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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Neutrino : jurnal fisika dan aplikasinya El-Hayah : Jurnal Biologi Journal of Agromedicine and Medical Sciences Journal of Islamic Medicine Bubungan Tinggi: Jurnal Pengabdian Masyarakat PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID)
Alvi Milliana
Department Of Microbiology, Faculty Of Medicine, And Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Social Sciences Other

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Journal : Jurnal Neutrino : jurnal fisika dan aplikasinya

 1 
NEUTRAL PH AND COLD TEMPERATURES STABILIZE THE PROTECTIVE EFFECT OF CRUDE PILI S. FLEXNERI ON THE ILEAL MUCOSA OF MICE Avin Ainur Fitrianingsih; Lailia Nur Rachma; Alvi Milliana
Jurnal Neutrino:Jurnal Fisika dan Aplikasinya Vol 12, No 1 (2019): October
Publisher : Department of Physics, Maulana Malik Ibrahim State Islamic University of Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/neu.v12i1.15525

Abstract

Alternative therapies are being sought as a result of the rising concerns with inadequate and untrustworthy medical treatments for Shigella flexneri. The current study aimed to assess the preventive and therapeutic effects of crude pili S. flexneri on of neutral pH and cold temperature against Shigella flexneri infection in immunocompetent mice. Twenty male Swiss albino mice were randomly assigned to one of two groups: control or experimental groups. Each group was subsequently separated into four equal subgroups. In order to infect the mice, 4 weeks before infection, the experimental subgroups were given crude pili S. flexneri orally in every week (three times) until the completion of the research. After following the treatment of crude pili S. flexneri, all group infected with Shigella flexneri. The small intestines of mice were processed and analyzed for the presence of the pathological lesions. Jejunal portions were measured. The findings revealed that vaccinated mice had a statistically significant increase in the quantity of health mucose as compared to non-infected group in ileal sections. Crude pili S. flexneri was administered to the intestinal portions of all subgroups before or after the infection, and the architecture was found to be more or less normal. Our data indicate that crude pili S. flexneri in neutral pH and cold temperature is a useful preventative and a potentially effective treatment medication for S. flexneri infection.
Co-Authors Adhitya Wishnu Kresnanda Astari, Lina Fitria Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Avin Ainur Fitrianingsih Christyaji Indradmojo Ermin Rachmawati Ermin Rachmawati Filzah, Sefira Maulida Fitriyani Fitriyani Indradmojo, Christyaji Indriana, Nurfianti Jatmiko, Ricko Arie Kresnanda, Adhitya Wishnu Lailia Nur Rachma M Abbas Arriziq Nurfianti Indriana Prawiro, Sumarno Reto Purnomo S, Fahrurrozi Hari Rahmi Annisa Ricko Arie Jatmiko Roihatul Mutiah Sanarto Santoso Sanarto Santoso Sefira Maulida Filzah Sumarno Reto Prawiro Tinny Endang Hernowati Tinny Endang Hernowati Usman Pagalay Wahyu Safitri Widowati, Ade Triana Wirda Anggraini Zainabur Rahmah