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All Journal Microbiology Indonesia Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Inovasi Teknik Kimia Mediagro Media Farmasi Indonesia

Maulita Cut Nuria

Universitas Wahid Hasyim

Author-ID : 334988

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Other

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PENELUSURAN POTENSI FRAKSI n-HEKSAN DAN ETIL ASETAT DARI EKSTRAK METANOL DAUN GUGUR KETAPANG (Terminalia catappa L.) SEBAGAI ANTIDIARE Maulita Cut Nuria; Zumrotul Chabibah; Syahar Banu; Risha Fillah Fithria
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Daun ketapang (Terminalia catappa L.). secara empiris digunakan sebagai obat diare. Bakteri yang dapat menyebabkan diare adalah E. coli dan S. aureus. Beberapa penelitian melaporkan bahwa ekstrak metanol daun ketapang memiliki aktivitas antibakteri, serta daun gugur ketapang memiliki aktivitas antibakteri lebih besar daripada daun hijau. Daun ketapang mengandung senyawa golongan flavonoid, tanin dan terpenoid. Penelitian ini bertujuan untuk menelusuri potensi fraksi n-heksan dan etil asetat dari ekstrak metanol daun gugur ketapang segar dan kering sebagai antidiare, serta mengidentifikasi senyawa aktif dalam fraksi tersebut. Bahan yang digunakan adalah daun gugur segar dan kering ketapang yang disari dengan pelarut metanol menggunakan metode maserasi dan difraksinasi secara bertingkat dengan pelarut n-heksan dan etil asetat (EA). Kedua fraksi tersebut kemudian diuji aktivitas antibakterinya terhadap E. coli dan S. aureus menggunakan metode difusi agar, dengan seri konsentrasi 1000; 500; 250; 125; dan 62,5 µg/disk. Identifikasi senyawa aktif menggunakan metode Kromatografi Lapis Tipis (KLT). Kedua fraksi uji mempunyai aktivitas antibakteri terhadap E. coli dan S. aureus mulai konsentrasi 62,5 µg/disk. Hasil KLT fraksi n-heksan menunjukkan adanya senyawa terpenoid sedangkan fraksi EA mengandung senyawa flavonoid. kata kunci : Fraksi n-heksan dan etil asetat dari ekstrak metanol daun gugur ketapang, E. coli, S. aureus, terpenoid, flavonoid.

AKTIVITAS STIMULANSIA EKSTRAK ETANOL BUNGA DAN DAUN CENGKEH (Syzygium aromaticum (L) Merr. & Perry.) PADA MENCIT JANTAN GALUR SWISS BESERTA IDENTIFIKASI GOLONGAN SENYAWA AKTIFNYA Yance Anas; Niken Puspitasari; Maulita Cut Nuria
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Keywords : Cloves’ buds and leaves (Syzygium aromaticum (L) Merr. & Perry.) ethanol extracts, stimulant, locomotoric activity, hole-board, open field, terpenoid, alkaloids One of the clove properties is as a stimulant. The purposes of this experimental study were to investigate stimulant effect of clove’s buds and leaves ethanol extracts through locomotoric activity studies on male Swiss strain mice and to identify its active compounds. The experiment was performed with pretest and posttest control group design. Thirty two mice ware divided into eight treatment groups. Locomotoric activity study was performed with hole-board and open-field method. Mice in group I (negative control) provide orally CMC-Na 1% 25 mL/kg BW. Mice in group II (caffeine group) provided orally caffeine 25 mg/kg BW. Six other treatment groups provide clove’s buds and leaves ethanol extracts (100, 200, and 400) mg/kg BW respectively. Frequency of mice head-deeping into holes in the floor and duration of movement in 5 minutes were accessed before and after treatment with extract. Data analyzed using paired-sample T test (p: 0.95). The result showed clove’s buds and leaves ethanol extracts to have stimulant properties on male Swiss strain mice through enhancing locomotoric activity in hole-board method (p<0.05). Clove’s buds and leaves ethanol extracts (100, 200 and 400) mg/Kg BW treatment on male Swiss strain mice can significantly increase mice head-deeping frequency into holes in the floor and exploratory behavior (p<0.05). There was no significant different on mice duration movement (p>0.05). Terpenoid and alkaloid active compounds in clove’s buds and leaves ethanol extracts though to play an important role in enhancing male Swiss strain mice locomotoric activities.

EVALUASI SISTEM PENGELOLAAN OBAT INSTALASI PERBEKALAN FARMASI DINAS KESEHATAN KOTA SEMARANG TAHUN 2007 mohammad djatmiko; aqnes tuning dyah a; maulita cut nuria
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 6 NO. 1 JUNI 2009
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTDrug management is an activity covering planning, provision, storing, distributing, administering andrecording or reporting on the drug used. The purpose of this research was to evaluate the management of the drugsin Departement of Pharmacy Inventories (DPI) of Semarang Health Office (SHO).This research was non-experimetal in nature in which the needed data were collected retrospectively. Thecollected data were in the forms of records on the drugs plans, Records on the Use dan Requests of Drugs (RURD)and results of interviews to the DPI head. The evaluation on the drug management used eleven indicators providedby the fixed procedures for drug management in central java province. The data were converted into percentages andrupiah values, which were then analyzed descriptively.The analyses showed that the drug management by DPI during the period of 2007 had produced effectiveresults as indicated by an effectiveness level of 97,59% for the drug provision, a accuracy level of 98,19% for drugplanning, an effectiveness level of 89,76% for safe provision of the drugs, a conformity level of 100% for the drugitems to the DOEN, a percentage of 0% for average drug supply, a percentage of 2,46% for the times during whichthere was a status of empty for the drug, an abuse level of 8,35% for the miss-distribution of the drugs, a percentageof 3,15% for non-prescription drugs, a percentage of 1,57% for expired drugs with a financial value of Rp.10.094.590 and a percentage of 3,94% for broken drugs with a financial cost of Rp. 43 2.537and a accuracy level of46,62% for delivery t imes for RURD.Keywords : evaluation, drug management, DPI Semarang

PEMERIKSAAN ANGKA KUMAN DAN JAMUR SERTA IDENTIFIKASINYA PADA JAMU GENDONG TEMU IRENG DAN KUNYIT ASAM DI KECAMATAN GAJAHMUNGKUR SEMARANG maulita cut nuria; yeni lutfiani; sulasmi sulasmi; sumantri sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 1 JUNI 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTThe herbal tonic is a product made from natural ingredients processed in traditional ways. A traditional herb made from Temu Ireng (Curcuma aeruginosa) is a kind of herb that still consumed by relatively many Indonesian citizens for enhanching appetite and acid turmeric often consumed by female for reducing the problems when they get haid. However, bacteria and fungi might grow in this traditional herb because of contaminated water (the diluting agent) and moisture, hygiene and sanitation factors. This study, therefore, was intended to find out the quantities and the species of these bacteria and fungi growing in the herb as it is sold in Gajah Mungkur district of Semarang City. This study also intended to compare these quantities to the prevailing standard stipulated. The samples for this study were taken from 36 producers Temu Ireng and acid turmeric herb, located in Gajah Mungkur District. The medium used for growing the material in an aerobic manner was PCA (Plate Count Agar), that used for growing in an anaerobic manner were TSA (Tripticase Soya Agar) and that used for growing the fungi were PDA (Potato Dextrose Agar). For counting the bacteria, we used the method of Standard Plate Count, for identifying the bacteria we used Gram Painting and chemical tested, and for identifying the fungi we used a 100-times amplifying microscope. The analysis showed in the sample Temu Ireng and acid turmeric are the average number of bacteria at the aerobic media were 7,4 x 106 and 2,1 x 105 CFU/ml, the average number of bacteria at the anaerobic media were 4,2 x 102 and 4,3 x 102 CFU/ml, the average number of fungi were 1,5 x 102 and 1,0 x 102 CFU/ml. The aerobic bacteria found in the study were Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, the anaerobic bacteria was peptococcus, and the fungi were Penisillium, Moniliaceae, A. niger, dan Rhizopus. Nearly all samples examined in this study did not meet the conditions based on statement Indonesia Minister of Health No 661/MENKES/SK/VII/1994 because they exceeded the upper limit bacteria (104 CFU/ml) and also contain pathogenic bacterias. However, the number of fungi did not exceed the prevailing standard. Keywords: Temu Ireng Herb, Acid Turmeric Herbs, Bacteria Number and Fungi Number.

PEMERIKSAAN ANGKA KUMAN DAN JAMUR SERTA IDENTIFIKASINYA PADA JAMU GENDONG BERAS KENCUR DAN TEMU LAWAK (Curcuma xanthorhiza Roxb.) DI KABUPATEN SEMARANG BAGIAN SELATAN maulita cut nuria; dedeh ratna dewi; septaningsih septaningsih; sumantri sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTTradisional herbs made from natural ingredients containing many organic elements as the material feed for microbe that caused self decompose during storage. On the previously result of research did by Subhan Ratnawati (2002) shows there were many bacteria, including pathogen bacteria on galian singset herbal tonic carried in Jogjakarta city. The purpose study was intended to find out quantities and identified of bacteria and fungus present in the herbal tonic at ten regions in southern Semarang District. This study was conducted using 52 samples of „beras kencur and temulawak herbs‟ sold in Southern Semarang District. ALT method was used on this experiment and the medium used for growing in an aerobic manner was PCA (Plate Count Agar), while that used for growing in an anaerobic condition were TSA (Tripticase Soya Agar) and was incubated at 37oC for 24 hours. The media used for fungi were PDA (Potato Dextrose Agar). We used a 100-times amplifying microscope for identifying the fungi. The analysis on the data were conducted by calculating the numbers of bacteria and fungi for each sample and by identifying the bacteria and fungi present in the herbs. These numbers then compared to the prerequisites contained in the Indonesian Health Office (MENKES RI) No. 661/MENKES/SK/VII/1994. The analysis showed that the average number of bacteria in the sample of „beras kencur and temulawak herbs‟ that grown at the aerobic media was 4.7x105 CFU/ml and 3.1x104 CFU/ml, but we found no bacteria in the sample grown in an anaerobic manner. The numbers of bacteria grown in the aerobic manner exceeded the upper limits for bacteria number 104 (10000 CFU/ml). The average number of fungi from all samples was 50.7 CFU/ml and 40.5 CFU/ml, which was below the standard of 103 (1000 CFU/ml). The aerobic bacteria found in this study were Pseudomonas aeruginosa and Eschericia coli while the fungi found were Rhizopus, Aspergillus niger, Moniliaceae and Penisillium. Nearly all samples that examined in this study did not meet the conditions stipulated by Indonesian Health Office (MENKES RI) Number 661/MENKES/SK/VII/1994. Keywords: Herbal tonic carried, Bacteria Number and Fungi Number

AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS NEONATAL STZ-INDUCED TYPE-2 DIABETES MELLITUS Yance Anas; Risha Fillah Fithria; Maulita Cut Nuria; Yunita Midkha; Agung Endro Nugroho; Puji Astuti
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Dalam penelitian ini, kami melakukan fraksinasi ekstrak etanol daun lenglengan dengan pelarut n-heksan untuk menyederhanakan kandungan zat aktif yang terkandung di dalamnya dan mengevaluasi efek antidiabetesnya. Penelitian ini bertujuan untuk mengevaluasi efek antidiabetes fraksi n-heksan ekstrak etanol daun lenglengan (FHDL) pada tikus neonatal STZ-induced type-2 diabetes mellitus. STZ 90 μg/KgBB diberikan secara i.p pada 35 ekor anak tikus galur Wistar umur 2 hari. Pada usia 3 bulan, dilakukan pengukuran kadar glukosa pre-prandial dan post-prandial. Sebanyak 25 ekor tikus neonatal STZ-induced type-2 diabetes mellitus dikelompokkan ke dalam lima kelompok perlakuan, terdiri dari kelompok kontrol diabetes (CMC-Na 0,5%; 25 mL/KgBB), kelompok glibenklamid 5 mg/KgBB dan tiga kelompok FHDL (62,5; 125 and 250) mg/KgBB. Sediaan uji diberikan selama 28 hari. Kadar glukosa darah pre-prandial dan post-prandial diukur pada hari ke-0, 7, 14 dan 28. FHDL secara signifikan berhasil menurunkan kadar glukosa darah pre-prandial dan post-prandial tikus neonatal STZ-induced type-2 diabetes mellitus (p<0,05). Perlakuan FHDL 62,5 mg/KgBB selama 28 hari memiliki efek antidiabetes yang tinggi, yaitu mampu menurunkan kadar glukosa darah pre-prandial tikus sebesar 45,99%. Perlakuan FHDL 250 mg/KgBB juga signifikan menurunkan kadar glukosa darah post-prandial tikus (p<0,05) dengan efek antidiabetes pada hari ke-7, 14 dan 28 berturut-turut adalah sebesar 19,28%; 22,68% dan 24,92%. Kata Kunci: Daun Lenglengan, Efek Antidiabetes, Fraksi n-Heksan, Neonatal STZ-induced type-2 diabetes mellitus

UJI AKTIVITAS ANTIBAKTERI FRAKSI KLOROFORM EKSTRAK ETANOL PEGAGAN (Centella asiatica (L) Urb) SERTA IDENTIFIKASI SENYAWA AKTIFNYA Fahrina Rachmawati; Maulita Cut Nuria; Sumantri )
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif"
Publisher : Universitas Wahid Hasyim Semarang

Penyakit infeksi merupakan penyakit yang banyak diderita oleh masyarakat dan terus berkembang dari waktu ke waktu dalam dunia kesehatan. Ekstrak etanol pegagan (Centella asiatica (L) Urb) memiliki aktivitas antimikroba yang lebih baik daripada ekstrak petroleum eter dan air (Jagtap et al., 2009). Penelitian ini bertujuan untuk mengetahui ada atau tidaknya aktivitas antibakteri fraksi kloroform dari ekstrak etanol pegagan terhadap bakteri Gram positif (S. aureus dan B. subtilis) dan Gram negatif (E. coli, P. aeruginosa dan S. typhi), mengetahui besarnya aktivitas antibakteri dari fraksi kloroform tersebut dan mengidentifikasi golongan senyawa yang terkandung dalam fraksi tersebut. Ekstrak etanol pegagan diperoleh dengan menyari simplisia menggunakan penyari etanol 96% secara sokletasi, lalu diuapkan dengan rotary evaporator. Ekstrak tersebut kemudian difraksinasi bertingkat dengan pelarut n-heksan dan kloroform. Fraksi kloroform yang diperoleh diuapkan hingga kekentalan sekitar 300 cps kemudian dilarutkan dalam DMSO, konsentrasi yang digunakan adalah 2063; 1031,5; 515,7; 257,8; 128,9 µg/disk. Aktivitas antibakteri dilakukan secara difusi agar, identifikasi senyawa aktif menggunakan metode Kromatografi Lapis Tipis (KLT). Fraksi kloroform memiliki aktivitas antibakteri terhadap B. Subtilis dan P.aeruginosa, tetapi tidak memiliki aktivitas antibakteri terhadap S. aureus, E. coli dan S. typhi. Fraksi kloroform tersebut dapat menghambat B. subtilis pada konsentrasi 257,8; 515,7; 1031,5; 2063 µg/disk dengan DDH berturut-turut sebesar 7,50; 7,86; 8,63; 9,76 mm, sedangkan P.aeruginosa pada konsentrasi 515,7; 1031,5; 2063 µg/disk dengan DDH berturut-turut sebesar 8,10; 9,10; 10,20 mm. Fraksi kloroform tersebut mengandung senyawa fenol dan terpenoid. Kata kunci : Fraksi kloroform ekstrak etanol pegagan, aktivitas antibakteri, senyawa fenol dan terpenoid.

Antibacterial Activity of Ethanol Extract of Portulaca oleracea L. Herb from Various Extraction Methods Against Salmonella typhimurium MAULITA CUT NURIA; AULIA EVERESTINA PUJAKA; ERIKA INDAH SAFITRI
Microbiology Indonesia Vol. 15 No. 4 (2021): December
Publisher : Indonesian Society for microbiology

Salmonella typhimurium bacteria could cause gastroenteritis and its growth could be controlled by the active compounds from natural products, which is Portulaca oleracea L. herb. Portulaca oleracea contained tannin, saponins and flavonoids compounds which had different characteristics towards temperature extraction. This study aims to determine the antibacterial activity of ethanol extract of the Portulaca oleracea herb from various extraction methods against S. typhimurium bacteria. Extraction of Portulaca oleracea herb was carried out with four variations methods which were the cold method (maceration and percolation) and heat method (soxhlet and refluxs) using 96% ethanol solvent. The four types of extract were tested for their antibacterial activity by disk diffusion at concentrations of 30%, 35%, 40%, 45% and 50% (b/v). The positive control was chloramphenicol 30 Âµg/disk, while the negative control was DMSO solvent. The results of antibacterial activity test in the form of zone of inhibition were statistically analyzed by Two Way Anova. The results showed that the ethanol extract of the Portulaca oleracea herb from various extraction methods had antibacterial activity against S. typhimurium. There was a significantly difference in the antibacterial activity of ethanol extract of the Portulaca oleracea herb obtained from the reflux method with other methods (maceration, percolation and soxhlet) against S. typhimurium. Keywords: ethanol extract of Portulaca oleracea L. herb, antibacterial, Salmonella typhimurium, various extraction methods

Co-Authors Abdur Rosyid Agung Endro Nugroho Agung Endro Nugroho Aminuyati Amprih Martha, Amprih Anita Dwi Puspitasari Aqnes Budiarti aqnes tuning dyah a Arvin Faizatun Asep Gana Suganda Asri Melati Dewi AULIA EVERESTINA PUJAKA dedeh ratna dewi Elin Yulinah Sukandar Enny Puji Astuti Erika Indah Safitri Fahrina Rachmawati Ikke Safitri mohammad djatmiko Muhamad Insanu Niken Puspitasari Nurahmah Hidayati Puji Astuti Puji Astuti Ratna Asmah Susidarti Ririn Lispita Wulandari risha fillah fithria septaningsih septaningsih Siska Maila Sari Sri Susilowati Sulasmi Sulasmi Sumantri ) Sumantri . Sumantri Sumantri Sumantri Sumantri Sumantri Sumantri Syahar Banu Wahyono . Yance Anas yeni lutfiani Yunita Midkha Zumrotul Chabibah

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