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All Journal Althea Medical Journal Jurnal Sain Peternakan Indonesia Naturalis : Jurnal Penelitian Pengelolaan Sumberdaya Alam dan Lingkungan Program Kreativitas Mahasiswa - Penelitian The Indonesian Biomedical Journal Biomedical Journal of Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Herb-Medicine Journal BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati ISM (Intisari Sains Medis) : Jurnal Kedokteran Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton Journal of Telenursing (JOTING) Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Jurnal Kesehatan Tambusai Edu Masda Journal Jurnal Kedokteran Raflesia JAMAS: Jurnal Abdi Masyarakat
Elvira Yunita
Departemen Biokimia, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Bengkulu, Bengkulu, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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POTENSI PERMEN TIRAMISU YANG BERKHASIAT ANTIKOLESTEROL Waliyuddin, Waliyuddin; Yunita, Elvira; Karomah, Nailatul; Irshan, Yusuf; Amellia, Amellia
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.577 KB)

Abstract

Tiramisu candy is made of oyster mushroom extract ethanol. Oyster mushroom (Pleurotus ostreatus) contains lovastatin that inhibit cholesterol synthesis in the body. Ethanol extract of oyster mushroom was expected to give an effect in lowering cholesterol. This experiment used 35 male Sprague dawley rats that were divided into 5 groups (n=7).  The treatment period was for 14 days, normal group fed by standard woof, hypercholesterolemic group (HK) were fed by high- cholesterol woof (3%) and PTU (0.5 mg/kg BW), the group of lovastatin(lovastatin+HK0.2857mg/kgBW), treatment I group (HK+ oyster mushroom ethanol extract 30 mg/kg BW), and treatment II group (HK+ oyster mushroom ethanol extract 60 mg/kg BW). Blood was taken through the eyes of rats with hematocrit-heparin. Candy is made with a mixture of 5% starch, maltodextrin 10%, 4% magnesium stearate, sucrose 81%, and ethanol extract 2.1 grams of white oyster mushroom.The results showed that the ethanol extract of oyster mushroom (30 mg/kg BW and 60 mg/kg BW ) may decrease 53.89%  and 66.43% of cholesterol concentration. AST and ALT results of the analysis showed that the ethanol extract of white oyster mushroom dose of 30mg/ kg and 60 mg/ kg did not cause liver damage. Based on HPLC analysis,  a gram of oyster mushroom ethanol extract containing 3.6x10- 6 grams of lovastatin. Tiramisu candy successfully made by weight 100 mg to extract content of 2.1 mg and 7.56x10-6mg of lovastatin. Keywords : AST ALT, candy, cholesterol, lovastatin, Pleurotus ostreatus.
Epigenetic Regulation of Breast Cancer Stem Cells Yunita, Elvira
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.289

Abstract

Breast cancer arises as a result of abnormal breast cells forming at an uncontrolled rate. Death in this case of breast cancer is due to the ability of cancer cells to adapt so that it can have an effect on metastasis and recurrence of cancer that was previously thought to have been resolved. The results showed, there is a stem cell population in breast cancer cases which will cause breast cancer to become increasingly difficult to treat. Such cells are known as breast cancer stem cells.Breast cancer cells have the ability to differentiate and contribute greatly to the breast cancer program, as well as to resistance to therapy. Therefore, epigeneticregulation of breast cancer cells is important to study in order to overcome cancer so that it can overcome progression and resistance to cancer therapy being carried out.Epigenetic regulation that has been known in cancer cases includes DNA methylation, histone acetylation, histone methylation and epigenetic regulation by miRNA. DNA methylation is the addition of a methyl group to the nitrogen base of DNA cytosine which will force the DNA transcription process. Acetylation of theaddition of an acetyl group at the end of the histone causes reduced chromatin condensation so that it will activate the transcription process. Methylation histones will also suppress transcription so that genes cannot be expressed. In addition, there is also a small RNA molecule known as miRNA which can bind to the transcribed mRNA. This binding will cause the mRNA to degrade or inhibit its translation.
AKTIVITAS ANTIOKSIDAN EKSTRAK JERUK KALAMANSI (CITRUS MICROCARPA), JERUK GERGA (CITRUS RETICULATE) DAN BUAH MANGROVE (SONNERATIA ALBA) DARI PROVINSI BENGKULU Elvira Yunita
Naturalis: Jurnal Penelitian Pengelolaan Sumber Daya Alam dan Lingkungan Vol. 10 No. 1 (2021)
Publisher : Badan Penerbitan Fakultas Pertanian (BPFP), Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31186/naturalis.10.1.14398

Abstract

Stres oksidatif dapat berkaitan erat dengan beberapa penyakit seperti Parkinson, Alzheimer, arterosklerosis, hipertensi dan diabetes. Antioksidan menjadi komponen penting untuk mengatasi stress oksidatif yang terjadi di dalam tubuh. Sumber antioksidan alami asal Provinsi Bengkulu yang telah didukung sebagai komoditas unggulan Pemerintah Provinsi yaitu jeruk kalamansi (Citrus microcarpa), jeruk gerga (Citrus reticulata) dan buah mangrove (Sonneratia alba). Ketiga komponen tersebut telah dijual dalam bentuk olahan makanan dan dikonsumsi oleh masyarakat. Meskipun demikian, aktivitas antioksidan dari ekstrak komoditas tersebut belum banyak dilaporkan. Tujuan penelitian ini yaitu menganalisis aktivitas antioksidan ekstrak jeruk kalamansi, jeruk gerga dan buah mangrove. Penelitian ini diawali dengan proses pembuatan ekstrak etanol dari ketiga komoditas tersebut dengan teknik maserasi. Setelah itu, aktivitas antioksidan dari ketiga ekstrak tersebut akan diperiksa dengan teknik 2,2-difenil-1-pikrilhidrazil (DPPH). Hasil pengukuran dengan DPPH dari ekstrak jeruk kalamansi, jeruk gerga dan buah mangrove dengan standar asam galat menunjukkan bahwa ekstrak buah mangrove memiliki aktivitas antioksidan terbesar (IC50 = 36,473 ppm) jika dibandingkan dengan ekstrak jeruk gerga (IC50 = 1257,77 ppm) maupun jeruk kalamansi (IC50 = 1593,72). Ekstrak buah mangrove memiliki aktivitas antioksidan lebih besar jika dibandingakan dengan ekstrak jeruk gerga maupun jeruk kalamansi.Kata kunci: antioksidan, jeruk, gerga, kalamansi, mangrove
MEKANISME KERJA ANDROGRAFOLIDA DARI SAMBILOTO SEBAGAI SENYAWA ANTIOKSIDAN Elvira Yunita
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 1 (2021): Herb-Medicine Journal Januari 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i1.8825

Abstract

Andrographolide is the main bioactive compound derived from sambiloto, Andrographis paniculata. Andrographolide compounds can potentially be used as phytopharmaca substances. Andrographolide has very broad pharmacological aspects, including anti-inflammatory, anticancer and anti-diabetic. The pharmacological aspects possessed by andrographolide are probably closely related to the chemical profile and the mechanism of action of andrographolide as an antioxidant in counteracting free radicals. Therefore, it is important to know the chemical profile and mechanism of action of andrographolide compounds as antioxidants to understand the mechanism of action of these compounds in dealing with various diseases. This study is based on a review of related literature. Based on the literature review, it was found that the mechanism of action of andrographolide as anti-cancer, anti-inflammatory and anti-dyslipidemia is closely related to the mechanism of action of this compound as an antioxidant. The unsaturated γ- lactone structure at C13 and C14 of andrographolide can neutralize superoxide anions. The double bond in this carbonyl ester group will affect the deprotonization of the H atone located at C15 so that the H atoms on C15 will be easily extracted by the highly reactive superoxide anion. Thus, andrographolide can stop the chain reaction of a radical molecule. This mechanism can cause andrographolide compounds to play a role in reducing the effects of free radicals in various diseases.
The Effect Of Black Tea (Camellia sinensis) Administration On Renal Histopathology Of Male White Rats (Rattus norvegicus) From Sprague Dawley Strain Induced By Used Cooking Oil Hilda Taurina; Jihan Vira Yuniar; Elvira Yunita
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i2.3432

Abstract

Used cooking oil is cooking oil that has been heated repeatedly, so that it can cause the formation of free radical compounds. Free radicals are toxic kidneys that generate cell injury via lipid peroxidation, DNA damage, and protein peroxidation. Black tea (Camellia sinensis) infusion has a strong polyphenol group, namely epigallocatechin gallate, thearubigin, theaflavin, the amino acid                L-theanine, flavonols, and catechins that can inhibit free radicals and protect organs from oxidative stress. This study was a post-only control group design experiment. The research subjects used were 24 Sprague Dawley male rats which were divided into six groups. The first group was the control group (K0). Treatment group 1 was given distilled water and used cooking oil after 12 times heating (K1), treatment group 2 was given black tea at a dose of 2.5g/ kg bw (body weight) and distilled water (K2), and treatment group 3 was given black tea at a dose of 3.75 g/kg bw and distilled water (K3). Treatment group 4 was given used cooking oil after 12 times heating and black tea with a dose of 0.50 gr/200 gr bw (K4), treatment group 5 was given used cooking oil after 12 times heating and black tea with a dose of 3.75 g/kg bw (K5). All groups were treated for 42 days. Then, the rats' kidney was collected, and data were analyzed by Kruskal Wallis and One Way ANOVA test. The results of the Kruskal Wallis and One Way ANOVA test showed a decrease in glomerular and tubular damage after the rats orally induced with black tea were given 12x heating used cooking oil (p<0.05). The mean histopathological score in the administration of black tea at a dose of 3.75 g/kg bw was lower than at a dose of 2.5 g/kg bw. This study shows that infusion of black tea (Camellia sinensis) can prevent glomerular and tubular damage induced by used cooking oil.
Histopatologi Testis pada Tikus Putih (Rattus norvegicus) yang Diberikan Minyak Jelantah dan Infusa Teh Hitam (Camellia sinensis) Gina Fendiati Putri; Liya Agustin Umar; Elvira Yunita
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol 4 No 1 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.09 KB) | DOI: 10.31539/bioedusains.v4i1.2171

Abstract

This study aimed to analyze the effect of infusion of black tea (Camellia sinensis) on the histopathological features of the testes in white rats (Rattus norvegicus) that had been induced with used cooking oil. The design of this research is an experimental post-test only control group design. The research subjects used 24 rats which were divided into six groups with six weeks of treatment. The testicular condition was assessed using the Johnsen Score criteria. The results of this study indicate that there are differences in testicular damage scores between treatment groups. The results of the histopathological score analysis showed that the group that was given only used cooking oil had a higher level of damage than the group that was only given black tea. The group that was given cooking oil and black tea one hour later affected testicular damage in rats with p significance values ​​of 0.018 and 0.018. In conclusion, giving black tea infusion at a dose of 0.50 g/200 gram BW and 0.75 gr/200 gram BW was able to prevent damage due to oil induction with 12x heating in the testes of Rattus norvegicus rats. Keywords: Camellia sinensis, Histopathology, Cooking Oil, Rat Testes
Uji In Vitro Aktivitas Imunomodulator Minyak Atsiri Serai Dapur (Cymbopogon citratus) terhadap Proliferasi Sel Limfosit Mencit Gustria Ernis; Doni Notriawan; Dyah Fitriani; Elvira Yunita; Inta Cantika
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 4 No 2 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (359.527 KB) | DOI: 10.31539/bioedusains.v4i2.2524

Abstract

This study aims to determine the immunomodulatory activity of lemongrass essential oil on the proliferation of mouse lymphocyte cells in vitro. The method used is steam distillation to obtain citronella essential oil. Isolation of lymphocyte cells was obtained from the spleen organ of Swiss-Webster strain mice which was carried out aseptically. The lymphocyte cell proliferation test was carried out using the MTT Assay method and the absorbance was measured using an ELISA reader at 550 nm. The results showed that the lemongrass essential oil contained positive alkaloids, flavonoids, saponins, and steroids/triterpenoids with an essential oil yield of 0.043%. The higher the volatile oil concentration, the higher the Optical Density (OD) value obtained, but the OD increase at a 50 to 100 g/mL concentration was not significantly different. In conclusion, lemongrass essential oil has immunomodulatory activity against lymphocyte cell proliferation in mice tested in vitro. Keywords: Immunomodulator, Essential Oil, Lemongrass (Cymbopogon citratus), Immune System
Polimorfisme Gen VEGF-A (rs2010963) pada Turunan Pertama Penderita Penyakit Jantung Koroner (PJK) Aurora Fajria Anwari; Novriantika Lestari; Marisadonna Asteria; Sipriyadi Sipriyadi; Ismir Fahri; Elvira Yunita
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 4 No 2 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (705.435 KB) | DOI: 10.31539/bioedusains.v4i2.2630

Abstract

This study aims to identify the VEGF-A gene polymorphism (rs2010963) in the first generation of patients with coronary heart disease (CHD) and non-CHD in Bengkulu City. The method used is molecular analysis of polymorphism through Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP). This type of research is descriptive observational with a cross-sectional research design. The results of this study indicate that the genotype frequency of the VEGF-A gene polymorphism (rs2010963) in the first generation of patients with CHD is genotype CC = 11 (52.4 %), GG = 7 (33.3%) and CG = 3 (14.3%). ). The distribution of the VEGF-A genotype (rs2010963) in the first non-CHD offspring, namely GG = 9 (42.9%), CC = 7 (33.3%) and GC = 5 (23.8%). The statistical analysis results showed that the p-value obtained was 0.460 for the VEGF-A gene polymorphism genotype (rs2010963) in the first CHD and Non-CHD derived samples. In conclusion, there was no significant difference in the VEGF-A gene polymorphism in the first generation of CHD and non-CHD groups in Bengkulu City. Keywords: PCR-RFLP, Coronary Heart Disease, Gene Polymorphism, VEGF-A
Ekstrak Labu Siam (Sechium edule) Dapat Menurunkan Kadar Serum Malondialdehid pada Tikus Putih (Rattus norvegicus) yang Diberikan Pakan Kolesterol Maria Eka Patri Yulianti; Elvira Yunita; Zhafran Hafizhki; Meiny Suzery; Neni Susilaningsih; Suhartono Suhartono
Journal of Telenursing (JOTING) Vol 4 No 1 (2022): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v4i1.3587

Abstract

This study aimed to analyze the effect of chayote extract (Sechium edule) on malondialdehyde serum levels in white rats (Rattus norvegicus) fed a high-cholesterol diet and to prove the antioxidant content of chayote. The method used is experimental with a post-test-only control group design. This study used white rats, which were divided into five groups. The results of this study indicate that the administration of chayote extract at a dose of 0.25 g/kg BW and 0.5 g/kg BW can reduce the serum MDA concentration, although it is not statistically significant, while the administration of a chayote extract at a dose of 0.75 g/Kg BW can significantly reduce serum MDA levels in white rats induced by hypercholesterolemia. In conclusion, chayote extract at a dose of 0.75 g/kg BW can reduce blood MDA serum levels in white rats induced by hypercholesterolemia. Keywords: Chayote Extract, Hypercholesterolemia, Malondialdehyde
Telekonsultasi Dalam Rangka Pemutusan Rantai Penularan Covid-19 di Kota Bengkulu Dessy Triana, M. Biomed; Hardiansyah Hardiansyah; Sri Yunita; Miftahul Haniyah; Enny Nugraheni Sulistiyorini; Riry Ambarsarie; Rizkianti Anggraini; Elvira Yunita; Mardhatillah Sariyanti
DHARMA RAFLESIA Vol 19, No 2 (2021): DESEMBER (ACCREDITED SINTA 5)
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/dr.v19i2.18373

Abstract

Coronavirus Disease-19 (Covid-19) is a disease that has become a global epidemic.  The World Health Organization (WHO) has declared Covid-19 a pandemic. Indonesia declared the status of the Covid-19 disease to be an Emergency Response. Supporting the social distancing, the right strategy is needed to continue implementing health services amid the Covid-19 pandemic. This activity aimed to provide knowledge related to Covid-19 to the community and health consultations and medical advice through applications (teleconsultation) to minimize patients queuing at Health Service Facilities directly. The activity partners were the Indonesian Medical Association (IDI) Bengkulu City Branch, Bengkulu City Health Office, and the Indonesian Red Crescent (BSMI) Bengkulu City Region. The method of this activity was to provide socialization, health consultation and medical advice through applications (teleconsultation) regarding the spread, transmission and prevention of Covid-19 from May 1 to August 31 2020. The number of participants was 41 people from Bengkulu City. The highest number of diseases consulted were acute respiratory infections (38.7%.) and Covid-19 independent protocol consultation (31.58%.) Teleconsultation can be continued and developed into a patentable application. Application development is indispensable in responding to the challenges of the health world in the digital era.
Co-Authors Ahmad Azmi Nasution Amellia Amellia Angelina Stevany Regina Masengi Annisa Puspa Sari Ashan, Hesty Rhauda Audia Indrian Aurora Fajria Anwari Ayu Suraduhita Bhayu Baruna Bastari Cindy Ernica Putri Debie Rizqoh Dessy Triana Diah Ayu Aguspa Dita Dyah Fitriani Ellen Maidia Djatmiko Ellfazmy, Asyifa Enny Nugraheni Fahira, Dita Fajrianti Haniyah Gina Fendiati Putri Gustria Ernis H. D. Putranto H. Kusnadi Hardiansyah Hardiansyah Hasanah, Qomariah Hilda Taurina Inta Cantika Ismir Fahri J. Firison Jihan Vira Yuniar Julian Famil Kartika Sari Kartika Sari Liya Agustin Umar Liya Agustin Umar Liya Agustin Umar Mardhatillah Sariyanti Maria Eka Patri Y Marisadonna Asteria Marisadonna Asteria Meiny Suzery Melva Louisa Miftahul Haniyah Muhammad Ridwan Mulyadi, Faizah Azzahrah N. J. Rangkuti Nailatul Karomah Neni Susilaningsih Nikki Aldi Massardi Noor Diah Erlinawati Notriawan, Doni Novriantika Lestari Novriantika Lestari Nur Hasanah Nurmeiliasari Oktoviani Putjha Melati Putri Maulida Rahmat, Arya Dwi Resda Akhra Syahrani Riry Ambarsarie Risti Dwi Ocktaviani Rizkianti Anggraini Sariyanti, Mardhatillah Septelia Inawati Wanandi Sipriyadi Sri Yunita Suhartono, Suhartono Sylvia Rianissa Putri Tauhid, Alfana Yudaru Tiara Ayoe Andita Waliyuddin Waliyuddin Yusuf Irshan Zhafran Hafizhki