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All Journal The Indonesian Biomedical Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jambura Journal of Health Sciences and Research Jurnal Pendidikan dan Konseling Syntax Idea PRIMER (Prima Medical Journal) Archives of The Medicine and Case Reports COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Riwayat: Educational Journal of History and Humanities
Juliana Lina
Departemen Patologi Anatomi, Fakultas Kedokteran, Kedokteran Gigi Dan Ilmu Keperawatan Universitas Prima Indonesia, Medan, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Histologi Kardiovaskular pada Wistar Diabetes Melitus Tipe 2 dengan Curcuma Zedoria Selly Rahmadiah Hasibuan; Juliana Lina; Nabila Dwi Putri; Izdihar Putri Hyachinta; Fiska Maya Wardhani
Syntax Idea 6500-6507
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/syntax-idea.v6i10.6449

Abstract

Penelitian ini bertujuan untuk mengevaluasi pengaruh ekstrak kunyit putih (Curcuma zedoria) pada tikus Wistar yang menderita diabetes melitus tipe 2. Penelitian menggunakan metode eksperimental dengan desain one-group post-test only. Hewan uji yang digunakan adalah tikus Wistar jantan yang diinduksi diabetes menggunakan aloksan, kemudian diberikan ekstrak kunyit putih dengan dosis 250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB. Hasil penelitian menunjukkan bahwa ekstrak kunyit putih dapat menurunkan kadar gula darah pada tikus yang diuji. Namun, analisis histopatologi jantung mengungkapkan adanya tingkat kerusakan yang bervariasi pada sel otot jantung, tergantung dosis ekstrak yang diberikan. Kesimpulannya, ekstrak kunyit putih memiliki potensi sebagai terapi penurun kadar gula darah pada diabetes melitus tipe 2, namun efek samping terhadap jantung harus diperhatikan
Granule Nanoparticle Citrus sinensis (L.) Osbeck Peel Lowers Blood Glucose Levels and HbA1C in Alloxan-induced Diabetes Rats Maya Sari Mutia; Yelvreza Rastiani Sipayung; Dwi Elmiam; Widya Yanti Sihotang; Juliana Lina
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3334

Abstract

BACKGROUND: The peel of Citrus sinensis (L.) Osbeck (sunkist orange) peels, which are often seen as waste, actually contains valuable properties such as antioxidants, hypoglycemic, nephroprotective, and anti-inflammatories. The potential effects of C. sinensis peel on diabetes have been discussed but not clear yet. Therefore, this study was performed to evaluate the effects of Granule Nanoparticle Sunkist Peel (GNSP) extracts as an antidiabetic agent in alloxan-induced diabetic rats.METHODS: The nanoparticle suspension was prepared by mixing a formulation of 0.2% chitosan and 0.1% sodium tripolyphosphate. The characteristics of nanoparticles were measured by flow time, tap index and angle of repose. Rats were induced with alloxan injection to create diabetes rat models. Rats were divided into five groups; normal control group, diabetic controls, and diabetic rats receiving either 50, 100, or 200 mg/kg/day GNSP. After 28 days of diabetes induction, rats were euthanized, and blood as well as tissue samples were collected. Blood glucose levels, HbA1c, and histopathology of the liver, kidneys, and pancreas were then assessed.RESULTS: The particle size of the synthesized material was 92.3 nm, which confirmed the nature of nanoparticle. The characteristics of the granule nanoparticle were also in accordance with the standards for drugs suitable for consumption. The administration of GNSP in dose dependent manner significantly decrease blood glucose levels and HbA1C to normal levels compared to control group (p<0.05). Histopathological analysis indicated recovery in pancreas, liver, and kidney tissues following GNSP administration.CONCLUSION: GNSP administration lowers blood glucose levels and HbA1C, as well as improved histopathological condition of pancreas, liver, and kidney in diabetic rats. These findings suggest the potential of utilizing GNSP as a potent antidiabetic agent.KEYWORDS: Citrus Sinensis (L.) Osbeck, histopathology, hyperglycemia, nano medicine, and type 2 diabetes mellitus
Effect of Pakkat Ethanol Extract (Calamus L. Blum) on Spermatogenesis and Testosterone Levels of Diabetes Mellitus Wistar Rats Yolanda Eliza Putri Lubis; Anggi Sri Ananda Aipin; Hanjaya; Juliana Lina; Suhartomi
Jurnal Penelitian Pendidikan IPA Vol 11 No 12 (2025): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i12.13495

Abstract

Diabetes mellitus is a metabolic disorder marked by high blood glucose levels (hyperglycemia) that is caused by insulin deficiency. It also affects male infertility. Pakkat, young rattan, contains various phytochemicals, which can affect blood glucose levels, spermatogenesis, and testosterone production. Objective: To assess the effectiveness of Pakkat extract in regulating blood glucose levels, testosterone hormone, and spermatogenesis in alloxan-induced diabetic rats. This experimental study used 25 diabetic male Wistar rats and was grouped into five groups including negative control (distilled water), positive control (metformin), Treatment 1 (125 mg/KgBW Pakkat extract), 2 (250 mg/KgBW Pakkat extract), and 3 (500 mg/KgBW Pakkat extract) for 14 days. All data were analyzed by One-way ANOVA followed by a Post-Hoc Test. Pakkat extract at 125 mg/kgBW dose effectively reduced glucose levels (P-Value < 0.001) after 14 days. It also significantly increased spermatogenesis (P-Value < 0.001) and testosterone levels (P-Value < 0.001) in alloxan-induced diabetic rats. Thus, it can be concluded that any doses of Pakkat (Calamus L. Blume) extract significantly improve blood glucose levels after 14 days of administration. However, a higher dosage is required to increase spermatogenesis and testosterone hormone in diabetic conditions.
Co-Authors Adrian Adrian Anggi Sri Ananda Aipin Arie Siah Putra Siahaan Carolina Yosita Cahya Rosari Christina J. R. Esmeralda Lumbantobing Christina J.R.E Lumbantobing Darnedy Fatwa Mely Santy Dicky Chandra Tafonao Dwi Elmiam Edlin - Eldora Lorenja Ambarita Emori Christina Simarmata Evelyn Angie Fiska Maya Wardhani Hanjaya Hans Hotma Haposan Marpaung Hermon Fanotona Marunduri Izdihar Putri Hyachinta Jenni Kristian Dachi Juliyanti Tarigan Maya Sari Mutia Nabila Dwi Putri Nurul Adilla Qori Fadillah* Rido Aliberto Sitanggang Riyani Susan Bt. Hasan Royali Alfindo Sarah Oculi Zaluchu Selly Rahmadiah Hasibuan Suhartomi Tasya Armadinah Vanessa Sinana Laurenxius Widya Yanti Sihotang Yelvreza Rastiani Sipayung Yeni Puspawani Yeni Puspawani Yolanda Eliza Putri Lubis