Article Per Year (5 Year)
p-Index From 2020 - 2025
2.147
P-Index
This Author published in this journals
All Journal Acta Interna : The Journal of Internal Medicine Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal NERS Jurnal Farmasi Klinik Indonesia Jurnal Surya Medika GIZI INDONESIA JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Medica Hospitalia Journal of Community Empowerment for Health
Probosuseno Probosuseno, Probosuseno
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 15 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 15 Documents
Search

 1   2 
Pengaruh Konseling Farmasis terhadap Kepatuhan dan Kontrol Hipertensi Pasien Prolanis di Klinik Mitra Husada Kendal Dewi, Melani; Sari, Ika P.; Probosuseno, Probosuseno
Indonesian Journal of Clinical Pharmacy Vol 4, No 4 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.447 KB) | DOI: 10.15416/ijcp.2015.4.4.242

Abstract

dalam keberhasilan terapi hipertensi. Penelitian ini dilakukan untuk mengetahui pengaruh konseling oleh farmasis terhadap kepatuhan dan hubungan antara kepatuhan dan hasil terapi pasien hipertensi anggota program pengelolaan penyakit kronis (PROLANIS) di Klinik Mitra Husada Kabupaten Kendal. Penelitian dilakukan pada November 2013–Januari 2014 melalui desain eksperimen semu (control group design with pretest posttest). Sebanyak 55 pasien dikelompokkan secara random menjadi kelompok yang memperoleh intervensi konseling (28 pasien) dan kelompok tanpa intervensi atau kontrol (27 pasien). Subjek penelitian diikuti selama dua bulan untuk mengamati tingkat kepatuhan minum obat dengan kuesioner MMAS dan penurunan tekanan darah sebelum dan sesudah konseling. Konseling oleh farmasis menyebabkan tingkat kepatuhan minum obat berubah signifikan pada pasien hipertensi, pasien hipertensi dengan DM, maupun pasien hipertensi dengan penyakit lain (p=0,015; 0,025; 0,009). Tingkat kepatuhan pasien kelompok kontrol sebelum dan setelah penelitian diketahui tidak signifikan (p≥0,05). Pemberian konseling mampu menurunkan tekanan darah sistolik/diastolik sebesar 10,7/8,2 mmHg. Penurunan tekanan darah ini belum menunjukkan perbedaan yang bermakna jika dibandingkan dengan kelompok kontrol.Kata kunci: Hipertensi, kepatuhan minum obat, konseling farmasis, penurunan tekanan darahThe Influence of the Pharmacists Counseling on Patient Adherence and Hypertension Control on Patient of Prolanis at Mitra Husada ClinicsPatient adherence and intensive treatment in controlling blood pressure are important factors for achieving success therapy in hypertension. This study was conducted to determine the effect of pharmacist counseling on patient adherence and to determine the relationship of adherence and clinical outcomes of patients with hypertension who is joining chronic disease management program (PROLANIS) on Mitra Husada Clinics in Kendal.The study was conducted during November 2013–January 2014 using quasiexperimental design (pretest-posttest). Fifty five patients were randomly divided into the intervention group who received pharmacist counseling (28 patients) and control group (27 patients). The patients were followed for two months to observe the level of drug adherence using MMAS questionnaires and therapeutic outcomes (decreased blood pressure) before and after counseling. Pharmacist counseling caused a significant increase in the patient adherence on drug administration in intervention group (p<0.05) compared to control group. The reduction of systolic/diastolic blood pressure of hypertension patient in intervention group is higher than control group (SBP/DBP=10.7/8.2 mmHg). However, this reduction does not achieve a significant blood pressure reduction compared to control group.Keywords: Adherence of drug administration, blood pressure reduction, hypertension, pharmacist
PERBANDINGAN RESPON KLINIK NIKARDIPIN DENGAN DILTIAZEM PADA HIPERTENSI EMERGENSI Palupi, Poppy Diah; Rahmawati, Fita; Probosuseno, Probosuseno
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 5, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.146

Abstract

Hipertensi emergensi merupakan suatu kedaruratan medik dan memerlukan tindakan yang cepat dan tepat untuk menyelamatkan jiwa penderita. Secara umum, obat antihipertensi yang digunakan pada pasien hipertensi emergensi diberikan secara parenteral. Tujuan penelitian adalah untuk mengetahui respon klinik nikardipin dengan diltiazem intravena dalam menurunkan tekanan darah, mean arterial pressure, dan denyut jantung pada pasien hipertensi emergensi. Penelitian merupakan penelitian analitik dengan rancangan retrospective cohort study. Data diambil dari rekam medik pasien hipertensi emergensi yang dirawat di Instalasi Gawat Darurat (IGD), Intensive Care Unit (ICU), maupun bangsal rawat inap selama periode Januari sampai Desember 2014 di RSUD Kota Semarang. Jumlah subjek penelitian sebanyak 117 pasien, terdiri dari 66 pasien kelompok nikardipin dan 51 pasien kelompok diltiazem. Nikardipin dapat menurunkan mean arterial pressure (MAP) sebesar 14,45%, sedangkan diltiazem sebesar 12,20%. Nikardipin menurunkan tekanan darah sistolik 17,69%, sedangkan diltiazem sebesar 17,63%. Nikardipin menurunkan tekanan darah diastolik 21,56% dan denyut jantung sebesar 1,74%, sedangkan diltiazem menurunkan tekanan darah sebesar 20,30% dan denyut jantung sebesar 7,83%. Tidak terdapat perbedaan signifikan dalam menurunkan tekanan darah dan MAP antara nikardipin dan diltiazem. Namun, terdapat perbedaan signifikan dalam menurunkan denyut jantung antara nikardipin dan diltiazem.
PENGARUH PUASA DUA KALI SEMINGGU TERHADAP BERAT TUBUH DAN PERSEN MASSA LEMAK DENGAN PEMANTAUAN MELALUI WHATSAPP DI YOGYAKARTA Nabawiyah, Hafidhotun; Probosuseno, Probosuseno; Rahmawati, Neni Trilusiana
GIZI INDONESIA Vol 42, No 1 (2019): Maret 2019
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v42i1.290

Abstract

The incidence of overweight and obesity in Indonesia is experiencing an upward trenin almost all levels of society; overweight women and obesity tend to be more than men. Fasting becomes one of the alternative supporters of a healthy lifestyle to lose weight and body fat mass. Objective of the study was to determine the effect of fasting intermittent twice a week on weight loss by monitoring WhatsApp. Method: Quasi experimental non-randomized pre-post control trial. The study sample was women aged 20 - 46 years who were divided into control group and intervention  group. Intervention groups were given intermittent fast twice each week for eight weeks.The research was conducted in Yogyakarta.  Results showed there was an average body weight difference of -0.07 ± 1.3 in the control group and -1.74 ± 1.5 in the intervention group with p value 0.97 and 0.00 respectively. Conclusions: There was a significant decrease in the intervention group but no differences in the variable body weight and fat mass between the control group and the intervention group. There is a difference in body weight in the intervention group.
Health measurement profile of older adults in Sleman District, Yogyakarta: its correlation with low-grade chronic inflammation in hypertension Adyarini, Dwita Dyah; Rohmah, Siti Nur Rohmah; Sattwika, Prenali Dwisthi; Handayaningsih, Anastasia Evi; Probosuseno, Probosuseno; Sinorita, Hemi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202307

Abstract

The older adult often experiences a low-grade chronic inflammation that commonly manifests in various conditions without infection, including hypertension. The serum neutrophil-to-lymphocyte ratio (NLR) and hyperuricemia are important markers for various diseases including hypertension. Older adult accounts for 17.33% of the total population of Yogyakarta Special Province, which is the highest compared to other provinces. The study aimed to evaluate the relationship between NLR and hyperuricemia with hypertension among adult patients in Sleman District, Yogyakarta, Indonesia. It was a community-based cross-sectional nested study involving 90 older adults aged ≥70 y.o. living around of the Sleman Health and Demographic Surveillance System (HDSS). Data of demographic and health characteristics of the subjects were collected. Independent t test, and Mann Whitney test were used to analyze mean differences between normotensive and hypertensive groups.  Multivariate analysis with logistic regression was used to analyze correlation between all variables. The results showed 59 respondents (65%) suffered from hypertension and 31 (35%) respondents had normal and pre-hypertension. No significantly different in almost of the subject characteristics between the normotensive and the hypertensive groups was observed (p>0.05). However, significantly different between the normotensive group and the hypertensive group was observed in the history of hypertension, blood pressure/BP, mean arterial pressure/MAP, abdominal circumstance/AC, fasting blood glucose/FBG, triglyceride, and hemoglobin (p<0.05). No significantly different in the NLR and HsCRP levels of the normotensive group compared to the hypertensive groups were observed (p>0.05). However, the uric acid level of the hypertensive group [5.6 (2.9-9.4 mg/dL)] was significantly higher than that the normotensive group [4.7 (2.9-8.0 mg/dL)] (p=0.042), although it was no significantly relationship with hypertension (p>0.05). In conclusion, there is no relationship between NLR, HsCRP and uric acid with hypertension among middle old and oldest old in Sleman District.
Pengaruh Pemberian Inhalasi Budesonid/Formoterol Fumarat Dibandingkan Dengan Flutikason Propionat/Salmeterol Xinafoat pada Rehospitalisasi Pasien PPOK di RS Paru Respira Yulianti, Eni; Probosuseno, Probosuseno; Ikawati, Zullies
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.75256

Abstract

Pencegahan rehospitalisasi terkait PPOK merupakan prioritas di dunia untuk memperlambat progresi penyakit. Pengontrol gejala PPOK yaitu kombinasi ICS/LABA sering digunakan, diantaranya adalah inhalasi budesonid/formoterol fumarat dan flutikason propionat/salmeterol xinafoat. Tujuan penelitian ini adalah mengetahui pengaruh pemberian inhalasi budesonid/formoterol fumarat terhadap kejadian rehospitalisasi pasien terkait PPOK dalam 6 bulan jika dibandingkan dengan inhalasi flutikason propionat/salmeterol xinafoat. Penelitian observasional dengan desain kohort retrospektif ini mengggunakan sampel data RM pasien post-ranap RS Paru Respira periode KRS 1 Januari 2019-31 Desember 2020. Pengaruh penggunaan kedua obat inhalasi terhadap kejadian rehospitalisasi terkait PPOK dalam 6 bulan setelah KRS dianalisis dengan survival analysis Kaplan-Meier test. Pengaruh variabel perancu terhadap outcome dianalisis dengan Cox Proportional Hazard Model. Pada penelitian diperoleh sebanyak 190 sampel yang terbagi dalam 2 kelompok yaitu kelompok inhalasi Bud/Form (n=95) dan kelompok inhalasi FP/Salm (n=95).  Hasil survival analysis menunjukkan persentase yang lebih besar pada inhalasi Bud/Form (87,4%) dibanding pada inhalasi FP/Salm (83,2%) namun tidak berbeda bermakna (p value 0,442). Analisis multivariat dengan melibatkan pengaruh variabel perancu menunjukkan penurunan hazard namun tidak bermakna pada penggunaan inhalasi Bud/Form dibanding FP/Salm (HR 0,689; 95% CI 0,313-1,517; sig. 0,355). Sebagai kesimpulan, persentase ketahanan terhadap rehospitalisasi terkait PPOK dalam 6 bulan pada penggunaan inhalasi budesonid/formoterol fumarat lebih besar dibanding pada penggunaan inhalasi flutikason propionat/salmeterol xinafoat tanpa beda bermakna. Kedua sediaan inhalasi ICS/LABA tersebut tetap dapat direkomendasikan sebagai terapi pengontrol pada pasien dengan PPOK.
Relationship Of Serum Hemoglobin And Vitamin D Levels With Posutral Balance Ngestiningsih, Dwi; Wicaksono, Maulana Akbar; Wicaksono, Muhammad Agung Wibowo; Probosuseno, Probosuseno; Supatmo, Yuswo; Rachmawati, Banundari
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.948

Abstract

Background: The population of the elderly in Indonesia has increased significantly in recent years. The incidence of falls is influenced by postural balance. Vitamin D and hemoglobin deficiency are associated with decreased muscle function and postural balance. This study is to investigate the relationship between vitamin D and hemoglobin levels with postural balance in the elderly. Methods: The study used a cross-sectional design with the participation of 33 patients (aged 64.94±5.42 years). The study sample was elderly individuals who fulfilled the inclusion criteria at Semarang Elderly Posyandu. Patients performed postural balance test, with Sharpened romberg and tandem gait test. The examination of vitamin D and hemoglobin was taken from the patient's venous blood. Vitamin D was measured using ELISA. Results: The results of the independent sample t-test analytic test revealed a P value of vitamin D (0.007) and a P value of hemoglobin of (0.021) (p<0.05). There is a meaningful relationship between vitamin D and hemoglobin levels with postural balance in the elderly.. Conclusion: Decreasing Haemoglobine and Vitamin D impair the postural balance.
The Association Between Physical Activity and Monocyte-HDL Ratio in Diabetes Mellitus Patients Who Have Exceed Life Expectancy in Yogyakarta Province Setiawan, Gibran Ilham; Probosuseno, Probosuseno; Sinorita, Hemi
Acta Interna The Journal of Internal Medicine Vol 13, No 1 (2024): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.101284

Abstract

Background: The elderly population is expected to double in the upcoming three decades, due to increase in life expectancy. The province of DIY has the highest life expectancy in Indonesia (73.13 years and 76.67 years for men and women). Physical activity can reduce insulin resistance, improve lipid metabolism and reduce levels of inflammation in diabetes mellitus (DM). Physical activity can increase life expectancy. Many factors affect life expectancy, one of which is physical activity. This study investigated the association between physical activity and monocyte to HDL ratio (MHR) in diabetes mellitus patients who had exceeded their life expectancy in Yogyakarta.Method: This cross-sectional study was conducted in September 2022-April 2023 and using purposive sampling. Participants who meet the criteria and consent were asked to fast at least 8 hours, then be interviewed by a physical activity questionnaire and checked complete blood tests, fasting blood glucose and HDL cholesterol. The association between physical activity and MHR then analyzed using SPSS.Result: There were 50 participants with median age 78 (74-91) years. The mean score of physical activity is 100.28±7.96. Mean MHR is 0.0147±0.005. There is a significant relationship with weak correlation between physical activity and MHR (p 0.034, r -0.301), weak correlation between MHR and body mass index (BMI) (p 0.015, r 0.343), obesity (p 0.019, r 0.331) central obesity (p 0.032, r 0.303) and smoking (p 0.039, r 0.293). Multivariate analysis was performed, there is a significant relationship with weak correlation between physical activity and MHR (p 0.033, r -0.297).Conclusion: There is a negative correlation with weak strength between physical activity and MHR in patients with diabetes mellitus who have reached the life expectancy of province of DIY.
Narrative Review: Keberhasilan Terapi Proton Pump Inhibitor (PPI) Pada Gastroesophageal Reflux Disease (GERD) Amalia, Retno; Nugroho, Agung Endro; Probosuseno, Probosuseno
Majalah Farmaseutik Vol 20, No 4 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i4.93163

Abstract

Gastroesophageal Reflux Disease (GERD) pada lazimnya disangka seperti penyakit yang ringan, namun mampu menimbulkan kekambuhan dan kematian bila tidak diatasi dengan benar. Tingkat kekambuhan terapi pada pasien GERD diperkirakan bahwa 10% sampai 40% dari pasien GERD. Studi berikut berupa narrative review dengan mengunakan pustaka acuan yang mengacu pada pangkalan data Cochrane, PubMed, dan Science Direct. Penggalian pustaka acuan memakai kata kunci GERD, PPI, keberhasilan terapi GERD.  Proton Pump Inhibitor (PPI) merupakan terapi yang sangat besar pengaruhnya akan memulihkan GERD, jika dipadankan terhadap antasida, prokinetik, dan H2 bloker receptor. Proton Pump Inhibitor (PPI) telah merevolusi penatalaksanaan pasien GERD karena efek penekanan asam yang mendalam dan berkepanjangan sehingga menjadi terapi andalan, bila dibandingkan dengan obat penekan asam lainnya, PPI menunjukkan penyembuhan mukosa dan pengendalian gejala yang lebih baik. serta mencegah mukosa dan gejala kambuh.
Factors associated with health preparedness (istithaah) status among Hajj pilgrims in Indonesia: a cross-sectional study Sugeng, Sugeng; Setiyarini, Sri; Probosuseno, Probosuseno; Kertia, Nyoman
Jurnal Ners Vol. 20 No. 1 (2025): VOLUME 20 ISSUE 1 FEBRUARY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jn.v20i1.58887

Abstract

Introduction: The Hajj pilgrimage presents unique health challenges due to the large gatherings, particularly affecting elderly participants with preexisting conditions. Health istithaah, referring to physical and mental readiness for Hajj participation, is crucial for ensuring the safety of pilgrims. This study aimed to identify the factors associated with health istithaah status among Indonesian Hajj pilgrims. Methods: This descriptive correlational study examined 1,305 pilgrims scheduled for the 2023 Hajj pilgrimage. The data collected included health istithaah status, age, gender, and medical diagnoses based on ICD-10. The analysis employed Chi-Square tests and multivariate logistic regression (p < 0.05). Results: Of the participants, 772 (59.2%) had unassisted health istithaah, while 533 (40.8%) required assistance. Diabetes mellitus showed the highest association with requiring assistance (PR = 4.938, 95% CI = 3.354–7.270, p = 0.001), followed by symptoms and signs not classified elsewhere (PR = 4.071, 95% CI: 3.091–5.362, p = 0.001) and essential hypertension (PR = 3.467, 95% CI = 2.565–4.685). Age and multiple diagnoses were significantly associated with health istithaah status (p = 0.001), while gender showed no significant association (p = 0.246). Conclusion: Age, multiple diagnoses, and chronic conditions, particularly diabetes, were key factors associated with requiring health istithaah assistance among Indonesian Hajj pilgrims. These findings emphasize the need for targeted health assessments and support for high-risk pilgrims.
Penggunaan Benzodiazepin Dalam Mengatasi Ansietas Pada Lansia: Narrative Review Pratiwi, Farni Yuliana; Probosuseno, Probosuseno; Ikawati, Zullies
Majalah Farmaseutik Vol 21, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i2.88795

Abstract

Gangguan ansietas seringkali menjadi salah satu penyebab masalah kesehatan yang umum dialami oleh kelompok lanjut usia. Lansia merupakan kelompok yang rentan dalam menghadapi kecemasan sehingga dapat memperburuk kualitas hidup, terutama bila tidak ditangani dan diobati. Dalam praktek klinik, benzodiazepin merupakan terapi yang sering diresepkan untuk mengatasi gangguan ansietas, namun penggunaan benzodiazepin sebagai terapi dalam mengatasi gangguan ansietas tidak tepat diberikan pada kelompok usia lanjut karena terkait risiko efek samping. Masalah keamanan utama dari penggunaan benzodiazepin dalam jangka waktu yang lama yang menjadi perhatian sebab dikaitkan dengan peningkatan efek samping seperti sedasi, amnesia, gangguan kognitif dan ataksia, serta dapat menyebabkan peningkatan risiko jatuh. Tujuan artikel ini memaparkan penggunaan benzodiazepin dalam mengatasi ansietas pada lansia. Artikel ini merupakan tinjauan naratif dengan penelusuran yang dilakukan menggunakan database elektronik seperti PubMed dan ScienceDirect. Kriteria inklusi dalam artikel ini mengggunakan literatur yang diterbitkan 10 tahun terakhir dengan subjek penelitian yaitu pasien lansia yang mengalami gangguan ansietas dan mendapatkan terapi jenis benzodiazepine. Hasil penulusuran diperoleh 4 artikel yang memenuhi kriteria inklusi. Gangguan ansietas lebih banyak terjadi pada perempuan dibandingkan laki-laki. Pemberian benzodiazepine dengan dosis rendah dan durasi waktu yang singkat mampu memperbaiki gangguan ansietas pada lansia, namun pemberiannya perlu diwaspadai terkait risiko efek samping yang tidak diinginkan.
Co-Authors Adyarini, Dwita Dyah Agung Endro Nugroho Amalia, Retno Astuti, Herni Atharini, Yanita Harliana Balgis, Pitri Banundari Rachmawati Chairun Wiedyaningsih Chusna, Nurul Dewi, Melani Djuara P Lubis Eni Yulianti Evelina, Lydia Sherly Fita Rahmawati Hafidhotun Nabawiyah, Hafidhotun Handayaningsih, Anastasia Evi Hasina, Raisya Hemi Sinorita Ika Puspitasari Isaura, Emyr Reisha Khasana, Tri Mei Mustofa Mustofa Nanang Munif Yasin Neni Trilusiana Rahmawati Neni Trilusiana Rahmawati Nugroho, Nidhar Ainu Faza Nyoman Kertia Oktaviyah, Dayanti PALUPI, Poppy Diah Pratiti, Budi Pratiwi, Farni Yuliana Prenali Dwisthi Sattwika Purwanta Purwanta Putri, Riandita Gusnanda Radiyanti, Radiyanti Rialihanto, Muhammad Primiaji Rohmah, Siti Nur Rohmah Sari, Ika P. Setiawan, Gibran Ilham Siti Hatijah SRI SETIYARINI, SRI Sri Suparti Sudar, Hasdiana Sugeng Sugeng Sugiyarto, Okky Puspitasari Sumarni DW, Sumarni Thristyaningsih, Sri Udji, Bambang Wicaksono, Maulana Akbar Wicaksono, Muhammad Agung Wibowo Yudani, Alfi Fatima Yuswo Supatmo