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IDENTIFIKASI PROBLEMA OBAT DALAM PHARMACEUTICAL CARE Yulistiani, .; Suharjono, .; Hasmono, Didik; Khotib, Junaidi; Sumarno, .; Rahmadi, Mahardian; Sidharta, Bambang
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 1 (2008)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Pharmaceutical care is a colaborative process which goal is to prevent, identify, and solve the drug problem. Pharmacists is the one who responsible to pharmaceutical care, to assure the safety and effectiveness of drug use. This works was aimed to identify and analyze drug problems happened during pharmaceutical care. Data was collected from Dr. Syaiful Anwar Hospital Malang, from 1 Januari until 31 August 2006. This was a prospective study (n=138) with descriptive analysis. From the results it can be concluded that drug problems happened during pharmaceutical care in Dr. Syaiful Anwar Hospital Malang consist of: Drug Adverse Reaction (non-elergy side effect 15.22% and toxic effect 3.62%), error in drug choice (untreated indication 18.12%, unappropriate drug to indication 11.59%, unclear drug use 4.35%, unappropriate drug duplication 1.45%), contraindication 0.72%, dosing problem (overtherapy dose 22.46%, overlength therapy 2.90%, subtherapy dose 0.72%), drug interaction (potential interaction 138 cases, manifested interaction 8 cases), and others (patient uncontentment 10.14% and patient unproper care about his/her own disease/therapy 4.35%). ABSTRAKPharmaceutical care merupakan proses kolaboratif yang bertujuan untuk mencegah, mengidentifikasi, dan menyelesaikan problema obat. Dalam pelaksanaan, pharmaceutical care merupakan tanggung jawab profesional farmasis untuk menjamin penggunaan obat yang aman dan efektif dalam meningkatkan kualitas hidup pasien. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisa problema obat yang terjadi dalam pharmaceutical care. Penelitian dilakukan di Rumah Sakit Umum Dr. Syaiful Anwar Malang periode 1 Januari s/d 31 Agustus 2006, merupakan penelitian observasional-data prospektif (n=138) dengan analisis deskriptif. Dari hasil penelitian dapat disimpulkan bahwa macam problema obat yang terjadi meliputi : Reaksi obat yang tidak dikehendaki terdiri dari: efek samping non alergi (15,22%), efek toksik (3,62%); pemilihan obat terdiri dari: obat tidak diresepkan tetapi indikasi jelas (18,12%), obat tidak sesuai indikasi (11,59%), indikasi penggunaan obat tidak jelas (4,35%),duplikasi obat tidak sesuai (1,45%), Kontraindikasi (0,72%); pemberian dosis terdiri dari: dosis terlalu tinggi (22,46%), durasi terapi terlalu panjang (2,90%), dosis terlalu rendah (0,72%); interaksi obat terdiri dari: interaksi potensial 138 kejadian (n=138), manifestasi interaksi (8 kasus); dan problema lain (ketidakpuasan pasien terhadap terapi yang diberikan (10,14%) dan kurangnya perhatian/kesadaran pasien terhadap kondisi/ penyakitnya (4,35%).

Effects of Probiotics and Vitamin B Supplementation on IFN-γ and IL-12 Levels During Intensive Phase Treatment of Tuberculosis Budi Suprapti; Suharjono Suharjono; Rahmawati Raising; Yulistiani Yulistiani; Zamrotul Izzah; Wenny Putri Nilamsari; Prastuti Asta Wulaningrum; Arief Bachtiar
Indonesian Journal of Pharmacy Vol 29 No 2, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Tuberculosis is an acute infectious disease that primarily affects the lungs. Probiotics supplementation can increase the number and activity of NK cell in peripheral blood by modulation of IL-12, thus increasing IFN-γ production by Th1 response. Vitamin B1 acts on macrophages and affects neutrophil motility. Vitamin B6 is associated with the release of cytokines and the responsiveness of NK cells, while vitamin B12 affects to lymphocytes, Tcell proliferation, CD4+ ratios, and NK cell activity. To analyze the effects of probiotics and vitamin B1, B6, B12 supplementation on IFN-γ and IL-12 levels during intensive phase of antituberculosis treatment. The study was pre-post test randomised control by time series. The control group was TB patients with standard therapy of antituberculosis and vitamin B6, while the intervention group was TB patients receiving therapy plus once daily probiotics and vitamin B1, B6, B12supplementation during the intensive phase. Blood samples were withdrawn at baseline, one month, and two months after therapy to measure plasma IFN-γ and IL-12 levels using the ELISA method. Twenty two patients were divided equally into two groups. There was a tendency to greater increase of IFN-γ in the first month of the intervention group, followed by a significant decline after two-month therapy (p < 0.05). In both groups there was a rise in IL-12 levels after one month followed by a decrease in the second month (p > 0.05). However, the percentage was higher in the supplementation group. Adding probiotics and vitamins B1, B6, B12 could improve immune response through IL-12 and IFN-γ modulation during intensive phase therapy.

Drug Review : Oksitosin dan Misoprostol Pada Postpartum Hemorrhage (PPH) Aghnia Fuadatul Inayah; Yulistiani Yulistiani; Ayu Ratnasari; Rahmadhani Tyas Angganawati; Agus Sulistyono
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 9 No. 1 (2022)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v9i1.5350

Postpartum Hemorrhage (PPH) merupakan penyebab yang sangat penting dari mortalitas dan morbiditas ibu di seluruh dunia. Seluruh pedoman merekomendasikan oksitosin intramuskular sebagai pengobatan uterotonik lini pertama untuk semua perempuan yang melahirkan pada persalinan trimester ketiga. Pengobatan ini untuk pencegahan PPH karena kemanjuran dan keamanannya, sementara misoprostol digunakan sebagai alternatif dalam kondisi di mana oksitosin tidak tersedia atau di daerah di mana pasien tidak memiliki akses ke perawatan yang terampil. Tujuan penelitian ini untuk membandingkan penggunaan oksitosin dan misoprostol berdasarkan dosis, dan aspek farmasi yang berupa bentuk sediaan, pemberian, stabilitas/penyimpanan dan efek samping umum yang terjadi pada pasien PPH. Studi ini merupakan narrative review yang dilakukan penelusuran pustaka melalui Google Scholar, Pubmed dan Science Direct. Hasil review menunjukkan profilaksis oksitosin mengurangi kehilangan darah dan kejadian PPH tanpa hasil yang merugikan. Penggunaan oksitosin dengan Uniject juga memberikan keuntungan pada penghematan biaya. Akan tetapi, penggunaan oksitosin harus diberikan oleh tenaga profesional. Pengunaan misoprostol adalah alternatif yang efektif untuk pengobatan PPH primer. Namun, penggunaan misoprostol dikaitkan dengan beberapa efek samping sehingga diberikan apabila ketersediaan oksitosin terbatas. Dengan demikian, dapat disimpulkan pemberian oksitosin lebih diutamakan untuk PPH karena dari efek samping lebih minimal dibandingkan misoprostol.

Drug Review : Oksitosin dan Misoprostol Pada Postpartum Hemorrhage (PPH) Aghnia Fuadatul Inayah; Yulistiani Yulistiani; Ayu Ratnasari; Rahmadhani Tyas Angganawati; Agus Sulistyono
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 9 No. 1 (2022)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v9i1.5350

Postpartum Hemorrhage (PPH) merupakan penyebab yang sangat penting dari mortalitas dan morbiditas ibu di seluruh dunia. Seluruh pedoman merekomendasikan oksitosin intramuskular sebagai pengobatan uterotonik lini pertama untuk semua perempuan yang melahirkan pada persalinan trimester ketiga. Tujuan penelitian ini untuk membandingkan penggunaan oksitosin dan misoprostol berdasarkan dosis, dan aspek farmasi yang berupa bentuk sediaan, pemberian, stabilitas/penyimpanan dan efek samping umum yang terjadi pada pasien PPH. Studi ini merupakan narrative review yang dilakukan penelusuran pustaka melalui Google Scholar, Pubmed dan Science Direct. Dari hasil pencarian, diperoleh sebanyak 5855 jurnal dan terpilih 40 jurnal yang memenuhi kriteria inklusi. Kriteria inklusi yaitu memenuhi kaidah introduction, method results and discussion dan terbit selama 10 tahun terakhir. Jurnal yang tidak dapat diakses secara lengkap dieksklusi dan diperoleh sebanyak 23 jurnal. Hasil review menunjukkan profilaksis oksitosin mengurangi kehilangan darah dan kejadian PPH tanpa hasil yang merugikan. Penggunaan oksitosin dengan Uniject juga memberikan keuntungan pada penghematan biaya. Akan tetapi, penggunaan oksitosin harus diberikan oleh tenaga profesional. Dengan demikian, dapat disimpulkan pemberian oksitosin lebih diutamakan untuk PPH karena dari efek samping lebih minimal dibandingkan misoprostol.

UJI STABILITAS SEDIAAN AMPISILLIN SULBAKTAM SETELAH REKONSTITUSI I Gede Edy Sagitha; Suharjono Suharjono; Yulistiani Yulistiani; Isnaeni Isnaeni
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 8 No 1 (2023): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v8i1.4333

Repeated use of antibiotic ampicillin sulbactam after reconstitution, therefore in storage various many factor can affect it stability such as type of solvent used, storage temperature and storage time. Objective of study is to analyze the chemical stability product of ampicillin sulbactam in repeated use with the parameters of the solvent and storage temperature Sample products were weighed and reconstituted using WFI and NS solvents, diluted ad 20 ppm and put into sterile vials. Then stored at room temperature (25-30 ° C) and refrigerator temperature (4-8 ° C). Storage is carried out for 24 hours which is divided into 4 -time series, namely 0, 1, 4 and 24 hours. Each time series is microbiological tested and after 18 hours incubation the inhibition zone is observed and its diameter measured using calipers. Result of study is at 0th hour showed a significant difference in different solvents. Samples dissolved with NS solvents have a greater inhibition zone than those dissolved using WFI. This happens because there is a primary salt effect that occurs with the influence of electrolytes (salt) or variations in the strength of ions can affect the coefficient of activity that affects the reaction rate. From the statistical analysis at the 1st and 4th hours, the storage temperature that provides significant result, storage in the refrigerator produces better results compared to storage at room temperature. At 24 hours the temperature and solvent did not give the significant result on the stability of the sulbactam ampicillin sample. Conclusion is NS solvents give better results than WFI solvents. Samples are more stable if stored in a refrigerator. After 4 hours based on the above study the sample no longer meets the requirements of Indonesian Pharmacopoeia 5th edition

Pola Pengobatan Badai Tiroid pada Pasien Lanjut Usia Cotama, Cahana Rastra; Yulistiani, Yulistiani
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 16, No 1 (2025): Januari-Maret 2025
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf16166

Thyroid storm is a clinical diagnosis that refers to a life-threatening hypermetabolic state due to excessive thyroid hormone levels, so it must be treated immediately with aggressive therapy. The mortality rate of this case is 8% -25% and involves severe organ damage. The purpose of this study was to determine the effective and safe treatment pattern to achieve a euthyroid state. This study was a literature review of thyroid storm therapy in elderly patients. The sources of literature were PubMed, Google Scholar and MDPI in the last 10 years. The search was carried out using PICO filtering, so that 52 articles were obtained and 20 articles were used as primary data consisting of 4 articles included in Scopus Q1, 3 articles in Scopus Q2, 6 articles in Scopus Q3, 1 article in Scopus Q4 and 6 other articles were not included in the quartile ranking in Scopus. The results of this review indicated that the main goal of thyroid storm therapy in elderly patients is to make the patient euthyroid as quickly and safely as possible. Thionamides were antithyroids that are the first choice for thyroid storm therapy, namely methimazole (MMI) or propylthiouracil (PTU). High-dose corticosteroids should be given as prophylaxis for relative adrenal insufficiency due to hypermetabolic conditions in thyroid storm. If tachycardia occurs in patients with thyroid storm, then beta adrenergic agonists should be chosen as therapy. Non-pharmacological therapy such as plasmapheresis should be considered if there is no clinical improvement within 24-48 hours after dose optimization in initial therapy. It was concluded that various guidelines recommend thyroid function tests to be performed 4-6 weeks after starting therapy and then every 2-3 months after the patient becomes euthyroid.Keywords: thyroid storm; elderly; antithyroid; euthyroid ABSTRAK Badai tiroid adalah suatu diagnosis klinis yang merujuk kepada suatu keadaan hipermetabolik yang mengancam jiwa karena kadar hormon tiroid yang berlebihan, sehingga harus ditangani segera dengan terapi yang agresif. Angka kematian dari kasus ini adalah 8%-25% dan melibatkan kerusakan organ yang parah. Tujuan dari studi ini adalah mengetahui pola pengobatan yang efektif dan aman untuk mencapai keadaan eutiroid. Studi ini merupakan tinjauan literatur tentang terapi badai tiroid pada pasien lanjut usia. Sumber literatur adalah PubMed, Google Scholar dan MDPI dalam 10 tahun terakhir. Pencaian dilakukan dengan penyaringan PICO, sehingga didapatkan 52 artikel dan 20 artikel yang dijadikan sebagai data primer yang terdiri atas 4 artikel termasuk dalam Scopus Q1, 3 artikel Scopus Q2, 6 artikel Scopus Q3, 1 artikel Scopus Q4 dan 6 artikel lainnya tidak masuk dalam pemeringkatan quartile di Scopus. Hasil dari tinjauan ini menunjukkan bahwa tujuan utama terapi badai tiroid pada pasien lanjut usia adalah untuk membuat keadaan pasien menjadi eutiroid secepat dan seaman mungkin. Thionamid adalah antitiroid yang dijadikan pilihan pertama terapi badai tiroid, yaitu methimazole (MMI) atau propiltiourasil (PTU). Kortikosteroid dosis tinggi harus diberikan sebagai profilaksis insufisiensi relatif adrenal akibat kondisi hipermetabolik pada badai tiroid. Jika terjadi takikardi pada pasien badai tiroid, maka beta adrenergic agonis harus dipilih sebagai terapi. Terapi non farmakologi seperti plasmapheresis harus dipertimbangkan jika tidak terdapat perbaikan klinis dalam 24-48 jam setelah optimalisasi dosis pada terapi awal. Disimpulkan bahwa berbagai pedoman merekomendasikan tes fungsi tiroid dilakukan 4-6 minggu setelah memulai terapi dan kemudian setiap 2-3 bulan setelah pasien menjadi eutiroid. Kata kunci: badai tiroid; lanjut usia; antitiroid; eutiroid

The Efficacy of Pharmacological and Non-Pharmacological Therapy In Thyroid Storm Patients With Cardiovascular Complications : Literature review Nur Rezky Rutami Amir; Yulistiani Yulistiani
Malahayati Nursing Journal Vol 7, No 5 (2025): Volume 7 Nomor 5 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i5.18694

ABSTRACT Tyroid storm is a life-threatening with clinical manifestation of thyrotoxicosis can cause other organ dysfuntion such as cardiovascular disorders. Therefore, eary detection using Burch and Wartofsky Point Scale that treatment can be optimally. The purpose of literature review is examine the treatment used thyroid storm with cardiovascular complications and the effectiveness of therapy achieve eutiroid. The research use a qualitative method with a literature review design. Data collected from article, journal using keywords and based on inclusion criteria been used Google Scholar and Science Direct databases. The results of journal screening is five journal with case report design. Pharmacological treatment use thionamides, beta blockers, corticosteroids, and potassium iodide, The efficacy of therapy depending on the patients complications. Non-Pharmacological therapy plasmapheresis, is used if the patient is given pharmacological therapy and does not show a response after 48 hours of administration. The efficacy of plasmapheresis shows improved clinical effect and euthyroid state. Keywords: Thyroid storm, Pharmacological, Non-Pharmacological, Eutiroid

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