

Efek pemberian propolis pada fungsi ginjal dan hepar tikus putih (Rattus Norvegicus) yang diinduksi cisplatin Novriantika Lestari; Fajrianti Haniyah; Annisa Puspa Sari; Liya Agustin Umar; Elvira Yunita
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Background: Cisplatin as an anticancer drug results in nephrotoxicity and hepatotoxicity. Accumulation of cisplatin in the body will produce reactive compounds in the form of free radicals which induce oxidative stress that affects kidney and liver functions. Propolis contains flavonoids, phenolic acid, and Caffeic Acid Phenethyl Ester (CAPE) which have the ability to prevent free radical formation and improve kidney and liver function. This study aims to determine the effect of propolis administration to ameliorate of BUN, creatinine, ALT and AST levels in cisplatin-induced rats (Rattus norvegicus).Methods: The experimental study was conducted with the pre-post-test with control group design approach. The research sample used 30 white rats which were divided into normal (aquadest), Cisplatin (5mg/kg i.p), and cisplatin+propolis groups. Propolis was given at a dose of 50mg/kg, 100mg/kg and 200mg/kg orally for seven days, four days after cisplatin induction. Rat blood was taken for analysis of Bloof Urea Nitrogen (BUN), Creatinine, ALT, and AST levels. Data were analyzed using SPSS version 26 for Windows.Results: The results showed that there were significant differences in levels of BUN, Creatinine, ALT and AST between groups (p<0.05). Propolis treatment at doses of 50 mg/kg, 100mg/kg and 200mg/kg can reduce levels of BUN/urea, creatinine, ALT, and AST in rats that have been induced by cisplatin significantly (p<0,05).Conclusion: Propolis has a therapeutic effect on cisplatin drug-induced nephrotoxicity and hepatotoxicity by affecting the BUN, creatinine, ALT, and AST levels in rats. Latar Belakang: Penggunaan cisplatin sebagai obat antikanker menghasilkan efek nefrotoksisitas dan hepatotoksisitas imbas obat. Akumulasi cisplatin di dalam tubuh akan menghasilkan senyawa reaktif berupa radikal bebas yang menginduksi terjadinya stress oksidatif sehingga akan berpengaruh ke fungsi ginjal dan hepar. Propolis mengandung flavonoid, asam fenolat, dan Caffeic Acid Phenethyl Ester (CAPE) yang memiliki kemampuan mencegah pembentukan radikal bebas dan memperbaiki fungsi ginjal dan hepar. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian propolis terhadap pemulihan kadar ureum, kreatinin, ALT dan AST darah pada tikus putih (Rattus norvegicus) yang telah diinduksi cisplatin.Metode: Penelitian eksperimental ini dilakukan dengan pendekatan pre-post-test with control group design. Sampel penelitian menggunakan 30 ekor tikus putih yang dibagi menjadi kelompok normal (aquadest), Cisplatin (5mg/kgbb i.p) dan kelompok cisplatin+propolis. Propolis diberikan dengan dosis 50mg/kgbb, 100mg/kgbb dan 200mg/kgbb secara oral selama tujuh hari, empat hari setelah induksi cisplatin. Darah tikus diambil untuk analisis kadar Blood Urea Nitrogen (BUN), Kreatinin, ALT, dan AST. Data dianalisis dengan SPSS versi 26 untuk Windows.Hasil: Hasil penelitian menunjukkan terdapat perbedaan kadar BUN, Kreatinin, ALT, dan AST yang bermakna antar kelompok (p<0,05). Pemberian propolis dengan dosis 50 mg/kgBB, 100 mg/kgBB dan 200 mg/kgBB dapat menurunkan kadar BUN/ureum, kreatinin, ALT, dan AST pada tikus yang telah diinduksi cisplatin secara bermakna (p<0,05).Kesimpulan: Propolis memiliki efek terapi pada nefrotoksisitas dan hepatotoksisitas akibat obat cisplatin dengan mempengaruhi kadar BUN/ureum, kreatinin, ALT, dan AST pada tikus.

Co-Authors Ahmad Azmi Nasution Annisa Puspa Sari Audia Indrian Aurora Fajria Anwari Bhayu Baruna Bastari Cindy Ernica Putri Debie Rizqoh Dessy Triana Diah Ayu Aguspa Dita Dyah Fitriani Ellen Maidia Djatmiko Enny Nugraheni Fajrianti Haniyah Gina Fendiati Putri Gustria Ernis Hardiansyah Hardiansyah Hilda Taurina Inta Cantika Ismir Fahri Jihan Vira Yuniar Julian Famil Kartika Sari Kartika Sari Liya Agustin Umar Liya Agustin Umar Liya Agustin Umar Mardhatillah Sariyanti Maria Eka Patri Y Marisadonna Asteria Marisadonna Asteria Meiny Suzery Miftahul Haniyah Muhammad Ridwan Neni Susilaningsih Nikki Aldi Massardi Noor Diah Erlinawati Notriawan, Doni Novriantika Lestari Novriantika Lestari Nurmeiliasari Oktoviani Putjha Melati Putri Maulida Riry Ambarsarie Risti Dwi Ocktaviani Rizkianti Anggraini Sipriyadi Sri Yunita Suhartono, Suhartono Sylvia Rianissa Putri Tiara Ayoe Andita Zhafran Hafizhki

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