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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Matematika & Sains INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Farmako Bahari Pharmaceutical Sciences and Research (PSR) Jurnal Sains dan Teknologi Farmasi Indonesia
Ilma Nugrahani
Fakultas Farmasi Universitas Pancasila Jakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Public Health

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Identifikasi Interaksi Kimia Fisika Pada Kombinasi Antibiotika Amoksisilina Trihidrat - Kalium Klavulanat Dengan Kalorimeter Larutan Dan Rekristalisasi Nugrahani, Ilma; Asyarie, Sukmadjaja; N.S, Sundani; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 4, No. 3
Publisher : UI Scholars Hub

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Abstract

Physico-chemical interaction of amoxicillin trihydrate - potassium clavulanate has been investigated. The method used in this experiment was solution calorimeter analysis that was collaborated by the re-crystallization observation. Amoxicillin-clavulanate were mixed on the variety ratios (0:10; 9:1; ...; 1:9; 0:10) and analyzed by solution calorimeter in the HCl 0,1 N and phosphate buffer pH 6,8 solution as the gastrointestinal liquids. After that, the re-crystallizations of amoxicillin-clavulanate on the variety ratios were analyzed by polarization microscope and digital camera. The results of observation showed that amoxicillin-clavulanate have the physical-chemical interactions in the ratios 3:7; 5:5; 7:3 respectively in both of pH models of gastrointestinal liquids.
Pengamatan Visual Tahap-Tahap Pembentukan Kristal Sistem Eutektikum Asetaminofen-Pseudoefedrin Hidroklorida Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

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The aim of this research was to observe the recrystallization process of two component, acetaminophen-pseudoephedrine hydrochloride in ethanol and the thermal profiles. The visual data resulted from polarization microscope observation confirmed with thermograph DSC showed that the crystal habit was represented to the intrinsic character representative by thermodynamic properties of the binary system.The visualization process proved that in different molar ratios, the binary system formed crystals habit with different and step by step showed inhibit, to form polycrystalline until at molar ratio 6:4 formed the fines single crystals mixture which was smaller than before co-recrystallization. Acetaminophen was observed as monoclinic hexagonal crystals while pseudoephedrine hydrochloride was observed monoclinic/orthorombic forms.
Polimorfisasi dan Solvatomorfi Amoksisilina Trihidrat setelah Proses beku Kering Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 2
Publisher : UI Scholars Hub

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The polymorphismof amoxicillin has been identified after freeze drying process. The freeze dried amoxicillin have some specific physical properties different from their raw material, that was proved by DSC, XRD, and polarize microscope. Exothermal curve from DSC thermogram changes to endothermal curve, diffractogram XRD changes to different profile, and the crystal shows different habit. All of data showed that freeze drying process improve amoxicillin to different crystal form which has higher melting oxidation point and lower hydrate. The improvement of the crystal structure might be impact to change physical-pharmaceutical properties like dissolution, absorption, and change it antibiotic potency.
Pengujian Mutu Sediaan Kapsul Minyak Hati Ikan Cucut Botol Dalam Beberapa Produk yang Beredar di Pasaran Wijaya, Triyadi Hendra; Kartawinata, Tutus Gusdinar; Nugrahani, Ilma
Pharmaceutical Sciences and Research Vol. 6, No. 3
Publisher : UI Scholars Hub

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National standard agency of Indonesia has set the quality standard of shark liver oil through the Indonesian national standard which consists of sensory test, moisture content, free fatty acid as well as squalene concentration. The purpose of this study is to evaluate quality of shark liver oil capsule on market. As many as 6 samples were tested for the quality in accordance to SNI through organoleptic test (< 7), moisture content (max 0.3%), free fatty acid content (max 1.5%) and squalene concentration (min 70%). The results showed that the level of squalene in all samples do not meet the standard requirement, however all samples meet the free fatty acid content requirements. One sample does not fit the standard criteria in the term of organoleptic test and moisture content.
DETERMINASI KADAR KAFEIN PRODUK TEH HITAM INDONESIA DENGAN MENGGUNAKAN SPEKTROFOTOMETER FOURIER TRANSFORM INFRARED Melvia - Sundalian; Ilma - Nugrahani
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 7, No 1 (2018)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (838.816 KB) | DOI: 10.58327/jstfi.v7i1.73

Abstract

AbstrakTeh hitam merupakan salah satu bahan minuman yang sangat diminati di Indonesia. Pada umumnya, penilaian kualitas produk teh hitam dilakukan oleh tea taster menggunakan metode organoleptis. Variabilitas komposisi kandungan kimia merupakan faktor penting yang menentukan rasa, aroma, dan manfaat terhadap kesehatan. Kafein merupakan senyawa alkaloid golongan metilxantin menjadi perhatian khusus, mengingat kandungannya yang cukup tinggi dan berperan pada penentuan kualitas teh hitam. Pada penelitian ini telah dilakukan analisis kadar kafein pada produk teh hitam dengan Spektrofometer FTIR (Fourier Transform Infrared). Sampel teh hitam yang diuji berasal dari 12 produk teh hitam yang beredar di Indonesia. Hasil analisis menunjukkan metode ini dapat memberikan hasil analisis yang baik dengan nilai koefisien korelasi (R2) sebesar 0,997, Relatif Standar Deviation (RSD) sebesar 1,2743 %, serta nilai persentase rekoveri dengan rentang 97 - 102 %. Selain itu, hasil analisis kadar kafein teh hitam menunjukkan bahwa kadar kafein berada pada rentang 1 – 5%. Sampel BBT_GOL memiliki kadar kafein terendah dengan persentase sebesar 1,56 %, sedangkan sampel BBT_QUA memiliki kadar kafein tertinggi, dengan persentase kadar sebesar 4,44%.  Kata kunci: Teh Hitam, Fourier Transform Infrared, Kafein  AbstractBlack tea is one of the most popular beverage ingredients in Indonesia. Generally, tea quality assessment is done by tea taster using organoleptic method. The variability of chemical composition is an important factor that determines taste, flavor, and health benefits. Caffeine is a type of methylxanthin alkaloid compound of particular concern, given its high content and a role in determining the quality of black tea. The analysis of caffeine content has been done in black tea product with FTIR (Fourier Transform Infrared) Spectrophotometer. The sample of black tea tested from 12 black tea products marketing in Indonesia. The result of the analysis shows that this method can give good analysis result with correlation coefficient value (R2) equal to 0.997, Relative Standard Deviation (RSD) equal to 1.2743%, and value of recovery percentage with range 97 - 102%. The results showed that black tea analysis for caffeine content in range 1 - 5%. In Sample BBT_GOL caffeine content averages at 1.56% (lowest), while in sample BBT_QUA caffeine content averages at 4.44% (highest).  Keywords: Black Tea, Fourier Transform Infrared, Caffeine
Simple Thermal Analysis as a Green Method for the Detection of Meat Adulteration Ilma Nugrahani; Aditya Aditya
Indonesian Journal of Chemistry Vol 23, No 5 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.79201

Abstract

Differential scanning calorimetry (DSC) is one of the most widely developed thermal analysis methods for meat samples for halal authentication of food or processed products. Research on adulteration detection for various types of meat and its derivatives has been developed before and still requires organic solvents. Therefore, the concept of the "green method" is being tried to develop in this research. DSC analyses are performed in the same experimental conditions for all sample powder: sample mass 2 mg, temperature range 30–400 °C, and heating rate 20 °C min−1. The results showed there is a characteristic minor endothermic peak for each meat. Chemometric analysis was carried out using the principal component analysis (PCA) method to ensure that the thermal characteristics of each meat were utterly different in both pure and mixed meat. The results of this analysis indicate that each pure meat has a different score plot. Therefore, the developed thermal analysis method is quite reliable in determining the different types of meat based on the characteristic minor endothermic peak in the thermogram and the score plot from PCA analysis.
Bahasa Inggris Abdillah, Muhammad Nur; Nugrahani, Ilma; Fidriany, Irda; Humairoh, Rosnaini
Jurnal Ilmiah Farmako Bahari Vol 16 No 1 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v16i1.41970

Abstract

Honey with a bitter flavour available on the market is expected to meet quality standards outlined by the Indonesian National Standard (SNI). This study aimed to determine adulteration in such honey products using SNI as the benchmark. Tests conducted included analyzing moisture content through Karl Fischer titration, diastase activity, hydroxymethylfurfural (HMF) levels, sucrose concentrations via the Anthrone method by UV-visible spectrophotometry, and reducing sugar content using HPLC-RI. Eight honey samples were assessed—seven bitter and one sweet (as a reference). Findings revealed several bitter honey samples failed to comply with SNI criteria, signalling possible adulteration. These results underscore the importance of adhering to SNI to ensure honey quality.
Co-Authors Abdillah, Muhammad Nur Aditya Aditya Andreanus Andaja Soemardji Andy Susbandiyah Ifada Astrini, Dwie Asyarie, Sukmadjaja Belda Nurmeyna Benny Permana Cintya Nurul Apsari Dea Dwi Puspita Debora Ronauli Dwie Astrini Hasan Rahmat Hasan Rahmat, Hasan Hidehiro Uekusa Humairoh, Rosnaini Irda Fidriany Joshita Djajadisastra Joshita Djajadisastra, Joshita Kartawinata, Tutus Gusdinar Marlia Singgih Wibowo Melvia Sundalian N.S, Sundani Ningsih, Listia Nurmeyna, Belda Okky D. Putra Okky Dwichandra Putra Pusparani Krisnamurthi Putra, Okky D. Rachmat Mauludin Ratna A. Utami Rozana Oktaviary Slamet Ibrahim Slamet Ibrahim Slamet Ibrahim Slamet Ibrahim Slamet Ibrahim Surantaatmadja Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sundani Noerono Soewandhi Sundani Nurono Soewandhi Sundani Nurono Soewandhi Triyadi Hendra Wijaya Tutus Gusdinar Kartawinata Utami, Ratna A. Wibowo, Marlia Singgih Winni Nur Auli