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All Journal Damianus Journal of Medicine The Indonesian Biomedical Journal Majalah Anestesia dan Critical Care Indonesian Journal of Perinatology Medical Clinical Update Journal

Theresia Monica Rahardjo

Faculty Of Medicine, Maranatha Christian University, Bandung, West Java, Indonesia

Author-ID : 354575

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

Published : 11 Documents Claim Missing Document

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Articles

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Blood Rheology and It’s Effect in Various Clinical Conditio Rahardjo, Theresia Monica; Wargahadibrata, Himendra
Majalah Anestesia dan Critical Care Vol 33 No 1 (2015): Februari
Publisher : Perdatin Pusat

Show Abstract | Download Original | Original Source | Check in Google Scholar

Blood ia a heterogen fluid consists of a suspension of blood cells, erythrocyte, leucocyte, thrombocyte, in a liquid plasma which contains water, proteins, mineral ions, hormones and glucose. Blood rheology is well known has an important rule in circulation. Blood viscosity depend on shear forces and determined by hematocrit, plasma viscocity, blood cells distribution and mechanical properties. Blood rheology can be altered in various pathology proccess like diorder of hematocrit, erytrocute deformability and aggregation. Hematocrit alteration contributed significantly to hemorheology variation and extreme physiologist conditions. Erytrocyte deformability sensitive to local and general homeostasis caused by endogen or exogen factors. Erythrocyte aggregation is determined by plasma protein composition and erythrocyte surface properties like acute phase of inflammation, other factors are in vivo aging, free radical and proteolitic enzymes. Rheology alteration will cause impairment of blood fluidity which is significantly affect tissue perfusion and result in organ function deteriorations, especially if disease processes also disturb vascular properties. This review will reveal blood rheology effect on various pathological conditions, like sepsis, hypertension and diabetes mellitus.

Propofol Effect on Stress Response and Free Radicals in Patient during Surgery and Sedation Procedure Theresia Monica Rahardjo
The Indonesian Biomedical Journal Vol 7, No 3 (2015)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v7i3.183

BACKGROUND: Propofol is an intravenous anesthetic used worldwide as an anesthesia induction and maintenance agent. Propofol also used as sedation agent in Intensive Care Unit (ICU). Despite it’s usual anesthesia properties, propofol has an unique pharmacologic characteristic, especially as antioxidant and stress response reduction. These advantages suggested propofol has positive effects when used as an anesthesia agent in surgery or sedation in ICU in conditions when high stress and free radical level are released.CONTENT:Stress response and free radical can be elevated in various conditions including surgery or during care in ICU, especially critical ill patient. Cortisol is a major stress hormone that influences metabolism, cardiovascular and central nervous system, either in acute or chronic phase. Oxidative stress was marked by free radical elevation called Radical Oxygen Species (ROS). Combination of both elements (cortisol and ROS) can worsen patient condition. Propofol with anti-stress and antioxidant properties could be used to reduce stress response and attenuate free radical level in order to improve patient condition.SUMMARY: The anti-stress and antioxidant properties of Propofol are interesting, because these benefits can be added as adjunctive therapy when propofol was used as an anesthetic agent in surgery and a sedation in ICU.KEYWORDS: propofol, stress response, antioxidant

The Role of Free Radicals and Antioxidant in Abortion Aloysius Suryawan; Theresia Monica Rahardjo
The Indonesian Biomedical Journal Vol 5, No 1 (2013)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v5i1.47

BACKGROUND: Free radicals and antioxidant exist in balance under normal condition. In prooxidant condition, excessive free radicals can initiate a state of oxidative stress (OS) followed by capillary endothelial cell damage, a process involved in the pathophysiology of abortion.CONTENT: Abortion is a common complication of pregnancy and occurs in 25% of women. Many factors can cause abortion including fetal factor, implantation process and hormonal status. Combination those factors with OS influence the entire reproductive life of a woman. Antioxidant can neutralize free radicals and used to reduce OS especially in recurrent abortion.SUMMARY: Antioxidant therapy is a very interesting field in abortion especially used as prevention approach mainly caused by the high cost of infertility treatment methods.KEYWORDS: free radical, antioxidant, abortion

Patient Satisfaction and Characteristics of Maternity Room from April to June 2022 at Unggul Karsa Medika Hospital Theresia Monica Rahardjo; Yoctaf Octora Kadam; Jeffrey Christian Mahardhika
Medical Clinical Update Vol. 1 No. 1 (2022): October
Publisher : Rumah Sakit Unggul Karsa Medika

Background Maternal Mortality Rate (MMR) is an indicator that reflects various aspects including the quality of healthcare from clinical standpoint, the quality of healthcare system, the quality of health insurance, the quality of referral systems and non-health aspects that related to healthcare such as economic, social, cultural, and education aspects. In order to reduce MMR, healthcare quality of maternity services should be increased. Patient satisfaction is one of indicators for healthcare quality. In this study, we aim to describe patient satisfaction in maternity room of Unggul Karsa Medika Hospital, Bandung, West Java, Indonesia. Methods This is a quantitative descriptive study conducted in Maternity Room, Unggul Karsa Medika Hospital, Bandung, West Java, Indonesia. The design of the study was cross-sectional. The research was conducted from April to June 2022. Minimal total sample of 97. Total sample that obtained in this study was 150 subjects. Sampling method used in this study was consecutive sampling. Results Percentage of total patient satisfaction of maternity room were slightly increasing from April to June 2022, with highest value was in June 2022 of 94,2%. Four out of six elements of patient satisfaction were increasing, which were speed of services, friendliness and responsiveness, clarity of information and instructions, and completeness of infrastructure and facilities. Conclusion Unggul Karsa Medika Hospital through its excellence service of maternity room has played a significant role to reduce maternal mortality rate in Indonesia, since good and increasing results in patient satisfaction of maternity room service from April to June 2022.

What Should We Know About Twin to Twin Transfusion Syndrome: A Case Report Novinka Iriane; Andrieta Berliana Marzani; Angelica Rosa Septiana Hartono; Chris Monalisa; Cindy Thalia Putri; Jessica Natasya; Kevin Axel; Zarahnaya Putri; Sheila Meriyani; Rizna Tyrani Rumanti; Theresia Monica Rahardjo; Aloysius Suryawan
Medical Clinical Update Vol. 1 No. 1 (2022): October
Publisher : Rumah Sakit Unggul Karsa Medika

Background Twin-to-twin transfusion syndrome (TTTS) is a condition that can occur as a complication of a monochorionic twin pregnancy that may develop at any stage of pregnancy and most cases are diagnosed in the second trimester of pregnancy. The syndrome is a placental vascular anomaly that can affect the two fetoplacental circulations which can result in hypotony, hypovolemia, anemia, and oliguria being developed in the donor, whereas the recipient fetus is at risk of hypertrophy, hypertension, hypervolemia, polycythemia, and polyhydramnios. Case presentation A 32-year-old multigravida woman (Gravida 5 Para 4 Abortion 0) with a gestational age of 26 weeks came to the Obstetrics and Gynecology Clinic of Unggul Karsa Medika Hospital with the results of the first ultrasound at 24 weeks of gestation which revealed monochorionic diamniotic intrauterine twins and anterior placenta with grade I maturity. Twin A Maturity of 23 weeks 2 days with a fetal weight of 578 grams, oligohydramnios, fetal kidney, and bladder are not visible, whereas Twin B Maturity of 26 weeks 6 days with a fetal weight of 1205 grams, polyhydramnios with a single 12 cm deepest pocket and normal fetal kidney with bladder distention. The diagnosis of twin-to-twin transfusion syndrome was made with twin A as donor twins and twin B as recipient twins. Conclusion TTTS can be diagnosed with routine prenatal ultrasound and can be deferred into 4 stages based on ultrasound and doppler results. There are multiple options for management including expectant management, amnioreduction, intentional septostomy, fetoscopic laser photocoagulation, selective reduction, and voluntary pregnancy termination.

Psoriasis: A Case Report Liyenka Belusi Tantra; Nathalia Gabriella; Stephanie Astrid Gunawan; Nabilla Aisya Zhavira; Theresia Monica Rahardjo; Epi Panjaitan; Peter Nugraha Soekmadji
Medical Clinical Update Vol. 1 No. 1 (2022): October
Publisher : Rumah Sakit Unggul Karsa Medika

Background Psoriasis is a chronic inflammatory skin disease with a strong genetic predisposition and autoimmune pathogenic traits. Psoriasis vulgaris is also called plaque-type psoriasis, and is the most prevalent type. Psoriasis vulgaris is chronic inflammatory disease and characterized by periods of attack and remission. The chronicity of psoriasis vulgaris can affect patient’s quality of life. Case presentation A 33-year-old male came to Unggul Karsa Medika Hospital’s outpatient department with itchy, scaly, red plaques all over his body except his palms, soles, and face. The patient went to the dermatologist because his symptoms were getting worse and worse. Dermatologic examination concludes the lesions as multiple, generalized, discrete, circumscriptive, elevated, dry, regular-discoid erythematous plaques with psoriasiform scales located at the patient’s head, ears, nape, back, chest, belly, both arms and legs. Conclusion The diagnosis of psoriasis vulgaris was made based on history and clinical symptoms, supported by histopathological results. Treatment optimization and transitioning for moderate-to-severe plaque psoriasis include methotrexate or cyclosporine, along with topical therapy and supportive therapy.

Paralysis Due to Hypokalemia and Hypocalcemia: A Case Report Ivanna Sarahfebi; Anastasia Nadya; Anisya Lisna; Parbati Anjali; Theresia Monica Rahardjo; Valentine Natasya Moenardi
Medical Clinical Update Vol. 1 No. 1 (2022): October
Publisher : Rumah Sakit Unggul Karsa Medika

Background Hypokalemia is the most frequent electrolyte disorder encountered in clinical practice. It caused by inadequate potassium intake or excessive renal or gastrointestinal potassium loss. Hypokalemia may associate with muscle weakness. Hypocalcemia can result from disorders of vitamin D metabolism and action, hypoparathyroidism, resistance to parathyroid hormone (PTH), or other conditions such as nutritional deficiency. Numbness and tingling sensation may occur on hypocalcemia. Case presentation A 36-year-old woman came with complaints of weakness of upper and lower limbs three days before admission. At first, the weakness felt suddenly on the left arm and left foot after waking up in the morning, making her not being able to walk. Patient felt tingling sensation on her face, upper limbs, and lower limbs. Her hands felt stiff as well as her mouth. Patient had a decreasing serum level (3 mEq/l) and decreasing total calcium level (4,8 mg/dL). Conclusion In young adult patients with limbs weakness, it is necessary to consider electrolyte imbalance, such as hypokalemia and hypocalcemia. Hypokalemia can be caused by decreased potassium intake, excessive vomiting, drug consumption, kidney disease, and endocrine disease. To diagnose hypokalemia, it is necessary to carry out further examinations such as basic biochemical laboratories (magnesium, calcium, phosphorus), blood gas analysis, TSHs, urine analysis (urine calcium, potassium excretion in 24-hour urine collection), drug screening.

Hyperglycemic Crisis in Uncontrolled Diabetes Mellitus Type 2 Presenting as Breathlessness Putu Intan Kusuma Wardani; Christina Pretaliana; Henry Theo Prawira Sugitto; Eqen Desmonta; Kevin Hersan; Vannesa Shelly; Varda Natasya Hutapea; Fadhilla Liefya Zahraisha; Jeffrey Christian Mahardhika; Nafthalena; Theresia Monica Rahardjo
Medical Clinical Update Vol. 1 No. 1 (2022): October
Publisher : Rumah Sakit Unggul Karsa Medika

Background Hyperglycemic crisis is emergency caused by metabolic problems due to uncontrolled diabetes mellitus. Hyperglycemic crisis consists of Hyperosmolar Hyperglycemic State (HHS) and Diabetic Ketoacidosis. Both are caused by relative or absolute deficiency of insulin; deficiency of insulin could be caused by type 1 and type 2 diabetes. Case presentation A 46-year-old woman came to the emergency room of Unggul Karsa Medika Hospital presenting with breathlessness which had occurred for a week. Her breathlessness was more severe on the day she presented to the emergency room. One week before, she went to a clinic nearby because of epigastric pain, but after returning home she felt breathless. After a few days, her breathlessness started to worsen, so she decided to go to emergency room. The patient had severe acidosis and high blood glucose. Hyperglycemia protocol of rehydration and insulin drip intravenously, accompanied by sodium bicarbonate and potassium chloride were given. Mechanical ventilation was used. The patient was healed and discharged safely after 9 days of hospitalization. Conclusion Hyperglycemic crisis is one of true emergency that can lead to mortality, thus prompt diagnosis and treatment should be done. It is important for clinicians to differ between HHS and DKA. HHS is caused by the relative or absolute deficiency of insulin while DKA is characterized by absolute insulin deficiency which prevents the body from metabolizing carbohydrates and results in severe hyperglycemia. In DKA and HHS the main goal of therapy is to rehydrate, correct hyperglycemia, and to correct electrolyte imbalances.

Effect Effect of Moringa Leaves (Moringa oleifera) on Fasting Blood Sugar Levels in Prediabetes Steffi, Steffi; Rahardjo, Theresia Monica; Suryawan, Aloysius
Bahasa Indonesia Vol 23 No 3 (2024): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v23i3.5576

Pendahuluan: Prediabetes merupakan fase awal dari Diabetes Melitus tipe 2 (DM2). Dalam setahun, sekitar 5-10% pasien prediabetes akan berlanjut menjadi Diabetes Melitus tipe 2. Daun kelor memiliki potensi dalam mengontrol kadar gula darah, khususnya sebagai terapi tambahan alami dalam pencegahan dan terapi Diabetes Melitus tipe 2. Penelitian ini bertujuan untuk mengevaluasi dampak daun kelor terhadap kadar gula darah puasa pada individu dengan prediabetes Metode: Penelitian ini menggunakan desain randomized controlled trial (RCT). Pengambilan sampel dilakukan di sebuah klinik di Bekasi secara consecutive sampling, dengan 88 subjek yang memenuhi kriteria: prediabetes, usia 25-55 tahun, tidak menggunakan ADO dan insulin minimal 3 bulan sebelum penelitian, serta tidak sedang hamil dan menyusui. Subjek dibagi menjadi dua bagian kelompok yaitu: kelompok perlakuan (MO) yang mendapat kapsul daun kelor 2.400 mg/hari (n=45) dan kelompok kontrol (PLC) yang mendapat kapsul plasebo (n=43) selama 50 hari. Pemeriksaan kadar gula darah puasa dilakukan setiap 3 hari, dan data dianalisis menggunakan uji T-test tidak berpasangan dan Mann-Whitney (α=0,05) Hasil: Terdapat perubahan yang bermakna dari rerata nilai kadar gula darah puasa pada kelompok perlakuan secara signifikan p <0.001 yaitu setelah 38 hari perlakuan. Simpulan: Pemberian daun kelor selama 38 hari memengaruhi kadar gula darah puasa pasien prediabetes (p=0.001).

Ethnopharmacological insights and clinical prospects of ten Indonesian medicinal plants for pregnancy, postpartum, and lactation: a systematic review Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Rahardjo, Theresia Monica; Suryawan, Aloysius; Rahardjo, Bambang; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Indonesian Journal of Perinatology Vol. 6 No. 1 (2025): (Available online: 1 June 2025)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v6i1.77

Background: The perinatal period involves significant physiological and metabolic transitions, particularly concerning hypertensive disorders, preeclampsia, hemorrhage, lactation challenges, and oxidative stress. Although pharmacological therapies are available, their safety and accessibility remain inconsistent, especially in resource-limited settings. Indonesia’s extensive biodiversity and deep-rooted ethnomedicinal traditions offer promising yet underutilized botanical alternatives. This study aimed to review the efficacy of Indonesian medicinal plants used in pregnancy, postpartum, and lactation. Methods: This systematic review investigates ten Indonesian medicinal plants traditionally used during pregnancy, postpartum recovery, and lactation: Sauropus androgynus, Curcuma longa, Moringa oleifera, Nigella sativa, Centella asiatica, Orthosiphon aristatus, Syzygium polyanthum, Andrographis paniculata, Solanum nigrum, and Zingiber officinale. Literature from 2000 to 2025 was reviewed using PRISMA guidelines across global and regional databases. Phytochemical composition, mechanisms of action, therapeutic effects (e.g., antihypertensive, antidiabetic, galactagogue, hemostatic, antioxidant), and clinical relevance were critically evaluated. Results: All ten plants demonstrated pharmacological potential relevant to perinatal health challenges. Notably, Zingiber officinale offers antiemetic and anti-inflammatory benefits during early pregnancy, complementing the lactogenic, antihypertensive, and wound-healing properties of other species. However, gaps persist in human trials, dosage standardization, and regulatory oversight. Conclusion: The review highlights the importance of integrating validated traditional botanicals into perinatal care through interdisciplinary research, targeted clinical trials, and culturally responsive health policies. Bridging ethnopharmacology with maternal health systems offers a scalable, sustainable pathway toward maternal wellness and equity in Indonesia and comparable global settings.

Co-Authors Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Aloysius Suryawan Aloysius Suryawan Anastasia Nadya Andonotopo, Wiku Andrieta Berliana Marzani Angelica Rosa Septiana Hartono Anisya Lisna Bachnas, Muhammad Adrianes Bambang Rahardjo Chris Monalisa Christina Pretaliana Cindy Thalia Putri Cut Meurah Yeni Epi Panjaitan Eqen Desmonta Evert Solomon Pangkahila Fadhilla Liefya Zahraisha Henry Theo Prawira Sugitto I Nyoman Hariyasa Sanjaya Ivanna Sarahfebi Iwan Fuadi Jeffrey Christian Mahardhika Jessica Natasya Julian Dewantiningrum Kevin Axel Kevin Hersan Kurjak, Asim Liyenka Belusi Tantra Monica Monica, Monica Nabilla Aisya Zhavira Nafthalena Nathalia Gabriella Novinka Iriane Nuswil Bernolian Parbati Anjali Peter Nugraha Soekmadji Pramono, Mochammad Besari Adi Putu Intan Kusuma Wardani Rizna Tyrani Rumanti Ryan Saktika Mulyana Sheila Meriyani Sri Sulistyowati Stanojevic, Milan Steffi, Steffi Stephanie Astrid Gunawan Tatang Bisri Valentine Natasya Moenardi Vannesa Shelly Varda Natasya Hutapea Wargahadibrata, Himendra Wiradnyana, Anak Agung Gede Putra Yoctaf Octora Kadam Zarahnaya Putri

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