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EVALUASI BIOLOGIS RADIOFARMAKA 186ReEDTMP SEBAGAI ALTERNATIF BONE PAIN PALLIATIVE AGENT Gunawan, Adang Hardi; Muthalib, Abdul; Bagiawati, Sri; Sovilawati, Evi; Lestiawati, Sri Aguswarini; Abidin, Abidin
Jurnal Radioisotop dan Radiofarmaka Vol 7, No 2 (2004): Jurnal PRR 2004
Publisher : Jurnal Radioisotop dan Radiofarmaka

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ABSTRAK Evaluasi Biologis Radiofarmaka 186Re_EDTMP (Ethylenediamine-N,N,N',N'-tetrakis(methylene phosphonic acidÂ» sebagai Alternatif Bone Pain Palliative Agent. Beberapa penyakit kanker seperti prostat, payudara, paru-paru dan ginjal dapat mengalami metastase ke tulang. Samarium153 EDTMP merupakan radiofarmaka yang sampai saat ini secara luas digunakan untuk mengurangi rasa sakit akibat metastase kanker ke tulang. Penandaan EDTMP dengan radionuklida 186Re telah berhasil dibuat dengan kemurnian radiokimia yang tinggi dan stabil sampai hari ke 8 setelah pembuatan. Pada komplek 186Re_EDTMP yang telah dibuat, dilakukan pengujian biologis seperti biodistribusi, uji pencucian dari darah, uji pencucian dari ginjal, uji lipofilisitas, uji pengikatan pada hidroksiapatit, pencitraan dengan kamera gamma, uji sterilitas dan uji pirogenitas. Hasil uji biodistribusi dan pencitraan dengan kamera gamma menunjukkan bahwa penimbunan pada tulang yang tinggi terjadi pada 24 jam setelah penyuntikan dan diperoleh gambaran kamera gamma yang lebih baik dari pada 2 jam setelah penyuntikan. Kadar kompleks dalam darah mencapai puncaknya setelah 5 menit setelah penyuntikan dan menurun drastis pada 1 jam setelah penyuntikan. Sedangkan dalam urin 24 jam setelah penyuntikan diperoleh aktivitas sekitar 38% yang diekskresikan dalam bentuk perenat bebas. Hasil uji pengikatan komplek dengan hidroksiapatit menunjukkan komplek terikat kuat pada hidroksiapatit (68%) sampai dengan hari ke 2 setelah pencampuran. Hasil pengujian sterilitas dan pirogenitas menunjukkan sediaan tersebut steril dan bebas pirogen. Kata Kunci : 186Re_EDTMP , tulang, kemurnian radiokimia, biodistribusi. ABSTRACT Biological Evaluation of 186Re_EDTMP (Ethylenediamine-N,N,N',N'-tetrakis(methylene phosphonic acidÂ» as an Alternative Bone Pain Palliative Agent. Bone pain is a common complication for patient with bone metastases from prostate, breasts, lung and renal cancers. Samarium-I53 EDTMP is one of the most widely used radiophannaceutical for the treatment of metastatic bone pain. Preparation of 186Re_EDTMP have been carried out with high radiochemical purity and this complex was stable up to 8 days. Biodistribution pattern of the injected complex in mice indicates that the accumulated optimum activity in the bone was obtained 24 hours post injection. Rhenium-186-EDTMP complex contents in the blood reach optimum activity after 5 minutes and decrease drastically at I hours post injection. The complex showed major renal clearance up to 38% as perrhenate ion within 24 hours after injection. Rhenium-186-EDTMP revealed strong binding to hidroxyapatite (Â± 68%) and stable up to 2 days. Sterility and pyrogenicity test indicated that the complex were sterile and pyrogen free. Keywords: 186Re_EDTMP, bone, radiochemical purity, biodistribution. Â

PREPARASI RADIOFARMAKA 99mTc-DTPA-INH UNTUK DIAGNOSIS TUBERKULOSIS Hamdani, Eki Mustofa; Pujianto, Anung; Muthalib, Abdul; Rukiah, Rukiah
Jurnal Radioisotop dan Radiofarmaka Vol 14, No 1 (2011): Jurnal PRR 2011
Publisher : Jurnal Radioisotop dan Radiofarmaka

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ABSTRAKPENYIAP AN DAN KARAKTERISASI SENY AWA KOMPLEKS RHENIUMMENGANDUNG LIGAN ASETILASETON.Kanker hati merupakan penyebab kematian terbesar. Nijsendkk telah berhasil menerapkan mikrosfer asam(L- poli laktat) atau PLLA yang mengandung 166Hountukterapi kallker hati. Sebelum digabungkan dengan PLLA, logam holmium dibentuk senyawa kompleksholmium tris-asetilasetonat (Ho(acac), ) terlebih dahulu sebagai prekursor. Mengacu pada percobaantersebut, ada kemungkinan yang cukup besar untuk menerapkan mikrosfer PLLA yang mengandung 186Redalam terapi kanker hati. Penelitian ini bertujuan untuk menyiapkan dan mengkarakterisasi senyawakompleks renium yang mengandung ligan asetilaseton. Tahap pertama adalah penyiapan senyawa kompleksdikloro( etoksiokso )bis(trifenilfosfin)renium(V) dan tahap berikutnya adalah penyiapan senyawa komplekskloroetoksi(pentana-2,4-dionato )bis(trifenilfosfin)renium(III). Karakterisasi senyawa tersebut dilakukanmenggunakan spektrofotometer UV-sinar tampak, spektrofotometer IR dan LCMS. Hasil karakterisasimenunjukkan bahwa terbentuk senyawa kompleks kloroetoksi(pentana-2,4dionato)bis(trifenilfosfin)renium(III) sebanyak 8,8% (44 mg) dengan Mr yang terlihat dari hasil spektrummassa (MS) sebesar 891 (C, 57,9%; P, 7%; 0, 5,4%; CI, 4%; H, 4,8%; Re, 20,9%). Hasil LCmemperlihatkan adanya tiga puncak, menunjukkan bahwa senyawa hasil tersebut tidak mumi. Uji kestabilansenyawa kompleks dengan spektrofotometer UV memperlihatkan senyawa kompleks masih stabil selamalima hari.Kata kunci: rhenium, asetilaseton, holmium-166.ABSTRACTPREPARATION AND CHARACTERIZATION OF RHENIUM COMPLEX COMPOUNDCONT AINING ACETILACETONE LIGAND. Liver cancer is the leading cause of death. Nijsen et.al.have been successfully applied poly (L-lactic acid) micro spheres or PLLA containing 166Hofor liver cancertherapy. Before combined with PLLA, holmium metal complex compounds fom1ed tris-asetilasetonatholmium (Ho(acac)3) first as a precursor. Referred to the experiment, there are considerable possibilities forimplementing the PLLA microspheres containing 186Rein liver cancer therapy. This research is being donein order to prepare and characterize rhenium complexes containing acetylacetone ligand. The first step is thepreparation of dichloro(etoksiokso)bis (triphenylphosphine)rhenium(V) compounds and the next step is thepreparati on of chloroetoksi(pentane-2,4-dionato )bis( tri phenylphosphine )rheni um(III) compounds.Characterization of these compounds was carried out using UV -visible spectrophotometer, IRspectrophotometer, and LCMS. The characterization results showed the formation of rhenium complexescontaining ligands chloroetoksi(pentane-2,4-dionato )bis(triphenylphosphine)rhenium(III) of 8.8% (44 mg)with Mr of 891 as observed in the mass spectrum (MS) (C, 57,9%; P, 7%; 0, 5,4%; CI, 4%; H, 4,8%; Re,20,9%). The Results of LC showed the presence of three peaks, showing that the compounds were not pure.The result of UV-visible showed that the complex compound was still stable for five days.Keywords: rhenium, acetylacetone, holmium-166

Effect of Yara Mila Pearl NPK Fertilizer and Nasa Liquid Organic Fertilizer on Growth and Yield of Beans (Phaseolus vulgaris L.) Muthalib, Abdul; Jannah, Noor
Agrifor : Jurnal Ilmu Pertanian dan Kehutanan Vol 17, No 2 (2018): Oktober
Publisher : Universitas 17 Agustus 1945 Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31293/af.v17i2.3610

The objective the research was to study the effect of NPK Mutiara YaraMila fertilizer and Nasa foliar fertilizeras well as their interaction on the growth and yield of stringbean, and to find proper dosage of NPK Mutiara YaraMila fertilizer and concentration of Nasa foliar fertilizer for optimal yield of stringbean.The research was conducted in the village of Rantau Panjang, sub district of Telen of East Kutai Regency. It carried out from March until June 2016. It applied Completely Randomized Block Design with factorial experiment 4 x 4 and three replications. The first factor was the dose of NPK Mutiara YaraMilafertilizer (P) consists of 4 levels, namely: no NPK Mutiara YaraMilafertilizer (p0), 100 kg ha⁻¹ equals to 25,6 g plot-1 (p1), 200 kg ha⁻¹ equals to 51,20 g plot-1(p2), and 300 kg ha⁻¹ equals to 76,80 g plot-1 (p3). The second factor was the concentration of Nasa foliar fertilizer (B) consists of 4 levels, namely: no Nasa foliar fertilizer (b0), 2 ml l-1 water (b1), 4 ml l-1 water (b2), and ), 6 ml l-1 water (b3).Result of the research revealed that : (1) the NPK Mutiara YaraMila fertilizer treatment affected very significantly on the plant lenght at 10, 20, and 30 days after planting, days of plant flowered, days of plant harvest, number of pods, weight of pods, and production of pods; (2) the Nasa foliar fertilizer was affected significantly to very significantly on thethe plant lenght at 10, 20, and 30 days after planting, days of plant flowered, days of plant harvest, number of pods, weight of pods, and production of pods; (3) interaction between NPK Mutiara YaraMila fertilizer and Nasa foliar fertilizer was affected significantly to very significantly on the plant lenght at 10 and 20 days after planting, days of plant flowered, but no significantly on the plant lenght at 30 days after planting, days of plant harvest, number of pods, weight of pods, and production of pods; (4) the highest pods production is attained by the 300 kg ha-1 NPK Mutiara YaraMila fertilizer (p3), namely 38,38 Mg ha-1 or by the 6 ml l-1 water Nasa foliar fertilizer (b3), namely 38,55 Mg ha ̵ ¹.

RAGAM ALTERNATIF MEDIA PEMBELAJARAN PAI BERBASIS PSIKOMOTORIK SELAMA MASA PANDEMI DI MA PERSIAPAN NEGERI 4 MEDAN Muthalib, Abdul; Aisyah, Aisyah; Sukari, Endang; Aulia, Rafika
Jurnal Bilqolam Pendidikan Islam Vol. 1 No. 2 (2020): Desember (2020)
Publisher : Prodi PAI Sekolah Tinggi Agama Islam Serdang Lubuk Pakam

The development of the Covid-19 outbreak has indeed had a major impact on all sides of human life, including in the world of education. The world of education seems to make the house an educational institution that can replace formal educational institutions. Learning using the internet network or so-called brave learning (online). Brave learning may be new to some teachers, but maybe some already consider it familiar. The purpose of this study was to find out about the Variety of Alternative Psychomotor-based PAI Learning Media During Covid-19 at MA Preparation 4 Medan.The results obtained from this research are learning that can be done in any condition, but of course the results will not be optimal learning that is done face-to-face in the classroom. To optimize it, of course many are done by teachers. Especially in the PAI subject, several innovations have been made to optimize learning outcomes, namely: 1) Innovations such as presenting learning with multimedia, 2) Online-based discussions and assignments. Teaching also has obstacles in its application, especially in the MA preparatory 4-field country, some of these obstacles: 1) Signal interference that cannot be avoided. 2) Lack of parental and teacher cooperation in managing courageous learning. 3) Limited costs make students reluctant to take bold lessons.

Syakhṣiyyah Zulaykhā fī Qiṣṣah Yūsuf ʽAlayh al-Salām fī al-Qurʽān al-Karīm Muthalib, Abdul
JILSA (Jurnal Ilmu Linguistik dan Sastra Arab) Vol. 4 No. 1 (2020): April
Publisher : Fakultas Adab dan Humaniora UIN Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15642/jilsa.2020.4.1.35-47

Kisah Yusuf dan Zulaikha adalah salah satu kisah yang diabadikan di dalam al-Qur’an. Kisah tersebut tertera dalam sebagian ayat al-Qur’an yang bisa dipetik hikmah dan pelajarannya bagi siapa saja yang mendalamminya. Dengan menggunakan metode deskriptif kualitatif, artikel ini mengkaji konsep-konsep atau teori-teori yang berkaitan dengan psikologi yang kemudian dijadikan sebagai landasan teori dalam menganalisis pewatakan (syahkshiyah) tokoh Zulaikha dalam kisah Yusuf dalam Al-Quran tersebut. Kesimpulan dari pembahasan ini adalah bahwa kepribadian perempuan ketika berada di puncak syahwatnya maka tidak mempunyai rasa malu dan harga diri, akan halnya dia tidak mampu menjaga etika kemasyarakatan dan keluarga, demikian juga upaya perempuan baik dalam hal melindungi diri atau menghindarkan dugaan pada dirinya.

The Objection to The Claim of Meeting The Prophet Muḥammad in a State of Awakedness According to Muḥammad al-Shinqīṭī Muthalib, Abdul
Refleksi: Jurnal Kajian Agama dan Filsafat Vol. 13 No. 3 (2012): Refleksi
Publisher : Faculty of Ushuluddin Syarif Hidayatullah State Islamic University, Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/ref.v13i3.902

This paper deals with the reaction of al-Shinqīṭī towards this latter way of mystical vision, particularly in the case of Aḥmad al-Tijānī. For al-Shinqīṭī, sufis’ claim of having a fully consciousness physical contact with the Prophet after his death is impossible because nothing, whether religious or rational proofs, can sustain it. The extreme case of such claim is expressed by Aḥmad al-Tijānī who, insists that a sufi (ṣūfī) can really see the Prophet with his physical eyes. In al-Tijānī’s opinion, the ability of the physical eyes to see the Prophet when awake was a common trait of those who attained the status of pole (quṭb).DOI: 10.15408/ref.v13i3.902

Karakteristik Gagal Nafas Mas’a, Hafifah Suci; Wahab, Iswan; Muthalib, Abdul
Innovative: Journal Of Social Science Research Vol. 4 No. 5 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i5.14942

Respiratory failure is a critical condition that requires intensive medical attention and is one of the leading causes of death among adult patients. This condition is characterized by the failure of the respiratory system to exchange oxygen and carbon dioxide effectively, which can lead to serious complications such as congestive heart failure, pneumonia, and organ failure. According to WHO and CDC data, respiratory failure contributes to a significant number of deaths with a fairly high incidence in Indonesia. Respiratory failure is a medical condition characterized by the occurrence of severe and sudden shortness of breath that usually occurs within 12-48 hours after a trigger, such as trauma, sepsis and aspiration (entry of gastric secretions or foreign objects into the lungs) due to decreased oxygen levels in the blood oxygen to enter the blood sufficiently. Respiratory failure can cause complications such as having a higher risk of congestive heart failure, having a high risk of pneumonia and suffering from organ failure. There are several types of respiratory failure that are classified based on the causative factors, namely severe acute lung disease, neuromuscular disorders, adult respiratory distress syndrome (ARDS), infant respiratory distress syndrome, acute chronic lung disease.

Faktor Risiko Kejadian Pre Eklampsia Pada Ibu Hamil Harmin, Yeyen Anugrah; Palupessy, Nugraha; Muthalib, Abdul
Innovative: Journal Of Social Science Research Vol. 4 No. 5 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i5.15210

Preeclampsia is a serious pregnancy complication that requires an in-depth understanding of risk factors for effective prevention and treatment. This study used a literature review method to evaluate various risk factors for preeclampsia, including demographics, pre-pregnancy health conditions, as well as genetics and environment. The results showed that older maternal age, lower socio-economic status, and pre-pregnancy conditions such as hypertension and diabetes significantly increased the risk of preeclampsia. In addition, genetic and environmental factors also contribute to this risk. The conclusions of this study emphasize the need for a multifaceted approach in preeclampsia prevention and management strategies, which includes health monitoring, lifestyle modification, and attention to environmental factors.

RAGAM ALTERNATIF MEDIA PEMBELAJARAN PAI BERBASIS PSIKOMOTORIK SELAMA MASA PANDEMI DI MA PERSIAPAN NEGERI 4 MEDAN Muthalib, Abdul; Aisyah, Aisyah; Sukari, Endang; Aulia, Rafika
Jurnal Bilqolam Pendidikan Islam Vol. 1 No. 2 (2020): Desember (2020)
Publisher : Prodi PAI Sekolah Tinggi Agama Islam Serdang Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51672/jbpi.v1i2.6

The development of the Covid-19 outbreak has indeed had a major impact on all sides of human life, including in the world of education. The world of education seems to make the house an educational institution that can replace formal educational institutions. Learning using the internet network or so-called brave learning (online). Brave learning may be new to some teachers, but maybe some already consider it familiar. The purpose of this study was to find out about the Variety of Alternative Psychomotor-based PAI Learning Media During Covid-19 at MA Preparation 4 Medan.The results obtained from this research are learning that can be done in any condition, but of course the results will not be optimal learning that is done face-to-face in the classroom. To optimize it, of course many are done by teachers. Especially in the PAI subject, several innovations have been made to optimize learning outcomes, namely: 1) Innovations such as presenting learning with multimedia, 2) Online-based discussions and assignments. Teaching also has obstacles in its application, especially in the MA preparatory 4-field country, some of these obstacles: 1) Signal interference that cannot be avoided. 2) Lack of parental and teacher cooperation in managing courageous learning. 3) Limited costs make students reluctant to take bold lessons.

SWOT: IMPLEMENTASI APLIKASI MOBILE BANKING TERHADAP KUALITAS LAYANAN BANK MUAMALAT Muthalib, Abdul; Hasan, Asyari
FINANSIA : Jurnal Akuntansi dan Perbankan Syariah Vol 6 No 2 (2023): FINANSIA : Jurnal Akuntansi dan Perbankan Syariah
Publisher : Fakultas Ekonomi Dan Bisnis Islam IAIN Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32332/finansia.v6i2.7127

This research identifies the advantages and disadvantages of using mobile banking in Islamic banking services, and looks for opportunities and threats that may arise as a result of the use of this technology. The purpose of the study was to analyze the implementation of mobile banking applications on the quality of Bank Muamalat's services using a SWOT analysis approach. Descriptive qualitative research methods, using primary and secondary data, provide a comprehensive overview of the strengths, weaknesses, opportunities, and threats associated with the use of mobile banking in Islamic banking services. Research shows that the use of mobile banking has great potential in improving the quality of Islamic banking services. The advantages found include efficiency, ease of access, low operational costs, and 24-hour service accessibility. However, there are also disadvantages such as reliance on a good internet connection, the risk of digital crime, and additional costs. This research makes an important contribution in understanding the factors that influence the implementation of mobile banking in the quality of Bank Muamalat KC's services. Pontianak.

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