Article Per Year (5 Year)
p-Index From 2021 - 2026
1.554
P-Index
This Author published in this journals
All Journal Record and Library Journal Dental Journal (Majalah Kedokteran Gigi) Journal Of Vocational Health Studies Darmabakti Cendekia: Journal of Community Service and Engagements Dentin Journal of Global Pharma Technology
Sianiwati Goenharto
Department Of Orthodontic Dentistry, Faculty Of Dental Medicine, Universitas Airlangga
Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Health Professions Library & Information Science Medicine & Pharmacology Public Health Social Sciences

Published : 22 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Journal of Global Pharma Technology

 1 
In Silico Study of Anti-Inflammatory Potential of 1.8-Cineole against Cox-2 and TLR-2 Sianiwati Goenharto
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (550.876 KB)

Abstract

Objective: To determine the anti-inflammatory activity of 1.8-cineole against COX-2 and TLR-2 using an in silico approach. Methods: In silico studies were conducted using the Molegro Virtual Docker (MolDoc) program to predict the anti-inflammatory potency of 1.8-cineole against COX-2 and TLR-2 receptors. Results: MolDoc score showed that 1,8-cineole (-49.1236) could be predicted to be an anti-inflammatory ligand demonstrating lower activity than diclofenac or COX-2 (-106.8010) ligand. 1,8-cineole (-42.7930) can also be predicted to be an anti-inflammatory ligand with lower activity than TLR-2 / CAS_673 ligand (-56.5640). Conclusion: 1.8-cineole possesses anti-inflammatory potential against COX-2 and TLR-2 receptors based on an in silico predictive study.
Protective Activity of 1, 8-Cineole against Inflammatory and Oxidative Stress Marker from Methyl Methacrylate Exposure Sianiwati Goenharto
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: This study was aimed to determine the potential of 1,8-cineole to reduce the amount of malondialdehyde (MDA), interleukins (IL)-8 and neutrophils in MMA-exposed lung alveolar cells. Methods: Thirty mice were divided into five groups: a normal control group (K0), a negative control group (K1) and a treatment group, further subdivided into P1, P2 and P3, whose members were administered 5 mg, 10 mg and 15 mg doses of 1,8-cineole. The treatment group subjects were placed in a glass cage containing 150 ppm MMA vapor that has been nebulated by 1.8-cineole vapor for 120 minutes. The mice were subsequently terminated, and tissue removed from their lungs. Observation of MDA and expression of IL-8 was conducted during immunohistochemical examination. Neutrophils was observed using Hematoxylin Eosin (HE) staining. Results: MMA exposure significantly increased MDA, IL-8 and neutrophil counts. Meanwhile, administration of 1, 8-cineole successfully reduced MDA numbers. Fifteen milligrams of 1, 8-cineole constituted the only dose which proved capable of reducing the expression of IL-8. Administration of 1, 8-cineole in all groups also decreased the number of neutrophils. Conclusion: 1, 8-cineole, especially at a dose of 15 mg, can reduce the levels of MDA, IL-8 and neutrophil in the lung tissue of mice following exposure to MMA vapor.Keywords: MMA, 1, 8-cineole, Inflammation, ROS, MDA.
Co-Authors Achmad Sjafei Ahmad Sjafei Alga Meisha Purwanto Anisa Nur Halimah Anisa Nur Halimah Asdika, Rere Gathi Dewi, Ajeng Firliana Dinda Nur Agustin Dini Setyowati, Dini Elly Rusdiana, Elly Eny Inayati, Eny Haula Robbi, M. Kautsar Ida Nurul Khairyyah, Ida Nurul Jovanka Yemima Putri Kusdarjanti, Endang Kusdaryanti, Endang Laksmi LR, Mia Lita Rosa, Mia Laksmi Melisa Budipramana, Melisa Narta Nikita Indiani Narta Nikita Sari Nirmala Ratna Harda, Sasadhara Nur Halimah, Anisa Pauline, Yobellivia Rahmadani, Annisa Ratwita, Rr. Dwiyanti Feriana Redjeki I, Sri Redjeki Indiani, Sri Rizka Amelia Mayasari Setyowati, Okti Sinkka Adekia Wulandandari Sri Redjeki Sri Redjeki Indiani Sri Redjeki Indiani, Sri Redjeki Sri Wahjuni Sujati Thalca Hamid Widiya Ulfa Widya Ulfa Winda Kusumawardani