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Correlation between duration of chronic renal failure patients undergoing hemodialysis and sensorineural hearing loss Primadewi, Novi; Pratiwi, Dewi; Dewi, Taufani
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 2 (2022): VOLUME 52, NO. 2 JULY - DECEMBER 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i2.453

ABSTRACTBackground: Along with the increasing incidence of chronic renal failure patients receiving hemodialysis, recently, the incidence of sensorineural hearing loss (SNHL) among patients with end-stage kidney disease undergoing hemodialysis had also increased. The cochlea and kidney have many anatomical, physiological, pharmacological and pathological similarities. Dialysis sometimes causes worsening of hearing function. Objective: To determine the correlation between the duration of renal failure patients undergoing hemodialysis and the degree of sensorineural hearing loss. Method: A retrospective study using cross sectional method, conducted from August–September 2018. The study began by identifying patients with chronic renal failure and then continued with Oto Acoustic Emission (OAE) examination and pure tone audiometry. Result: The results of the Spearman rank statistical test for the correlation between duration of hemodialysis and the degree of SNHL in the right and left ears in patients with chronic renal failure found a significant positive correlation r= 0.498 and p=0.001 (right) , and r= 0.400 and p=0.006 (left). Conclusion: There was a significant correlation between the length of hemodialysis and the degree of sensorineural hearing loss. ABSTRAKLatar belakang: Seiring dengan peningkatan angka kejadian pasien gagal ginjal kronik yang mendapatkan hemodialisa, akhir-akhir ini didapati peningkatan angka kejadian Sensorineural Hearing Loss (SNHL) di antara pasien dengan penyakit ginjal stadium akhir yang menjalani hemodialisa. Koklea dan ginjal memiliki banyak kesamaan anatomis, fisiologis, farmakologis dan patologis. Dialisa terkadang menyebabkan memburuknya fungsi pendengaran. Tujuan: Untuk mengetahui hubungan lama pasien gagal ginjal yang menjalani hemodialisa dengan derajat gangguan pendengaran tuli sensorineural. Metode: Penelitian retrospektif dengan metode potong lintang, dilakukan dari Agustus-September 2018. Penelitian dimulai dengan mengidentifikasi pasien gagal ginjal kronik kemudian dilanjutkan dengan pemeriksaan tes Oto Acoustic Emission (OAE) dan audiometri nada murni. Hasil: Hasil uji statistik Spearman rank untuk korelasi lama hemodialisa dengan derajat SNHL telinga kanan dan kiri pada pasien gagal ginjal kronik didapatkan korelasi positif yang signifikan: r= 0,498 dan p=0,001 (kanan) dan r= 0,400 dan p=0,006 (kiri). Kesimpulan: Terdapat korelasi yang bermakna antara lama hemodialisis dengan derajat tuli sensorineural.

Adaptation of Chronic Otitis Media Questionnaire (COMQ-12): reability and validity of the Indonesian version Sudrajad, Hadi; Hendradewi, Sarwastuti; Primadewi, Novi; Kandhi, Putu Wijaya; Seytopambudi, Kukuh
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.688

Background: Chronic suppurative otitis media (CSOM) is one of the most common ear diseases that has a major impact on quality of life (QoL). The Chronic Otitis Media Questionnaire 12 (COMQ-12) is a CSOM-specific questionnaire that aims to assess QoL. Until currently, there is no questionnaire that has been tested for reliability and validity in the Indonesian version. Purpose: To assess the reliability and validity of the Indonesian version of COMQ-12. Method: An analytic observational study with a cross-sectional design, conducted in Dr. Moewardi General Hospital Surakarta Indonesia from March to May 2024. Reliability was assessed by internal consistency, and validity was assessed by Pearson correlation. Result: The reliability test with internal consistency obtained Cronbach’s alpha value for all question items >0.7. This indicated that all question items had good reliability. Meanwhile, the validity test with the Pearson correlation test obtained a p-value <0.05 for all question items with coefficients, all of which were positive. This indicated that all question items had good validity. Conclusion: Indonesian version of COMQ-12 has good reliability and validity to assess QoL in CSOM patients. Keywords: CSOM, COMQ-12, QoL, reliability, validity ABSTRAK Latar belakang: Otitis media supuratif kronik (OMSK) merupakan salah satu penyakit telinga yang paling umum dijumpai, dan berdampak besar pada kualitas hidup (QoL). Kuesioner Otitis Media Kronik 12 (COMQ-12) merupakan kuesioner khusus Otitis Media Supuratif Kronik (OMSK) yang bertujuan untuk menilai QoL, namun saat ini kuesioner COMQ-12 dalam versi Bahasa Indonesia belum teruji reliabilitas dan validitasnya. Tujuan: Untuk menilai reliabilitas dan validitas COMQ- 12 versi Bahasa Indonesia. Metode: Penelitian observasi analitik dengan desain potong lintang, yang dilakukan di RSUD Dr. Moewardi Surakarta, Indonesia dari bulan Maret sampai Mei 2024. Reliabilitas dinilai dengan konsistensi internal, dan validitas dinilai dengan korelasi Pearson. Hasil: Uji reliabilitas dengan konsistensi internal memperoleh nilai Cronbach’s alpha untuk semua butir soal >0,7. Hal ini menunjukkan bahwa semua butir soal memiliki reliabilitas yang baik. Sementara itu, uji validitas dengan uji Pearson correlation memperoleh nilai p<0,05 untuk semua butir soal, dengan koefisien yang semuanya positif. Hal ini menunjukkan bahwa semua butir soal memiliki validitas yang baik. Kesimpulan: COMQ-12 versi Indonesia mempunyai reliabilitas dan validitas yang baik untuk menilai kualitas hidup pasien OMSK.

Antioxidant Ability of the 2% Indonesian Mount Lawu Propolis Ear Drops Sudrajad, Hadi; Setiamika, Made; Hendradewi, Sarwastuti; Primadewi, Novi; Kandhi, Putu Wijaya; Pratiwi, Dewi; Kesumo, Aningdita; Pratiwi, Primadita Asis
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.53208

Propolis ear drops are natural antioxidants that have been developed for various health purposes. There are many types of propolis ear drops available today, including the Indonesian Mount Lawu Propolis ear drop (IMLPED). Indonesian Mount Lawu Propolis ear drop is proven to contain many antioxidant substances such as flavonoids, phenolic acids, caffeic acid pethyl ester, and quercetin. However, to date, no study has assessed the antioxidant activity of IMLPED, especially the 2% IMLPED. This study aims to assess the antioxidant activity of the 2% IMLPED. This is an in vitro study to assess the antioxidant activity of the 2% IMLPED with 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) method based on the inhibitory concentration at 50% (IC50) value. The IC50 represents the concentration required to reduce 50% of the free radicals. The result of this study showed that the IC50 value of the 2% IMLPED is 30.71 µg/mL. Based on the IC50 value, the 2% IMLPED formula exhibits a robust antioxidant effect. The implications of this revelation establish IMLPED as a promising candidate in combating oxidative stress.

PENEGAKAN DIAGNOSIS NEUROPATI AUDITORI : SEBUAH LAPORAN KASUS Primadewi, Novi; Anggraini, Rinda Putri; Aditya, Destar
Indonesian Basic and Experimental Health Sciences Vol. 12 No. 1 (2023): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol12iss1pp41-54

PENDAHULUAN Neuropati auditori merupakan bagian dari tuli sensorineural, dimana suara dapat masuk hingga telinga dalam, tetapi transmisi sinyal dari telinga dalam ke otak terganggu pada jaras tertentu. Evaluasi klinis serta pemeriksaan yang tepat dibutuhkan pada penegakkan diagnosis neuropati auditori sehingga tatalaksana yang tepat dapat segera diberikan. LAPORAN KASUS Dilaporkan seorang anak laki-laki umur 1 tahun 8 bulan dengan keluhan belum dapat bicara sesuai usianya dan tidak respon terhadap panggilan ataupun suara keras. Pasien mempunyai riwayat hiperbilirubinemia pada usia 2 minggu. Pasien dilakukan pemeriksaan OAE dengan hasil normal, ABR/BERA terdapat gelombang mikroponik koklea pada intensitas 90-95 dB dan tidak tampak gelombang V pada intensitas 70-95 dB dan ASSR hasil ambang dengar gangguan derajat berat. DISKUSI Diagnosa neuropati auditori dapat ditegakkan dengan pemeriksaan Otoacoustic Emission (OAE) dengan hasil fungsi sel rambut luar koklea normal dan pada auditory brainstem respons (ABR/BERA) didapatkan Cochlear Microphonic (CM) normal atau pernah ada dalam satu waktu tetapi respons gelombang tidak normal atau tidak ada. Pada kasus ini telah dilakukan penegakan diagnosis yang sesuai dengan panduan. KESIMPULAN Diagnosa neuropati auditori dapat ditegakkan dengan pemeriksaan Otoacoustic Emission (OAE) dengan hasil fungsi sel rambut luar koklea normal dan pada auditory brainstem respons (ABR/BERA) didapatkan Cochlear Microphonic (CM) normal atau pernah ada dalam satu waktu tetapi respons gelombang tidak normal atau tidak ada.

The Effect Of Administration Of Mecobalamin & Curcumin As Antioxidants In Nasopharynx Carcinoma Patients Post Cisplatin Regimen Chemotherapy With Hearing Impairment Matea, Ari; Primadewi, Novi
Indonesian Basic and Experimental Health Sciences Vol. 13 No. 1 (2024): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol13iss1pp1-6

INTRODUCTION Nasopharyngeal carcinoma (NPC) is a common type of cancer in Southeast Asia, and its treatment often involves a cisplatin chemotherapy regimen. Ototoxicity is a side effect that often occurs in patients receiving this regimen. Antioxidant therapy, both synthetic and natural, such as curcumin, has been studied as having the potential to reduce ototoxicity due to cisplatin. This study was conducted to evaluate the effect of administering mecobalamin and curcumin as antioxidants in patients with nasopharyngeal carcinoma after cisplatin chemotherapy regimen with hearing loss. METHOD This study was an observational study with a cross sectional design, using consecutive sampling with inclusion criteria, namely patients diagnosed with NPC receiving the cisplastin regimen and willing to take part in the study. The data obtained was then analyzed using the Rank-Biserial Correlation's Test. Research approval was obtained from the Medical Research Ethics Commission, Faculty of Medicine, Sebelas Maret University/RSUD Dr. Moewardi Surakarta. RESULTS Of the 30 NPC patients who received cisplatin from the ENT-KL installation section of Dr Moewardi Hospital in the period March - September 2023, 30 data were obtained for each right ear and left ear. The average hearing threshold before intervention was 33.79 ± 10.40 dB and 34.10 ± 9.75 for the right and left ears. There was a difference in the average increase in hearing threshold for all parameters (Group I: Mecobalamin, Group II: Curcumin, Group III: Curcumin + Mecobalamin), with a value of p=0.000 (p<0.05). From these data it was concluded that the combined therapy of both was able to increase the hearing threshold along with the chemotherapy series. CONCLUSION Based on the research results, administration of mecobalamin and curcumin as antioxidants has a significant effect on patients with nasopharyngeal carcinoma after cisplatin chemotherapy regimen with hearing loss.

Adaptation of Chronic Otitis Media Questionnaire (COMQ-12): reability and validity of the Indonesian version Sudrajad, Hadi; Hendradewi, Sarwastuti; Primadewi, Novi; Kandhi, Putu Wijaya; Seytopambudi, Kukuh
Oto Rhino Laryngologica Indonesiana Vol. 54 No. 2 (2024): VOLUME 54, NO. 2 JULY - DECEMBER 2024
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v54i2.688

Background: Chronic suppurative otitis media (CSOM) is one of the most common ear diseases that has a major impact on quality of life (QoL). The Chronic Otitis Media Questionnaire 12 (COMQ-12) is a CSOM-specific questionnaire that aims to assess QoL. Until currently, there is no questionnaire that has been tested for reliability and validity in the Indonesian version. Purpose: To assess the reliability and validity of the Indonesian version of COMQ-12. Method: An analytic observational study with a cross-sectional design, conducted in Dr. Moewardi General Hospital Surakarta Indonesia from March to May 2024. Reliability was assessed by internal consistency, and validity was assessed by Pearson correlation. Result: The reliability test with internal consistency obtained Cronbach’s alpha value for all question items >0.7. This indicated that all question items had good reliability. Meanwhile, the validity test with the Pearson correlation test obtained a p-value <0.05 for all question items with coefficients, all of which were positive. This indicated that all question items had good validity. Conclusion: Indonesian version of COMQ-12 has good reliability and validity to assess QoL in CSOM patients. Keywords: CSOM, COMQ-12, QoL, reliability, validity ABSTRAK Latar belakang: Otitis media supuratif kronik (OMSK) merupakan salah satu penyakit telinga yang paling umum dijumpai, dan berdampak besar pada kualitas hidup (QoL). Kuesioner Otitis Media Kronik 12 (COMQ-12) merupakan kuesioner khusus Otitis Media Supuratif Kronik (OMSK) yang bertujuan untuk menilai QoL, namun saat ini kuesioner COMQ-12 dalam versi Bahasa Indonesia belum teruji reliabilitas dan validitasnya. Tujuan: Untuk menilai reliabilitas dan validitas COMQ- 12 versi Bahasa Indonesia. Metode: Penelitian observasi analitik dengan desain potong lintang, yang dilakukan di RSUD Dr. Moewardi Surakarta, Indonesia dari bulan Maret sampai Mei 2024. Reliabilitas dinilai dengan konsistensi internal, dan validitas dinilai dengan korelasi Pearson. Hasil: Uji reliabilitas dengan konsistensi internal memperoleh nilai Cronbach’s alpha untuk semua butir soal >0,7. Hal ini menunjukkan bahwa semua butir soal memiliki reliabilitas yang baik. Sementara itu, uji validitas dengan uji Pearson correlation memperoleh nilai p<0,05 untuk semua butir soal, dengan koefisien yang semuanya positif. Hal ini menunjukkan bahwa semua butir soal memiliki validitas yang baik. Kesimpulan: COMQ-12 versi Indonesia mempunyai reliabilitas dan validitas yang baik untuk menilai kualitas hidup pasien OMSK.

Gambaran Klinis Telinga Hidung Tenggorokan Pasien SARS CoV-2 di RSUD Dr. Moewardi Pratiwi, Dewi; Sudrajad, Hadi; Hendradewi, Sarwastuti; Setiamika, Made; Kandhi, Putu Wijaya; Primadewi, Novi; Hariyadi, Vicky Eko Nurcahyo; Wicaksono, Adisetya; Dewi, Marisa Rizqiana
Smart Medical Journal Vol 5, No 1 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i1.54111

ABSTRAKPendahuluan: COVID-19 merupakan infeksi yang disebabkan oleh SARS-CoV-2. Prevalensi kasus COVID-19 di Indonesia pada akhir tahun 2020 mencapai 750.000 kasus dan terus meningkat hingga saat ini. Manifestasi klinis yang dialami oleh pasien COVID-19 cukup beragam. Tujuan penelitian ini adalah untuk mengetahui gambaran klinis telinga hidung tenggorokan (THT) pasien SARS CoV-2 di RSUD Dr. Moewardi Surakarta.Metode: Penelitian cross-sectional melibatkan 316 pasien terkonfirmasi SARS-CoV-2 positif di RSUD Dr. Moewardi, Surakarta, Jawa Tengah selama April sampai Juni 2021. Dilakukan pemeriksaan PCR untuk melihat status infeksi SARS-CoV-2 dan anamnesis untuk melihat gambaran klinis telinga hidung tenggorokan pasien menggunakan kuesioner. Data univariat dianalisis secara deskriptif kuantitatif dan disajikan dalam bentuk distribusi frekuensi.Hasil: Secara umum, distribusi empat gejala THT terbanyak pada pasien terinfeksi SARS-CoV-2 berturut-turut adalah nyeri tenggorok (21.52%), hilang penciuman (11.71%), hilang rasa pengecapan (10.44%), dan hidung tersumbat (9.18%). Gejala non-THT yang terbanyak ditemukan meliputi demam (73.73%) dan batuk (57.91%). Keempat gejala THT terbanyak tersebut juga ditemukan pada usia 15-64 tahun, kecuali pada usia ≥65 tahun dimana gejala sakit kepala (3.17%) merupakan gejala terbanyak kedua setelah nyeri tenggorok. Tidak ditemukan gejala hidung tersumbat pada usia ≥65 tahun. Gejala THT terbanyak pada pasien pria terinfeksi SARS-CoV-2 berturut-turut adalah nyeri tenggorok (9.82%), hilang penciuman (4.75%), hidung tersumbat (4.44%), dan hilang pengecapan (2.85%). Sementara itu, gejala THT terbanyak pada wanita terinfeksi SARS-CoV-2 berturut-turut meliputi nyeri tenggorok (11.07%), hilang pengecapan (7.59%), hilang penciuman (6.96%), dan hidung tersumbat (4.74%).Kesimpulan: Gambaran klinis telinga hidung tenggorokkan pasien terinfeksi SARS-CoV-2 yang paling sering muncul berturut-turut adalah nyeri tenggorok, hilang penciuman, hilang pengecapan, dan hidung tersumbat. Frekuensi gejala ini bervariasi akibat banyak faktor, diantaranya adalah umur dan jenis kelamin.

When the Eustachian Tube Is Normal: Selective Epitympanic Dysventilation Syndrome in Primary Acquired Cholesteatoma – An Evidence-Based Case Report Pratiwi, Dewi; Sudrajad, Hadi; Primadewi, Novi; Ramliana, Dienia Nop
Indonesian Journal of Medicine Vol.11 No.2 (2026)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2026.11.2.953

Background: Primary acquired cholesteatoma is a benign yet locally destructive middle ear lesion with an incompletely understood pathogenesis. While Eustachian tube dysfunction is commonly implicated, it does not explain cases with normal middle ear pressure. Selective epitympanic dysventilation syndrome (SEDS) has been proposed as an alternative mechanism involving localized ventilation impairment within the epitympanum. This study aims to provide a clearer understanding of the clinical features of cholesteatoma associated with SEDS, which may help clarify its etiopathogenesis, support earlier detection, limit disease progression, and guide more appropriate, individualized clinical decision-making. Case presentation A 55-year-old female presented with one year of persistent, malodorous left otorrhea and progressive hearing loss over three months. Otoscopy revealed mucopurulent discharge with an attic perforation. Nasoendoscopy showed a patent Eustachian tube. Audiometry demonstrated mild conductive hearing loss (31.25 dB), and tympanometry showed a Type A curve, indicating normal middle ear pressure. Mastoid MSCT revealed opacification of mastoid air cells and antrum with intact ossicles and no mesotympanic involvement, suggesting a localized ventilation disorder consistent with SEDS. Conclusion: SEDS is an important and underrecognized mechanism in primary acquired cholesteatoma. Its recognition is essential for early diagnosis and for guiding surgical strategies that restore epitympanic ventilation to prevent recurrence.

Validity And Reliability Of Parents' Knowledge And Attitudes Toward Hearing Impairment In Children Questionnaire Adaptation In Bahasa Indonesia Annisa Nurul Khakimah; Dewi Pratiwi; Novi Primadewi
Eduvest - Journal of Universal Studies Vol. 6 No. 2 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i2.52312

Hearing impairment in children is a health issue that significantly affects communication abilities and social development. The role of parents is crucial in the early detection and intervention process, which is influenced by the level of knowledge and attitude toward the child’s condition. The research aim to evaluate the validity and reliability parents' knowledge and attitudes toward hearing impairment in children questionnaire adaptation in bahasa indonesia. In the context of the Deaf Family Solo Raya (DFSR) community. This research employed a descriptive quantitative approach with a cross-sectional design. The sample consisted of 30 parents who are members of the DFSR community. The instrument used was a questionnaire adapted from the 2007 Position Statement and studies by Kaspar et al. and Alsudays et al., comprising 25 items on knowledge and 6 items on attitude. Validity was tested using Pearson correlation, and reliability was assessed using Cronbach’s Alpha. The relationship between variables was analyzed using Pearson correlation with the assistance of SPSS version 26. All items on the knowledge and attitude variables were declared valid (p < 0.05) and reliable, with Cronbach’s Alpha values of 0.963 (knowledge) and 0.761 (attitude). A significant positive correlation was found between parental knowledge and attitudes toward childhood hearing loss (r = 0.761; p = 0.000). A high level of knowledge is closely associated with a positive attitude in addressing childhood hearing loss. This study recommends the importance of community-based educational and parental empowerment programs to support optimal early detection and intervention.

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