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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Majalah Kesehatan FKUB Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) ISM (Intisari Sains Medis) : Jurnal Kedokteran Heart Science Journal Asian Journal of Health Research
Nugrahanti Prasetyorini
Laboaratorium Obstetri Ginekologi Fakultas Kedokteran Universitas Brawijaya/ RS. Dr. Saiful Anwar
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : asian journal of health research

 1 
In Vivo Studies Exploring the Impact of IUGR in Rat Models on Offspring Malnutrition: A Systematic Review Sukandar, Umar Gunarsa; Prasetyorini, Nugrahanti
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.194

Abstract

Introduction: Intrauterine growth restriction (IUGR), stemming from inadequate fetal nutrition due to maternal or placental factors, affects 10–15% of pregnancies worldwide. Animal models reflect human IUGR, showing malnutrition-associated outcomes like impaired growth, reduced body weight, delayed puberty, and disruptions in genetic and hormonal processes. Despite extensive research, gaps persist in understanding how IUGR impacts fetal outcomes, particularly regarding malnutrition-related outcomes. Material and Methods: The literature search was conducted in four databases. Several outcomes were analyzed, including the timing of puberty, weight and body composition, and organ development, which represented the IUGR rat's malnutrition condition. Throughout the identification process, 11 articles were included in the systematic review. Results: Research consistently demonstrates that IUGR in rat models results in delayed puberty, characterized by delayed vaginal opening and lower body weights compared to controls across early and later developmental stages. Additionally, IUGR adversely affects organ development, with studies showing reduced brain weights, diminished ovarian and mammary gland development, and altered sizes of reproductive organs. Furthermore, IUGR disrupts hormonal and genetic profiles, as evidenced by changes in ovarian follicle counts, altered gene expressions related to testicular development, and dysregulated metabolic pathways. All malnutrition-related outcomes significantly differed between IUGR and control rats (p < 0.05). Conclusion: IUGR in rat models consistently induces developmental delays and physiological impairments in offspring, characterized by delayed puberty, reduced body weights, and compromised organ development, highlighting the adverse consequences of malnutrition associated with IUGR.
Pregnancy with Bidirectional Dominant Left-To-Right Shunt due to Ventricular Septal Defect and Large Secundum Atrial Septal Defect with Left-To-Right Shunt: A Case Report Destikatari, Lovin; Prasetyorini, Nugrahanti; Putri, Valerinna Yogibuana Swastika
Asian Journal of Health Research Vol. 4 No. 1 (2025): Volume 4 No 1 (April) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i1.218

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Introduction: Congenital heart disease (CHD) is the most common birth defect in humans, affecting approximately 0.8% of all live births. The spectrum of defects is broad, ranging from complex defects that lead to severe disability and death in infancy, to mild defects that may only be discovered later in asymptomatic adults. Case Presentation: This case report discusses a 21-year-old female in her second pregnancy was diagnosed with complex congenital heart disease after presenting with shortness of breath. Pulmonary hypertension was established by echocardiography. The woman did not obtain proper therapy since she was not aware of her cardiac problem during her pregnancy. There were no fetal abnormalities found during prenatal exams. At 38 weeks gestation, an IUD-assisted cesarean surgery was scheduled. While a cesarean section is performed on individuals with certain problems, the majority of CHD cases may be successfully delivered vaginally. Another crucial factor to take into account is the choice of postpartum contraception. Conclusion: A personalized strategy is needed to manage congenital heart disease throughout pregnancy. This includes risk education, careful observation, and modification of interventions to guarantee the best possible results for both mother and child.
Elevated Blood Pressure in Rat Offspring with Induced Intrauterine Growth Restriction: A Systematic Review Patridina, Geneung; Prasetyorini, Nugrahanti
Asian Journal of Health Research Vol. 4 No. 2 (2025): Volume 4 No 2 (August) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i2.244

Abstract

Introduction: Intrauterine growth restriction (IUGR), often caused by placental insufficiency, is a significant obstetric issue associated with adverse long-term health outcomes, including hypertension. This systematic review investigates the association between induced IUGR and elevated blood pressure in rat offspring.    Material and Methods: A systematic search of PubMed, SpringerLink, and the Cochrane Library was conducted on February 10, 2023, following PRISMA guidelines. Studies were included if they involved rat models of placental insufficiency-induced IUGR with documented birth weight reduction and blood pressure measurements compared to a control group. Data were extracted for meta-analysis using Review Manager 5.    Results: Eight studies met the inclusion criteria. Meta-analysis revealed a significant increase in both mean arterial pressure (MAP) (Mean Difference: 9.84, 95% CI: 2.69–16.99, p = 0.007) and systolic blood pressure (SBP) (Mean Difference: 13.09, 95% CI: 7.87–18.32, p < 0.00001) in IUGR offspring compared to controls. The increase in SBP was more pronounced in male offspring than in females.    Conclusion: Induced IUGR in rats leads to significantly elevated blood pressure, with a greater effect observed in males. Rat models provide valuable insights into the developmental origins of hypertension, though they may overestimate the effect and not fully replicate the human condition. The endothelin system and sex hormones are implicated in this sexually dimorphic response.
Co-Authors Ade Setyagraha Bambang Rahardjo Dea Florensia Destikatari, Lovin Dewi, Ratih Frastika Dhelya Widasmara Harumsari, Stefani I Wayan Subage Insanitaqwa, Aleyda Zahratunany Kusnarman Keman Madeline J. Langgar Mohammad Saifur Rohman Noorhamdani AS Pande Made Dwijayasa Patridina, Geneung Puspita Handayani Putri, Valerinna Yogibuana Swastika Santosa Basuki Sukandar, Umar Gunarsa Tatit Nurseta Wibisono, Hermawan Wiyasa, I Wayan Arsana Yahya Irwanto Yogibuana, Valerinna