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All Journal Vis Vistalis AL KAUNIYAH E-Journal Widya Kesehatan dan Lingkungan Pro-Life Jurnal Mikologi Indonesia JFIOnline Journal of Microbial Systematics and Biotechnology Journal of Social Political Sciences (JSPS) Journal of Tropical Biodiversity DEDIKASI : Jurnal Pengabdian Kepada Masyarakat
Noverita
Universitas Nasional
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Journal : Journal of Tropical Biodiversity

 1 
Antibacterial Activities of Ethanol Extracts Fruit Bodies of Ganoderma Lucidum and Rigidoporus Microphorus Against Escherichia Coli and Staphlyococcus Aureus Noverita Noverita; Ritchie Y.H L.T
Journal of Tropical Biodiversity Vol 1 No 1 (2020): December 2020
Publisher : Universitas Nasional Jakarta

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Abstract

Ganoderma lucidum and Rigidoporus microporus are two examples of macro fungi that are commonly found in forest areas in the highlands of Indonesia, and are even found in lowlands such as in urban forests in DKI Jakarta. Many of these macro fungi have been reported as potential medicinal substances, especially from the species G. lucidum, whose fruit bodies are usually obtained from forests in upland areas. The purpose of this study was to determine the antibacterial activity of the fungi G. lucidum and R. microporus obtained from several places in South Jakarta against the growth of E. coli and S. aureus bacteria. Testing for antibacterial activity was carried out using the Kirby-Bauer diffusion method. The results showed that the extract of G. lucidum fruit bodies was only able to inhibit the growth of S. aureus bacteria. While the fruit body extract of R. microporus was able to inhibit both types of tested bacteria (E. coli and S. aureus). The results showed that G. lucidum extract was only able to inhibit S. aureus bacteria. Meanwhile R. microporus extract was able to inhibit E.coli and S.aureus. There was no significant effect of increasing the concentration of mushroom fruit extract on the inhibition zone of the tested bacteria.
Antibacterial Bioactivity from Extract of Reundeu Caret (Staurogyne longata) and Honje (Etlingera hemisphaerica) Noverita Noverita; Ernawati Sinaga
Journal of Tropical Biodiversity Vol 2 No 1 (2021): December 2021
Publisher : Universitas Nasional Jakarta

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Abstract

Reundeu caret (Staurogyne longata) and Honje (Etlingera hemisphaerica) are two examples of plants commonly used by rural tribal communities as medicinal ingredients, one of which is by the Baduy tribal community. These two plans are usually used by local people to treat infectious diseases (wounds) and stomach aches. Therefore, it is necessary to prove the medical potential of these plants. This study was conducted with the aim of knowing the antibacterial potential of the extracts of the Reundeu caret (Staurogyne longata) and Honje (Etlingera hemisphaerica) plant extracts against the growth of Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Bacillus cereus. The method used in this study is the Disc Diffusion method. The results showed that Reundeu caret and Honje plant extracts were only able to inhibit the growth of Staphylococcus aureus and Bacillus cereus. The antibacterial activity of the plant extracts of Rendeu Caret and Honje was moderate to strong. This study concluded that Honje and Reundeu caret plant extracts were more potential to be used to treat infectious diseases (wounds).
Antibacterial of Eight Macrofungi Species Against Noverita Noverita; Nyoman Ayu Ratmini
Journal of Tropical Biodiversity Vol 2 No 2 (2022): April 2022
Publisher : Universitas Nasional Jakarta

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Abstract

Indonesia is a newly developing country, with many problems, one of which is health problems related to medicinal ingredients (antibiotics). Many microorganisms, especially bacteria, are resistant to various types of antibiotics. Various efforts have been made by the government to find new antibiotics, to reduce the use of semisynthetic or synthetic antibiotics which are very dangerous. One of them uses macrofungi.The antibacterial activity of eight species of macrofungi (Ganoderma applanatum, G. boninense, Ganoderma sp1, Ganoderma sp2, Trametes sp1, Trametes sp2, Trametes sp3, Microporus xanthopus and Suillus sp1) against Escherichia coli and Staphylococcus aureus has been carried out, using the diffusion method. The results showed that six species were able to inhibit the growth of Staphylococcus aureus. The species were Ganoderma applanatum, Ganoderma sp1, Trametes sp.1, Trametes sp.2, Trametes sp.3, and Suillus sp. The resulting limiting zone ranged from 6.5-11 mm. The zone of inhibition produced by Trametes, the smallest inhibition zone of Ganoderma sp1. The higher the concentration of the extract, the greater the ability to inhibit the growth of the test bacteria.
Endophytic Fungus from Soursop (Annona Muricata L) and Potential Antibacteria Noverita Noverita; Nastiti Nastiti; Endang Wahyu Ningsih
Journal of Tropical Biodiversity Vol 3 No 2 (2023): April 2023
Publisher : Universitas Nasional Jakarta

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Abstract

The aim of this research was to isolate endophytic fungi from different parts of soursop plantations in Cikareo Village, Sukabumi, West Java and to test their antibacterial activity. The researchers obtained six isolates from leaves, stems, and fruits of the soursop plant. These isolates displayed varying growth abilities, with only two (Le-1 and St-2) found to inhibit the growth of Escherichia coli bacteria. Overall, this study highlights the potential of endophytic fungi from soursop plantations as a source of antibacterial agents.
Bioactivity of Fungi from the Thousand Islands Against Staphylococcus aureus and Escherichia coli Using Dilution Method Noverita Noverita; Samitri P. Debby
Journal of Tropical Biodiversity Vol 3 No 3 (2023): August 2023
Publisher : Universitas Nasional Jakarta

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Abstract

The rapid advancement of science and technology has brought numerous benefits to human life; however, it is unfortunate that this progress has not extensively tapped into one of Indonesia's abundant biological resources, which is fungi, especially marine fungi. This research was conducted to explore the antimicrobial potential of marine fungi isolated from the Thousand Islands against Staphylococcus aureus and Escherichia coli using the dilution method. The study aimed to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the obtained isolates against the two test bacteria. The research comprised two phases: the collection of samples in the field, followed by the antimicrobial activity assay using the dilution method in the laboratory. The findings are expected to reveal several types of marine fungi from the Thousand Islands with antimicrobial capabilities that could be developed as alternative antibiotics to replace those that have lost their potency. The results of the study showed that out of the 10 tested marine fungi isolates, all of them exhibited inhibition against the growth of Staphylococcus aureus and Escherichia coli. The concentrations of 100% and 75% proved to be the most effective in inhibiting bacterial growth. The MIC of the tested marine fungi extracts was determined to be 25%. Moreover, five isolates of marine fungi demonstrated MBC against S. aureus and E. coli: S.KL5 isolate at concentrations of 75% and 50%, S.AL and S.KL1 isolates at concentrations of 100% and 50%, and S.MA2 and S.KL1 isolates at concentrations of 100% and 75%. The identified best isolates were found to belong to the species Penicillium sp. and Aspergillus niger .
Edible Mushrooms in The Surroundings of Bangbayang Village, Situraja, Sumedang, West Java Qonitah, Tsabitah Athifah; Aryyanto, Muhammad Raul Alfadri; Suteja, Hardiansyah; Murti, Alena Puspa; Noverita, Noverita
Journal of Tropical Biodiversity Vol 4 No 1 (2023): December 2023
Publisher : Universitas Nasional Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59689/bio.v4i1.203

Abstract

Bangbayang is one of the villages located in the Situraja Subdistrict, Sumedang Regency, West Java. The natural conditions around the area are very cool with various types of plants, which also make it likely to find mushrooms, especially macro mushrooms that have the potential as food ingredients, but have not been reported. This study aims to inventory macro mushrooms with the potential as food ingredients in Bangbayang Village, Situraja Subdistrict, Sumedang Regency, West Java. The research method used is exploratory, and each sample of macro mushrooms obtained is observed based on the macroscopic characteristics of its fruiting body. The results of the study obtained a total of 12 species of macro mushrooms with the potential as food ingredients, namely; Agaricus campestris, Auricularia auricula, A. cornea, Boletus edulis, Cortinarius caperatus, Filoboletus manipularis, Lentinus sajor-caju, Lepista nuda, Russula rosea, Sarcomyxa edulis, Termitomyces clypeatus, and Tricholoma fraticum.
Macro Fungi Diversity in The Sanggabuana Mountain Area, Karawang Regency, Tegalwaru District, West Java Sumarouw, Achmad Alfio Dalish; Yafi, Ikhwal; Vansha, Fahriza Kemal; Noverita, Noverita
Journal of Tropical Biodiversity Vol 4 No 2 (2024): April 2024
Publisher : Universitas Nasional Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59689/bio.v4i2.216

Abstract

Sanggabuana Mountain is a mountain located within the territory of Karawang Regency. Administratively, the mountain is situated in Karawang Regency, Tegalwaru District, West Java. The height of the mountain is 1,291 meters above sea level (MDPL) and is the highest and only mountain in Karawang. The area has a high biodiversity, making it highly likely to find many macrofungi, especially macrofungi. This research was conducted to determine the diversity of macrofungi in the Sanggabuana Mountain area of Karawang Regency, Tegalwaru District, West Java. The type of research is exploratory and descriptive research, conducted on three observation routes; Route A (Cigentis), Route B (local plantations), and Route C (Kejayaan). The research results obtained a total of 23 species from 17 genera of macrofungi across the three observation routes, with the species diversity index in all three routes falling into the moderate diversity category. The highest encounter frequency of macrofungi on Route B was Ganoderma applanatum (23%), on Route A was Trametes sp (19%), and on Route C was Microporus xanthopus, Xylaria sp, and Inonotus sp (10%). The species dominance index on Route A falls into the high dominance category, while on Route B and C, it falls into the low dominance category.
Anti-Aging Potential of Moringa oleifera Bioactive Compounds: A Molecular Docking Approach Targeting Sirtuin Proteins Marthin, Jeffrey; Noverita, Noverita; Prasasty, Vivitri Dewi
Journal of Tropical Biodiversity Vol 5 No 2 (2025): April 2025
Publisher : Universitas Nasional Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59689/bio.v5i2.268

Abstract

Moringa oleifera has long been valued in traditional skincare, but its molecular interactions with key aging regulators remain poorly understood. This study elucidates the anti-aging potential of Moringa oleifera bioactive compounds through their modulation of sirtuin proteins (SIRT2, SIRT5, SIRT6), which govern genomic stability and oxidative stress responses. Using computational approaches, we performed molecular docking simulations (AutoDock Vina) on 20 bioactive compounds against sirtuin crystal structures from the Protein Data Bank. Comparative analysis with commercial anti-aging agents (niacinamide, AHA, ceramide) identified three Moringa compounds with superior binding affinities: rutin (-10.7 kcal/mol), quercetin (-8.9 kcal/mol), and chlorogenic acid (-7.9 kcal/mol), all outperforming niacinamide (-6.1 kcal/mol). SwissADME profiling confirmed their drug-like properties, including high oral bioavailability, blood-brain barrier penetration, and minimal toxicity risks. Mechanistically, these compounds demonstrated dual antioxidant and anti-inflammatory capacities, suggesting synergistic protection against oxidative damage and inflammation-driven aging. Our results position Moringa oleifera as a rich source of multitarget anti-aging candidates, combining computational validation with biological relevance to advance natural product-based interventions against cellular senescence.
Co-Authors Afifah Intan Kamila Ahmad Habib Nur Fikri Arum Lintang Dyah Lestari Aryyanto, Muhammad Raul Alfadri Astri Oktavina Atna Permana Batari Wahyu Pangesti Bhakti Nur Avianto Caroline Humaira Rifalina Rosyid Dennys Perdana Armanda E Sinaga Endang Sukara Endang Wahyu Ningsih Ernawati Sinaga Evi Nuraeni F Y Siti Fia Fadlun Fitria, Dinah Hana Kifayah Ikhsan Matondang Ilmi, Fauziah Marthin, Jeffrey Murti, Alena Puspa Nabilah Nabilah Nastiti Nastiti Nonon Saribanon Nuniek Ina Ratnaningtyas Nuraeni Ekowati Nyoman Ayu Ratmini Qonitah, Tsabitah Athifah Ragamustari, Safendrri K. Ratna Wati Ratna Wati Ratna Zahara Mahajarifar Ritchie Y.H L.T Samitri P. Debby Sara Pebrina Sri Lestari Sumarouw, Achmad Alfio Dalish Suprihatin Suprihatin Suteja, Hardiansyah Tatang M Setia Tatang Mitra Setia Vansha, Fahriza Kemal Vivitri Dewi Prasasty Widyastuti, Anisa Yafi, Ikhwal Yudistari Yudistari