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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Media Penelitian dan Pengembangan Kesehatan ASPIRATOR Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Ilmu Ternak Veteriner Majalah Kedokteran The Indonesian Biomedical Journal Universa Medicina Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Media Ilmu Kesehatan Majalah Kedokteran Andalas jurnal Teknik Industri - Unisi Riset Informasi Kesehatan Jurnal Kedokteran Meditek Jurnal Intelek Dan Cendikiawan Nusantara Indonesian Journal of Biomedicine and Clinical Sciences
Heri Wibowo
Department Of Parasitology, Faculty Of Medicine, Universitas Indonesia, Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : Media Ilmu Kesehatan

 1 
Analisis Titer dan Subtipe Antibodi pada Inkompatibilitas ABO yang Menyebabkan Hemolytic Disease of Fetus and Newborn Sheila Nurrahmah; Heri Wibowo; Ria Syafitri Evi G
MEDIA ILMU KESEHATAN Vol 11 No 1 (2022): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v11i1.675

Abstract

Background: Hemolytic disease of the fetus and newborn (HDFN) is a type of anemia in the fetus or newborn. Clinical features of HDFN such as hepatosplenomegaly, liver failure, ascites, at birth die from heart failure to brain damage. One of the most common causes is incompatibility of blood groups such as ABO. Differences in clinical manifestations that occur in HDFN are caused by differences in antibody titers and IgG subtypes.Objective: The aim of this study was to determine the anti-A and anti-B antibody titers and the types of immunoglobulins that affect HDFN due to ABO incompatibility.Methods: The sample used in this study was blood and umbilical cord blood from 30 pairs of mother-babies who had different blood groups. Titration examination by tube method and IgG subtype by ELISA method were performed on maternal samples.Results: The correlation of total bilirubin levels with maternal Anti-A and Anti-B titers are p= 0.023 and p= 0.001, in addition there are significant increase in OD of Anti-A IgG1 and Anti-B IgG1 againts elevated infant bilirubin levels.Conclusion: IgG titers >8 causing hyperbilirubinemia, but no jaundice and IgG titers >16 causing hyperbilirubinemia to jaundice. The IgG subtype that plays a more role in causing clinical problems is IgG1.
High-Fat Diet Impact on T Cell Polarization in First Degree relative (FDR) Subject with Type 2 Diabetes Mellitus Dini Aulia Cahya; Heri Wibowo; Alida Rosita Harahap
MEDIA ILMU KESEHATAN Vol 11 No 2 (2022): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v11i2.681

Abstract

Background: The prevalence of high-fat diet consumption that triggered obesity is increasing in last 2 decades. Type 2 diabetes mellitus is associated by the increasing number of inflammation marker, Acute phase protein in blood serum. In type 2 diabetes mellitus, combination of lifestyle and genetic factors is the most influential factors. Due to that fact, person with First Degree Relative ( FDR) in type 2 diabetes mellitus has the higher risk to develop into type 2 diabetes mellitus. T cell is one of leucocyte that has a significance role in adaptive immune response.T cell polarization will show the profile of adaptive immune response in chronic inflammation Objective: This study is purposed to analyse how T cell polarized in First Degree Relative (FDR) subject in risk of type 2 diabetes mellitus with high fat diet treatment.Methods: 30 Non-FDR subjects and 30 FDR subjects who included in parameter inclusion were treated with 250 mL whipping cream per day in 5 days. Pre and post treatment blood collection were tested for blood profile and flowcytometry intraseluler staining.Results: BMI is significantly increasing in Non-FDR subject meanwhile Cholesterol and HDL are significantly increasing in FDR subject. There are no significant changes in T cell subset including Th1, Th2, Th17 and Treg.Conclusion: Short term high fat diet treatment in 5 days increased some metabolic profiles on both group but there are no significantly different changes in T cell polarization.
Deteksi Antibody Anti-Human Leukocyte Antigen (HLA) Kelas I Pada Donor Darah Wanita Eti Herani; Ni Ken Ritchie; Heri Wibowo
MEDIA ILMU KESEHATAN Vol 11 No 2 (2022): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v11i2.673

Abstract

Background: HLA class I is very polymorphic, if it enters the body of another person it will be considered foreign so that alloimmunization can occur by producing class I anti-HLA antibodies. These antibodies are found in individuals exposed to allogeneic cells due to transfusion, problems, and pregnancy. Female blood donors who have anti-HLA class I antibodies when donating blood and transfused to patients who have the appropriate HLA can cause a transfusion reaction. Research on class I anti-HLA antibodies in female blood donors in Indonesia is still very rare. This research is further to get an overview of class I anti-HLA antibodies in female blood donors.Objective: To determine the presence of potential class I anti-HLA antibodies in female donors.Methods: The subjects of this study were 30 female donors who had never been pregnant and 60 donors who had been pregnant and gave birth who donated their blood at UTD PMI DKI Jakarta. The collected samples were screened using the whole platelet ELISA method to detect platelet antibodies, namely anti-HPA and anti-HLA class I antibodies, followed by consulting anti-HLA class I antibodies with the MAIPA method.Results: Sixteen samples were detected to contain anti-platelet antibodies and 74 were negative. Identification of class I anti-HLA antibodies in 16 samples showed all negative results.Conclusion: Identification of 16 positive anti-platelet antibody samples in female donors did not show class I anti-HLA antibodies
Deteksi Varian Rhesus Dweak pada Populasi Rhesus Negatif di Provinsi DKI Jakarta Endang Pratiwi; Ni Ken Ritchie; Heri Wibowo
MEDIA ILMU KESEHATAN Vol 11 No 2 (2022): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v11i2.744

Abstract

Background: The Rhesus blood group system is determined by the presence or absence of the D-antigen, and has clinical importance because it can cause Haemolytic Transfusion Reaction (HTR) and Haemolytic Disease of the Newborn (HDN). There are several variants of the D-antigen which are weak, so it will be detected as Rhesus Negative.Objective: The purpose of this study was to determine the prevalence of the Rhesus D weak blood group variant in DKI Jakarta Province, so that it could determine the identity status of the blood group correctly.Methods: The samples used in this study were whole blood samples with a maximum storage time of three days in the blood refrigerator. The examination used in this study is the Indirect Antiglobulin Test (IAT).Results: Rhesus Dweak variant was detected in 103 samples examined using the IAT examination method.Conclusion: Determination of the Rhesus variant in individuals is necessary to prevent clinical impact on the patient. Further examination is needed to ensure the D-antigen of the Rhesus blood group
Co-Authors Agus Aulung Agus Aulung Alida Rosita Harahap Ambar Hardjanti Ananta Putri Oktafianti Andi Yasmon Anis Shafa Anna Rozaliyani Annisa Mulia Anasis April Hari Wardhana Arleni Bustami Armedy Ronny Hasugian Ceisar Pawenang Aji Cicilia Febriani Hayuningrum Cityta Putri Kwarta Din Syafruddin Dini Aulia Cahya Dyah Haryuningtyas Sawitri Elita Donanti Emiliana Tjitra Endang Pratiwi Eti Herani Hanny Siti Nuraeni Helena Ullyartha Pangaribuan Hendri Astuty Ibnu Agus Ariyanto Inge Sutanto Iris Rengganis Irma Safitri Ismail E Prayitno Isna Indrawati Kustina, Amelia Maya Ulfah Melani Anggraini Monica Puspa Sari Muammar Khadaffi Muammar Khaddafi Muhammad I. Kahtan Muharam Natadisastra Nadar Sukri Ndaru Andri Damayanti Ni Ken Ritchie Ni Ken Ritchie Nora Harminarti Nurhadi Eko Firmansyah Oky Satiagraha Patra Patiah Perdana Heriyoko Puji Budi Setia Asih, Puji Budi Puspita Eka Wuyung Rayyan Firdaus Ria Kodariah Ria Syafitri Evi G Rizal Subahar Rizal Subahar Rona Kartika Rona Kartika Sari, Monica Puspa Sheila Nurrahmah Siti Aqila Zahra Nst Suradi Suradi Suriyani Tan Sylvia Sance Marantina Talitha Vania Salsabella Taniawati Supali Taniawati Supali Taniawati Supali Taniawati Supali Utami, Diah Dwi Viya Aurelia Salsabila Wahyu Pangestuti Lestari Widiastuti Widiastuti Yolazenia Yolazenia Yordan Khaedir Zulhasril Zulhasril