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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Orthopaedi and Traumatology Surabaya (JOINTS) SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Indian Journal of Forensic Medicine & Toxicology CRJIM (Clinical and Research Journal in Internal Medicine) Jurnal Rekonstruksi dan Estetik Cermin Dunia Kedokteran Physical Therapy Journal of Indonesia Cermin Dunia Kedokteran Folia Medica Indonesiana
Wardhani, Indrayuni Lukitra
Department Of Physical And Rehabilitation Medicine, Faculty Of Medicine Universitas Airlangga, Surabaya, Indonesia - Dr. Soetomo General Hospital Surabaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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The expression of tgf-1 after low level laser therapy in inflammation animal model Subadi, Imam; Wardhani, Indrayuni Lukitra; Andriati, Andriati
Folia Medica Indonesiana Vol. 53, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Pain is the most common complaints in everyday practice. Pain is a clinical manifestation caused by stimuli due to potential tissue damage. Low level laser therapy (LLLT) has been used in reducing pain. One of indicator tissue healing is activation of transforming growth factor -b1(TGF-b1). Tissue healing will eliminate the pain. Do LLLT stimulate TGF-b1 expression? The objective of this study was to investigate the expression of TGF-b1 in low level laser therapy. Thirty male Wistar rats, body weight 250 – 300 gram, 3 month old, were divided into 3 groups, negative control (n=10), positive control (n=10) and treatment groups (n=10). The positive control and treatment groups were injected with Complete's Freund Adjuvant (CFA) 100 mL at left footpad. The treatment group treated with low level laser therapy Lasermed type 2100 wavelength 905 nm, out power 25-500 mW, dose 1 joule/cm2;5 times with interval 24 hours on left footpad. Samples were taken from the skin of footpad and immunohistochemical examination with monoclonal antibody anti- TGF-b1. Calculations carried out on brown reaction in macrophage cell. Data were analyzed using the Games Howell with SPSS 17. There were significant differences in the expression of TGF-b1 in treatment group (15.8±3.1) compared with the positive control group (3.9±1.1) and negative control group (4.6±2.1). There were no significant differences between expression TGF-b1 in positive control group and negative control group. In conclusion, low level laser therapy increased the expression of TGF-b1.
Risk Factors of Body Mass Index (BMI), Age of Menarche, Parity and Hormonal Contraception of Genu Osteoarthritis in Female Patients Alisiya, Alisiya; Sulistiawati, Sulistiawati; Kurniawati, Patricia Maria; Wardhani, RR Indrayuni Lukitra
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Osteoarthritis (OA) is a degenerative disease related to joint cartilage and commonly occurs in the knee joint. The 2013 National Survey recorded the prevalence of joint diseases in East Java was 26.9%. OA affected more women than men due to the estrogen and caused disabilities in many women. This study aimed to find the relationship between Body Mass Index (BMI), age of menarche, parity, and the use of hormonal contraceptives against OA in genu at Universitas Airlangga Hospital, Surabaya. This was an analytic observational study with a case-control approach. Data collection was carried out through a short interview using a questionnaire. The sample size was calculated using a formula and found that the study required 42 patients with OA in the case group and 42 patients without OA in the control group. The case group was dominated by patients with 56-60 years old age (62.1%), BMI 23-24.9 kg/m2 (58.7%), menarche age 12-13 years (53.6%), multiparous (52.6%), having contraception pill usage history (62.3%) particularly using combination pills (60.5%) with a mean duration of use > 1 year (56.8%). There was a relationship between BMI and type of hormonal contraceptive used against genu OA in female patients at Universitas Airlangga Hospital Surabaya.
High-Fat Diet Increases Serum HDL, but Not for LDL and HDL/LDL Ratio in MICE Laksana, Iqbal; Rejeki, Purwo Sri; Herawati, Lilik; Arif, Mohammad Anam Al; Wardhani, Indrayuni Lukitra
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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The use of a ketogenic diet with an increased proportion of fat is rampant lately, both as a therapy or even lifestyle. The use of a ketogenic diet is feared to cause dyslipidemia. It will also lead to atherosclerosis and thrombosis. This study aimed to determine the effect of a high-fat diet on HDL, LDL, and HDL/LDL ratio in mice. Thirty male Mus Musculus, 2-3 mo, 15-25 g divided into five groups diet. K1 (12% fat, 20% protein, 62% carb), K2 (30% fat, 60%protein), K3 (45% fat, 45% protein), K4 (60% fat, 30% protein) and K5 (75% fat, 15% protein) for 4 weeks. Feed and water by adlibitum. Blood for serum was taken from the ventricle, while in the measurement of HDL serum level, the LDL used ELISA. Normality of data analyzed by Shapiro Wilk, and homogeneity by Levene test. HDL serum was analyzed using equality test followed by Games Howell, LDL serum and ratio of HDL/LDL was tested by ANOVA followed by LSD with significance 0,05. HDL serum in K1 (62,50±9.94) mg/dL, K2 (78,40±18,76) mg/dL, K3 (79,00±3,81) mg/dL, K4 (80,00±2,16) mg/dL, and K5 (83,50±5,62) mg/dL with p<0,05 in K1, K2 to K3, K4 and K5. LDL serum in K1 (21,67± 4,80) mg/dL, K2 (23,00±12,70) mg/dL, K3 (18,40±4,34) mg/dL, K4 (24,00 ±1,83) mg/dL and K5 (22,00 ± 4,08) mg/dL with p>0,05. Ratio HDL/LDL K1 (3,01±0,91), K2 (4,10±1,86), K3 (4,53±1,5), K4 (3,35±0,34), and K5 (3,96 ± 1,25) with p>0,05.
EFFECT OF LOW INTENSITY AEROBIC EXERCISE ON VO2PEAK OF WOMEN WITH BREAST CANCER UNDERGOING CHEMOTHERAPY Novayanti, Etta; Wardhani, Indrayuni Lukitra; Narasinta, Inggar; Suprabawati, Desak Gede Agung; Pratiwi, Niken; Soebadi, Ratna Daryanti
Folia Medica Indonesiana Vol. 61, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Breast cancer treatments, particularly chemotherapy, have been associated with significant declines in cardiopulmonary fitness, a key determinant of functional independence and survival. VO2peak, a marker of cardiopulmonary function, is often reduced in patients undergoing chemotherapy, increasing morbidity risks. Researchers have proposed exercise interventions to mitigate these effects. However, most studies focused on moderate-to-high-intensity regimens, with limited data on the efficacy of low-intensity aerobic exercise. This study aimed to explore the impact of low-intensity cycle ergometer aerobic exercise on VO2peak in women undergoing chemotherapy for breast cancer. A randomized controlled trial with twenty participants randomly assigned to an intervention group (n = 10, low-intensity aerobic exercise twice per week for 8 weeks) or a control group (n = 10, usual care). VO2peak was estimated using the 30-Second Sit-to-Stand (30STS) test. Statistical analysis was performed using paired and independent t-tests, with effect size (Cohen’s d) calculated to assess clinical significance. The intervention group demonstrated a significant increase in VO2peak (Δ= +1.93 mL/kg/min, p < 0.001), while the control group showed a non-significant change (Δ= +0.25 mL/kg/min, p = 0.31). Between-group analysis suggested a significant difference in favour of the intervention (p = 0.02, Cohen’s d = –2.56), indicating a large effect size.
Effect of low-intensity aerobic exercise using a cycle-ergometer on insomnia level and quality of life in breast cancer patients undergoing chemotherapy Cipta perdana, Difitasari; Lukitra Wardhani, Indrayuni; Suprabawati, Desak Agung Gede; Tinduh, Damayanti
Physical Therapy Journal of Indonesia Vol. 7 No. 1 (2026): Inpress January-June 2026
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v7i1.325

Abstract

Background: Patients undergoing chemotherapy are two to three times more likely to experience insomnia, with the highest prevalence reported among breast cancer patients. This condition markedly reduces quality of life. This study aimed to assess whether a low-intensity aerobic exercise program using a stationary bicycle could alleviate insomnia and improve patients’ quality of life. Methods: A randomized controlled trial was conducted at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, involving female breast cancer patients undergoing chemotherapy. Participants were assigned to either a treatment group, which performed low-intensity cycling twice weekly for eight weeks, or a control group with no exercise intervention. Changes in insomnia severity and quality of life were assessed using validated questionnaires before and after the intervention. Results: Among the 20 participants who completed the study, the treatment group showed a significant reduction in insomnia severity (p < 0.001) and greater improvements in physical function, symptom management, and overall well-being compared to the control group. Conclusion: Low-intensity aerobic exercise on a cycle ergometer is a safe and effective way to reduce insomnia and improve quality of life in breast cancer patients undergoing chemotherapy.
Hubungan antara Skor Beighton dan Usia Berjalan pada Anak Lavenia Kurniawati; Indrayuni Lukitra Wardhani; Nur Rochmah; Sulistiawati Sulistiawati
Majalah Kedokteran Indonesia Vol 71 No 1 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.1-2021-355

Abstract

Introduction: Studies showed that the condition of joint hypermobility is quite common in children. In general, joint hypermobility asses through the Beighton score method. The objective of this research was to investigate the relationship between beighton score and walking age in children.Method: This research was conducted at a kindergarten in Surabaya using an observational analytic research type and a cross-sectional design. Data collected through interviews and physical examinations. A joint hypermobility examination performed using the Beighton score criteria. Meanwhile data was analyzed using the crosstabulation and Spearman test.Result: It was found that 84% of children had ≥4/9 score on the Beighton score and there were 92% with positive Beighton score in the knee joint. In this study, as many as 20 children experienced the first independent walks over 18 months when 18 of them who has Beighton score ≥4 points. However, there is no correlation found on the Beighton score and the walking age [sig. (2-tailed) = 0.053].Conclusion: Children who have ≥4 points of Beighton score are mostly found in this study. The relationship between the Beighton score and walking age was not statistically significant.
Co-Authors -, Andriati Agus Budi Wirawan, I Ketut Gede Al arif, Mohammad Anam Alisiya Alisiya Alisiya, Alisiya Andriana, RA Meisy Andriati Andriati Andriati Andriati Ayu Susanti, Ayu Cipta perdana, Difitasari Damayanti Tinduh Desnantyo, Andre Triadi Difitasari Cipta Perdana Ditaruni Asrina Utami Dwikora Novembri Utomo Fikri Rasikh Pritanto Gutama Arya Pringga Hanif, Hanan Hening Laswati Putra HERAWATI, LILIK I Ketut Gede Agus Budi Wirawan I Putu Dharma Kresna Imam Subadi Iqbal Laksana Iswinarno Doso Saputro Jahidi, Savero Mizan Kukuh Dwiputra Hernugrahanto Laksana, Iqbal Lavenia Kurniawati Linda Dewanti Lukas Widhiyanto Lydia Arfianti M. Rasyidin Alamsyah Siregar Maria, Patricia Mayori Rachmawati Mohammad Zaim Chilmi Mouli Edward Narasinta, Inggar Ni Ketut Maya Purvitagiri Niken Pratiwi, Niken Novayanti, Etta Nuniek Nugraheni Sulistiawaty Nunuk Mardiana, Nunuk Nur Rochmah Patricia Maria Patricia Maria Kurniawati Paulus Sugianto Pawana, I Putu Alit Prawitri, Yudith Dian Putri, Nelsya Safira Aulia Rejeki, Purwo Sri Rio yudistira christanto Rwahita Satyawati Dharmanta Samiyah Setiawati, Rosy Soebadi, Ratna Daryanti Stephanie Theodora Sulis Bayusentono Sulistiawati Sulistiawati Sulistiawati Sulistiawati Suprabawati, Desak Gede Agung Wicaksono Alim Budihartanto