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All Journal JURNAL TEKNOLOGI LINGKUNGAN Media Penelitian dan Pengembangan Kesehatan Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Buletin Kebun Raya BERITA BIOLOGI Jurnal Penelitian Pembelajaran Fisika MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Teknologi Indonesia Molekul: Jurnal Ilmiah Kimia Berita Biologi
Praptiwi Praptiwi
Puslit Biologi LIPI, Jl. Raya Jakarta-Bogor Km. 46 Cibinong 16911 Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Uji Aktivitas Antibakteri dan Sitotoksik Ekstrak Metanol Aglaia silvestris (M.Roemer) Merr. Praptiwi, Praptiwi
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 12, No 1 (2007): February 2007
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (158.795 KB) | DOI: 10.24002/biota.v12i1.2532

Abstract

The antibacterial and sitotoxic activities of ganggo (Aglaia silvestris (M.Roemer) Merr. methanol extract were determined in this study. Antibacterial in-vitro test of ganggo methanol extract was exposed to Gram positive (Staphylococcus aureus ATCC 25923, Streptococcus agalactiae ATCC 8190, and Streptococcus sp.) and Gram negative (Salmonella typhii NCTC 786 E, Eschericia coli ATCC 25922, and Pseudomonas pseudomallei ATCC 15682) bacteria. The extract concentrations were 50, 25 and 12.5%, and done in triplicate. The growth inhibition area of extract was compared to those of standard antibiotic (10 unit ampicilin). Cytotoxic test of ganggo extract was done utilizing Brine Shrimp Lethality Test (BST) with Artemia salina.The result showed that growth inhibition area of 12.5% ganggo methanol extract to P. pseudomallei (19 mm) was wider than that of 10 unit ampicilin (0 mm). It showed that P. pseudomallei was sensitive to ganggo methanol extract. The result of BST showed that LC50 of ganggo extract was 345.44 ppm. It was concluded that ganggo methanol extract had antibacterial effects on some bacteria isolates and had cytotoxic effects with LC50 345.44 ppm.
TOKSISITAS AKUT ORAL DUA SENYAWA BISANTRAKUINON (+)-2,2’-EPISITOSKIRIN A DAN (+)-1,1’-BISLUNATIN [ORAL ACUTE TOXICITY OF TWO BISANTHRAQUINONES (+)-2,2’-EPICYTOSKYRIN A AND (+)-1,1’-BISLUNATIN] Praptiwi, Praptiwi; Nurkanto, Arif; Wulansari, Dewi; Agusta, Andria
BERITA BIOLOGI Vol 14, No 1 (2015)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v14i1.1858

Abstract

Bisanthraquinones (+) - 2,2'-epicytoskyrin A and (+) -1,1'bislunatin produced by the endophytic fungus Diaporthe sp. GNBP-10 showed potent antibacterial activity on in-vitro test and have the opportunity to become new antibiotics candidates. The aspects of safety and toxicity of drug candidates have to be examined before applying to human. This study was conducted to determine the safety aspects of the compounds through acute oral toxicity testing in mice (Mus musculus). Acute toxicity of (+) - 2,2'-epicytoskyrin A and (+) - 1,1'-bislunatin evaluated by the method of Up and Down Procedure with limit test at a dose of 2000 mg / kg. Results of acute toxicity test showed that the LD50 of (+) - 2,2'-epicytoskyrin A and (+) - 1,1'-bislunatin were of 1638.87 mg / kg and > 2000 mg / kg respectively. Administration of (+)- 2,2'-epicytoskyrin A resulted in increased miliari multifocal hepatitis, fatty degeneration and necrosis of liver cells, and the renal tubule epithelial degeneration. Administration of (+) - 1,1'-bislunatin at a dose of 2000 mg / kg resulted in multifocal accumulation of inflammatory cells in the liver and degeneration of cells in the islets of Langerhans although not resulting in death. The administration of those compounds indicated the changes in the organs, but based on the UN/ECE classification of LD50 value showed that (+) 2,2'- epicytoskyrin A and (+) -1,1'-bislunatin included as low acute toxicity substance.
SKRINING AWAL AKTIVITAS ANTIBAKTERI DAN ANTIOKSIDAN EKSTRAK SEMUT (INSECTA: FORMICIDAE) DARI GARUT - JAWA BARAT Efendy, Oscar; Fathoni, Ahmad; Praptiwi, Praptiwi; Royyani, Mohammad Fathi; Wulansari, Dewi; Agusta, Andria
BERITA BIOLOGI Vol 18, No 2 (2019)
Publisher : Research Center for Biology-Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/beritabiologi.v18i2.3621

Abstract

Studies on the therapeutic use of insects and insect products have been neglected compared to the use of other animals or plants.This study aims to determine the antibacterial and antioxidant potential of ants extracts. Preliminary study related to antibacterial and antioxidant screeningof 17 extracts of ant colonies that belongs to 8 species were performed by Thin Layer Chromatography (TLC)-Bioautography. Antioxidant activity was measured by DPPH free radical scavenging method. The antibacterial activity was done against three pathogenic bacteria, i.e Bacillus subtilis InaCC B-1, Staphylococcus aureus InaCC B-4 and Escherichia coli InaCC B-5 were performed by non-eluted TLC-autobiography assay. The minimum inhibitory concentration (MIC) and IC50 values of DPPH radical scavenging activity of active extracts were determined by microdilution in 96-well microplate. The results showed 6 extracts active against B.subtilis, 5 extracts active against S.aureus. The lowest MIC value was 512 µg/ ml.  Ten extracts had the antioxidant activity with various IC50 values. The extracts of ants might be used as bioactive resources for antibacterial and antioxidant.  
IDENTIFIKASI SENYAWA KIMIA DAN AKTIVITAS ANTIBAKTERI EKSTRAK Piper Sp. ASAL PAPUA Priyono, Sumarnie; Praptiwi, Praptiwi
Jurnal Teknologi Lingkungan Vol. 10 No. 3 (2009)
Publisher : Center for Environmental Technology - Agency for Assessment and Application of Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.327 KB) | DOI: 10.29122/jtl.v10i3.1473

Abstract

The aim of this study was to identity the chemical compounds of the piper sp.Fruit originated from Papua, that has been used as “sirih pinang”(chew betle)and to determine the antibacterial activity of hexane and chloroform extraxt ofpiper sp. to Gram + bacteria isolates(Bacillus subtilis, Listeria monocytogenesdan Staphylococcus aureus) and Gram – bacteria isolates(Salmonellatyphimurium, Eschericia coli and Pseudomonas pseudomallei). The extractconcentration were 50 % and 25 %, and every treatment consisted of 3replications. The bacteriae growth media was Mueller Hinton Agar(MHA). Theresult of phytochemical screening of Piper sp.fruit(ether, alcohol,and waterextracts)showed that it contained esential oil, lipid,emodol,tannin,reducingsugar, anthrasenoid,polyuronide,glucocide,steroid glycoside.
Manfaat Buah Kurma Praptiwi, Praptiwi; Arti, Dwi Windu Kinanti
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 4 (2017): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (122.928 KB) | DOI: 10.26714/magnamed.1.4.2017.20-25

Abstract

Benefits of DatesBackground: Sweetener is always related to its cariogenecity. White sugar is the most cariogenic sweetener, while date rich of natural sucrose and fructose. Date tannin and magnesium have anti infection and anti inflammation properties. The analytical laboratoric study using experimental design wanted to know the differencies between saliva pH after consumptions of sucrose, fructose, and date. The study was executed in Faculty of Dentistry and Integrated Laboratory of Muhammadiyah University in Semarang, 2016.Methods: Sample of study was 18 students of the Faculty having caries ≤ 2. Initial pH saliva was measured after ½ hour fasting, followed by tap water rinsing, consumptions of 1 g sucrose, 1 g fructose, and a date. Result: T dependent test, and one way Anova were used. Mean of saliva pH and SD were found consecutively as follows, initial 6.92; 0.217; tap water rinsing 6.91; 0.151, sucrose consumption 6.83; 0.229, fructose 6.90; 0.156, and date 7.04; 0.086. No significant difference between initial pH and after tap water rinsing. There was significant difference between saliva pH after sucrose, fructose, and date consumptions (p value 0.002; p < 0.05).Conclusion: Saliva pH after consumptions of sucrose and fructosa were lower than date; sucrose and fructose were more acidic and cariogenious than date.
Antioxidant and Antibacterial Activities of Plant and Endophytic Fungi Extracts from Syzygium myrtifolium Walp, with LC-HRMS Profiling of Active Extracts Efendi, Sintia Frisky; Suryati, Suryati; Rahmi, Dwinna; Praptiwi, Praptiwi; Ilyas, Muhammad; Agusta, Andria
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.16366

Abstract

ABSTRACT. The emergence of antibiotic resistance and oxidative stress-related diseases highlights the urgent need for novel bioactive compounds. This study investigates the potential of Syzygium myrtifolium Walp. and its endophytic fungi as sources of antibacterial and antioxidant agents. Sixteen endophytic fungi isolates were obtained from six plant parts and identified morphologically. Thin layer chromatography (TLC)-based chemical profiling demonstrated comparable secondary metabolite patterns between the plant and its endophytic fungi, indicating possible shared biosynthetic pathways. Antibacterial screening using TLC-bioautography and minimum inhibitory concentration (MIC) assays demonstrated that both the plant and endophytic fungi extracts inhibited the growth of Staphylococcus aureus and Escherichia coli, with Xylaria sp. showing notable activity. (SmDh4) exhibiting the strongest activity (MIC = 64 µg/mL). Antioxidant activity determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay indicated high to very high radical inhibition capacity, especially in SmRTd (AAI = 25.91) and SmAk1 (AAI = 24.97). Liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis unique secondary metabolites on endophytic fungi, including L-α-palmitin, α-eleostearic acid, and 8-methylnaphthalene-1,2-diol, which were detected exclusively in the endophytic fungi extracts, highlighting their potential as alternative antibacterial and antioxidant agents. Keywords: Antibacterial, antioxidant, endophytic fungi, secondary metabolites, Syzygium myrtifolium Walp.
ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF ETHYL ACETATE EXTRACT OF ACTINOMYCETES ISOLATED FROM TERMITE NESTS Fathoni, Ahmad; Kamal, Andi Saptaji; Hafid, Lukman; Marlina, Lina; Efendy, Oscar; Putri, Ade Lia; Praptiwi, Praptiwi; Agusta, Andria
Berita Biologi Vol 23 No 1 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/beritabiologi.2024.3618

Abstract

Actinomycetes are an important source for the discovery of bioactive secondary metabolite compounds. Over 10,000 bioactive metabolite compounds have been isolated from terrestrial actinomycetes with various biological activities, such as antibiotic, antiviral, anti-inflammatory, antitumor, anticancer, and antioxidant. One source of origin for actinomycetes is soil, including termite nests. Utilization of natural sources such as actinomycetes from termite nests as antioxidants and antibacterials can be an alternative source of production of new secondary metabolite compounds. This research aims to evaluate the antioxidant and antibacterial activities of actinomycete extracts from termite nests. Antioxidant activity using the DPPH free radical scavenging method, and antibacterial activity against S. aureus. Antioxidant and antibacterial activity were performed by using the TLC dot-blot, TLC bioautography, and microdilution methods to determine the inhibitory concentration of 50% (IC50), antioxidant activity index (AAI), and minimum inhibitory concentration (MIC). From the 33 extracts tested, 16 extracts showed antioxidant activity with IC50 values range of 76.64-126.22 µg/mL or AAI value > 0.05 (moderate), and 8 extracts had moderate antibacterial activity against S. aureus (MIC values range of 256-512 µg/mL). Future research for scaling-up of actinomycete culture, isolating of active compounds, determining of the chemical structure of active compounds, and further testing as antioxidants and antibacterials still need to be carried out.
Co-Authors Ahmad Fathoni ANDRIA AGUSTA Arif Nurkanto Arti, Dwi Windu Kinanti Arti, Dwi Windu Kinanti Chairunnisa Chairunnisa Dewi Ratih Agungpriyono DEWI WULANSARI Dwinna Rahmi Efendi, Sintia Frisky Efendy, Oscar Emma Sri Kuncari Hafid, Lukman Hartutiningsih-M. Siregar Jeffry Handhika Kamal, Andi Saptaji Kartika Dyah Palupi lina marlina, lina Mindarti Harapini Mohammad Fathi Royyani, Mohammad Fathi Muhammad Ilyas Priyono, Sumarnie Putra, Aldho Pramana Putri, Ade Lia R. Subekti Purwantoro SUDARMONO SUDARMONO Suryati Suryati Tri Murningsih, Tri Yuliasri Jamal