Garuda - Garba Rujukan Digital

PERBANDINGAN RESPON KLINIK NIKARDIPIN DENGAN DILTIAZEM PADA HIPERTENSI EMERGENSI Palupi, Poppy Diah; Rahmawati, Fita; Probosuseno, Probosuseno
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 5, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.146

Hipertensi emergensi merupakan suatu kedaruratan medik dan memerlukan tindakan yang cepat dan tepat untuk menyelamatkan jiwa penderita. Secara umum, obat antihipertensi yang digunakan pada pasien hipertensi emergensi diberikan secara parenteral. Tujuan penelitian adalah untuk mengetahui respon klinik nikardipin dengan diltiazem intravena dalam menurunkan tekanan darah, mean arterial pressure, dan denyut jantung pada pasien hipertensi emergensi. Penelitian merupakan penelitian analitik dengan rancangan retrospective cohort study. Data diambil dari rekam medik pasien hipertensi emergensi yang dirawat di Instalasi Gawat Darurat (IGD), Intensive Care Unit (ICU), maupun bangsal rawat inap selama periode Januari sampai Desember 2014 di RSUD Kota Semarang. Jumlah subjek penelitian sebanyak 117 pasien, terdiri dari 66 pasien kelompok nikardipin dan 51 pasien kelompok diltiazem. Nikardipin dapat menurunkan mean arterial pressure (MAP) sebesar 14,45%, sedangkan diltiazem sebesar 12,20%. Nikardipin menurunkan tekanan darah sistolik 17,69%, sedangkan diltiazem sebesar 17,63%. Nikardipin menurunkan tekanan darah diastolik 21,56% dan denyut jantung sebesar 1,74%, sedangkan diltiazem menurunkan tekanan darah sebesar 20,30% dan denyut jantung sebesar 7,83%. Tidak terdapat perbedaan signifikan dalam menurunkan tekanan darah dan MAP antara nikardipin dan diltiazem. Namun, terdapat perbedaan signifikan dalam menurunkan denyut jantung antara nikardipin dan diltiazem.

UJI EFEKTIVITAS EKSTRAK ETANOL 70% EKSTRAK KAWISTA (Limonia acidissima ) SEBAGAI TONIKUM PADA MENCIT JANTAN GALUR SWISS Metrikana Novembrina; Poppy Diah Palupi; Felisia Bani
Jurnal Farmasi & Sains Indonesia Vol 2 No 1 (2019)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Latar belakang: Indonesia merupakan negara beriklim tropis yang kaya akan keanekaragaman hayati, di antaranya tumbuh-tumbuhan. Salah satunya adalah buah kawista (Limonia acidissima). Berdasarkan sejumlah penelitian, buah kawista berkhasiat menurunkan panas, pengelat dan bersifat tonikum (Dewi, 2013). Penelitian ini bertujuan untuk menguji efektivitas ekstrak etanol 70% Buah kawista (Limonia acidissima) sebagai tonikum terhadap mencit jantan Galur Swiss. Metode: Hewan uji sejumlah 25 ekor secara random dibagi ke dalam lima kelompok perlakuan : Kontrol negatif (suspensi Na CMC 0,5%), kontrol posistif (suspensi coffein 13 mg/kgBB) dan tiga kelompok variasi dosis ekstrak etanol 70% Buah Kawista (50%, 75% dan 100%). Sebelum diberikan perlakuan, mencit direnangkan dalam kolam dan dicatat waktu lelahnya (pre-test). Setelah itu, pada masing-masing kelompok uji diberi perlakuan, kemudian direnangkan kembali dan dicatat waktu lelahnya (post-test). Data yang diperoleh kemudian diuji dengan menggunakan uji statistik one way anova dan dilanjutkan dengan uji statistik post-hoc LSD. Hasil: Data waktu lelah yang ditunjukkan dengan frekuensi menenggelamkan kepala > 7 detik dalam waktu 10 menit yang diperoleh secara berturut-turut adalah sebagai berikut : kontrol negatif 20.59 ± 1,5165, kontrol positif 11.86 ± 2,1679, kelompok dosis 50% 20,31 ± 0,8367, kelompok dosis 75% 16,64 ± 0,8367 dan kelompok dosis 100% 14,33 ± 1,0000. Kesimpulan: Ekstrak etanol 70% Buah Kawista pada dosis 75 % memiliki efektivitas sebagai tonikum, terlihat dari penurunan frekuensi menenggelamkan kepala > 7 detik selama 10 menit yang signifikan dibanding dengan kelompok kontrol negatif.

ANTIANEMIA SUPPLEMENTATION COMBINATION WITH VITAMIN C ON HEMOGLOBIN LEVELS AMONG PREGNANT WOMEN IN PRIMARY HEALTH CARE CENTER, JEPARA, INDONESIA Poppy Diah Palupi; Mohammed Safwan Ali Khan; Kukilo Kenuk Karseno
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Blood volume escalation during pregnancy leads to an increase in iron needs. Pregnant women are prone to maternal anemia that is caused by iron, folic acid, vitamins B2, B12, A, and C deficiency and may serve as causative factors that aggravate anemia. Concerning the problem, this clinical investigation determined the effect of antianemia supplementation and its combination with vitamin C on hemoglobin levels during pregnancy. This study is a quasi-experimental involving 34 patients who consumed antianemia supplements with or without vitamin C. The treatment group was given a combination of antianemia supplement Fe Fumarate 180 mg-Folic Acid 400 mcg and vitamin C 100 mg. The positive-control group was administrated with antianemia supplement Fe Fumarate 180 mg-Folic Acid 400 mcg. After 28 days, blood samples were taken to measure the hemoglobin levels. The hemoglobin levels were found to have a statistically significant difference (p0.05) between that group receiving a combination of antianemia-vitamin C and the other group administered with antianemia alone.

PERBANDINGAN RESPON KLINIK NIKARDIPIN DENGAN DILTIAZEM PADA HIPERTENSI EMERGENSI Poppy Diah Palupi; Fita Rahmawati; Robosuseno Robosuseno
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 5, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.206

Hipertensi emergensi merupakan suatu kedaruratan medik dan memerlukan tindakan yang cepat dan tepat untuk menyelamatkan jiwa penderita. Secara umum, obat antihipertensi yang digunakan pada pasien hipertensi emergensi diberikan secara parenteral. Tujuan penelitian adalah untuk mengetahui respon klinik nikardipin dengan diltiazem intravena dalam menurunkan tekanan darah, mean arterial pressure, dan denyut jantung pada pasien hipertensi emergensi. Penelitian merupakan penelitian analitik dengan rancangan retrospective cohort study. Data diambil dari rekam medik pasien hipertensi emergensi yang dirawat di Instalasi Gawat Darurat (IGD), Intensive Care Unit (ICU), maupun bangsal rawat inap selama periode Januari sampai Desember 2014 di RSUD Kota Semarang. Jumlah subjek penelitian sebanyak 117 pasien, terdiri dari 66 pasien kelompok nikardipin dan 51 pasien kelompok diltiazem. Nikardipin dapat menurunkan mean arterial pressure (MAP) sebesar 14,45%, sedangkan diltiazem sebesar 12,20%. Nikardipin menurunkan tekanan darah sistolik 17,69%, sedangkan diltiazem sebesar 17,63%. Nikardipin menurunkan tekanan darah diastolik 21,56% dan denyut jantung sebesar 1,74%, sedangkan diltiazem menurunkan tekanan darah sebesar 20,30% dan denyut jantung sebesar 7,83%. Tidak terdapat perbedaan signifikan dalam menurunkan tekanan darah dan MAP antara nikardipin dan diltiazem. Namun, terdapat perbedaan signifikan dalam menurunkan denyut jantung antara nikardipin dan diltiazem.Kata kunci : hipertensi emergensi, tekanan darah, nikardipin, diltiazem

Blood Glucose Level Lowering Effect Of Alkaline Reduced Water (ARW) In Streptozotocin-Induced Diabetic Rats Poppy Diah Palupi; Metrikana Novembrina; Buanasari Buanasari; Fita Rahmawati; Tri Murti Andayani
Majalah Farmaseutik Vol 16, No 1 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Alkaline Reduced Water (ARW) is beneficial to prevent oxidative stress disease such as diabetes. The aim of the study is to determine the effect of ARW on reducing blood glucose level in diabetic rats induced streptozotocin. Fifteen male Wistar rats were divided into 3 groups. Group 1 (normal) nondiabetic rats, group 2 diabetic rats (negative control) received single intraperitoneal of streptozotocin (65mg/kg), group 3 was diabetic rats treated with ARW 20 mL/kg/day, orally for 28 days. Blood samples were collected through retro-orbital method before and after the experiment. Measured parameter were body weight and blood glucose concentration. Data were analyzed using one-way analysis of variance test followed by Dunnet multiple comparisons post hoc test. Administration of ARW for 28 days resulted in significant (p< 0.05) lowering of blood glucose. In conclusion, the results show that ARW can lower elevated blood glucose against streptozotocin-induced diabetes in rats.

Pengaruh Pemilihan Anti-Psikotik Pada Pasien Depresi Tanpa dan Dengan Gejala Psikotik Terhadap Lama Hari Rawat Inap Palupi Poppy Diah; Buanasari Buanasari
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1469

Antipsychotic therapy is given frequently to the patient with depressive symptoms. Antipsychotics are used to enhance the effects of antidepressants in the depressive patients. The aim of this study was to evaluate the length of stay of antipsychotic therapy selection in the depressive patient without/with psychosis symptoms. This study was conducted by quantitative method, multicenter, non-experimental approach, and cohort design study. Data were collected from medical records of 187 patients diagnosed with depression without/with psychosis symptoms from the various mental-illness hospital in Central Java Province. There was a significant difference (p 0.05) in the length of stay with the selection of antidepressants in depressive patients without psychotic symptoms, and there was no significant difference (p 0.05) in the length of stay with the selection of antipsychotic agents in depressive patients without/with psychotic symptoms.Keywords— Length of stay, depression, without/with psychosis symptoms, antipsychotic

ANALISA DRUG RELATED PROBLEMS (DRPs) PADA PASIEN CHRONIC KIDNEY DISEASE (CKD) DI INSTALASI RAWAT INAP KLINIK SARI MEDIKA KABUPATEN SEMARANG: Analisa DRP pada pasien CKD Poppy Diah Palupi; Veronika Jayaningsih
Jurnal Farmasi & Sains Indonesia Vol 4 No 1 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.v4i1.57

Drug-Related Problems(DRPs) are unwanted events affecting patients related to treatment that can interfere with the success of therapy. This study aims to determine and analyze the DRPs that occur in Chronic Kidney Disease (CKD) patients in the Sari Medika Clinic, Semarang. This research is a descriptive study with retrospective design on CKD patients by taking samples using purposive sampling technique compared to the several Guidelines Pharmacotherapy Handbook 9th edition 2015, Kidney Disease Improving Global Outcomes (KDIGO), The Renal Drug Handbook Third Edition 2009, Clinical Practice Guide & Clinical Pathway for Heart Disease, Blood Vessels 2016, and Henry Ford Health System six edition 2011. The results of the study conducted on 84 CKD patients showed there were DRPs in 66 patients: Indication without therapy (30.86%), therapy without indication (6.17%), sub-therapeutic dose (1.23%), excessive drug doses (13.58%), improper drug selection (45.68%), and patients failing to receive drugs (2.47%).

EVALUASI TERAPI ANTIDEPRESAN PADA PASIEN DENGAN GEJALA DEPRESI DI RSJD AMINO GONDOHUTOMO SEMARANG Palupi, Poppy Diah; Novembrina, Metrikana
Media Farmasi Indonesia Vol. 12 No. 2 (2017): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.518 KB)

ABSTRACTDepression is a unipolar mood disorder, where emotions are expressed with depressed feelings, which in extreme conditions greatly affects one's perception. The purpose of this study was to evaluate antidepressant therapy in patients with depressive symptoms at RSJD Dr. Amino Gondohutomo Semarang, Central Java, Indonesia. This study was conducted with a quantitative, non-experimental approach, and cohort design study. Data were collected by retrospective method from the medical records of depressed patients. The number of subjects was 83 patients, consisting of 3 patients with medium depression diagnosis, 7 patients with severe asymptomatic depression diagnosis, and 73 patients with severe depression diagnosis with psychotic symptoms. Using one-way anova, the length of hospitalization days between depression groups showed no significant difference (p> 0.05). So it can be said that the type of depression does not affect to the length of hospitalization days. The length of hospitalization days in severe depression group with psychotic symptoms using TCA, SSRI, and TCA-SSRI were tested using one way anova, and the results were no significantly different (p> 0.05). This result showedanti-depressant selection in patients with severe depression and psychotic symptoms does not affect to the length of hospitalization days. The result of Fisher exact test in all subjects with depression showed there was no relation between anti depressant selection on length of stay (LOS). There were no significant differences between length of stay (LOS) with type of depression and selection of antidepressant. There was no association between anti-depressant group and length of hospitalization days (LOS).

Title

Found 8 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 8 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 8 Documents
Search