Article Per Year (5 Year)
p-Index From 2021 - 2026
1.116
P-Index
This Author published in this journals
All Journal Journal of Nutrition and Health JURNAL GIZI INDONESIA Journal of Nutrition College Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Biosaintifika: Journal of Biology & Biology Education Medica Hospitalia Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Poltekita: Jurnal Ilmu Kesehatan Bali Medical and Wellness Journal
Siti Fatimah Muis
Faculty Medicine Science, Diponegoro University, Indonesia
Agriculture, Biological Sciences & Forestry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
Effect of Leunca Fruit (Solanum nigrum L.) on Oxidative Stress in rats fed a High Fat High Sucrose Diet Nurdin, Nurhanifah Muthmainnah; Muis, Siti Fatimah; Anjani, Gemala; Noer, Etika Ratna; Ayustaningwarno, Fitriyono
Poltekita: Jurnal Ilmu Kesehatan Vol. 18 No. 3 (2024)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v18i3.3818

Abstract

Decreased levels of superoxide dismutase (SOD) and increased levels of malondialdehyde (MDA) are markers of oxidative stress and indicate obesity. Leunca fruit (Solanum Nigrum L) is a plant that contains antioxidants that can reduce the level of oxidative stress in obesity. The purpose of this study was to determine the effect of leunca fruit administration on SOD and MDA levels in obese rats. This type of research is true experimental with a post-test-only research design where 30 male Sprague Dawley rats were divided into five groups consisting of 2 control groups K(-) and K(+) and three treatment groups (P1, P2, P3). Groups K+, P1, P2, and P3 were fed a high-fat and sucrose diet (21% lard, 34% sucrose). The K (-) control group is a group of healthy rats that only receive standard feed without being given leunca fruit. Group K (+) is a group of obese rats without leunca fruit. Leunca fruit was given for six weeks at a dose of 0.8g (P1), 1.6g (P2), and 2.4g (P3). Serum SOD levels were measured by ELISA method and MDA levels were measured by TBARS method. Statistical analysis using One Way Anova test. Administration of leunca fruit with graded doses can significantly increase SOD activity p=0.000 (p<0.05) and can significantly reduce MDA levels in obese rats in each treatment group p=0.000 (p<0.05). Leunca fruit with a dose of 2.4g/BB rat is the most effective dose to increase SOD levels and reduce MDA levels. The limitation of this study that there is no weighing of the remaining rat feed at each meal, so that the percentage of rat intake is was unknown.
Effect of leunca (Solanum nigrum) on inflammatory status in rats induced by high-fat and high-sucrose diet Gunawan, Sekar Ayu Putri; Muis, Siti Fatimah; Anjani, Gemala; Noer, Etika Ratna; Ayustaningwarno, Fitriyono
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 2 (2025): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.2.99-104

Abstract

Background: Consumption of foods that are high in calories over a long period of time is a cause of obesity and can increase proinflammatory cytokines. Leunca fruit contains various phytochemicals that act as anti-inflammatory, antioxidant, and antiobesity but not many people utilize leunca fruit as daily food.Objective: To analyze the effect of leunca fruit on TNF-α and IL-6 levels in rats induced by high fat and sucrose diet (HFSD).Methods: The research design was Randomized Post Test Only Control Group Design. The sample was 30 male Sparague Dawley rats and divided into 5 groups, namely group K1 which was given standard feed, group K2 which was induced by HFSD, group P1 which was induced by HFSD and leunca 0.8g/200gBW, group P2 which was induced by HFSD and leunca 1.6g/200gBW, and group P3 which was induced by HFSD and leunca 2.4g/200gBW. The research was conducted at the Nutrition Laboratory of the Center for Food and Nutrition Studies of Gadjah Mada University (PSPG PAU UGM) Yogyakarta in January-March 2024. Testing TNF-α and IL-6 levels through rat blood serum using the ELISA method. Data were analyzed by ANOVA and Post Hoc test.Results: There was a significant difference in TNF-α and IL-6 levels between experimental groups (p=0.00). The levels of TNF-α and IL-6 in the P1, P2, and P3 groups that received HFSD + leunca were lower than in the K2 group that received HFSD only.Conclusion: Leunca fruit can reduce proinflammatory cytokine levels (TNF-α and IL-6) in HFSD-induced rats.
Body Mass Index and Postoperative Lumbar Pain Relief Following Surgery for Degenerative Lumbar Spine Disease: A Correlative Study Siallagan, Rini Martina; Probosari, Enny; Brotoarianto, Happy Kurnia; Muis, Siti Fatimah; Murbawani, Etisa Adi
Bali Medical and Wellness Journal Vol. 2 No. 2 (2025): Bali Medical and Wellness Journal
Publisher : PT BMW Journal Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71341/bmwj.v2i2.33

Abstract

Background: The prevalence of obesity and overweight is consistently rising. An increase in body mass index (BMI) above the normal range heightens the risk of chronic diseases, including musculoskeletal conditions such as lumbar degeneration and low back pain. The association between elevated BMI and postoperative lumbar pain remains debated. Objective: This study aims to assess the correlation between BMI and the improvement of postoperative lumbar pain. Methods: In this correlational study, 48 adults meeting specific inclusion and exclusion criteria were observed at a spine surgery clinic in Semarang, Central Java, Indonesia. BMI was calculated by dividing weight (kg) by height squared (m²). Pain levels were assessed using a visual analogue scale (VAS). The study controlled for variables such as age, gender, diabetes mellitus, osteoporosis, and type of surgery. Results: A positive correlation exists between increased BMI and elevated pain scale scores post-lumbar surgery in patients with lumbar degeneration (r = 0.654, p = 0.001). Additionally, the type of surgery and the presence of osteoporosis were found to correlate with pain levels. Conclusion: Patients with higher BMIs exhibited more pronounced postoperative pain compared to those with lower BMIs.
Supplementation of omega-3 fatty acids can reduce tumor necrosis alpha ( TNF-α) levels and pain intensity in osteoarthritis patients Adengganan, Yogi; Muis, Siti Fatimah; Muniroh, Muflihatul
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 6, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(6).406-412

Abstract

ABSTRAK Latar Belakang: Osteoarthritis (OA) merupakan penyakit sendi yang paling umum di seluruh dunia, dengan dampak yang kuat pada kesehatan individu dan populasi. Secara global prevalensi OA meningkat sebesar 113,2% dari 247,5 juta pada tahun 1990 menjadi 527,8 juta pada tahun 2019. Prevalensi OA di Indonesia meningkat seiring bertambahnya usia yaitu sebesar 5% pada individu berusia kurang dari 40 tahun, 30% pada usia 40-60 tahun, dan 65% pada usia di atas 60 tahun. Angka kejadian OA lutut relatif tinggi, yaitu 15,5% pada pria dan 12,7% pada wanita. Penyakit ini dapat menyebabkan nyeri kronis, kecacatan, dan menurunkan kualitas hidup penderita. Tingginya kadar sitokin pro inflamasi seperti TNF-α pada penderita OA dapat berperan sebagai faktor utama yang menginduksi kematian krondosit dan menghambat diferensiasi serta proliferasi kondrosit. Penelitian sebelumnya mengatakan bahwa suplementasi omega 3 dapat menurunkan kadar sitokin proinflamasi, memperbaiki nyeri, dan kekakuan fungsi fisik pada individu dengan OA lutut, namun belum ada yang meneliti pengaruh suplementasi omega 3 ini dengan penurunan kadar Tumor Necrosis Factor α (TNF-α).Tujuan: Menganalisis pengaruh  suplementasi asam lemak omega 3 terhadap kadar TNF-α dan intensitas nyeri pada penderita osteoarthritis. Metode: Studi ini merupakan quasi-experimental desain kelompok tunggal dengan rancangan penelitian one group pre-post test without control group design pada 31 pasien. Pengumpulan data dilakukan dengan pengukuran antropometri, pengambilan sampel darah dan pengukuran skor nyeri dilakukan sebanyak dua kali, yaitu sebelum dan sesudah dilakukannya intervensi. analisa TNF-α menggunakan Enzym Linked Immunosorbent Assay (Elisa), intensitas nyeri menggunakan numeric rating scale (NRS). Analisis uji statistik pengaruh suplementasi asam lemak omega 3 terhadap kadar TNF-α dan intensitas nyeri menggunakan uji Wilcoxon.Hasil: Hasil yang diperoleh pada TNF-α dengan nilai P=0,007 dan intensitas nyeri dengan nilai P=0,001 yang menunjukkan hasil yang signifikan.Kesimpulan: Suplementasi asam lemak omega 3 pada penderita OA dapat mengasilkan beberapa mediator anti inflamasi yang mampu menurunkan kadar sitokin pro inflamasi TNF-α dan intensitas nyerisecara siginifikan.KATA KUNCI: asam lemak omega 3 ; tumor necrosis alpha (TNF-α); intensitas nyeri; inflamasi; osteoarthritis ABSTRACTBackground: Osteoarthritis (OA) is the most common joint disease worldwide, strongly impacting individual and population health. Globally, the prevalence of OA increased by 113.2% from 247.5 million in 1990 to 527.8 million in 2019. The prevalence of OA in Indonesia increases with age, namely by 5% in individuals under 40 years, 30% in those aged 40-60 years, and 65% in those over 60 years. The incidence of knee OA is relatively high, namely 15.5% in men and 12.7% in women. This disease can cause chronic pain and disability and reduce the quality of life of sufferers. High levels of pro-inflammatory cytokines such as TNF-α in OA sufferers can act as a major factor in inducing chondrocyte death and inhibiting chondrocyte differentiation and proliferation. Previous studies have shown that omega-3 supplementation can reduce proinflammatory cytokine levels and improve pain and stiffness of physical function in individuals with knee OA. Still, no one has studied the effect of omega-3 supplementation on reducing TNF-α levels.Objectives: To analyze the effect of omega-3 fatty acid supplementation on TNF-α levels and pain intensity in patients with osteoarthritis.Methods: This study is a quasi-experimental single-group design with a one-group pre-post test without a control group design in 31 patients. Data collection was carried out by anthropometric measurements, blood sampling, and pain score measurements twice, namely before and after the intervention. TNF-α analysis using Enzyme-Linked Immunosorbent Assay (Elisa), pain intensity using a numeric rating scale (NRS). Statistical analysis of the effect of omega 3 fatty acid supplementation on TNF-α levels and pain intensity using the Wilcoxon test.Results: The results obtained on TNF-α with a P value = 0.007 and pain intensity with a P value = 0.001 showed significant results.Conclusion: Supplementation of omega-3 fatty acids in OA patients can produce several anti-inflammatory mediators that significantly reduce the levels of pro-inflammatory cytokines TNF-α and pain intensity.KEYWORDS: omega 3 fatty acids; tumor necrosis alpha (TNF-α); pain intensity; inflammation; osteoarthritisReceived: August 14, 2024; Revised: Nov 18 2024; Accepted: Nov 20, 2024; Available online: Nov 30, 2024; Published: Nov 30, 2024.
Co-Authors Adengganan, Yogi Adriyan Pramono Ahmad Syauqy Aiman Farag Mohammed Ali, Aiman Farag Mohammed Anjani, Gemala Apoina Kartini BR Purba, Martalena Brotoarianto, Happy Kurnia Christianto, Febe Dewi Pertiwi Dyah Kusudaryati Enny Probosari Etika Ratna Noer Etisa Adi Murbawani Fitriyono Ayustaningwarno Gunawan, Sekar Ayu Putri Hartanto, Okky Haslina Haslina Heri Nugroho Indri Mulyasari Khairuddin - Laksmi Widajanti Muniroh, Muflihatul Niken Puruhita Nurdin, Nurhanifah Muthmainnah Nurhasanah Nurhasanah Nuryanto Nuryanto Pramana, Noor Purwanti Susanti Pusaka, Semerdanta Ria Ambarwati Siallagan, Rini Martina Suyatno Suyatno Tri Susilowati Yenni, Fitri