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All Journal Jurnal Ilmu Dasar e-Journal Pustaka Kesehatan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia JFIOnline Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Applied Research (IJAR) International Journal of Islamic and Complementary Medicine Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia Journal of Agropharmacy Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Yudi Wicaksono
Faculty Of Pharmacy, University Of Jember
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Education Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Development of cassava starch-avicel PH 101 for coprocess diluent of direct compression tablet Yudi Wicaksono; Nailis Syifa'
Indonesian Journal of Pharmacy Vol 19 No 4, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.443 KB) | DOI: 10.14499/indonesianjpharm0iss0pp165-171

Abstract

Cassava starch is tablet excipient with poor of both flowability and compressibility which can not be used as diluent of direct tablet compression. The purpose of this research was to develop co-process of cassava starch-Avicel PH 101 for diluent of direct compression tablet. To achieve this goal, the thing that has been done are : (1) isolation of cassava starch (2) co-processing of cassava starch-Avicel PH 101 (3) testing of mechanic-physic properties of co-process of cassava starch-Avicel PH 101 (4) evaluation of co-process of cassava starch-Avicel PH 101 as diluent of direct compression tablet. The results indicated that ratio cassava starch-Avicel PH 101 (60:40) provided co-process with the best of mechanical-physical and compression properties. The best of mechanical-physical properties were flowability about 6,70±0,28 g/dt and tapping index about 12,57±1,18.%. The best compression properties of cassava starch-Avicel PH 101 co-process were crushing strength about 4,97±0,23 kp and friability about 0,52±0,03.% with disintegration time and tablet uniformity fulfill with requirement of pharmacopoeia.Key words: cassava starch, Avicel PH 101, co-process, direct compression tablet
Co-processing of the arrowroot-chitosan by spray drying Yudi Wicaksono; Yuli Witono; Herlina .; Nuri .
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (241.49 KB) | DOI: 10.14499/indonesianjpharm0iss0pp171-177

Abstract

Starch is one of the most widely used excipient in the manufacture of solid dosage forms. One of few problems associated with starch is its poor flowability so  can’t  used  as  excipient  in  direct  compression  tablet.  The  purpose  of  these studies  was  to  develop  of  the  arrowroot  starch  for  use  as  excipient  in  direct compression  tablet.  The  arrowroot  starch  was  co-processing  with  chitosan  by spray  drying.  The  suspension  of  arrowroot  starch-chitosan  for  feed  in  spray drying were prepared with three different ratios (1:1, 2:1 and 3:1). The product of  co-processing  were  evaluated  for  morphology,  moisture  content,  viscosity, angle  of  repose,  flow  rate  of  granules,  bulk  density,  tapped  density  and  Carr’s index.  Results  showed  that  co-process  excipient  of  arrowroot  starch-chitosan have  spherical  in  shape,  moisture  content  in  the  range  of  4.70–5.10  % w/w, viscosity  in  the  range  of   1.77-2.17  mPas,  angle  of repose  was  found  to  be  < 380, flow rate of granules in the range of 1,5 – 4,0 g/s, bulk density in the range of  0.47-0.59 g/mL,  tapped  density  in  the  range of 0.59–0.79  g/mL  l and Carr’s index in the range of 19.03-25.08 %.Key words: arrowroot starch, co-process excipient, direct compression
Co-Authors Ameliana, Lidya Barikah, Kuni Zu'aimah Barikah, Kuni Zuaimah Barikah, Kuni Zu’aimah Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Dwi Nurahmanto Dwi Setyawan Eka Deddy Irawan Elok Rimadani Frida Oktaningtias Widiarthi Herlina . Herlina . Jingga, Mutiara Dara Kuni Zu''aimah Barikah Kuni Zu’aimah Barikah Laily, Aisyah Prida Lita Putri Ayu Lestari Lusia Oktora Ruma Kumala Sari Lusia Oktora Ruma Kumala Sari nafisah isnawati Nailis Syifa&#039; Nuri Nuri . Nuri Nuri Nuri Nuri Nuri, . Nuri, . Prihandini , Khairinna Priyadi, Karina Priyadi Devi Wahyu Putri, Salsabila Bara Rahardi, Verdian Septi Sudianingsih Seva, Any You Shafira Faradiba Tsaniyah Siswandono, S. Siswandono, Siswandono Susanti, Devi Feby Tri Agus Siswoyo Viddy Agustian Rosyidi Wisudyaningsih , Budipratiwi Wiwien Sugih Utami Yuli Witono Yunita Armiyanti Zulfatul Maskuriah, Dian