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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Orthopaedi and Traumatology Surabaya (JOINTS) SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Indian Journal of Forensic Medicine & Toxicology CRJIM (Clinical and Research Journal in Internal Medicine) Cermin Dunia Kedokteran Physical Therapy Journal of Indonesia Cermin Dunia Kedokteran Folia Medica Indonesiana
Wardhani, Indrayuni Lukitra
Department Of Physical And Rehabilitation Medicine, Faculty Of Medicine Universitas Airlangga, Surabaya, Indonesia - Dr. Soetomo General Hospital Surabaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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High-Fat Diet Increases Serum HDL, but Not for LDL and HDL/LDL Ratio in MICE Laksana, Iqbal; Rejeki, Purwo Sri; Herawati, Lilik; Arif, Mohammad Anam Al; Wardhani, Indrayuni Lukitra
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

The use of a ketogenic diet with an increased proportion of fat is rampant lately, both as a therapy or even lifestyle. The use of a ketogenic diet is feared to cause dyslipidemia. It will also lead to atherosclerosis and thrombosis. This study aimed to determine the effect of a high-fat diet on HDL, LDL, and HDL/LDL ratio in mice. Thirty male Mus Musculus, 2-3 mo, 15-25 g divided into five groups diet. K1 (12% fat, 20% protein, 62% carb), K2 (30% fat, 60%protein), K3 (45% fat, 45% protein), K4 (60% fat, 30% protein) and K5 (75% fat, 15% protein) for 4 weeks. Feed and water by adlibitum. Blood for serum was taken from the ventricle, while in the measurement of HDL serum level, the LDL used ELISA. Normality of data analyzed by Shapiro Wilk, and homogeneity by Levene test. HDL serum was analyzed using equality test followed by Games Howell, LDL serum and ratio of HDL/LDL was tested by ANOVA followed by LSD with significance 0,05. HDL serum in K1 (62,50±9.94) mg/dL, K2 (78,40±18,76) mg/dL, K3 (79,00±3,81) mg/dL, K4 (80,00±2,16) mg/dL, and K5 (83,50±5,62) mg/dL with p<0,05 in K1, K2 to K3, K4 and K5. LDL serum in K1 (21,67± 4,80) mg/dL, K2 (23,00±12,70) mg/dL, K3 (18,40±4,34) mg/dL, K4 (24,00 ±1,83) mg/dL and K5 (22,00 ± 4,08) mg/dL with p>0,05. Ratio HDL/LDL K1 (3,01±0,91), K2 (4,10±1,86), K3 (4,53±1,5), K4 (3,35±0,34), and K5 (3,96 ± 1,25) with p>0,05.
EFFECT OF LOW INTENSITY AEROBIC EXERCISE ON VO2PEAK OF WOMEN WITH BREAST CANCER UNDERGOING CHEMOTHERAPY Novayanti, Etta; Wardhani, Indrayuni Lukitra; Narasinta, Inggar; Suprabawati, Desak Gede Agung; Pratiwi, Niken; Soebadi, Ratna Daryanti
Folia Medica Indonesiana Vol. 61, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Breast cancer treatments, particularly chemotherapy, have been associated with significant declines in cardiopulmonary fitness, a key determinant of functional independence and survival. VO2peak, a marker of cardiopulmonary function, is often reduced in patients undergoing chemotherapy, increasing morbidity risks. Researchers have proposed exercise interventions to mitigate these effects. However, most studies focused on moderate-to-high-intensity regimens, with limited data on the efficacy of low-intensity aerobic exercise. This study aimed to explore the impact of low-intensity cycle ergometer aerobic exercise on VO2peak in women undergoing chemotherapy for breast cancer. A randomized controlled trial with twenty participants randomly assigned to an intervention group (n = 10, low-intensity aerobic exercise twice per week for 8 weeks) or a control group (n = 10, usual care). VO2peak was estimated using the 30-Second Sit-to-Stand (30STS) test. Statistical analysis was performed using paired and independent t-tests, with effect size (Cohen’s d) calculated to assess clinical significance. The intervention group demonstrated a significant increase in VO2peak (Δ= +1.93 mL/kg/min, p < 0.001), while the control group showed a non-significant change (Δ= +0.25 mL/kg/min, p = 0.31). Between-group analysis suggested a significant difference in favour of the intervention (p = 0.02, Cohen’s d = –2.56), indicating a large effect size.
Co-Authors -, Andriati Agus Budi Wirawan, I Ketut Gede Al arif, Mohammad Anam Alisiya Alisiya Andriana, RA Meisy Andriati Andriati Andriati Andriati Damayanti Tinduh Desnantyo, Andre Triadi Difitasari Cipta Perdana Dwikora Novembri Utomo Fikri Rasikh Pritanto Gutama Arya Pringga Hanif, Hanan Hening Laswati Putra HERAWATI, LILIK I Ketut Gede Agus Budi Wirawan I Putu Dharma Kresna Imam Subadi Iqbal Laksana Jahidi, Savero Mizan Kukuh Dwiputra Hernugrahanto Kurniawati, Lavenia Laksana, Iqbal Linda Dewanti Lukas Widhiyanto Lydia Arfianti M. Rasyidin Alamsyah Siregar Maria, Patricia Mayori Rachmawati Mohammad Zaim Chilmi Mouli Edward Narasinta, Inggar Ni Ketut Maya Purvitagiri Niken Pratiwi, Niken Novayanti, Etta Nuniek Nugraheni Sulistiawaty Nunuk Mardiana, Nunuk Nur Rochmah, Nur Patricia Maria Patricia Maria Kurniawati Paulus Sugianto Pawana, I Putu Alit Prawitri, Yudith Dian Putri, Nelsya Safira Aulia Rejeki, Purwo Sri Rio yudistira christanto Rwahita Satyawati Dharmanta Setiawati, Rosy Soebadi, Ratna Daryanti Stephanie Theodora Sulis Bayusentono Sulistiawati Sulistiawati Suprabawati, Desak Agung Gede Suprabawati, Desak Gede Agung Utami, Ditaruni Asrina Wicaksono Alim Budihartanto