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Wahyuningsih Safitri
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THE EFFECTIVENESS OF GALENIC CREAM OF DURIAN PEEL EXTRACT AND CHITOSAN FOR TREATMENT OF DIABETIC ULCERS Wahyu Rima Agustin; Agnes Sri Harti; Hanugrah Ardya Crisdian S; Wahyuningsih Safitri; Sutiyo Dani Saputro; Saelan Saelan
INDONESIAN NURSING JOURNAL OF EDUCATION AND CLINIC (INJEC) Vol 11, No 1 (2026): INJEC
Publisher : Asosiasi Institusi Pendidikan Ners Indonesia (AIPNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24990/injec.v11i1.594

Abstract

Introduction: The chemical substance of durian peel (Durio zibethinus L.) is a polysaccharide polymer of D-galacturonic acid which is polar and anti-microbial. Chitosan is a derivative of chitin from the peels of Crustaceae animals, which is polycationic and antimicrobial; biodegradable, and biocompatible with animal tissues. Diabetic ulcers are chronic wounds due to neurological disorders and vascular disorders in the legs, causing tissue damage. The purpose of the study was to analyze the effectiveness of galenic preparations of durian peel extract and chitosan for the treatment of diabetic ulcers.Method: This research is experimental including testing the quality of 5% durian peel extract cream preparations; 2% chitosan, a mixture of both ratio = 1:1; 1:2 physically, chemically, microbiologically, and the rate of wound healing in test animals. Statistical data analysis of One Way Anova parametric test.Results:  The results showed that the preparation of galenic durian peel extract cream and chitosan and their combination ratio (1:1), (1:2) could be formulated and met the quality test of cream preparations physically, chemically, and microbiologically according to the requirements of BPOM No. 32 of 2019 and is effective for healing diabetic ulcers on the 8th day.Conclusions: The preparation of galenic durian peel extract cream and chitosan and their combination ratio (1:1), (1:2) can potentially be developed as a cream preparation for healing diabetic ulcers.
Co-Authors Agnes Sri Harti Ajeng Maharani Atiek Murharyati Febriana Sartika Sari Frieda Ani Noor Galih Priambodo Hanugrah Ardya Crisdian S Ika Subekti Wulandari Intan Maharani Sulistyawati Batubara Kartika Dian Listyaningsih Lenny Blegur Maria Wisnu Kanita O Oktavianus Prastyoningsih, Aris RAHAJENG PUTRININGRUM Riska Indah Damastuti Risma Eka Pristasari Saelan Saelan Saputro, Sutiyo Dani Tresia Umarianti TRI ASTUTI Wahyu Rima Agustin Wahyu Rima Agustin