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All Journal Indonesian Journal of Urology Indonesian Journal of Tropical and Infectious Disease JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Paediatrica Indonesiana Syntax Literate: Jurnal Ilmiah Indonesia Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Anesthesiology and Reanimation (IJAR) Majalah Biomorfologi (Biomorphology Journal) Green Medical Journal JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology
Ninik Asmaningsih Soemyarso
Department Of Child Health, Airlangga University Medical School/Dr. Soetomo General Hospital, Surabaya, East Java
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Increased Interleukin-6 as Infl ammatory Response and Magnesium Defi ciency in Pre-dialysis Chronic Kidney Disease of Indonesian Children Kardani, Astrid Kristina; Soemyarso, Ninik Asmaningsih; Aras, Jusli Aras; Prasetyo, Risky Vitria; Noer, Mohammad Sjaifullah
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 2 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i2.21479

Abstract

Chronic kidney disease (CKD) is a serious health problem in children, with increasing morbidity and mortality rates throughout the world. Children with CKD tend to experience magnesium (Mg) defi ciency that can stimulate an infl ammatory response in the body. One of the infl ammatory responses is an increase of Interleukin-6 (IL-6).  Study to analyze the correlation between Mg and IL-6 in pre-dialysis CKD children. The methods a cross sectional study was conducted in Dr Soetomo General Academic Hospital from November 2018 to April 2019. Children with pre-dialyis CKD were included in this study. Variables of serum Mg level (mg/dL) and infl ammatory marker (IL-6) were measured from the blood and analyzed by ELISA method. The correlation between Mg and IL-6 was analyzed with Spearman's correlation test with p <0.05.  Result a total of 47 children (27 boys vs 20 girls) between 3 months to 18 years old, with pre-dialysis CKD and no history of magnesium supplementation were included. The primary disease that causes of CKD were lupus nephritis (38.3%), nephrotic syndrome (23.4%), urologic disorder (23.4%),  tubulopathy (10.6%) and others (4.3%). The average IL-6 level was 55.42±43.04 pg/dL and Mg level was 2.06±1.54 mg/dL. There were no signifi cant correlation between IL-6 level and Mg level with staging of CKD and duration of illness (p>0.05), but there was a signifi cant correlation between serum Mg level and IL-6 level (r=-0.748; p<0.001). Magnesium levels have a signifi cant inverse correlation with IL-6 levels in pre-dialysis CKD children. The lower the Mg levels in the blood, the higher IL-6 levels and vice versa. 
The Impact of Community Service on Early Detection of Conenital Anomalies of the Kidney and Urinary Tract and Congenital Heart Disease in Children at Primary Health Care Sobo, Banyuwangi, Indonesia Risky Vitria Prasetyo; Arief Rakhman Hakim; Fandaruzzahra Putri; Susianto, Steven Christian; Agus Budiarto; Muhammad Riza Kurniawan; Ninik Asmaningsih Soemyarso; Mohammad Sjaifullah Noer
Journal of Community Medicine and Public Health Research Vol. 6 No. 2 (2025): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v6i2.75284

Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) and congenital heart disease (CHD) represent significant global public health challenges, contributing substantially to childhood morbidity and mortality. This study aimed to determine the impact of the community service on CAKUT and CHD early detection conducted by Universitas Airlangga, Surabaya, Indonesia, at Puskesmas Sobo, Banyuwangi Regency. This pre-test post-test design study was conducted among health cadres, parents of students, and the elderly in Puskesmas Sobo District. The subjects' knowledge was assessed by comparing pre- and post-test scores, which included 10 questionnaire questions. We conducted an early detection program for children in grades 4-6 of elementary school, which included weight, height, blood pressure, saturation, heart sound screening, and a complete urine dipstick examination. 62 subjects participated in the community service, with Pre-Test Scores of 62.9±16.5 and Post-Test Scores of 71.7±20.2. There were 25 children examined in our community service, with 100% regular heart examination and 76% with trace proteinuria; systolic blood pressure 90 ± 11.7 mmHg and diastolic blood pressure 59.4 ± 11.6 mmHg. This community service initiative demonstrated its dual impact on enhancing health knowledge and facilitating the early detection of potential congenital abnormalities in children. The findings underscore the critical need for more systematic, comprehensive screening programs for kidney and heart health in children across the region.
Effect of Atorvastatin on Lipoprotein Lipase and Lipid Profile in Children with Refractory Nephrotic Syndrome and Hyperlipidemia Damayanti, Nurul; Yulistiani; Ninik Asmaningsih Soemyarso; Mariyatul Qibtiyah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.84-91

Abstract

Background: Statin are Food and Drug Administration (FDA)-approved for hyperlipidemia but remain controversial in children. This study provides novel evidence of the molecular effects of atorvastatin on lipoprotein lipase (LPL) in children with refractory nephrotic syndrome, a population in which such data are limited. Objectives: This study aims to evaluate the effects of atorvastatin on serum lipoprotein lipase (LPL) levels and lipid profile parameters in children with refractory nephrotic syndrome. Methods: Randomized controlled trial (RCT) double-blind study of 31 children with hyperlipidemia and refractory nephrotic syndrome, included pre- and post-test groups. A placebo was given to the first group (n = 18 patients), while atorvastatin was administered to the treatment group (n = 13 patients). Results: Total cholesterol and Low-Density Lipoprotein (LDL) levels decreased significantly after treatment in both groups (p<0.05). In the atorvastatin group, LDL reduction was more pronounced compared to baseline. High-Density Lipoprotein (HDL) and Triglyceride (TG) levels showed no significant changes in either group (p>0.05). Lipoprotein Lipase (LPL) levels increased in the atorvastatin group and decreased in the control group; however, these changes were not statistically significant. No significant differences were observed between the atorvastatin and control groups in terms of changes in lipid profile parameters and LPL levels (p>0.05). Conclusions: Atorvastatin reduced cholesterol and LDL levels within the treatment group, although no significant differences were observed compared to the control group.
Co-Authors Agus Budiarto Aras, Jusli Aras, Jusli Aras Arief Rakhman Hakim Atika Atika Chairunnisa Chatarina Widianti Dessy Surya Setyani Dewi Ratna Sari Dwi Susanti Dwiyanti Puspitasari, Dwiyanti Esthy Poespitaningtyas Fandaruzzahra Putri Hanindita, Meta Herdiana Heru Setiawan I Dewa Gede Ugrasena Irwanto, Irwanto Ismoedijanto Jusak Nugraha Kardani, Astrid Kristina Lucky Andriyanto Lukman Oktadianto Lutifta Hilwana Mariyatul Qibtiyah Mariyatul Qibtiyah Mohammad Sjaifullah Noer Muhammad Riza Kurniawan Ni Wayan Tirthaningsih Noershanti Ramadhani Nugroho Setia Budi Nur Annisa Nugraheningtyasari Nurul Damayanti Paul L Tahalele Prastiya Indra Gunawan Putu Dian Saraswati Riskky Vitria Prasetyo Risky Vitria Prasetyo Roedi Irawan Rozalina Loebis, Rozalina Semedi, Bambang Pujo Sherly Yuniarchan Shidi Laras Pramudito Sri Andreani Utomo, Sri Andreani Susianto, Steven Christian Utariani, Arie Windhu Poernomo Yulistiani Yulistiani Yulistiani Yulistiani Yulistiani Yuni Hisbiiyah