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All Journal Journal Of Vocational Health Studies Jambura Nursing Journal PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat 2-TRIK: TUNAS-TUNAS RISET KESEHATAN Jurnal Kesehatan Terpadu (Integrated Health Journal) PREPOTIF : Jurnal Kesehatan Masyarakat Community Development Journal: Jurnal Pengabdian Masyarakat Media Gizi Kesmas Jurnal Nasional Pengabdian Masyarakat Global Health Science (GHS) Gema Lingkungan Kesehatan Media Kesehatan Politeknik Kesehatan Makassar Poltekita: Jurnal Ilmu Kesehatan Science Techno Health Journal Jurnal Ilmu Keperawatan dan Kebidanan
Suardi Zurimi
Poltekkes Kemenkes Maluku
Agriculture, Biological Sciences & Forestry Humanities Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Toluene Exposure Concentration and Neurotoxic Risk Quotient among Industrial Workers in Surabaya: A Cross-Sectional Study Zurimi, Suardi; Tualeka, Abdul Rohim
Poltekita: Jurnal Ilmu Kesehatan Vol. 19 No. 3 (2025)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v19i3.4213

Abstract

Background: Toluene poses significant health hazards to humans. Occupational exposure among workers who use toluene as a solvent may lead to various adverse health effects, including dizziness, vertigo, ocular and skin irritation, respiratory disturbances, as well as disorders of the liver, kidneys, and central nervous system. This study aimed to examine the association between toluene concentration and non-carcinogenic risk characteristics with neurotoxic effects across five industrial settings in the Surabaya region. Methods: This observational study employed a cross-sectional design and was conducted in five industries in Surabaya that utilize toluene as a solvent in their production processes, located in Osowilangun, Ketintang, Jemursari, Kalijudan, and AUP Which will be implemented in 2025. The study population consisted of 90 workers exposed to toluene, of whom 77 participants were selected using an accidental sampling technique. The variables examined included toluene concentration, toluene risk quotient (RQ), and neurotoxic effects. Results: Overall, 50 workers (65%) had unsafe risk quotient (RQ) levels, and 48 workers (62.3%) experienced neurotoxic effects. Although the majority of workers (52.0%) were exposed to toluene concentrations below the threshold limit value, those exposed to concentrations above the threshold had a 1.38-fold higher risk of neurotoxic effects, and workers with unsafe RQ had a 1.4-fold increased risk compared with those with safe RQ. Statistical analysis showed no significant association between toluene concentration or RQ and neurotoxic effects (p > 0.05). Conclusion: Although not statistically significant, the study suggests that the Risk Quotient (RQ) of toluene is a key determinant of neurotoxic risk, highlighting the importance of monitoring and controlling exposure in the workplace.
Efek Asupan Antioksidan Kaya Enzim Cytochrome P450 2E1 (CYP2E1) Terhadap Kadar Leukosit Baharuddin M. Subandi; Suardi Zurimi; Abdul Rohim Tualeka; Nanda Bella Puspitaloka
Media Kesehatan Politeknik Kesehatan Makassar Vol 19 No 2 (2024): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v19i2.1051

Abstract

The human body has an enzymatic antioxidant system, but its capacity is not always sufficient when the amount of free radicals is excessive. The approach of consuming antioxidants rich in the CYP2E1 enzyme is used to help the body detoxify benzene metabolites so they can be excreted from the body. The aim of this study is to analyze the effect of consuming antioxidants rich in the CYP2E1 enzyme on changes in leukocyte levels among workers in the Tambak Osowilangun Surabaya home-based shoe industry. This type of research is a pre-experimental study using a one-group pre-test post-test design. The sample used in this study was total population sampling, consisting of all 27 workers in the Tambak Osowilangun home-based shoe industry. The intervention provided was in the form of antioxidant supplements in powder form, with a dosage of 15 grams, consumed twice a day for 5 consecutive days. Leukocyte levels were measured by taking blood samples from the workers on the first day before the intervention and on the fifth day after the intervention. The results of the study showed changes in the leukocyte levels of all workers after the treatment. There was an increase in the number of workers who reached normal leukocyte levels (92.6%). However, some workers did not reach normal leukocyte levels (7.4%) despite experiencing changes in their leukocyte levels. The conclusion of this study is that the intervention was effective in normalizing the workers' leukocyte levels, particularly in female workers, those of productive age, with normal BMI, non-smokers, those who engage in physical activity/exercise, and those who do not use personal protective equipment (PPE). It is recommended that workers regularly engage in exercise that suits their preferences and body needs, adopt a balanced diet, consume foods rich in antioxidants, use brushes when applying glue, and use standard PPE such as N95 masks, gloves, and aprons..  Keywords: leukocyte count; antioxidant; CYP2E1
Co-Authors Abdul Rohim Tualeka Adolfina Bumbungan Adolfina Bumbungan Ahsan Ahsan Aisa Jiali Akbar, Muhammad Ihzario Ibrahim Azeez Olawale Ojelabi Baharuddin M. Subandi Baharudin M. Subandi Farha Assagaf Hairudin Rasako Hariawan, Hamdan Ida Djafar Indriati Paskarini Jalaludin, Juliana Juliana Jalaludin Lain, Bachrudin Mintje M Nendissa Nanda Bella Puspitaloka Nendissa, Mintje Maria Pudji Rahmawati Rizal Rizal Rizaldy Fathur Rachman Sahalessy, Yona C. Salsabila Novianti Suratno Kaluku Tamilanban Thamaraikani Tidore, Martini Tomasoa, Johanna Velu Perumal Y Denny Ardyanto W