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All Journal ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Conservative Dentistry Journal Indonesian Journal of Dental Medicine Indian Journal of Forensic Medicine & Toxicology Odonto dental journal
Ira Widjiastuti
Faculty Of Dental Medicine, Airlangga University
Dentistry Health Professions Medicine & Pharmacology Public Health

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Biocompatibility of 0,78% tannin of garciniamangostanalinnpericarp extract and 0,2% chlorhexidinegluconateagainst BHK-21 fibroblast cells culture Monika Werdiningsih; Ira Widjiastuti; Febriastuti Cahyani; Dian Agustin Wahjuningrum
Conservative Dentistry Journal Vol. 10 No. 1 (2020): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.872 KB) | DOI: 10.20473/cdj.v10i1.2020.36-39

Abstract

Background.Chlorhexidinegluconate is one of endodontic irrigants potential due to its antibacterial activity. Although it is an effective antibacterial agent, chlorhexidinegluconate cannotdissolve organic substances and necrotic tissue present in the root canal. In addition, same as other chemicals, chlorhexidinegluconate also cause a cytotoxic effect. Tannin extracts of mangosteenpericarp (Garciniamangostana Linn.) demonstrated various biological activities including antibacterial, antioxidant, anticancer and anti-inflammatory. Tannin extracts of mangosteenpericarp can be considered as an alternative endodontic irrigation for dental application.Purpose.The aim of this study was to compare the biocompatibility between 0,78% tannin extracts of mangosteen pericarp and 0,2% chlorhexidinegluconate to BHK-21 fibroblass cell. Method.Tannins obtained from extracts of mangosteenpericarp. Preliminary test was conducted in the biocompatibility of tannin extracts of mangosteenpericarp in various concentrations of the BHK-21 fibroblass. Tannins extracts of mangosteenpericarp was at concentrations of 0,78% less toxic than the other concentrations. Then biocompatibility of 0,78% tannin extracts of mangosteenpericarp compare with 0.2% chlorhexidinegluconate using cytotoxicity test on BHK-21 fibroblass cells with MTT method and observed by ELISA reader. Results.0,78% tannins extracts of  mangosteenpericarp showed good biocompatibility with fibroblass BHK-21 than 0,2% chlorhexidinegluconate. There was a significant differences between the results of treatment with 0,78% tannin extracts of mangosteenpericarp and 0.2% chlorhexidinegluconate. Conclusion. 0,78% tannin extracts of mangosteenpericarp has better biocompatibility than 0,2% chlorhexidinegluconate as an endodontic irrigants.
THE EFFECT OF CALCIUM HYDROXIDE-PROPOLIS ON THE NUMBER OF MACROFAG CELLS ON THE WISTAR RAT DENTAL WITH PULPA PERFORMANCE Setyabudi Setyabudi; Devi Eka Juniarti; Ira Widjiastuti; Maughfirah Shintya Fathori
Conservative Dentistry Journal Vol. 10 No. 2 (2020): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v10i2.2020.58-61

Abstract

Background: Cellular response of dental pulp to existing lesions, caused by infiltration of inflammatory cells that migrate from blood vessels to the site of injury. Macrophages are the cells that most appear when inflammation occurs. Treatment for maintaining pulp tissue vitality is called pulp capping. Calcium hydroxide as a pulp capping material has the ability to trigger the growth of dentin bridges or remineralization, but calcium hydroxide can induce migration and proliferation of inflammatory cells. Currently the field of dentistry is developing propolis as an alternative pulp capping material. That is because propolis has anti-inflammatory properties. Objective: To analyze the effect of the combination of calcium hydroxide-propolis on the number of macrophage cells in the teeth of wistar rats with pulp perforation. Method: This study used 30 samples of Wistar rats which were preparated until perforation and then divided into 3 groups. The first group continued with filling with cention, the second group continued with application of calcium hydroxide and filled with cention, and the third group continued with the application of combination of calcium hydroxide and propolis and then being filledwithcention. Macrophage cell is calculated histopathologically by using compound light microscope on the 3rd day with 400x magnification. Results: The Kruskal-Wallis test results showed significant differences in macrophages after the combination of calcium hydroxide and propolis (p = 0,000). The combined application of calcium hydroxide and propolis showed higher macrophages than the application of calcium hydroxide and the control group. Conclusion: Application of calcium hydroxide - propolis combination was proven increase the number of macrophage cells in Wistar Rats (Rattus Norvegicus) with pulp perforation
THE EFFECT OF COMBINATION CALCIUM HYDROXIDE-PROPOLIS APPLICATION TO AMOUNT OF NEUTROFIL CELLS ON WISTAR RAT PULP PERFORATION Ira Widjiastuti; Setyabudi Setyabudi; Nia Nur Haliza
Conservative Dentistry Journal Vol. 10 No. 2 (2020): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v10i2.2020.66-70

Abstract

Background: Pulp inflammation can be treated with pulp capping by calcium hydroxide as the gold standard. Pulp capping by calcium hydroxide could causing tissue necrosis followed by inflammation. Calcium hydroxide combined with propolis which have anti-inflammatory effects through inhibition of the Nf-kB pathway and pro-inflammatory cytokines. That process will inhibit the increase of vascular permeability and neutrophil chemotaxis. Inflammatory process can accelerate by controlling the amount of neutrophil cells as a acute phase marker, so the healing process occurs more quickly. Therefore it is necessary to study the amount of neutrophil cells in the pulp perforation of Wistar rats after applicated by combination of calcium hydroxide-propolis. Purpose: To analyze the difference amount of neutrophil cells on the Wistar rats pulp perforation after applicated by calcium hydroxide-propolis combination compared with calcium hydroxide-aquadest Method: M1 tooth perforated for all groups with three types tratment: no medication (control group), calcium hydroxide-aquadest 1: 1 (P-1 group), and calcium hydroxide-propolis 1: 1.5 (P-2 group) and closed with cention. Observations were made on the 1st, and 3rd day with HE staining. Results: One Way ANOVA shown a significant difference (p <0.05) of the average amount of neutrophil cells between all treatment groups on 1st day (p=0,000) and 3rd day (p=0,000). The amount of neutrophil cells in the calcium hydroxide-propolis (P-2) combination group was lower than control group and calcium hydroxide-aquadest (P-1) group on the 1st and 3rd day. Conclusion: The amount of neutrophil cells after application of calcium hydroxide-propolis is lower than calcium hydroxide-aquadest application.
The Role of Propolis in Pulp Pain by Inhibiting Cyclooxygenase-2 Expression Ira Widjiastuti; Widya Saraswati; Annisa Rahma
Conservative Dentistry Journal Vol. 11 No. 1 (2021): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v11i1.2021.11-18

Abstract

Background: Inflammation of the pulp can lead to elicit pain. Pain in inflammation is induced by the cyclooxygenase-2 enzyme (COX-2) which induces prostaglandin E2 (PGE2) resulting in pain. Pain in the pulp can be relieved by eugenol. In its application, eugenol is toxic to pulp fibroblasts. Due to the side effect, it is worth considering other biocompatible materials with minimal side effects, such as propolis. Flavonoids and phenolic acids that contained in propolis can inhibit COX-2. Therefore, an analysis outlined in the literature review is needed to examine the results of research related to the role of propolis as pulp pain relief by inhibiting COX-2 expression. Purpose: To analyze the role of propolis in pulp pain by inhibiting COX-2 expression. Reviews: Propolis extract that extracted by ethanol, water, and hydroalcohol has pain relief properties in the pulp by inhibiting COX-2 by directly binding to the COX-2 receptors and by reducing the production of proinflammatory cytokines which are COX-2 inducers, proven through in vivo, in vitro, and in silico studies in various target cell organs. Conclusion: Propolis extract has high prospect as inflammatory pain inhibitor in the pulp by inhibit COX-2 expression.
BULKFILL TECHNIQUES WITH INTERMEDIATE LAYER TO MARGINAL ADAPTATION RESTORATION OF CLASS II COMPOSITE RESIN Mochammad Raidjffan Zulkarnaen Tabona; Adioro Soetojo; Ira Widjiastuti
Conservative Dentistry Journal Vol. 11 No. 1 (2021): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v11i1.2021.32-37

Abstract

Background: Dental caries is a hard tissue disease caused by bacterial metabolic activity that causes demineralization, teeth that have caries should be filled in order to function again. One of the restorative materials closer to natural teeth is composite resin because it is the same colour as natural teeth and is easy to shape. As for the placement technique, bulkfill is also used because it is more time-efficient, and irradiation is accompanied by applying the restoration material in one batch. However, the bulkfill technique often causes micro-leakage of dental caries deposition. The intermediate layer is an intermediate layer used to prevent micro-leakage at the edges of the restoration as a base layer for restoration to create a good adaptation before applying packable composite resin. Therefore, bulkfill coating technique with the intermediate layer can reduce the risk of microleakage. Purpose: To describe the bulkfill technique with an intermediate layer against marginal adaptation with class II composite resin restorations. Review: The literature sources used in the preparation of the articles through several databases with descriptions. More journals say that micro-leakage in class II cavity deposition with the intermediate layer technique is better than the bulkfill technique because the intermediate layer technique has better bond strength than the bulkfill technique. If the Bulkfill technique is modified with the Intermediate layer technique, it can show good correlation and internal adaptation. Conclusion: Bulkfill technique with an intermediate layer against marginal adaptation with class II composite resin restorations can reduce the microleakage rate by reducing the polymerization's shrinkage strain.
STIMULASI EKSTRAK PROPOLIS PADA ODONTOBLAST LIKE CELLS YANG DIINDUKSI LACTOBACILLUS ACIDOPHILUS INAKTIF TERHADAP EKSPRESI TLR2 DAN TNFα Ira Widjiastuti; Nadia Irnatari; Mandojo Rukmo
Odonto : Dental Journal Vol 4, No 2 (2017): December 2017
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (446.899 KB) | DOI: 10.30659/odj.4.2.85-93

Abstract

Background: Lactobacillus acidophilus, Gram-positive bacterias that enterthe dentinal tissue during the carious process are suspected to influence the immune response in human dental pulp. Odontoblasts situated at the pulp dentin interface are the frst cells encountered by these bacteria and have an important role in this response. Lipoteichoic acid (LTA), a wall component of Gram-positive bacteria, triggered the activation of the odontoblasts. LTA upregulated the expression of its own receptor TLR2, as well as the production of proinflammatory cytokineTNFα. Propolis is a resinous material that holds a great potential as an antiinflammatory agent. Present studies have shown that propolis has a reduction effect towards the proinflammatory cytokines expression and favor pulp healing.Purpose: To reveal the moleculer mechanism of propolis stimulation onodontoblast like cells, induced by inactive Lactobacillus acidophilus.Methods: This review was presented in odontoblasts like cells culture induced by inactive Lactobacillus acidophilus and exposed to propolis extract. Pulp cell culture isolated from human impacted thirds molar that has been extracted. Observation and measurement the expression of TLR2 and TNFα was processed by using immunocytochemistry (ICC) technic.Result: Data analysis with ANOVA test, a signifcant difference in every group(p<0,05) was present. The expression of TLR2 and TNFα were shown at lowlevel percentation on odontoblast like cells, induced by Lactobacillus acidophilus and propolis extract stimulation.Conclusion: Propolis extract stimulations lower the TLR2 and TNFα expression on odontoblast like cells, induced by inactive Lactobacillus acidophilus
Effective dose of propolis extract against pain response in mice (Mus musculus) using writhing test method Salsabilla Zamrutizahra, Chonny; Widjiastuti, Ira; Kunarti, Sri
Conservative Dentistry Journal Vol. 12 No. 2 (2022): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v12i2.2022.86-89

Abstract

Background: Odontogenic pain has a high prevalence. One of the alternative materials used as medicine in dentistry is propolis. Propolis is a mixture of natural resins containing flavonoid and phenolic acids that play a role in suppressing the pain response through COX and NF-kB inhibition mechanisms. The content of active propolis compounds is influenced by the type of bee, region, geographical conditions, climate change, seasons, and botanical sources causing different effectiveness of propolis. This is supported by several studies that show a variety of effective doses that produce an optimal analgesic effect, thus a research plan was developed to discover the effective dose of propolis extract on suppressing pain response in mice using the writhing test method. Purpose: To determine the effective dose of propolis extract towards pain response in mice. Methods: This study was conducted using the writhing test method to see the analgesic effect of propolis extract. The research sample consisted of 30 mice which were divided into five treatment groups, namely the piroxicam control group, and the propolis extract group at doses of 35 mg/kgBW, 70 mg/kgBW, 105 mg/kgBW, 140 mg/kgBW. Results: The results showed that the propolis extract dose of 70 mg/kgBW had no significant difference with the piroxicam control group, while between the doses of 35 mg/kgBW, 105 mg/kgBW, 140 mg/kgBW there was a significant difference towards the piroxicam control group. Conclusion: Propolis extract 70 mg/kgBW is the effective dose in suppressing pain response in mice
Management of Enamel Hypoplasia in Maxillary Incisors with Composite Direct Veneers: Case Report Rafania Atikah, Ayu; Irwantoro, Edward; Widjiastuti, Ira
Conservative Dentistry Journal Vol. 12 No. 2 (2022): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v12i2.2022.100-104

Abstract

Background: Dental esthetics is an important aspect that needs to be considered in today's dental treatment planning. Enamel hypoplasia is teeth discoloration from yellowish to brownish due to disturbances during the amelogenesis process. Direct veneers are a conservative treatment option that supports the esthetics of anterior teeth. Purpose: To improve patient's appearance by a viable treatment option that offered rehabilitation of anterior teeth. Case: A 18-year-old female patient felt uncomfortable and wanted to improve her appearance because the front teeth had old fillings turned yellowish and white spots. Objective examination showed enamel hypoplasia in 12, 11, 21, 22 and secondary caries in 11 and 22. Case Management: The treatment plan was direct composite veneers. The initial stage is digital smile design analysis and composite shade selection using the button try technique. Minimally invasive preparations were performed on teeth 12, 11, 21, 22. Etching using 37% phosphoric acid and bonding agent was applied to the prepared enamel. The layering technique is used for composite applications. Finishing, contouring and polishing using Soflex Disc Coarse and Diacomp Twist. Conclusion: Direct composite veneers are a viable treatment option for patients requiring rehabilitation of anterior teeth.
Effective Dose of Nano Propolis as Anti-Pain in Animal Models of Mus Musculus Using Writhing Test Method Witjaksana, Annisa Salsabila; Widjiastuti, Ira; Juniarti, Devi Eka
Conservative Dentistry Journal Vol. 13 No. 1 (2023): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v13i1.2023.7-10

Abstract

Background: Odontogenic pain has a high prevalence where this pain is the result of noxious physical stimuli or calming inflammatory mediators that stimulate receptors located at the terminal ends of nociceptive C and Aδ afferent nerve fibers. Nano propolis is an alternative material that is used as a medicine in dentistry. Nano propolis is a mixture of natural resins containing flavonoids and phenolic acids which play a role in suppressing pain response through COX and NF-kB inhibition mechanisms. Nanoparticle technology is capable of preparing active drug ingredients in nano-sized particles and can affect drug effectiveness, because particle size affects the process of solubility, absorption and distribution of drugs. Research on the potential of nano propolis as an anti-pain is still minimal, so further research is needed on the function of nano propolis as an alternative anti-pain agent. Purpose: To determine the effective dose of nano propolis on pain response in Mus musculus. Methods: This research was conducted using the writhing test method to see the analgesic effect of nano propolis. The research sample consisted of 28 Mus musculus which were divided into four treatment groups, namely the piroxicam control group, and the nano propolis treatment group of 17.5 mg/kg, 35 mg/kg, and 70 mg/kg. Results: The results showed that the four treatment groups did not have a significant difference, in other words, they had the same anti-pain effect. Conclusion: Nano propolis 35 mg/kgBB is an effective dose in suppressing pain response in Mus musculus.
The potency of propolis extract as anti-inflammatory agent for stimulation of reparative dentin formation Anindya, Cinitra; Widjiastuti, Ira; Zubaidah, Nanik
Conservative Dentistry Journal Vol. 13 No. 1 (2023): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v13i1.2023.42-47

Abstract

Background: As an effort to treat a deep caries lesion with a diagnosis of reversible pulpitis, one of the treatment options is pulp capping. For decades, calcium hydroxide has been considered the most acceptable pulp capping material and has been routinely used in dental practice, but it also has some weakness. To overcome that, alternative materials are needed that can provide a better effect. Recently, a lot of research has been done using natural ingredients, including Propolis. Propolis has been known to have strong antimicrobial and anti inflammatory properties. Therefore, it is necessary to conduct a deeper study regarding the potency of propolis extract as an anti inflammatory agent for the stimulation of reparative dentin formation so that it can be considered to be used as a pulp capping material. Objective: The aim of this literature review is to highlight the potency of propolis extract as anti inflammatory agent in the natural stimulation of reparative dentin formation. Methods: The search strategy consist of an electronic research using databases such as PubMed, Google Scholar, Science Direct, dan Springer Link for studies published from 2003 to 2021 regarding the potency of propolis extract as anti inflammatory agent for stimulation of reparative dentin formation, including review articles and research articles. Results: Propolis and its constituents have been proven to be used as a potent natural anti inflammatory, it also considered to have the ability to promote reparative dentin formation. However, there are some literatures stated that reparative dentin does not form with the application of propolis, and the causes may vary. Conclusion: Propolis extract has a potency as an anti inflammatory agent in dental pulp inflammation by inhibiting TNFα expression, and increasing TGF-β1 expression, as well as its potency in stimulating the formation of reparative dentin. Based on this review, further studies are needed.
Co-Authors Adeline Jovita Tambayong Adioro Soetojo Aga Satria Nurrachman Agata Nadia Agnes Melinda Wong Agus Subiwahjudi Agus Subiwahjudi Alhidayati Asymal Alvita Wibowo Amalia Dara N Amelia Kristanti Rahardjo Rahardjo Andrie Handy Kusuma Annisa Rahma Ari Subiyanto Aulia, Zahra Maulida Cecilia G. J. Lunardhi Chatarina Umbul Wahyuni Chonny Salsabilla Zamrutizahra Christian, Bernardus Daniel Cinitra Anindya Daniyal Lazuardi Ramadhan Debby Fauziah Suryani Derice Putri Nourah Serena Devi Eka Juniarti Devi Puspitasari Dian Agustin Wahjuningrum Djoko Agus Purwanto Dwina Rahmawati Junaedi Edhie Arif Prasetyo Eric Priyo Prasetyo Erika Setyowati Evri Kusumah Ningtyas Fauziah Diajeng Retnaningsih Febriastuti Cahyani Febriastuti Cahyani Galih Sampoerno Grace Angelina Samuel Hanun, Hafshah Zhafirah Siri Irwantoro, Edward Ivan Nur Fadela Ketut Suardita, Ketut Kharisna, Deaniddo Kun Ismiyatin Kuntaman Kuntaman Laksmiari Setyowati M. Aditya Syahputra M. Mudjiono Mandojo Rukmo Maughfirah Shintya Fathori Michael Golden Kurniawan Moch. Mudjiono Mochammad Raidjffan Zulkarnaen Tabona Monika Werdiningsih Nabila, Rizka Affan Nadia Irnatari Nancy Cynthia Sudiartha Nanik Zubaidah Nastiti Faradilla Ramadhani Ni Putu Sawitri Mega Nia Nur Haliza Nirawati Pribadi Nur Dianawati Nurkhalidah, Binar Najwa Pramesty, Azzahra Kinaya Putra, Mohammad Gerald Athallah Rafania Atikah, Ayu Raftiani, Ardelia Sabrina Rendy Popyandra Rini Devijanti Ridwan Riyan Iman Marsetyo Ruslan Effendy Ruslan Effendy Sagita Putri Andyningtyas Salsabilla Zamrutizahra, Chonny Serena, Derice Putri Nourah Setyabudi Setyabudi Setyabudi Shufiyah Nurul Aini Sri Kunarti Sri Kunarti, Sri Sri Wigati Mardi Mulyani Sukaton, Sukaton Syahria, Hania Dana Tiara Dyah Iswari Tiara Sukmawati Valensia, Theodora Wahyu Setyarini Widya Saraswati Wijanarko, Christina Immee Witjaksana, Annisa Salsabila Yunita Savitri