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All Journal e-Journal Pustaka Kesehatan Dentika Dental Journal Jurnal Ilmu Kesehatan Masyarakat STOMATOGNATIC- Jurnal Kedokteran Gigi Majalah Kedokteran Gigi Indonesia Jurnal Kesehatan Gigi UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Health Notions Meditory : The Journal of Medical Laboratory Jurnal Pengabdian Nasional (JPN) Indonesia
Zahara Meilawaty
Department Of Biomedical, Faculty Of Dentistry, Universitas Jember, Jember, East Java
Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : UNEJ e-Proceeding

 1 
THE PROGRESSIVE LOW CHRONIC INFLAMMATION ON ORAL TISSUES IN ELDERLY Zahreni Hamzah; Dyah Indartin; Zahara Meilawaty
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Aging is a normal process, as inevitable biologicalphenomenon. Generally, this process characterizedby a decrease in the ability of resolution,regeneration, and reparation of cell and tissues, So,those cells and tissues cannot function properly andits will grow up and die.(1) WHO reports that thepopulation of elderly people worldwide increases by1.7% annually, whereas the population of peopleaged ≥ 65 years old increases by 2.5%. WHOclassified the elderly based on their chronologic/biologic state in 4 groups: (1) the middle age ranged45-59 years old, (2) the older/elderly age ranged 60-74 years old, (3) the advanced old age ranged 75-90years old, and (4) the very old age over 90 years old.Generally, elders ≥ 65 years old have healthproblems as effects of aging process. That meansthey need to have a special concern about theirhealth condition include in dental care.(2,3)Low, systemic and progressive chronic inflammationin elderly age is called inflammaging. This conditioncan occur as the effects of injury on cells andtissues.(4,5) There are some factors that cause injuryon cells, such as; hypoxia, chemical materials (toxins,drugs), physical agents (mechanical trauma,temperature, sudden changes in atmosphericpressure, radiation, electrical potency), microbiologyagents (virus, microbes, fungi), immune systemdisorder, genetic disorder, or malnutrition. Whenthe cells got injuries, there are some possibilityreactions on cells and tissues, e.g. retrogressivereaction, progressive reaction; and adaptationreaction. The main cause and the response towardsinflammaging that linked to illness are stillunknown.(6)
ROLE OF REACTIVE OXYGEN SPECIES ON DEVELOPMENTS OF OSTEOCLASTOGENESIS IN AGING Dyah Indartin Setyowati; Zahreni Hamzah; Zahara Meilawaty
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

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Osteogenesis is a process of development which is perfectly controlled by a number of extrinsic and instrinsic factors that consists of hormones, growth factors, cytokines produced in the bone marrow micro environment, due to process of molecules adhesion that mediate by the interaction of cells and cell-matrix, osteoblasts-specific signaling proteins and transcription factors (TFs). Recently, research explained that adherence osteoclasts on the bone surface and secretion of protons into an extracellular compartment between osteoclasts and bone surface together with the production of Reactive Oxygen Species (ROS) involved in the complex process of bone resorption. Superoxide role in the activation and transcription NF-κB factor is to increase osteoclastogenesis. Furthermore, it is alleged that ROS is involved in both differentiation of osteoclasts and osteoblast cell. Aging and diseases which associated with aging is a result of ROS that cause damage was reported increase with age. This review, which is dedicated to geriatric physicians, geriatric dentistry or gerodontology reviews ROS-related osteoclastogenesis in aging and as the basic of the research to determine benefit of ROS through NADPH oxidase activation in the osteopetrotic case.
Co-Authors Agustin Wulan Suci Dharmayanti Alisah, Putri Alisah Amandia Dewi Permana Shita Amandia Dewi Permana Shita Amelia Nur Ilahi Ari Tri Wanodyo Handayani Banun Kusumawardani Budi Prabowo Budi Prabowo Desi Sandra Sari Desi Sandrasari Dessy Rachmawati Dhea Ayu Dewanti Dyah Indartin Dyah Indartin Setyowati Ernie Maduratna Setiawatie Galau, Argha Sirna Galdhisia Devita Caresya Happy Harmono Hendy Hendarto Hestieyonini Hadnyanawati Kholidiya, Wulan Ratna Nur Kiswaluyo . Lutfi Meiga Sari M. Nurul Amin Muhammad Nurul Amin Nabilla, Purry Roro Nulend, Jenneke Klein Octaviana Putri Puspita Sari Oktavia Nur Vitasari Paramudibta Lungit Kuncaraningtyas Permata, Dea Permatasari, Sabania Dinar Pradnyani, Ni Luh Kadek Ardhia Swari Prafitasari, Dinar Pudji Astuti PUDJI ASTUTI Ratna Dewanti, I Dewa Ayu Rendra Chriestedy Prasetya Rido Tri Andika Firdyansyach Ristya Widi Endah Yani Rothschildi, Dhesyarmani Putri Sari Setyaningsih Setyaningsih, Sari Tantin Ermawati Tecky Indriana Widodo, Alaya Dwi Salvahira Yunianti, Ervisya Nandya Zahreni Hamzah Ziaulhaq, Mochamad Najib