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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) The Indonesian Biomedical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) The Journal of Hospital Accreditation (JHA) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Budi Mulyono
Department Of Clinical Pathology And Laboratory Medicine, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Correlation between Adiponectin and Triglyceride Levels in Pregnancy with and without Gestational Diabetes Mellitus I Nyoman Gde Sudana; Windarwati Windarwati; Budi Mulyono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 3 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i3.1697

Abstract

Gestational Diabetes Mellitus (GDM) is glucose intolerance during pregnancy. Adiponectin causes a decrease in glucose transporter 4 translocation, which reduces glucose uptake due to downstream insulin signal delivery and decreases non-esterified fatty acids so that triglyceride synthesis decreases in pregnancy. This study was conducted to determine the relationship between adiponectin and triglyceride levels in pregnancy, especially in a pregnant female with and without gestational diabetes mellitus. This observational cross-sectional study was conducted by measuring the levels of adiponectin and triglycerides in pregnancy, with and without gestational diabetes mellitus. Researchers proved by analyzing 75 subjects, 24-28 weeks pregnant females who were examined at the primary health center and Dr. Sardjito Hospital, Yogyakarta. Adiponectin levels have a moderate negative correlation with triglycerides in pregnant females (r= -0.420 and p=0.002), a strong negative correlation with GDM (r = -0.680 and p=0.001), and moderate negative correlation (r= -0.455, and p=0.022) with those without GDM. Based on this research can be concluded that adiponectin has a moderate negative correlation with triglycerides in pregnancy, a strong negative correlation in pregnant females with gestational diabetes mellitus, and a moderate negative correlation in those without gestational diabetes.
The Relationship of Neutrophil-Lymphocyte Ratio and Glycemic Control in Type 2 Diabetes Mellitus Patients Nurahmi Nurahmi; Budi Mulyono; Windarwati Windarwati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 1 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i1.1739

Abstract

Progressivity of type 2 Diabetes Mellitus (DM) is associated with a condition of chronic inflammation. The Neutrophil-Lymphocyte Ratio (NLR) has become a potential new marker of inflammation to detect chronic inflammation. This research aimed to determine NLR differences between controlled type 2 DM and uncontrolled type 2 DM groups. This research conducted an observational with a cross-sectional approach to 56 patients with type 2 diabetes. The identity, anthropometric measurements, and laboratory data of routine blood exam and HbA1c were carried out on each research subject, and then the NLR calculations were performed. The subjects were 20 (35.70%) controlled type 2 DM patients, 36 (64.30%) uncontrolled type 2 DM patients, consisting of 36 (64.30%) male and 20 (35.70%) females. The NLR value was statistically significantly higher in uncontrolled type 2 DM patients than controlled type 2 DM patients, which was 1.90±0.84 compared to 1.52±0.50 (p=0.035). There was a significant difference in the NLR value between the uncontrolled type 2 DM group and the controlled type 2 DM group.
Correlation of Nitrite Oxide with Severity and Survival Rate of Sepsis Patients Sotianingsih Sotianingsih; Budi Mulyono; Andaru Dahesihdewi; Samsirun Halim; Ahmad Syauqi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 1 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i1.1749

Abstract

The objective of this research was to determine the correlation between Nitric Oxide (NO) levels with the severity of sepsis, to describe the kinetics of NO levels, and to evaluate it in predicting mortality. This research was a longitudinal cohort observational analytical study. The variables were serum NO levels and SOFA scores, which were serially evaluated. The correlation test and difference test were used for statistical analysis. The survivor and the non-survivor group consisted of 14 (41.18%) and 20 (58.82%) patients, respectively. There was a correlation between serum NO levels and the SOFA score at the 24-hour observation (r=0.403; p=0.041). Non-parametric Mann-Whitney test showed that there was no kinetics of NO th levels at 0, 24, 72, and 144-hour observation (p-values =0.897 and 0.703, respectively). NO levels > 111,16 μmol/L at the 24 hour could predict the risk of death with hazard ratio 4.7 compared to NO levels < 111,16 μmol/L. The survival rate of patients with serum NO levels <111,16 μmol/L and > 111,16 μmol/L was 83.3% and 37.5%, respectively. There was a correlation between serum NO levels and SOFA scores at the 24-hour observation. However, there was no kinetics of NO levels at serial evaluations. Nitric oxide levels with a cut-off of 111,16 μmol/L at 24 hours could predict the survival of septic patients. Utilization of serum NO level at 24 hour can be used to evaluate the severity of septic patients and aggressive management if there is an increase in serum NO levels > 111,16 μmol/L at 24 hours.
Co-Authors . Windarwati Abdul Salam Sofro Adika Zhulhi Arjana Ahmad Syauqi Andaru Dahesihdewi Banundari Rachmawati Bhisma Murti Carla R. Marchira Dea Noviana Pramantik I Nyoman Gde Sudana Ignatius Riwanto, Ignatius Ingesti Bilkis Zulfatina Isti Anindya Iwan Dwiprahasto Linda Rosita Liong Boy Kurniawan Lisyani Budipardigdo Suromo Marsetyawan HNE Soesatyo Marsetyawan HNE Soesatyo Meita Hendrianingtyas Mohammad Juffrie, Mohammad Mutalazimah Mutalazimah Nurahmi Nurahmi Saifuddin Azwar Samsirun Halim Sotianingsih Sotianingsih Suhartono, Suhartono Supra Wimbarti Sutaryo Sutaryo Teguh Triyono Tri Indah Winarni Tri Ratnaningsih Yanri W Subronto Yuantari, Rahma Yunika Puspa Dewi