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Tiyan Febriyani Lestari
Sekolah Tinggi Ilmu Kesehatan Jayapura
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Journal : Journal of Midwifery

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Differences of the Insulin and Brain Derived Neurotrophic Factor Between Normal Born Weight Baby and Baby With Intrauterine Growth Restriction Tiyan febriyani lestari; Yusrawati Yusrawati; Arni Amir
Journal of Midwifery Vol 3, No 2 (2018): Published on December 2018
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (508.282 KB) | DOI: 10.25077/jom.3.2.103-112.2018

Abstract

Background: Intrauterine Growth Restriction (IUGR), is a condition in which the fetal growth rate is less than 10 percentiles. Fetal growth is affected by maternal health and nutrition, the hormone insulin and placenta. Placental development is influenced by the Brain Derived Neurotropic Factor (BDNF). Insulin deficiency and BDNF can interfere with fetal development.Method: This study used an observational research method, with a comparative cross sectional design. The place of research was conducted at Bayangkara Hospital, Dr. Rasidin, TK.III Reksodiwiryo Hospital, and Biomedical Laboratory, Faculty of Medicine, Andalas University. Research time starts from October 2017 to January 2018. The sample of this study was 25 normal babies and 25 babies with IUGR. Insulin levels and BDNF were examined by enzyme-linked immunosorbent assay (ELISA). Test the normality of the data using the Kolmogorov-Smirnov test. Statistical analysis using independent t test.Results: Insulin levels of 13.2 ± 1.7 mIU / L in infants with normal birth weight and 8.5 ± 1.7 mIU / L in infants born with IUGR (p = 0.000) and BDNF levels 1.5 ± 0.2 ng / ml for infants with normal birth weight and 1.4 ± 0.3 ng / ml in infants born with IUGR (p = 0.008).Conclusion Insulin levels and BDNF levels of normal birth weight babies are higher than babies born with IUGR.
Co-Authors Agapa , Ancelince Agapa, Ancelince Alfina Ayu Tri syafitri Amir, Arni Amyol , Emeliana Apaseray, Yuliana Antoneta Arum Surya Utami Asmawati, Hardini Anna Astutik , Eftyaningrum Dwi Astutik, Eftya Ningrum Dwi Wahyu Astutik, Eftyaningrum D W Astutik, Eftyaningrum Dwi Awairaro, Yurida Daap , Silpa Demetaouw, Novalin demi kogoya Dinge, Fenny Dionesia Pri Utami Dolvy, Dolly Dude , Nadia Eftyaningrum Dwi Wahyu Astutik endah purwanit handayani Endah Purwanti Handayani febriani gea Fretes, Rachel De Harlinda Widia Putri Hasanah hasnia Hasnia Hasnia hasnia, Hasnia Inderyeta daundi Irianti, Oktavia Syam Itlay, Ona Januarti, Putri Amelia Karoba , Senita kusmawati hasanah Kwano , Welmince Lestari , Susi Mallo , Anice Mendila, Hermin Nasrianti, Nasrianti Nopeliana, Nopeliana Nurhilmi, Nurhilmi Palino, Keryn Amanda Putri, Harlinda. W Putri, Herlinda W. Rahmawati, Yustika riswati toba Saldianti , Siti Saldianti, Siti Salla, Nirani Sobolim, Heni susi lestari SUSI LESTARI Susi Lestari Toba, Riswati Utami, Fetty Satu Ryan Viania, Wiwit Wally , Jenny F Wamu, Alin Wandik, Temide Wetapo , Nosti Wiwit Vitania yanes ohee Yusrawati Yusrawati Yustika Rahmawati Pratami