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All Journal Jurnal Ilmu Dasar e-Journal Pustaka Kesehatan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia JFIOnline Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Applied Research (IJAR) International Journal of Islamic and Complementary Medicine Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia Journal of Agropharmacy Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Yudi Wicaksono
Faculty Of Pharmacy, University Of Jember
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Education Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Journal : UNEJ e-Proceeding

 1 
COCRYSTAL OF ATORVASTATIN CALCIUM – MALONIC ACID Yudi Wicaksono; Budipratiwi Wisudyaningsih; Tri Agus Siswoyo
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Cocrystal is a relatively new solid form of activepharmaceutical ingredient that offers an alternativeplatform in improving physicochemical properties ofactive pharmaceutical ingredients Padrela et al.,2009; Mashhadi et al., 2004. Cocrystal is defined asa stoichiometric multi-component system connectedby non-covalent interactions where all thecomponents neutral and solid under ambientconditions Thakuria et al., 2013. Cocrystal can beconstructed through interaction hydrogen bonding,pi-stacking, and van der Waals forces  Mashhadi etal., 2004. A pharmaceutical cocrystal is composed ofan API and an appropriate coformer as carboxylicacids and amides Qiao et al., 2011.Cocrystallization of active pharmaceutical ingredientis an opportunity for enhancement of importantphysiochemical properties of an activepharmaceutical ingredient without changing itsmolecular structure Maeno et al., 2014.Atorvastatin Calcium (AC), ([(R-(R*,R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid), calcium salt (2:1)trihydrate ([C33H34FN2O5]2Ca.3H2O), is considered asone of the most effective of synthetic lipid loweringagent Shete et al., 2010. The drug is orally used toreduce of total cholesterol, low density lipoproteinand triglycerides Anwar et al., 2011. There are 42crystalline structures of AC Shayanfar et al., 2013.However, chance to create AC into another crystalstructure to improving physicochemical properties ofAC is still fully open Chadha et al., 2012.In the present study, we explored cocrystallization ofAC by solvent evaporation method. This study aimedto confirm whether AC was able to form cocrystalwith malonic acid (MA) as coformer. AC-MAcocrystal was prepared by solvent evaporationmethod by using methanol as solvent.Characterization of cocrystal was done by powder Xraydiffractometry (PXRD), differential scanningcalorimetry (DSC), fourier transform infrared (FTIR)spectroscopy and scanning electron microscopy(SEM).
Co-Authors Ameliana, Lidya Barikah, Kuni Zu'aimah Barikah, Kuni Zuaimah Barikah, Kuni Zu’aimah Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Budipratiwi Wisudyaningsih Dwi Nurahmanto Dwi Setyawan Eka Deddy Irawan Elok Rimadani Frida Oktaningtias Widiarthi Herlina . Herlina . Jingga, Mutiara Dara Kuni Zu''aimah Barikah Kuni Zu’aimah Barikah Laily, Aisyah Prida Lita Putri Ayu Lestari Lusia Oktora Ruma Kumala Sari Lusia Oktora Ruma Kumala Sari nafisah isnawati Nailis Syifa' Nuri Nuri . Nuri Nuri Nuri Nuri Nuri, . Nuri, . Prihandini , Khairinna Priyadi, Karina Priyadi Devi Wahyu Putri, Salsabila Bara Rahardi, Verdian Septi Sudianingsih Seva, Any You Shafira Faradiba Tsaniyah Siswandono, S. Siswandono, Siswandono Susanti, Devi Feby Tri Agus Siswoyo Viddy Agustian Rosyidi Wisudyaningsih , Budipratiwi Wiwien Sugih Utami Yuli Witono Yunita Armiyanti Zulfatul Maskuriah, Dian