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Faktor risiko disfungsi endotel pada prediabetes Eliana, Fatimah; Suwondo, Pradana; Hakim Makmun, Lukman; Saksono Harbuwono, Dante
Jurnal Kedokteran YARSI Vol 17, No 3 (2009): SEPTEMBER - DESEMBER 2009
Publisher : Lembaga Penelitian Universitas YARSI

Prevalensi kasus prediabetes di Indonesia pada saat ini cukup tinggi, dan oleh karena itu proporsi wanita berisiko penyakit kardiovaskular meningkat. Penelitian ini bertujuan untuk mengetahui faktor risiko disfungsi endotel pada wanita prediabetes melalui pemeriksaan kadar asymmetric dimethylarginine (ADMA) serum. Penelitian ini dilakukan dengan desain case control pada populasi wanita prediabetes berusia 30-55 tahun. Kriteria prediabetes ditentukan dari pemeriksaan toleransi glukosa oral (TTGO) dengan pemberian 75 gram glukosa. Selanjutnya dilakukan pemeriksaan kadar kolesterol total, LDL, HDL, trigliserida dan HbA1c sebagai variabel independen, serta ADMA sebagai variabel dependen. Terdapat 41 subjek wanita prediabetes yang memenuhi kriteria inklusi dan dimasukkan dalam kelompok kasus, dan 39 subjek yang dimasukkan dalam kelompok kontrol. Terdapat hubungan yang bermakna dan korelasi yang kuat antara peningkatan kadar ADMA dengan glukosa darah puasa, glukosa darah pasca pemberian glukosa 75 gram dan HbA1c. Namun hasil analisis multivariat membuktikan bahwa faktor yang menentukan kadar ADMA adalah HbA1c.Probabilitas subjek prediabetes dengan HbA1c lebih dari 6% untuk mendapatkan kadar ADMA yang tidak normal adalah 96,03%. Faktor risiko terjadinya disfungsi endotel pada wanita prediabetes adalah peningkatan HbA1c lebih dari 6%.

Pengaruh Aktivitas Fisik Terstruktur Terhadap Peningkatan Persentase Massa Otot Pada Anggota Sanggar Senam Zahida, Farah; Taufik, Fatimah Eliana; Muchtar, Diniwati
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2018): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Health is very important in life. They are many ways for life healthy such as by doing structured physical activity. Physical activity has positive effect to prevent the decrement of muscle mass. Muscle mass is important for energy, performance and metabolism regulation. Therefore, the purpose of this study is to find out the effect of the structured physical activity with the increment of muscle mass percentage on member of gymnastics studio This study is used the one group pretest postest design. The population and the sample are the member of R and K gymnastic studio in Cempaka Putih and Johar Baru with 36 people. The samples are chosen by purposive sampling. The data are collected by measuring the respondent's body with Bioelectrical Impedance Analysis on the begining and the ending of this study. The data is analyzed with t-test used Wilcoxon method. Fourteen respondents (56%) from twenty-five have their muscle mass percentage increased with the p value 0,253. There are no significant effect within the strucured physical activity and the increase of muscle mass percentage on member of gymnastics studio.

Structured Physical Activity did not Affect the Body Fat Percentage among Gymnastics Studio Members Widiastari, Erina Febriani; Taufik, Fatimah Eliana; Mukhtar, Diniwati
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 1: January 2020
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200135

The excess of body fat in the body can be associated with the risk of diabetes, cardiovascular disease, and other metabolic diseases.Â Activities which can reduce the body fat percentage is a structured physical activity.Â This study aims to identify the effect of the structured physical activity on the decrease in body fat percentage on members of the gymnastics studio. This study used one group of pretest-posttest design.Â The intervention was an aerobic exercise, conducted for a minimumÂ duration ofÂ 150 minutes per week, and followed up for three months. The samples were selected by using purposive sampling andwere collected by measuring the respondent's weight with Bioelectrical Impedance Analysis at the beginning and the end of this study.Â The data were analyzed by using paired sample t-test. The result showed that theÂ average of the bodyÂ fat percentageÂ on the pre-test was 33.156Â %, and on the post-test was 32.920Â %.Â Based on the data, there was a decrease in a bodyÂ fat percentageÂ on pre-test and post-test in 13 out of 25 respondents.Â The p-value was 0.357, and itÂ can beÂ concluded that the structured physical activity did not have a significant effect on the decreasein body fat percentage.

Structured Physical Activity did not Affect the Body Fat Percentage among Gymnastics Studio Members Widiastari, Erina Febriani; Taufik, Fatimah Eliana; Mukhtar, Diniwati
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 1 (2020): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200135

The excess of body fat in the body can be associated with the risk of diabetes, cardiovascular disease, and other metabolic diseases.Â Activities which can reduce the body fat percentage is a structured physical activity.Â This study aims to identify the effect of the structured physical activity on the decrease in body fat percentage on members of the gymnastics studio. This study used one group of pretest-posttest design.Â The intervention was an aerobic exercise, conducted for a minimumÂ duration ofÂ 150 minutes per week, and followed up for three months. The samples were selected by using purposive sampling andwere collected by measuring the respondent's weight with Bioelectrical Impedance Analysis at the beginning and the end of this study.Â The data were analyzed by using paired sample t-test. The result showed that theÂ average of the bodyÂ fat percentageÂ on the pre-test was 33.156Â %, and on the post-test was 32.920Â %.Â Based on the data, there was a decrease in a bodyÂ fat percentageÂ on pre-test and post-test in 13 out of 25 respondents.Â The p-value was 0.357, and itÂ can beÂ concluded that the structured physical activity did not have a significant effect on the decreasein body fat percentage.

Profil Respons Glukosa Darah dan Tingkat Rasa Kenyang setelah Pemberian DiabetasolÂ® Dibandingkan Makanan Padat Gizi Terkontrol pada Pasien Diabetes Melitus tipe 2 Eliana, Fatimah; Handoko, Iwan Surjadi; Diah Ambarwati, Fransisca; Setiawati, Arini
Cermin Dunia Kedokteran Vol 45, No 7 (2018): Onkologi
Publisher : PT. Kalbe Farma Tbk.

Tujuan penelitian ini adalah untuk menentukan stabilitas kadar glukosa darah harian, tingkat kenyang, dan keamanan setelah menggunakan DiabetasolÂ® dibandingkan dengan makanan padat dengan gizi terkontrol. DiabetasolÂ® adalah makanan indeks glikemik rendah mengandung isomaltulosa, resisten dekstrin, dan inulin. Penelitian ini merupakan studi awal, prospektif, acak, terbuka, dan melibatkan 30 subjek DM tipe 2 pria dan wanita. Pengukuran glukosa darah dengan continuous glucose monitoring selama 48 jam di setiap kunjungan. Tingkat rasa kenyang diukur dengan kuesioner satiety quotient dengan visual analog scale (VAS) pada interval 0, 15, 30, 60, dan 120 menit. Evaluasi efek samping didasarkan pada terjadinya hipoglikemia dan masalah pencernaan selama masa pengobatan. Hasil penelitian menunjukkan respons glikemik DiabetasolÂ® lebih rendah dibandingkan makanan padat gizi terkontrol kendati tidak bermakna, di lain pihak DiabetasolÂ® memberikan rasa kenyang lebih lama tanpa efek samping serius.The purpose of this study was to determine the stability of daily blood glucose level, satiety level, and safety after using DiabetasolÂ® in comparison with controlled nutrition solid food. DiabetasolÂ® is low glycemic index foods contained of isomaltulose, resistant dextrin, and inulin. This study is a preliminary, prospective, randomized, open-ended study, and involving 30 male and female type 2 DM subjects. Blood glucose was measured with continuous glucose monitoring within 48 hours after every visit. The satiety level was measured with satiety quotient questionnaire with visual analog scale (VAS) at interval of 0, 15, 30, 60, and 120 minutes. The evaluation of side effects was based on the occurrence of hypoglycemia and digestive problems during the treatment period. Eventhough not stastistically significant, DiabetasolÂ® leads to decreased glycemic response and longer satiety compared to controlled nutrition solid foods, with no serious side effects.

Pengaruh Aktivitas Fisik Terstruktur Terhadap Peningkatan Persentase Massa Otot Pada Anggota Sanggar Senam Farah Zahida; Fatimah Eliana Taufik; Diniwati Muchtar
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2018): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Health is very important in life. They are many ways for life healthy such as by doing structured physical activity. Physical activity has positive effect to prevent the decrement of muscle mass. Muscle mass is important for energy, performance and metabolism regulation. Therefore, the purpose of this study is to find out the effect of the structured physical activity with the increment of muscle mass percentage on member of gymnastics studio This study is used the one group pretest postest design. The population and the sample are the member of R and K gymnastic studio in Cempaka Putih and Johar Baru with 36 people. The samples are chosen by purposive sampling. The data are collected by measuring the respondent's body with Bioelectrical Impedance Analysis on the begining and the ending of this study. The data is analyzed with t-test used Wilcoxon method. Fourteen respondents (56%) from twenty-five have their muscle mass percentage increased with the p value 0,253. There are no significant effect within the strucured physical activity and the increase of muscle mass percentage on member of gymnastics studio.

Profil Respons Glukosa Darah dan Tingkat Rasa Kenyang setelah Pemberian Diabetasol® Dibandingkan Makanan Padat Gizi Terkontrol pada Pasien Diabetes Melitus tipe 2 Fatimah Eliana; Iwan Surjadi Handoko; Fransisca Diah Ambarwati; Arini Setiawati
Cermin Dunia Kedokteran Vol 45, No 7 (2018): Onkologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i7.640

Tujuan penelitian ini adalah untuk menentukan stabilitas kadar glukosa darah harian, tingkat kenyang, dan keamanan setelah menggunakan Diabetasol® dibandingkan dengan makanan padat dengan gizi terkontrol. Diabetasol® adalah makanan indeks glikemik rendah mengandung isomaltulosa, resisten dekstrin, dan inulin. Penelitian ini merupakan studi awal, prospektif, acak, terbuka, dan melibatkan 30 subjek DM tipe 2 pria dan wanita. Pengukuran glukosa darah dengan continuous glucose monitoring selama 48 jam di setiap kunjungan. Tingkat rasa kenyang diukur dengan kuesioner satiety quotient dengan visual analog scale (VAS) pada interval 0, 15, 30, 60, dan 120 menit. Evaluasi efek samping didasarkan pada terjadinya hipoglikemia dan masalah pencernaan selama masa pengobatan. Hasil penelitian menunjukkan respons glikemik Diabetasol® lebih rendah dibandingkan makanan padat gizi terkontrol kendati tidak bermakna, di lain pihak Diabetasol® memberikan rasa kenyang lebih lama tanpa efek samping serius.The purpose of this study was to determine the stability of daily blood glucose level, satiety level, and safety after using Diabetasol® in comparison with controlled nutrition solid food. Diabetasol® is low glycemic index foods contained of isomaltulose, resistant dextrin, and inulin. This study is a preliminary, prospective, randomized, open-ended study, and involving 30 male and female type 2 DM subjects. Blood glucose was measured with continuous glucose monitoring within 48 hours after every visit. The satiety level was measured with satiety quotient questionnaire with visual analog scale (VAS) at interval of 0, 15, 30, 60, and 120 minutes. The evaluation of side effects was based on the occurrence of hypoglycemia and digestive problems during the treatment period. Eventhough not stastistically significant, Diabetasol® leads to decreased glycemic response and longer satiety compared to controlled nutrition solid foods, with no serious side effects.

DNA METHYLATION IN THYROID-STIMULATING HORMONE GENE: PREDICTOR OF GRAVE’S DISEASE RECURRENCE IN INDONESIA Luluk yunaini; Dwi Anita Suryandari; Trisia Lusiana Amir; Dwi Yanti; Fatimah Eliana
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Thyroid-stimulating hormone receptor (TSHR) has a critical role in Graves’ disease (GD). GD is an autoimmune disease which is multifactorial. Environmental factors can affect the epigenetic, a changes in gene expression without any changes in base sequence of the DNA. One of the epigenetic types is methylation. This study aims to determine the status of DNA methylation in TSHR gene in patients with GD to be one of the predictors of recurrence. This study used a case control design with 58 samples of GD patients divided into 29 groups of recurrence and 29 groups of non-recurrence. DNA methylation examination used methylation-specific PCR (MSP) method. Our result found that DNA methylation profile of GD in Indonesia were 5% with complete DNA methylation, 17% complete DNA unmethylation and 78 partial DNA methylation. Statistical analysis showed no significant different between recurrence and non-recurrence group (p>0.05). Nevertheless, our result showed no patient with complete status DNA methylation was found in recurrence group. This shows that in recurrence occur a reduction of DNA methylation resulting in increasing of TSHR production. Thus, DNA methylation in TSHR gene might be has a role in the risk of recurrence GD.

Profil Respons Glukosa Darah dan Tingkat Rasa Kenyang setelah Pemberian Diabetasol® Dibandingkan Makanan Padat Gizi Terkontrol pada Pasien Diabetes Melitus tipe 2 Fatimah Eliana; Iwan Surjadi Handoko; Fransisca Diah Ambarwati; Arini Setiawati
Cermin Dunia Kedokteran Vol 45 No 7 (2018): Onkologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i7.749

Tujuan penelitian ini adalah untuk menentukan stabilitas kadar glukosa darah harian, tingkat kenyang, dan keamanan setelah menggunakan Diabetasol® dibandingkan dengan makanan padat dengan gizi terkontrol. Diabetasol® adalah makanan indeks glikemik rendah mengandung isomaltulosa, resisten dekstrin, dan inulin. Penelitian ini merupakan studi awal, prospektif, acak, terbuka, dan melibatkan 30 subjek DM tipe 2 pria dan wanita. Pengukuran glukosa darah dengan continuous glucose monitoring selama 48 jam di setiap kunjungan. Tingkat rasa kenyang diukur dengan kuesioner satiety quotient dengan visual analog scale (VAS) pada interval 0, 15, 30, 60, dan 120 menit. Evaluasi efek samping didasarkan pada terjadinya hipoglikemia dan masalah pencernaan selama masa pengobatan. Hasil penelitian menunjukkan respons glikemik Diabetasol® lebih rendah dibandingkan makanan padat gizi terkontrol kendati tidak bermakna, di lain pihak Diabetasol® memberikan rasa kenyang lebih lama tanpa efek samping serius. The purpose of this study was to determine the stability of daily blood glucose level, satiety level, and safety after using Diabetasol® in comparison with controlled nutrition solid food. Diabetasol® is low glycemic index foods contained of isomaltulose, resistant dextrin, and inulin. This study is a preliminary, prospective, randomized, open-ended study, and involving 30 male and female type 2 DM subjects. Blood glucose was measured with continuous glucose monitoring within 48 hours after every visit. The satiety level was measured with satiety quotient questionnaire with visual analog scale (VAS) at interval of 0, 15, 30, 60, and 120 minutes. The evaluation of side effects was based on the occurrence of hypoglycemia and digestive problems during the treatment period. Eventhough not stastistically significant, Diabetasol® leads to decreased glycemic response and longer satiety compared to controlled nutrition solid foods, with no serious side effects.

Overview of Antibiotic Sensitivity Patterns in Diabetic Ulcers at Gatot Soebroto Army Hospital and Fatmawati General Hospital and The Review According to Islamic Perspective Sherly Idhalhijah; Fatimah Eliana; Andri Gunawan
Junior Medical Journal Vol 1, No 6 (2023)
Publisher : Junior Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v1i6.3133

Backgorund : One of the complications of DM is diabetic ulcers which occur due to reduced pain sensation due to neuropathy. Diabetic ulcers are a state of finding infection, destruction to the deepest skin tissue in the feet in patients with diabetes mellitus (DM) due to nerve abnormalities and peripheral arterial vascular disorders, so an overview of the pattern of antibiotics is very important in overcoming the severity of ulcers that can expand.Methodolgy : This research used secondary data from medical records on the antibiotic sensitivity of diabetic foot ulcer patients at the Gatot Subroto Army Hospital and Fatmawati General Hospital from January 2018 to December 2021.Results : There are ten types of antibiotics that sensitive to diabetic foot ulcer patients at Gatot Soebroto Army Hospital, including tigecycline, cefepime, piperacillin tazobactam, amikacin, aztreonam, ceftazidime, ciprofloxacin, gentamicin, meropenem, and ceftriaxone. While the types of antibiotics at Fatmawati General Hospital, include amikacin, piperacillin tazobactam, imipenem, meropenem, ertapenem, gentamicin, trimethophrim sulfamethoxazole, tigecycline, fosfomycin, and cefepime.Conclusion : Sensitive antibiotics in the two hospitals include tigecycline, cefepime, piperacillin tazobactam, amikacin, gentamicin and meropenem. In the view of Islam treatment is a form of effort to seek healing, after which surrender everything to Allah SWT.Keywords : Antibiotic, diabetic ulcer, Army hospital, Fatmawati

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