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Alfa Mangostin Extract (Garcinia Mangostana L) Effectiveness on the Biofilm Thickness Growth of Streptococcus Sanguinis. Rahmawati Sri Praptiningsih; Rosa Pratiwi; tazkia Yustisiani Nurafifah
Odonto : Dental Journal Vol 10 (2023): Special Issue 1. October 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.0.7-14

Background: Periodontal disease is caused by the accumulation of bacteria from biofilms in the periodontal tissues. Streptococcus sanguinis is one of bacteria lives in biofilm. One of the herbal ingredients that can be used as an antibacterial is the mangosteen fruit (Garcinia mangostana L.), especially the rind of the mangosteen fruit. The main compound in the mangosteen rind is known as alfa-mangostin, the compound alfa-mangostin has anti-bacterial benefits. The purpose of this research is to determine the effectiveness usage of alpha mangostin toward Streptococcus sanguinis biofilm thickness growth. Method: Experimental research design, with post-test only control group design with a sample size of 27. The treatment group consisted of alpha mangostin 3.125, 6.25, and 12.5 g/ml and the control group were distilled water. Measurement of Streptococcus sanguinis biofilm thickness was carried out by ELISA-reader. The statistical test was carried out using the One Way Anova test. Results: The results showed the lowest average thickness of Streptococcus sanguinis with the addition of -mangostin 12.5 g/ml was 0.371, while the thickness of Streptococcus sanguinis with the addition of chlorhexidine was the highest at 1.860. One Way Anova test obtained a significance number of 0.001 (p

ANALYSIS OF THE DETERMINING FACTORS OF SMILE AESTHETICS (STUDIES ON STUDENTS OF THE ISLAMIC UNIVERSITY OF SULTAN AGUNG SEMARANG) Elhakamy, Nurul Azkia; Noviyanti, Shella Indri; Praptiningsih, Rahmawati Sri
Jurnal Medali Vol 6, No 1 (2024): Media Dental Intelektual March 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.6.1.26-34

Background: A smile is one of the main components of the attractiveness of a personâ€™s face. Several things build an aesthetic smile. The aesthetic assessment of a smile is a subjective matter, so each individual has their assessment. The purpose of this study was to determine the studentâ€™s assessment of the four components of a smile. Method: The research design used in this study was an observational study with a cross-sectional approach with a total of 100 research subjects, which included diploma, bachelor, professional education, master, and postgraduate students. Result: The result obtained from this study showed different results between male and female students. Conclusion: The high smile line was considered by male and female respondents to be aesthetic, and the medium smile line was considered unaesthetic by male respondents and aesthetically for women. The low smile line was considered unaesthetic by both of them. In the smile arc, the parallel smile arc is regarded as an aesthetic smile by both male and female respondents, while the straight smile arc is assessed as an unaesthetic smile by male and female respondents. For male respondents, a smile with a reverse smile arc was assessed as a very unaesthetic smile, while female respondents rated this smile as unaesthetic. In the upper lip curvature aspect, male respondents rated a smile with an upward upper lip curvature as very aesthetic, while female respondents rated it as aesthetic. Both male and female respondents rated Straight upper lip curvature as an aesthetic smile. A smile with downward upper lip curvature is rated as very unaesthetic by male respondents and unaesthetic by female respondents. In the buccal corridor aspect, male and female respondents rated a smile with a narrow and medium buccal corridor as an aesthetic smile. A smile with a wide buccal corridor was rated as very unaesthetic by male respondents, while female respondents rated this smile as unaesthetic.

Antibacterial effect of alpha-mangostin from Garcinia mangostana. L against oral streptococci and staphylococci biofilms: a systematic review Praptiningsih, Rahmawati Sri; Siswomihardjo, Widowati; Jonarta, Alma Linggar; Yulianto, Heribertus Dedy Kusuma; Syifa, Liftia Layyinatus; Rochmah, Yayun Siti; Ichwan, Solachuddin Jauhari Arief
Padjadjaran Journal of Dentistry Vol 36, No 2 (2024): July 2024
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol36no2.53957

ABSTRACTIntroduction: Interactions among competing bacteria, which inhibit each other's growth to maintain the balance of microorganisms in the biofilm, can influence oral cavity homeostasis. Natural products contain compounds with the potential to combat various diseases, including caries. Alpha-mangostin from Garcinia mangostana. L exhibits antibacterial properties against oral streptococci and staphylococci, acting through several mechanisms, including the disruption of peptidoglycan, which ultimately leads to cell brittleness and rupture. This study aims to assess the impact of antibacterial alpha-mangostin on oral streptococci and staphylococci biofilm. Methods: The research methodology employed secondary data collection through a systematic review study. We conducted searches across databases including PubMed, ScienceDirect, and Google Scholar to identify Indonesian and English references encompassing textbooks, research findings, reviews, and internet articles relevant to the topic published between 2014 and 2024. Following a thorough screening process, we selected articles deemed pertinent for inclusion in the review. Subsequently, these articles underwent evaluation for full-text accessibility, language compatibility, and availability of information from the respective journals, resulting in the selection of 20 articles. Results: Analysis was carried out on 20 articles. Ten articles described the effects of alpha-mangostin's inhibit oral biofilm, 6 articles discussed the effects of alpha-mangostin's antibacterial activity against Streptococcus mutans and Streptococcus sanguis, 3 article state mechanism alpha-mangostin inhibit membrane enzymes such as F(H+)-ATPase and the phosphoenolpyruvate-sucrose phosphotransferase system on Staphylococcus aureus. Additionally, one article described inhibition mechanisms of aldolase, glyceraldehyde-3-phosphate dehydrogenase, and lactic dehydrogenase on Staphylococcus epidermidis. Conclusion: Alpha-mangostin inhibits and disrupts biofilm defense mechanisms. It possesses antimicrobial properties effective against oral streptococci and staphylococci, including Streptococcus mutans, Streptococcus sanguis, Staphylococcus aureus and Staphylococcus epidermidis. These properties operate through various mechanisms, including enhancing the permeability of bacterial cell walls, ultimately leading to bacterial cell death.KEYWORDSOral biofilm, alpha-mangostin, oral streptococci, staphylococci

The Effectiveness Of Black Cumin Nanoemulsion Gel Concentration 10% And 15% On Staphylococcus Aureus Biofilm Thickness (In Vitro) Praptiningsih, Rahmawati Sri; Feranisa, Anggun; Amalina, Rizki; Nur Istighfah, Jafifah Mega
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.136-145

Background: Periodontal disease is a disease that often occurs in the oral cavity with prevalence in Semarang City increasing in 2016 by 67.18% to 89.53%. One of the causes of periodontal disease is the buildup of Stapylococcus aureus bacterial biofilm during the initial colonization of the tooth pellicle formation. One herbal ingredient that can be used as an antibacterial is black cumin (Nigella sativa). Gel nanoemulsion technology has the advantage of increasing material stability. This research aims to determine the effectiveness of black cumin gel nanoemulsion on the growth of Stapylococcus aureus biofilm thickness. Methods:The treatment group consisted of black cumin gel nanoemulsion with a concentration of 10% and a concentration of 15% and the control group, namely 0.2% chlorhexidine and distilled water. Stapylococcus aureus biofilm thickness was measured using an ELISA-reader. Statistical tests were carried out using the One Way Anova test. Results: The average thickness of Stapylococcus aureus with the addition of black cumin gel nanoemulsion with a concentration of 15% was the lowest, namely 0.046, while the thickness of Stapylococcus aureus with the addition of distilled water was the highest, namely 0.158. The One Way Anova test obtained a significance figure of 0.000 (p<0.05) so it could be concluded that there were significant differences in the 4 Stapylococcus aureus thickness test groups.Conclusion: Black cumin gel nanoemulsion concentrations of 10% and 15% have antibacterial properties which can reduce the thickness of Stapylococcus aureus biofilm.

The effect of brown algae (Sargassum sp.) gel on the number of osteoclasts in periodontitis rats S. Abdurrohman, Muhamat Muhtar; Praptiningsih, Rahmawati Sri; Yulistinawati, Yulistinawati
Padjadjaran Journal of Dentistry Vol 34, No 3 (2022): November 2022
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol34no3.39285

ABSTRACTIntroduction: Alveolar bone resorption in periodontitis is caused by increased activation of osteoclasts, causing an imbalance of bone remodeling. Periodontitis treatment can be done mechanically with Scaling and Root Planing and accompanied by metronidazole. Antibiotics have long-term drawbacks and can cause allergies, thus requiring an alternative to natural topical drugs such as brown algae gel. This study aimed to to analyzed the effect of brown algae gel (sargassum sp) on the number of osteoclasts of alveolar bone in periodontitis rats. Methods: The research method was a True Experimental with a pretest-posttest-only control group design. Rats were divided into three groups; negative control (K-) was not given any treatment, positive control (K+) was given metronidazole ties plus 25% concentration, and the treatment group (KP) was given brown algae gel (Sargassum sp) 75% concentration. Data were analyzed by Friedman and Kruskal Wallis test. Results:There was a significant difference in the number of osteoclasts on days 8, 10, and 12, the decrease in the number of osteoclasts was higher in the brown algae treatment group than the negative control group (p=0.051). In the positive control group, there was a significant difference in the decrease of the number of osteoclasts compared to the brown algae treatment group (p=0.029). The number of osteoclasts was significantly different on day 12 (p=0.026).Conclusion: Adhering brown algae (Sargassum sp.) gel decreases osteoclasts in periodontitis rats.Keywords: bone remodeling; bone resorption; brown algae gel (sargassum sp.); osteoclasts; periodontitis.

EDUKASI PEMANFAATAN BAHAN ALAM UNTUK KEBERSIHAN GIGI PADA WARGA KELURAHAN KALIGAWE Praptiningsih, Rahmawati Sri; Feranisa, Anggun
Jurnal Pengabdian Masyarakat DentMas Vol 2, No 2 (2024): Desember 2024
Publisher : Faculty of Dentistry Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/dentmas.2.2.29-33

Background: Dental cavities or caries are ranked first in oral diseases in the world population. In Indonesia, RISKESDAS 2018 data shows that the greatest prevalence of caries is in the age groups of 5 years (93.4%), 12 years (68.8%), 15 years (68.1%), 35-44 years (92.1%) and 65-74 years (95.2%). Dental plaque control can use natural resources that are widely available in Indonesia. However, the proper use of natural materials and adequate knowledge of the advantages and disadvantages of each type of natural resource are very important for the success of dental plaque control in the community.Objective : This community service is to provide education about natural ingredients for dental health as well as the advantages and disadvantages of each ingredient to the Kaligawe Village community and provide education about oral health and the importance of maintaining dental hygiene to maintain oral homeostasis.Method: The methods used to increase community knowledge and awareness are counseling and interactive discussions.Result: The results of this community service include an increase in understanding and community interest.Conclusion: This educational activity has succeeded in increasing the knowledge and awareness of the Kaligawe Village community about the importance of dental hygiene and the use of natural substances.

PROBIOTICS VS. BACTERIA: HOW LACTOBACILLUS CASEI BATTLES STREPTOCOCCUS MUTANS BIOFILM (IN VITRO) Praptiningsih, Rahmawati Sri; Sari, Rina Kartika; Ikhsandarujati, Renanda Rifki; Putranto, Rama
Jurnal Medali Vol 7, No 1 (2025): Media Dental Intelektual February 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.1.12-21

Background:Caries formation is influenced by several factors such as teeth, microorganisms, biofilm, and also time. The initial bacteria that play an important role in biofilm formation is Streptococcus mutans. Probiotics made from these bacteria are considered capable of overcoming dental and oral health problems because they are able to suppress the biofilm which will coat and protect the mucosa from invasion by cariogenic bacteria such as caries.Purpose:To determine the effect of the probioticLactobacillus casei in reducing Streptococcus mutans biofilm growth (in vitro).Method:The research design carried out was experimental research with a post test only control group design. The research samples were divided into 3 groups, namely the chlorhexidine, distilled water and probiotic groups. Biofilm thickness testing was carried out by OD (Optical density) using an ELISA-reader. Parametric statistical test analysis using the Kruskal Wallis Test.Results:The results of the Kruskal Wallis statistical test showed P= 0.000 there is a significant difference in the 3 Streptococcus mutans thickness test groups.Conclusion:The probioticLactobacillus casei has the effect of reducing the thickness of the Streptococcus mutans biofilm

The Effect Of Aloe Vera And Manuka Honey On IL-1 Level In Periodontitis Rats Muchaeroni, Isa Anshori; Praptiningsih, Rahmawati Sri; Feranisa, Anggun Feranisa; Aziz, Brahmadhia Satrio
Jurnal Medali Vol 7, No 2 (2025): Media Dental Intelektual August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.7.2.109-114

Background: Periodontitis is a chronic inflammatory disease that occurs as a result of the immune system's response to bacterial infection of the gums and surrounding tissues. This condition is caused by chronic inflammation and increased levels of proinflammatory mediators associated with chronic infectious conditions. Periodontitis can trigger inflammation by increasing the level of interleukin-1 (IL-1), which plays a role in the inflammatory response. Aloe vera (Aloe vera) and manuka honey are known to have anti-inflammatory properties and inhibits the production of pro-inflammatory cytokines, including IL-1. Purpose of this research to determine the effect of Aloe Vera and Manuka Honey on IL-1 level in periodontitis rats..Method: 30 rats were randomly divided into four groups; control group, Aloe vera groups, Madu manuka group, combination of Aloe Vera and Manuka Honey group. Aloe vera and Manuka Honey were injected at doses 150 uL in the gingival. At the 5th day after treatment, all rats were terminated and Elisa from gingival tissue was performed to identify the level of IL-1.Result: The results a significant decrease of IL-1 in combination of manuka honey and Aloe Vera group(p<0.000) compared to control groupConclusion: The combination of Aloe Vera and manuka honey significantly decreased on IL-1 level.

The Effectiveness Of Black Cumin Nanoemulsion Gel Concentration 10% And 15% On Staphylococcus Aureus Biofilm Thickness (In Vitro) Praptiningsih, Rahmawati Sri; Feranisa, Anggun; Amalina, Rizki; Nur Istighfah, Jafifah Mega
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.136-145

Background: Periodontal disease is a disease that often occurs in the oral cavity with prevalence in Semarang City increasing in 2016 by 67.18% to 89.53%. One of the causes of periodontal disease is the buildup of Stapylococcus aureus bacterial biofilm during the initial colonization of the tooth pellicle formation. One herbal ingredient that can be used as an antibacterial is black cumin (Nigella sativa). Gel nanoemulsion technology has the advantage of increasing material stability. This research aims to determine the effectiveness of black cumin gel nanoemulsion on the growth of Stapylococcus aureus biofilm thickness. Methods:The treatment group consisted of black cumin gel nanoemulsion with a concentration of 10% and a concentration of 15% and the control group, namely 0.2% chlorhexidine and distilled water. Stapylococcus aureus biofilm thickness was measured using an ELISA-reader. Statistical tests were carried out using the One Way Anova test. Results: The average thickness of Stapylococcus aureus with the addition of black cumin gel nanoemulsion with a concentration of 15% was the lowest, namely 0.046, while the thickness of Stapylococcus aureus with the addition of distilled water was the highest, namely 0.158. The One Way Anova test obtained a significance figure of 0.000 (p<0.05) so it could be concluded that there were significant differences in the 4 Stapylococcus aureus thickness test groups.Conclusion: Black cumin gel nanoemulsion concentrations of 10% and 15% have antibacterial properties which can reduce the thickness of Stapylococcus aureus biofilm.

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