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All Journal ACTA VETERINARIA INDONESIANA Pharmacon Sains Natural: Journal of Biology and Chemistry Pharmacology and Clinical Pharmacy Research Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Entomologi Indonesia Sainstech Farma: Jurnal Ilmu Kefarmasian Patria : Jurnal Pengabdian Kepada Masyarakat Jurnal Sains dan Kesehatan
MOERFIAH .
Pakuan University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Analgesic Activity of Bitter Melon Leaves Ethanol Extract in Mice (Mus musculus) Nisa Najwa Rokhmah; Moerfiah Moerfiah; Hijib Sihabullah
Jurnal Sains dan Kesehatan Vol. 3 No. 4 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i4.438

Abstract

Pain is an unpleasant sensation and can be felt as sore sensation. This can be caused by mechanical, chemical or physical stimulation that could cause damage to the tissueand trigger the release of certain substances called pain mediators, such as histamine, bradykinin, leukotrienes and prostaglandins. Pain overcome by giving analgesic drugs. This study aims to determine the effectivity and effective duration of bitter melon (Momordica charantia L.) leaf extract as analgesic in mice (Mus musculus). The test method used in this study is the Hot plate method. This study was divided into 5 treatment groups animals with 5 experimental animals in each group. Animal treatment of this study consist of a negative control group using CMC-Na (0.5%), a positive control group using Paracetamol, a suspension group of pare leaf ethanol extract with a dose of 0.212mg / 20gBW. , the ethanol extract suspension group of bitter melon leaves with a dose of 0.423mg / 20gBW, the suspension group of ethanol extract of pare leaves with a dose of 0.635mg / 20gBW. The results of this study indicate that the ethanol extract of 96% bitter melon leaves has activity as an analgesic in mice with the best dose of 0.635mg / 20gBW and the highest duration of analgesic activity was in 40 minutes, these activity was the closest result to positive control of paracetamol in mice.
The Effectiveness of Beetroot and Apple Juice Combination on Physical Endurance and Hemoglobin Levels in Sprague Dawley Rats Setiawan, Deni; Moerfiah, Moerfiah; Yulianita, Yulianita
Journal of Science Innovare Vol 7, No 2 (2024): Journal of Science Innovare, Volume 07 Number 02 2024
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jsi.v7i2.11303

Abstract

The present study investigates the stimulant and hematological effects of combined beetroot (Beta vulgaris L.) and apple (Malus pumila Mill.) juice on the physical endurance and hemoglobin (Hb) levels of Sprague Dawley rats. Adequate Hb concentration plays a critical role in oxygen transport and energy metabolism during physical activity. Thus, natural stimulant sources rich in bioactive compounds were evaluated as potential alternatives to synthetic energy supplements. Twenty-five male rats were divided into five treatment groups (n = 5): three groups receiving different ratios of beetroot and apple juice (1:1, 2:1, and 1:2), a negative control (CMC-Na 0.5%), and a positive control (caffeine 20 mg/200 g body weight). Stimulant activity was assessed using a rotarod endurance test, while Hb levels were measured by the Sahli method using a hemometer. The results demonstrated that the combined beetroot and apple juice significantly enhanced both endurance duration and hemoglobin concentration compared to the negative control (p 0.05). The optimal stimulant and hematopoietic effects were observed in the 2:1 beetroot-to-apple ratio, corresponding to doses of 5.6 g and 0.63 g per 200 g body weight, respectively. This combination yielded prolonged rotarod retention time and elevated Hb levels up to 18.5 g/dL, exceeding baseline and control values. The observed enhancement is attributed to the synergistic effects of bioactive constituents such as iron, potassium, flavonoids, and vitamin C, which facilitate oxygen transport, neuromuscular coordination, and erythropoiesis. These findings indicate that beetroot–apple juice exerts a physiological stimulant effect while improving hematological parameters without the adverse effects commonly associated with synthetic caffeine-based stimulants. This study highlights the potential of functional plant-based beverages as safe natural ergogenic aids for improving endurance and blood health.
Co-Authors - Affandi . Yulianita, . Achmad Supriadi Agus Ismanto Akhmad Rizali Auliya, Risa Bandung Sahari D Prasetyorini DAMAYANTI BUCHORI DENI SETIAWAN Deni Setiawan Dwi Ambarwati E Mulyati Effendi, E Mulyati ENRI AGUS SETIANI Erni Rustiani Hijib Sihabullah Iyan Mulyana Lusi Agus Setiani Muhamad Nizar Zulfikar Muztabadihardja, - Najwa Rokhmah, Nisa Nina Herlina Pungky Umi Sa’diyah Puspita Dewi, Santi Rangga Eka S. P Restu T. Purnama Sara Nurmala Septiani, Desi Sri Wardatun Supomo, Fira Diah Setiawaty Triastinurmiatiningsih, Triastinurmiatiningsih Winardiana, Yuda Yulianita, Yulianita Zunnita, Oktaviana