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All Journal Jurnal Teknologi Informasi dan Ilmu Komputer Techne : Jurnal Ilmiah Elektroteknika Jurnal Pengembangan Rekayasa dan Teknologi Elektrika Journal Of World Science Archive: Jurnal Pengabdian Kepada Masyarakat Electrician : Jurnal Rekayasa dan Teknologi Elektro
Andi Kurniawan Nugroho
Jurusan Teknik Elektro Fakultas Teknik Universitas Semarang
Religion Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Law, Crime, Criminology & Criminal Justice Mechanical Engineering Public Health Social Sciences Transportation

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Journal : Journal Of World Science

 1 
Stem Cell Therapy For Men’s Vitality: A Comprehensive Review And Meta-Analysis Susanti Vinski, Deby; Quintosa , Jaime Rodriguez; Trofimova , Svetlana; Nugroho, Andi Kurniawan; Vinski, Natasha Cinta; Hardjo, Marhaen
Journal of World Science Vol. 3 No. 9 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i9.722

Abstract

One of the many potential benefits of stem cell therapy is that it may enhance men’s vitality by addressing conditions such as erectile dysfunction and hypogonadism. The current comprehensive review and meta-analysis evaluate the efficacy, safety, and mechanisms of stem cell therapy in improving male sexual health. Data from previously published clinical trials, reviews, and preclinical studies indicate that stem cell therapy significantly enhances erectile function, increases testosterone levels, and improves sperm quality. The regenerative potential of mesenchymal stem cells (MSCs), including their ability to differentiate into various cell types and secrete bioactive molecules, underpins these benefits. Additionally, MSCs modulate the immune response, reducing inflammation and promoting tissue repair. Despite these promising results, current research is limited by heterogeneity among studies, lack of long-term data, and the absence of standardized treatment protocols. Future research can focus on large-scale randomized controlled trials with standardized protocols to validate the long-term efficacy and safety of stem cell therapy. The results of the review support the potential of stem cell therapy as a novel approach in regenerative medicine, offering innovative solutions for men’s health and vitality. Addressing the current limitations and exploring future directions will pave the way for the clinical adoption of stem cell therapy, advancing the treatment options for conditions affecting men’s vitality and improving the quality of life for millions of men worldwide.
Stem Cell Therapy for Chronic Fatigue Syndrome: A Promising Approach Pada Vinski, Deby Susanti Pada Vinski; Trofimova, Svetlana; Quintosa, Jaime Rodriguez; Nugroho, Andi Kurniawan; Schroeter, CA; Jovanovic, Stevan
Journal of World Science Vol. 3 No. 11 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i11.1231

Abstract

Chronic Fatigue Syndrome (CFS), or Myalgic Encephalomyelitis (ME), is a debilitating condition marked by persistent fatigue, cognitive dysfunction, and chronic pain, severely affecting quality of life. This study explores the potential of mesenchymal stem cell (MSC) therapy as an innovative treatment for CFS. Using a qualitative descriptive design and case studies, data were gathered through interviews, medical record reviews, and observations of patients undergoing MSC therapy. The findings revealed significant improvements in fatigue, cognitive function, and physical well-being, with participants reporting better memory, concentration, reduced pain, and improved daily functioning. While some sleep disturbances persisted, their severity was reduced. These results highlight the potential of MSC therapy to alleviate CFS symptoms and enhance quality of life. Despite its promise, challenges such as high costs, regulatory hurdles, and the need for standardized protocols persist. Further research is required to confirm long-term efficacy and safety, contributing to the growing evidence for regenerative medicine in treating chronic conditions like CFS.
Exploring the Role of Stem Cell Therapy in Improving Cognitive and Physical Outcomes for Down Syndrome Patients Pada Vinski, Deby Susanti Pada Vinski; Nugroho, Andi Kurniawan; Vinski, Natasha Cinta; Dollar, Dollar; Gunawan, Dahlan
Journal of World Science Vol. 4 No. 1 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i1.1293

Abstract

This review explores the benefits of Mesenchymal Stem Cell (MSC) therapy concerning Down syndrome (DS), cognitive and behavioral disorders, and other related physiological complications. Two pediatric patients with DS participated in this study, receiving MSC therapy over six months through a qualitative case study approach. Patient A was a 5-year-old male experiencing moderate developmental delays and recurrent infections. Patient B was a 6-year-old female facing mild intellectual disabilities and difficulties in social interaction. The initial and follow-up assessments conducted at baseline, three months, and six months after treatment revealed that patients A and B significantly improved in linguistic abilities, attention, social interactions, and motor coordination. Moreover, enhancing inflammatory indices, such as CRP and IL-6, indicated effective regulation of the immune response and reduced inflammation. Both patients adhered to the therapy without any reported side effects. Thus, the findings highlight the potential neuroprotective and immunomodulatory effects of MSC therapy, suggesting it may serve as a viable adjunct treatment for DS. However, due to the limited number of participants and the relatively short observation period, some limitations, such as the small group size and brief study duration, should be acknowledged, necessitating further larger-scale trials to validate these results and establish protocols. This study adds to the existing literature on MSCs in neurodevelopmental disorders and aims to provide a foundation for exploring new treatment options for DS.
The Role of Mesenchymal Stem Cells in Stroke Recovery: A Regenerative Medicine Approach with Medical Rehabilitation Vinski, Deby Susanti Pada; Sinjari, Bruna; Ernandini, Endang; Vinski, Natasha Cinta; Nugroho, Andi Kurniawan
Journal of World Science Vol. 4 No. 4 (2025): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v4i4.1404

Abstract

This study examines the role of mesenchymal stem cells (MSCs) in stroke recovery, exploring their regenerative properties and potential to enhance rehabilitation outcomes. Stroke remains a leading cause of long-term disability, with limited treatment options for functional recovery. This research investigates how MSC therapy, combined with conventional rehabilitation methods, can improve motor and cognitive function in stroke patients. Using case studies and patient care records, the study analyzes the effectiveness of MSC therapy in promoting neural repair, reducing disability levels, and improving overall quality of life. The findings suggest that MSC therapy significantly enhances functional recovery when integrated with rehabilitation, particularly when cerebrospinal fluid treatment is used before MSC administration. Imaging and biomarker analyses support these results, showing improvements in neurogenesis, synaptic plasticity, and reduced neuroinflammation. This research highlights the synergistic effects of MSC therapy and rehabilitation, presenting a promising approach to stroke recovery. The study also emphasizes the need for further research to optimize MSC-based treatments, refine delivery methods, and evaluate long-term safety and effectiveness. The implications of this study contribute to the development of integrated therapeutic strategies for stroke patients, offering a more holistic approach to recovery.
Integrative Regeneration of Articular Cartilage Using Mesenchymal Stem Cells and Gene Therapy: A Precision Medicine Approach Vinski, Deby Susanti Pada Vinski; Vinski, Natasha Cinta; Nugroho, Andi Kurniawan; Kusumo, Sunaryo; Griffin, Darren Karl
Journal of World Science Vol. 5 No. 1 (2026): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v5i1.1607

Abstract

Osteoarthritis (OA) is a prevalent and debilitating chronic condition that primarily affects the articular cartilage, leading to pain, stiffness, and loss of function. Despite significant advancements in understanding its pathophysiology, an effective cure remains elusive. This paper explores the integrative regeneration of articular cartilage using mesenchymal stem cells (MSCs) combined with gene therapy as a precision medicine approach. MSCs are particularly promising due to their chondrogenic potential and ability to repair damaged cartilage. However, the inflammatory environment in OA often limits the survival of MSCs. Gene therapy emerges as a solution to modulate this environment, enhancing the regenerative capacity of MSCs. This study highlights the synergy between MSC therapy and gene therapy in promoting cartilage repair, focusing on the Vinski protocol. By targeting the joint's microenvironment and using MSCs in combination with gene therapy, this integrated approach aims to provide a more effective treatment for OA. The application of gene therapy is expected to not only sustain MSC survival but also improve their therapeutic effects, making this method a promising avenue for OA treatment.
Co-Authors Agus Supriyanto Aji Jr., Edwin Bayu Angkoso, Cucun Very Ari Kusumaningsih Asror, Khozainul Budiani Destyningtias Daniyah, Daniyah Dollar, Dollar Ernandini, Endang Griffin, Darren Karl Gunawan, Dahlan Hardjo, Marhaen Harsoyo, Imam Tri Idris, La Ode Muhamad Jovanovic, Stevan Juliartadi, Hendra Ady Kusumo, Sunaryo Mudjiastuti Handajani Muliandhi, Puri Nuriman Nuriman, Nuriman Pada Vinski, Deby Susanti Pada Vinski Quintosa , Jaime Rodriguez Quintosa, Jaime Rodriguez Ramdani, Dicky Rivaldo Schroeter, CA Setiawan, Muhammad Ikhsan Sinjari, Bruna Sri Heranurweni Supari Supari, Supari Susanti Vinski, Deby Titik Nurhayati Trofimova , Svetlana Trofimova, Svetlana Vinski, Deby Susanti Pada Vinski, Deby Susanti Pada Vinski Vinski, Natasha Cinta