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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Nusantara Hasana Journal
Debie Anggraini
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Neuroscience Nursing Social Sciences

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CORRELATION OF ADVANCED GLYCATION END PRODUCTS WITH URINARY ALBUMIN CREATININ RATIO IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Debie Anggraini; Rismawati Yaswir; Lillah Lillah; Husni Husni
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1129

Abstract

Nefropati diabetik merupakan komplikasi mikrovaskular di pasien Diabetes Melitus (DM) yang menyebabkan End Stage RenalDisease (ESRD). Proses glikasi non-enzimatik asam amino bebas di hiperglikemia kronis menghasilkan advanced glycation end-products(AGEs). Advanced glycation end-products dimetabolisme di ginjal sehingga terjadi penumpukan yang memicu kerusakan glomerulusginjal. Advanced glycation end-products terbukti berperan dalam perjalanan penyakit nefropati diabetik. Pemeriksaan mikroalbuminuriadengan rasio air kemih albumin kreatinin merupakan pemeriksaan yang disarankan untuk mendeteksi nefropati lebih awal. Tujuanpenelitian ini untuk mengetahui kenasaban kadar AGEs dengan rasio air kemih albumin kreatinin di pasien DM tipe 2. Penelitian inimenggunakan metode analitik dengan desain potong lintang di 30 orang pasien DM tipe 2 yang memenuhi patokan kesertaan dannonkesertaan serta melakukan pemeriksaan darah di Instalasi Laboratorium Sentral RSUP Dr. M. Djamil Padang masa waktu Mei2015-Maret 2016. Pemeriksaan kadar AGEs dilakukan dengan metode sandwich ELISA. Pemeriksaan mikroalbumin air kemih dilakukandengan metode imunoturbidimetri. Data dianalisis dengan uji kenasaban Spearman, bermakna jika p<0,05. Rerata kadar AGEs di DMtipe 2 adalah 1052,18±750,25 ng/L. Rerata nilai rasio air kemih albumin kreatinin di pasien DM tipe 2 adalah 23,77±16,58 mg/g.Uji kenasaban Spearman menunjukkan kenasaban sangat kuat antara kadar AGEs dan rasio air kemih albumin kreatinin dengannilai r=0,85 dan nilai p<0,05. Terdapat kenasaban sangat kuat antara kadar AGEs dengan rasio air kemih albumin kreatinin di DMtipe 2.
The Relationship of Pregnant Mother's Compliance with Antenatal Care with the Event of Preeclampsia in Tanjung Bingkung Puskesmas Rhandyka Rafli; Indah Salsabila; Ferry Iskandar; Debie Anggraini; Dian Ayu Hamama Pitra
Budapest International Research and Critics Institute (BIRCI-Journal): Humanities and Social Sciences Vol 5, No 1 (2022): Budapest International Research and Critics Institute February
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birci.v5i1.4381

Abstract

Preeclampsia is an increase in blood pressure experienced by pregnant women, at gestational age above 20 weeks which is treated with routine antenatal visits, this research was conducted at the Tanjung Bingkung Health Center because there is a behavior of young mothers who are ashamed to admit their pregnancy. The purpose of this study was to determine the relationship between pregnant women's adherence to antenatal care with the incidence of preeclampsia at the Tanjung Bingkung Health Center. This research method includes obstetrics and gynecology, conducted at the Tanjung Bingkung Health Center from September to November 2020. The research design was correlation analytic and case control design. The research target population was 54 samples selected by simple random sampling. Data analysis using SPSS application. So the results of this study explain that the compliance of pregnant women in antenatal care is 67% seen from the age of the highest adherence at the age of 20-35 years (80%) and seen from the parity status the highest is multigravida (68%). The incidence of preeclampsia is 13%, judging by age, the highest incidence occurs at the age of 20-35 years (80%) and from multigravida pregnant women (70%). The relationship between adherence of pregnant women to antenatal care with the incidence of preeclampsia, found p value > 0.05 with the conclusion that there is no relationship between adherence of pregnant women to antenatal care with the incidence of preeclampsia.
HUBUNGAN HIPERTENSI DENGAN SKOR GENSINI PASIEN PENYAKIT JANTUNG KORONER STABIL DI RSUP DR. M. DJAMIL PADANG TAHUN 2021-2022 Prima Adelin; Indriana Mukti; Yuni Handayani; Dian Puspita; Debie Anggraini; Ruhsyahadati
Nusantara Hasana Journal Vol. 4 No. 5 (2024): Nusantara Hasana Journal, October 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hypertension is one of the risk factors that can cause Coronary Artery Disease (CAD) beginning with the formation of atherosclerotic plaques that can cause arterial stenosis can be assessed using the gensini score. This study aims to determine the relationship between hypertension and gensini scores of stable coronary heart disease patients at Dr. M. Djamil Padang Hospital in 2021-2022. This type of research is a cross-sectional approach using medical record data. An affordable population of research is stable coronary heart disease patients who underwent coronary angiography at Dr. M. Djamil Padang Hospital in 2021-2022 with 52 samples using consecutive sampling techniques. Univariate analysis is displayed in the frequency distribution and average distributions while bivariate analysis is performed using the rank spearman test. The results showed that most coronary artery disease patients are men ≥ 45 years (53.8%) and women ≥ 55 years (26.9%), the majority of patients are men (59.6%), 67.3% of patients do not have a family history, the average systolic blood pressure is 152.42 mmHg, the average diastolic blood pressure is 85.98 mmHg, the average gensini score is 63.33. There is a significant correlation between systolic blood pressure and diastolic blood pressure with gensini score. (p<0.05).
HUBUNGAN GANGGUAN KECEMASAN TERHADAP KEJADIAN MIGRAIN PADA MAHASISWA KEDOKTERAN: SYSTEMATIC REVIEW Meta Zulyati Oktora; Debie Anggraini; Sari Oktavia; Rizky Mar Atusholeha; Salsabilla Umairah
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1430

Abstract

Migraine is a common neurological condition that significantly impacts the academic performance and quality of life of medical students. Anxiety disorders, often triggered by academic stress, are recognized as major contributors to the onset and exacerbation of migraine episodes. Comorbid mental health conditions such as anxiety and depression further increase migraine-related disability. This systematic review employed a qualitative meta-synthesis approach in accordance with the PRISMA 2020 protocol. Relevant articles published between 2019 and 2024 were retrieved from PubMed and EBSCO databases using keywords such as “anxiety disorder,” “migraine,” and “medical students.” The selected studies were screened based on defined inclusion criteria focusing on qualitative data and mental health correlations. Five eligible studies were included in the final analysis. All studies demonstrated a significant association between anxiety and migraine among medical students. Academic stress was identified as a key contributing factor, with female students showing higher susceptibility. The coexistence of anxiety and depression was associated with increased frequency, intensity, and disability due to migraine. There is a strong correlation between anxiety disorders and migraine among medical students. This comorbidity negatively affects both academic performance and mental health. Psychological interventions and stress management strategies are essential to improve students' quality of life and academic resilience.
RISK FACTORS OF HYPERTENSION IN THE ELDERLY Debie Anggraini
Nusantara Hasana Journal Vol. 3 No. 8 (2023): Nusantara Hasana Journal, January 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i8.1043

Abstract

Hypertension is caused by an abnormal increase in blood pressure beyond normal values, namely systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg measured at least twice in a sitting position. Hypertension indicates the occurrence of hemodynamic imbalance in the cardiovascular system caused by several aspects or multi-aspects and difficult to detect with one aspect only Methods: Hypertension detected during a physical examination is caused by certain diseases, so it is referred to as "The Silent Killer" because it often appears without symptoms. Elderly is someone who has entered the age of ≥60 years. Result: The elderly are at high risk of degenerative diseases, one of which is hypertension because the elderly will experience the aging process that causes changes in the body's work system such as cardiovascular. As we get older, the walls of blood vessels tend to be more rigid and their elasticity will decrease so that blood is forced to pass through narrow blood vessels and result in hypertension. Conclusion: Factors that often cause hypertension are divided into two factors such as gender, age, genetics and factors that can be changed such as diet, stress, obesity, physical activity, and smoking.
IMMUNOPATHOGENESIS OF HIV INFECTION: THE COMPLEX ROLE OF THE IMMUNE SYSTEM IN DISEASE DEVELOPMENT AND CONTROL Debie Anggraini
Nusantara Hasana Journal Vol. 3 No. 7 (2023): Nusantara Hasana Journal, December 2023
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i7.1044

Abstract

Human immunodeficiency virus (HIV) infection remains a global challenge in public health, and a deeper understanding of its immunopathogenesis is essential for the development of more effective therapies and more efficient vaccines. the complexity of the interaction between HIV and the human immune system leads to a diverse course of the disease. Explanation of the main role of immune system components in detecting and responding to HIV infection, with special emphasis on the role of CD4+ T cells and the evation mechanisms applied by the HIV virus to avoid destruction by the immune system as well as the impact of HIV infection on dendritic cells, which play an important role in antigen presentation and initiation of immune response. We discuss how HIV utilizes dendritic cells for more efficient dissemination in the body and its impact on specific immunity. By integrating an in-depth understanding of the interaction between HIV and the immune system, this article aims to provide comprehensive insight into the immunopathogenesis of HIV infection and highlight future research directions to combat the disease. A better understanding of these complexities will hopefully support more effective HIV prevention and control efforts in the future.
THE RELATIONSHIP BETWEEN DIET AND NUTRITIONAL STATUS BALANCE IN ADOLESCENTS Dita Hasni; Ratna Ellia; Aissa Syifa Khalila; Debie Anggraini
Nusantara Hasana Journal Vol. 3 No. 6 (2023): Nusantara Hasana Journal, November 2023
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i6.1084

Abstract

Background: Nutritional status is the end result of harmony between the intake of nutrients received by the body and the needs of nutrients needed. This balance determines a person's nutritional status, which can be divided into three categories: less, normal, or excessive. The adolescent phase is a crucial period in which nutritional needs increase significantly along with rapid physical growth and developmental processes. The transition from childhood to adolescence becomes a period in which the body requires more nutrients to support these changes. In addition to physical growth, factors such as lifestyle changes and the diet of adolescents also affect their intake and nutritional needs. An unbalanced diet or lack of attention to the nutrients needed can result in insufficient or excess nutritional status. This paper aims to determine the relationship between diet and nutritional status balance in adolescents. Method: This systematic review uses the PRISMA-P protocol (Preferred Reporting item for Systemic Review and Meta-Analysis Protocol). The study was collected through searches on Google Scholar and PubMed data sources ranging from 2018-2023. Keyword search using PICO-S (Population Intervention Technique Compare Results-Study). Results: Results from journals on Google Scholar and PubMed obtained 10 journals related to the title of literature review. Conclusions: From various studies in adolescents, it can be seen that there is a relationship between a healthy diet and a balance of nutritional status.
RELATIONSHIP BETWEEN AGE AND HISTOPATHOLOGICAL TYPE OF MENINGIOMA ACCORDING TO THE WORLD HEALTH ORGANIZATION (WHO) Meta Zulyati Oktora; Ruhsyahadati; Debie Anggraini; Alzeri Fajar Sirfa
Nusantara Hasana Journal Vol. 3 No. 12 (2024): Nusantara Hasana Journal, May 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i12.1128

Abstract

Background: Meningiomas are the second most common intracranial tumors. The 2016 WHO classification divides the histopathological types of meningiomas into benign (WHO grade I) and malignant (WHO grade II or III). Benign meningiomas are characterized by a well-defined mass adhering to the dura mater and compressing the brain, whereas malignant meningiomas, though rare, are aggressive. Age is a factor that could influence the histopathological type of meningiomas, with incidence increasing with age. Meningiomas commonly occur in middle and old age, peaking in the sixth decade. Age is also a prognostic factor in meningioma occurrences. Method: This was an observational analytic study with a retrospective cross-sectional design on the medical records of meningioma patients at the Anatomical Pathology Laboratory of Dr. M. Djamil Padang Hospital from May 2023 to January 2024. The study included a total of 72 patients. Results: The Chi-Square test showed a p value of 0.330 (p>0.05), indicating no significant relationship between age and the histopathological type of meningiomas. Most meningioma patients were ≥40 years old (76.4%) and female (87.5%). The predominant histopathological type was WHO grade I (88.9%), with tumors ≤5 cm in size (65.3%). Conclusions: There is no significant relationship between age and the histopathological type of meningiomas according to WHO criteria.
LITERATURE REVIEW: DAMPAK PENGGUNAAN MEDIA SOSIAL TERHADAP KESEHATAN MENTAL REMAJA Haqila Khairunnisa; Fitria Nanda; Debie Anggraini
Nusantara Hasana Journal Vol. 4 No. 1 (2024): Nusantara Hasana Journal, Juny 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i1.1147

Abstract

Due to its ability to transfer all actions online, mobile phones have become an essential tool for everyone. More than 2,000 teens access social media via their phones, 92% of the time, according to a 2015 survey. Physical and mental illnesses of teens including obesity, changes in sleep patterns, dangerous lifestyles (drugs and alcohol), and increased stress are some of the main impacts from social media. Therefore, in utilizing social media on a daily basis, time management is very important. Finding the relationship between teenagers' social media use and their physical and mental health was the goal of this study. In this research, researchers used a systematic observation method, where articles were selected using the PRISMA method. The articles used were obtained from online database facilities via the Google Scholar and ScienceDirect pages. The articles obtained were selected based on publications published from 2020 to 2023 (3 years). Of the eight selected articles, the results show that all articles state that there is a relationship between the use of social media and the mental and physical health of teenagers. Therefore, it can be concluded that the better teenagers manage their time in using social media every day, the lower the incidents that affect teenagers' mental and physical health.
Co-Authors Adelin, Prima Aissa Syifa Khalila Alzeri Fajar Sirfa Dian Ayu Hamama Pitra Dian Puspita Dita Hasni Ferry Iskandar Fitria Nanda Haqila Khairunnisa Husni Husni Indah Salsabila Indriana Mukti Lillah Lillah Meta Zulyati Oktora Ratna Ellia Rhandyka Rafli Rismawati Yaswir Rizky Mar Atusholeha Ruhsyahadati Salsabilla Umairah Sari Oktavia Yuni Handayani