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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Reproduksi Indonesian Journal of Biotechnology The Indonesian Biomedical Journal Jurnal Gizi Klinik Indonesia Jurnal Kesehatan Reproduksi Berita Kedokteran Masyarakat Medical and Health Journal
Heru Pradjatmo
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Jl. Farmako, Sekip Utara, Yogyakarta 55281
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Changes in CA 125 Level Pre and Post Ovarian Cancer Surgery Aprivinta, Sherlyana Mega; Pradjatmo, Heru; Hadiati, Diah Rumekti
JURNAL KESEHATAN REPRODUKSI Vol 10, No 3 (2023)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.79928

Abstract

Background: Ovarian cancer is one of the gynecological cancers that has a fairly high mortality rate and has a poor prognosis. Ovarian cancer management includes optimal operation followed by chemotherapy, which at follow up will have an effect on decreasing CA 125 levels. But in fact there are several studies showing increased CA 125. Given these differences in findings, this study attempted to evaluate the pre and post operation changes in CA 125 levels in ovarian cancer patients.Objective: This study aims to determine the changes in pre and post operation CA 125 levels in ovarian cancer patients. And to find out the optimal relationship between CA 125 level post operation and post operation.Methods: The type of research is an analytic study with a prospective cohort design. The source comes from secondary data taken from Simetris dr. Sardjito Hospital within 6 months.Results: The distribution of the age < 40 years was 11 and 19 were 40 years old. There was a significant change in pre operation log CA 125 levels (mean = 2,53 or 902,03U/ml) and post operation log CA 125 levels (mean = 1,92 or 406,23 U/ml). With a difference or delta mean of 0,61 or 495,80 U/ml and p value = 0.001. There was a significant difference in post operation log CA 125 levels between optimal and non optimal operation. Based on risk factors, there was a significant change or decrease in log CA 125 levels pre and post operation, but there was no significant difference in log CA 125 levels pre and post operation.Conclusion: There was a significant decrease in log CA 125 levels pre and post operation in patients with ovarian cancer who underwent operation. The post operation log CA 125 level in optimal operation is lower than in non-optimal operation.Keywords: CA 125, Ovarian Cancer, Operation, Optimal
Hubungan Nilai Rasio Platelet-Limfosit Pra Pembedahan pada Kanker Ovarium Epitelial dengan Respon Kemoterapi Berbasis Platinum di RSUP Dr. Sardjito putra, prayuna; Lutfi, Muhammad; Pradjatmo, Heru
JURNAL KESEHATAN REPRODUKSI Vol 11, No 1 (2024)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.94622

Abstract

ABSTRAKLatar Belakang: Respon inflamasi memiliki hubungan yang signifikan terhadap nilai prognostik dari suatu keganasan. Rasio platelet-limfosit (RPL) sebagai salah satu penanda inflamasi pada keganasan sehingga menjadi prediktor terhadap prognosis pasien kanker pada umumnya.Tujuan: Mengetahui hubungan antara RPL pra pembedahan dan respon kemoterapi berbasis platinum pada kanker ovarium epithelial di RSUP DR. Sardjito.Metode: Penelitian kohort retrospektif untuk menilai hubungan antara RPL pra pambedahan dan faktor-faktor risiko terhadap respon kemoterapi berbasis platinum pada pasien kanker ovarium epitelial.Hasil dan Pembahasan: Nilai cut-off RPL pra pembedahan adalah 203 dengan sensitivitas dan spesifitas=76,2%, nilai AUC=0,786, dan akurasi=76,2%. Ditemukan hubungan signifikan antara RPL pra pembedahan dan respon kemoterapi pada pasien kanker ovarium epitelial, p=0,001, RR(CI95%)=3,200(1,815-5,640). Terdapat hubungan yang signifikan antara jenis histologi dan respon kemoterapi, p=0,001, RR(CI95%)=2,384(1,424-3,989).Kesimpulan: Kejadian resisten kemoterapi berbasis platinum pada pasien kanker ovarium epitelial signifikan lebih tinggi pada pasien dengan nilai RPL pra pembedahan ≥203 dan jenis histologi (serosa 2 kali lebih tinggi dan  non serosa 4 kali lebih tinggi yang disertai dengan nilai  RPL ≥203)(efek modifikasi
Microrna Profile of Plasma Exosomes by Nanostrings in Early Onset Compared Late Onset Preeclampsia: Preliminary Study Sumawan, Herman; Pradjatmo, Heru; Hadiati, Diah Rumekti; Mubarika, Sofia; Giantari, Ifrinda
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17598

Abstract

Research on miRNA biomarkers in preeclampsia as part of screening, diagnosis, and prognosis has been widely conducted, but the results show contradictory results and vary based on the type of preeclampsia. This study aims to compare the profile of plasma exosome miRNA in early onset compared late onset as a preliminary study to identify the miRNA profile of preeclampsia patients in Indonesia. The study was conducted at Margono Hospital,Indonesia using plasma exosomes samples of three patients with early-onset preeclampsia and three patients with late-onset preeclampsia and processed with NanoStrings. KEGG was used to identify preeclampsia pathophysiological pathways by bioinformatic analysis of DIANA-miRPath v3.0 and microT-CDS v5.0. The results showed that the characteristics of parity, hemoglobin, systolic and diastolic blood pressure, proteinuria and BMI did not differ between EOPE and LOPE. Significantly different variables were the age of the EOPE (28 ± 5.29) vs LOPE (38.67 ± 2.06 mmHg), pregnancy weight gain (10.0 vs 15.33), and fetal weight in EOPE (1550 ± 132 g) vs LOPE (2693 ± 716 g). The results showed that the 24 miRNAs differed significantly. The three highest expression miRNAs in the EOPE group were miR-196b-5p, miR-190a-5p, and miR-515-3p. In contrast, the three lowest expression miRNAs are miR-3179, miR-181a-5p, and miR-15b-5p. Pathway analysis of the upregulated miRNA involved the ErbB signalling pathway, Proteoglycan in cancer, and Lysin degradation. Downregulated miRNA targets involved in the HIPPO signalling pathway, fatty acid biosynthesis, and TGF-β signalling pathway. Conclusions: The preliminary study results indicated significant differences in miRNA expression, suggesting that EOPE is influenced by aggressive cellular signaling and metabolic dysregulation, while LOPE is more linked to the disruption of growth-inhibiting pathways and fatty acid metabolism. These unique miRNAs establish a robust foundation for subsequent validation studies utilizing bigger samples as a prospective biomarker panel.
Exosomal miRNAs as Potential Biomarkers for Preeclampsia: miR-1283 Has the Highest Expression, while miR-152-3p Has the Lowest Expression Sumawan, Herman; Giantari, Ifrinda; Mubarika, Sofia; Hadiati, Diah Rumekti; Pradjatmo, Heru
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3197

Abstract

BACKGROUND: Preeclampsia management is necessary, as it is one of the leading causes of death during pregnancy. Exosomal microRNAs (miRNAs) can serve as biomarkers for early detection, diagnosis, and prognosis of preeclampsia. NanoStrings is an effective method for identifying exosomal miRNA due to their high sensitivity and ability to work with small amounts of miRNA; however, the analysis using this method for determining preeclampsia biomarker is still limited. Therefore, this study was conducted to utilize the NanoStrings method in identifying preeclampsia biomarkers related to its underlying pathophysiology.METHODS: This study involved 12 pregnant women at 20–40 weeks of gestation, including 6 preeclampsia women and 6 normotension women. The miRNAs from plasma exosomes were processed using NanoStrings method with NanoString nCounter SPRINT Profiler. Enrichment analysis of The Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways were performed to examine the pathophysiological pathways of preeclampsia, using the DIANA–miRPath v3.0.RESULTS: Forty-eight miRNAs were downregulated and 7 were upregulated (miR-1283, miR-613, miR-520a-3p, miR-3185, miR-556-3p, miR-1973, and miR-598-3p) in women with preeclampsia. The highest expression was observed in miR-1283 (log fold-change: 3.69) and the most lowest expression was in miR-152-3p (log fold-change: 1.41). Enrichment analysis showed that the most upregulated miRNAs pathways was estrogen signaling pathway, and the most downregulated was Hippo signaling pathways.CONCLUSION: miR-1283 has the highest expression, while and miR-152-3p has the lowest expression in preeclampsia women. These miRNAs are shown to be linked to specific pathways, shedding light on the pathophysiology of preeclampsia, and may serve as promising biomarkers.KEYWORDS: exosomes, biomarker, miRNAs, pathophysiology, preeclampsia, pregnancy
Co-Authors Addin Trirahmanto Adelina Amelia Adelina Amelia Adintyo Rahman, Muhammad Nur Afif Fuadi Ahsanuddin Attamimi Ahsanudin Attamimi Akbar Satria Fitriawan Alkaff, Muhammad Lutfi Aprilia Indra Kartika Aprivinta, Sherlyana Mega Ardhanu Kusumanto Ardhanu Kusumanto Attamimi, Ahsanuddin Bob Irsan Bob Irsan Choery Novitasari Dewi Sahfitri Tanjung Deyna Primavita Pahlevi Diah Rumekti Hadiati Djaswadi Dasuki Djaswadi Dasuki Djaswadi Dasuki Emilia Theresia Eny Fatmawati Ery Kus Dwianingsih Fatmawati, Eny Geni, Puti Lenggo H.R. Siswosudarmo Hari Kusnanto Ifrinda Giantari Irianiwati Widodo Irsan, Bob Irwan Taufiqur Rachman Ksyatria, Yudhistya Ngudi Insan Laili Chilmawati Laili Chilmawati Mardiana Mardiana Mardiana Mardiana Moh Nailul Fahmi Mohammad Hakimi Muhammad Lutfi Muhammad Lutfi Muhammad Nur Adintyo Rahman Novitasari, Choery Nuratul Awaliyah Nurul Hikmah Petrana Ova Emilia Pahlevi, Deyna Primavita Petrana, Nurul Hikmah Puti Lenggo Geni putra, prayuna Rifqi, Rifqi Shinta Prawitasari Shinta Prawitasari Siti Nur Chasanah Siti Sholikhah Sofia Mubarika Haryana Sumawan, Herman Syamsul Arifin Teguh Aryandono Tri Gunawan Tri Gunawan, Tri Yudhistya Ngudi Insan Ksyatria