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All Journal Jurnal Kreativitas PKM Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Yulia Nadar Indrasari
Departemen Patologi Klinik Fakultas Kedokteran Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Comparative Analysis of Erythrocyte, Leukocyte, and Platelet Indices through Examinations using Sysmex XN-3000 and Yumizen H2500 in Clinical Practice Wardani, Yuniar Putri; Indrasari, Yulia Nadar; Amrita, Putu Niken Ayu; Fuadi, Muhamad Robi'ul
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 1 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i1.65391

Abstract

Introduction: Examining erythrocyte, leukocyte, and platelet indices is critical for diagnosis, disease management, therapy selection, and monitoring. It is imperative to evaluate the hematology analyzer used for a complete blood examination, as each device possesses distinct specifications, methods, and technologies. This study aimed to compare complete blood count parameters, specifically the erythrocyte, leukocyte, and platelet indices, using Sysmex XN-3000 and Yumizen H2500. Methods: This cross-sectional study used blood samples from adult outpatients aged >18 years at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Samples were collected using purposive sampling, resulting in 100 blood specimens for complete blood count analysis. The examined variables included erythrocyte, leukocyte, and platelet indices, which were compared across two different instruments, i.e., Sysmex XN-3000 and Yumizen H2500. The data were analyzed using either the Spearman or Pearson correlation test (p<0.05). The Bland-Altman plotting was employed to assess the differences between variables, with a minimum of five agreed-upon outliers. Results: Significant correlations were observed across all parameters, except for the mean corpuscular hemoglobin concentration (MCHC), which showed limited agreement in the Bland-Altman analysis. The Pearson and Spearman analyses revealed a significant correlation in the parameters of erythrocytes (0.00), leukocytes (0.00), and platelets (0.00). The Bland-Altman plot indicated seven outliers in the average MCHC values from the two analyzers, demonstrating insufficient agreement. Conclusion: There is significant agreement and correlation in the erythrocyte, leukocyte, and platelet indices from both analyzers. This finding affirms the compatibility of both instruments for clinical use, with caution advised when interpreting MCHC values.   Highlights: 1. This study evaluated the validity of different hematology analyzers for complete blood count examinations in medical laboratories, a topic that has rarely been discussed in detail. 2. The results of this study are expected to contribute to the quality improvement of medical laboratory technologies in Indonesia.
Correlation between IL-1beta and IL-18 Levels with Dengue Virus Infection Severity Sari, Arabella Vonia; Aryati, Aryati; Budhy, Theresia Indah; Ma`ruf, Anwar; Husada, Dominicus; Palupi, Retno; Sunari, I Gusti Agung Ayu Eka Putri; Indrasari, Yulia Nadar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2682

Abstract

Activated monocytes/macrophages and T lymphocytes that generate a cytokine storm are thought to play a critical role in the development of dengue. Cytokine storms, characterized by the excessive production of proinflammatory cytokines, can result in cellular dysfunction and organ failure, often contributing to the severity of dengue in affected patients. Interleukin-18 (IL-18), like IL-1beta, is a proinflammatory cytokine released during inflammation triggered by inflammasome activation. Increased IL-1beta and IL-18 during dengue virus infection (DVI) are known to worsen the host's vascular permeability, increasing hemostasis disorders and potentially, all of which are important elements in the pathophysiology of dengue fever. This study investigates the association between IL-1beta levels, IL-18 levels, age, dengue virus serotype, and the severity of dengue virus infection, aiming to understand how these factors interact and influence disease outcomes. This study is an observational cross-sectional design from 59 DVI patients in Dr. Soetomo General Hospital, Surabaya with positive dengue PCR results. Both IL-1beta and IL-18 levels reveal no significant relationship with the patient's age, infection status, and dengue virus serotype. A weak negative significant relationship between IL-1beta levels and the severity of DVI, indicating an inverse relationship between IL-1beta levels and the severity. Further studies are required to investigate the function of these cytokines in severe dengue.
Laboratory Parameter Profile in Hepatocellular Carcinoma Patients admitted to the wards of Internal Medicine at an Indonesian Tertiary Hospital Septiarini, Namira Amelia; Wardhani, Puspa; Indrasari, Yulia Nadar; Maimunah, Ummi
Current Internal Medicine Research and Practice Surabaya Journal Vol. 7 No. 1 (2026): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

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Abstract

Background: Hepatocellular Carcinoma (HCC) is a liver cancer caused by abnormal cell changes, potentially fatal, and is the eighth most common cancer in the world. Diagnosis can be done through liver function tests, tumor markers, and imaging examinations. Thus study aimed to determine the profile of laboratory parameters in HCC patients at Dr. Soetomo Hospital Surabaya in 2020-2022. Methods: The method used was a retrospective study of 67 patient medical records with secondary data collection through total sampling techniques. Laboratory tests performed included SGOT, SGPT, Albumin, Direct Bilirubin, Total Bilirubin, PT, aPTT, and AFP. Results: This study showed that the most common age group was 55-59 years, with the majority of patients being male (70.14%) from East Java (91%). The main complaints were abdominal discomfort and abdominal enlargement (61.19%), with the highest causative factor being Hepatitis B (44.77%). Most patients were at BCLC stage D (17.18%). Laboratory parameters showed median and minimum maximum values for SGOT were 135 (20.76–1436), SGPT 59 (17–671), albumin level 2.96 ± 0.62, direct bilirubin 1 (0.02–22.96), total bilirubin 2.05 (0.09–30.84), PT 14.7 (10.1–47.7), and aPTT 30.2 (20.7–85.5). A total of 16 patients had AFP levels above 400ng/mL. The results of USG and CT Scan examinations showed multiple tumors in most patients. Conclusion: The profile of HCC patients in the inpatient room internal medicine Dr. Soetomo Hospital Surabaya in 2020-2022 was dominated by male patients aged 55-59 years, the main complaint was abdominal discomfort, the most common risk factors were Hepatitis B, BCLC stage D, abnormal liver function, total AFP levels above 400 ng/mL, and USG and CT-Scan examinations showed multiple tumors.
Co-Authors Amrita, Putu Niken Ayu Ana Murtasyidah Andrianto Aryati Aryati Betty Agustina Tambunan Dominicus Husada Elfrida Ratnawati Fauqa Arinil Aulia Fransiska Sri Oetami Fuadi, Muhamad Robi'ul Harida Zahraini Hartono Kahar, Hartono Indriastuti, Endah Jusak Nugraha Ma`ruf, Anwar Puspa Wardhani Puspitasari, Yessy Rahmawati, Lita Diah Retno Palupi Sari, Arabella Vonia Septiarini, Namira Amelia Sunari, I Gusti Agung Ayu Eka Putri Theresia Indah Budhy Sulisetyawati Ummi Maimunah Veithzal Rivai Zainal Wardani, Yuniar Putri Wardhani, Puspa Yetti Hernaningsih Yudha, Cahaya Prasta