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All Journal Damianus Journal of Medicine The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Perinatology Medical Clinical Update Journal Jurnal Kedokteran Meditek

Aloysius Suryawan

Faculty Of Medicine, Maranatha Christian University, Bandung, Indonesia

Author-ID : 3209836

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 12 Documents Claim Missing Document

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MMP-9 Level Comparation between Spontaneous Abortion and Normal Pregnancy Aloysius Suryawan; Johanes C Mose; Budi Handono
The Indonesian Biomedical Journal Vol 4, No 3 (2012)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v4i3.178

BACKGROUND: Abortion remains a problem in the obstetric care as it is one of the causes of maternal and fetal death. Bleeding or miscarriage threat in the first trimester comprises 20% to 25% of all pregnant women, and 50% of them will end as spontaneous abortion. The major cause of maternal death in abortion is hemorrhage. Some recent studies have indicated that MMP-9 is important in the process of embryo implantation into the endometrium and spontaneous abortion occurs when there is an overwhelming increase of MMP-9. This data indicate the importance of a further research to elucidate the role of MMP-9 in spontaneous abortion.METHODS: This was a cross sectional study, included 70 pregnant women with gestational age <20 weeks who came for examination and treatment at the Department of Obstetrics and Gynecology, Medical Faculty of Padjadjaran University/Hasan Sadikin Hospital, Bandung. RESULTS: There were differences in the MMP-9 levels in spontaneous abortion compared to normal pregnancy and MMP-9 had a cut-off point >1221.7 with the sensitivity of 48.6% specificity of 80%, and accuracy of 60.9%.SUMMARY: The MMP-9 level in spontaneous abortion was higher than in normal pregnancy.KEYWORDS: MMP-9, spontaneous abortion, normal pregnancy

The Role of Free Radicals and Antioxidant in Abortion Aloysius Suryawan; Theresia Monica Rahardjo
The Indonesian Biomedical Journal Vol 5, No 1 (2013)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v5i1.47

BACKGROUND: Free radicals and antioxidant exist in balance under normal condition. In prooxidant condition, excessive free radicals can initiate a state of oxidative stress (OS) followed by capillary endothelial cell damage, a process involved in the pathophysiology of abortion.CONTENT: Abortion is a common complication of pregnancy and occurs in 25% of women. Many factors can cause abortion including fetal factor, implantation process and hormonal status. Combination those factors with OS influence the entire reproductive life of a woman. Antioxidant can neutralize free radicals and used to reduce OS especially in recurrent abortion.SUMMARY: Antioxidant therapy is a very interesting field in abortion especially used as prevention approach mainly caused by the high cost of infertility treatment methods.KEYWORDS: free radical, antioxidant, abortion

What Should We Know About Twin to Twin Transfusion Syndrome: A Case Report Novinka Iriane; Andrieta Berliana Marzani; Angelica Rosa Septiana Hartono; Chris Monalisa; Cindy Thalia Putri; Jessica Natasya; Kevin Axel; Zarahnaya Putri; Sheila Meriyani; Rizna Tyrani Rumanti; Theresia Monica Rahardjo; Aloysius Suryawan
Medical Clinical Update Vol. 1 No. 1 (2022): October
Publisher : Rumah Sakit Unggul Karsa Medika

Background Twin-to-twin transfusion syndrome (TTTS) is a condition that can occur as a complication of a monochorionic twin pregnancy that may develop at any stage of pregnancy and most cases are diagnosed in the second trimester of pregnancy. The syndrome is a placental vascular anomaly that can affect the two fetoplacental circulations which can result in hypotony, hypovolemia, anemia, and oliguria being developed in the donor, whereas the recipient fetus is at risk of hypertrophy, hypertension, hypervolemia, polycythemia, and polyhydramnios. Case presentation A 32-year-old multigravida woman (Gravida 5 Para 4 Abortion 0) with a gestational age of 26 weeks came to the Obstetrics and Gynecology Clinic of Unggul Karsa Medika Hospital with the results of the first ultrasound at 24 weeks of gestation which revealed monochorionic diamniotic intrauterine twins and anterior placenta with grade I maturity. Twin A Maturity of 23 weeks 2 days with a fetal weight of 578 grams, oligohydramnios, fetal kidney, and bladder are not visible, whereas Twin B Maturity of 26 weeks 6 days with a fetal weight of 1205 grams, polyhydramnios with a single 12 cm deepest pocket and normal fetal kidney with bladder distention. The diagnosis of twin-to-twin transfusion syndrome was made with twin A as donor twins and twin B as recipient twins. Conclusion TTTS can be diagnosed with routine prenatal ultrasound and can be deferred into 4 stages based on ultrasound and doppler results. There are multiple options for management including expectant management, amnioreduction, intentional septostomy, fetoscopic laser photocoagulation, selective reduction, and voluntary pregnancy termination.

Placental Abruption as a Complication of Preeclampsia that Causes Fetal Distress Indra Hapdijaya; Ecclesia Tessalina; Elisabeth Mariska Natasha Herdiana; Janice Natalia; Gede Anggara Setya Dewa Brata; Hendrik Andrianto; Catharine Welanai Jemarut; Livia Devina; Aloysius Suryawan
Medical Clinical Update Vol. 1 No. 1 (2022): October
Publisher : Rumah Sakit Unggul Karsa Medika

Background Placental abruption is a common complication of preeclampsia. It is an obstetric emergency which occurs when the placenta partially or completely separates from the uterine wall. The diagnosis is usually made clinically or objectively. It is relatively rare but put a serious risk for both the fetus and the mother. Case presentation We reported a case of a 32-year-old multigravida patient at 35-36 weeks gestation presented with moderate vaginal bleeding and lower abdominal pain. Her obstetric history included one premature vaginal delivery. Her blood pressure started to rise in the second trimester of pregnancy. The examination revealed that her blood pressure was 190/120 mmHg, she had pitting edema on her extremities and tender uterine fundus. The fetal heart rate was bradycardia at 100 beats per minute. Placental abruption and fetal distress were diagnosed. An emergency cesarean section was performed. Intraoperatively, the uterus showed intramural bleeding and was livid, with the beginning of Couvelaire-uterus. The uterus was left in situ. Conclusion As a conclusion, placental abruption interrupts the vital function of the placentae which leads to fetal hypoxia and even fetal death. It is an obstetric emergency that requires immediate intervention to save the fetus and reduce the risk of complications in the mother.

Peri Partum Cardiomyopathy: A Case Report Aloysius Suryawan; Theresia Monica Rahardjo; Fabianus Ferdian Damario; Alicka Octorevia Witjaksono; Angela Mulyana Sugiaman; Kellen Clementine; Nafisya Dhira Bella; Winda Permata Sari; Yoshua Adhi Nicholaus; Yovita Hamdani; I Made Putra Rena
Medical Clinical Update Vol. 2 No. 1 (2023): February
Publisher : Rumah Sakit Unggul Karsa Medika

Cardiomyopathy that appears around the end of pregnancy or in the first few weeks after delivery is known as peripartum cardiomyopathy (PPCM). The pathogenesis of PPCM is unknown, however a number of factors, including viral myocarditis, an atypical resistance to pregnancy, an odd reaction to the increased hemodynamic weight of pregnancy, hormone interactions, ill health, aggravation, and apoptosis, are thought to contribute to this illness.

The Effectiveness of Plasma Convalescent in Pregnant Women with COVID-19 At Unggul Karsa Medika Hospital: A Case Series Aloysius Suryawan; Theresia Monica Rahardjo; Rizna Tyrani Rumanti; Angel Yustina Ngongo; Difati Cesar Marselino; Indry Andy Ginting; Johanna; Liana Alvitri; Sharone Amabel; Tiara Margaretha Tabolong; Trengginas Aji Suroso; Yosua Kristian Setia Budi
Medical Clinical Update Vol. 3 No. 1 (2023): June
Publisher : Rumah Sakit Unggul Karsa Medika

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At the beginning of 2020, a pandemic caused by a novel coronavirus began to have devastating effects worldwide. The etiological agent was Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the disease named coronavirus disease or COVID-19. Nearly 109 million people have been infected by the virus and more than 2.4 million people have died. An intense debatehas started on therapeutic possibilities for COVID-19 in pregnancy. The management of the disease is essentially driven by the symptoms. Asymptomatic or pauci-symptomatic women do not require inpatient care or medications, but simply need monitoring of respiratory function for up to two weeks for evidence of deterioration. Convalescent plasma from individuals who have recovered from COVID-19, a blood component that is not contraindicated in pregnant women and has been transfused safely for at least 30 years, deserves special consideration.

Caesarean Section as A Prevention of Intrapartum Transmission in Pregnant Woman with Syphilis: A: Case Report Chandni P. Daryanani; Aloysius Suryawan; Theresia Monica Rahardjo; Apriani Lam; Maxzillion Sky Kasnadi; Nadya Ariella; Stefanie Sumartono; Syifa Navisah
Medical Clinical Update Vol. 3 No. 1 (2023): June
Publisher : Rumah Sakit Unggul Karsa Medika

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Syphilis is an infectious disease caused by spirochete bacterium Treponema pallidum. Most of the new case of syphilis occur in men, but there is a tendency of increasing infection rate in reproductive-aged women, with the highest rates observed in 20-24 years old. Syphilis can be transmitted by sexual intercourse, blood products transfusion, or transplacental known as congenital syphilis and during delivery process as intrapartum transmission. Syphilis is a relapsing and remitting disease with early and late stages. Congenital syphilis is caused by foetal infection of Treponema pallidum, transmission mostly occurs transplacental, and it may occur at any time during gestation.

Severe Preeclampsia Complicated by Placental Abruption Leads to Fetal Distress Indra Hapdijaya; Aloysius Suryawan; Ecclesia Tessalina; Elisabeth Mariska Natasha Herdiana; Janice Natalia; Gede Anggara Setya Dewa Brata; Hendrik Andrianto; Catharine Welanai Jemarut; Livia Devina
Jurnal Kedokteran Meditek Vol 29 No 1 (2023): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v29i1.2432

Placental abruption is a common complication of preeclampsia. It is an obstetric emergency that occurs when the placenta partially or completely separates from the uterine wall. The diagnosis is usually made clinically or objectively. It is relatively rare but put a serious risk for both the fetus and the mother. We reported a case of a 32-year-old multigravid patient at 35-36 weeks gestation who presented with moderate vaginal bleeding and lower abdominal pain. Her obstetric history included one premature vaginal delivery. Her blood pressure started to rise in the second trimester of pregnancy. The examination revealed that her blood pressure was 190/120 mmHg, and she had pitting edema on her extremities and tender uterine fundus. The fetal heart rate was bradycardia at 100 beats per minute. Placental abruption and fetal distress were suspected. An emergency cesarean section was performed. Intraoperatively, the uterus showed intramural bleeding and was livid, with the beginning of Couvelaire-uterus. The uterus was left in situ. In conclusion, placental abruption interrupts the vital function of the placentae which leads to fetal hypoxia and even fetal death. It is an obstetric emergency that requires immediate intervention to save the fetus and reduce the risk of complications in the mother.

Effect Effect of Moringa Leaves (Moringa oleifera) on Fasting Blood Sugar Levels in Prediabetes Steffi, Steffi; Rahardjo, Theresia Monica; Suryawan, Aloysius
Bahasa Indonesia Vol 23 No 3 (2024): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v23i3.5576

Pendahuluan: Prediabetes merupakan fase awal dari Diabetes Melitus tipe 2 (DM2). Dalam setahun, sekitar 5-10% pasien prediabetes akan berlanjut menjadi Diabetes Melitus tipe 2. Daun kelor memiliki potensi dalam mengontrol kadar gula darah, khususnya sebagai terapi tambahan alami dalam pencegahan dan terapi Diabetes Melitus tipe 2. Penelitian ini bertujuan untuk mengevaluasi dampak daun kelor terhadap kadar gula darah puasa pada individu dengan prediabetes Metode: Penelitian ini menggunakan desain randomized controlled trial (RCT). Pengambilan sampel dilakukan di sebuah klinik di Bekasi secara consecutive sampling, dengan 88 subjek yang memenuhi kriteria: prediabetes, usia 25-55 tahun, tidak menggunakan ADO dan insulin minimal 3 bulan sebelum penelitian, serta tidak sedang hamil dan menyusui. Subjek dibagi menjadi dua bagian kelompok yaitu: kelompok perlakuan (MO) yang mendapat kapsul daun kelor 2.400 mg/hari (n=45) dan kelompok kontrol (PLC) yang mendapat kapsul plasebo (n=43) selama 50 hari. Pemeriksaan kadar gula darah puasa dilakukan setiap 3 hari, dan data dianalisis menggunakan uji T-test tidak berpasangan dan Mann-Whitney (α=0,05) Hasil: Terdapat perubahan yang bermakna dari rerata nilai kadar gula darah puasa pada kelompok perlakuan secara signifikan p <0.001 yaitu setelah 38 hari perlakuan. Simpulan: Pemberian daun kelor selama 38 hari memengaruhi kadar gula darah puasa pasien prediabetes (p=0.001).

Ethnopharmacological insights and clinical prospects of ten Indonesian medicinal plants for pregnancy, postpartum, and lactation: a systematic review Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Rahardjo, Theresia Monica; Suryawan, Aloysius; Rahardjo, Bambang; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Indonesian Journal of Perinatology Vol. 6 No. 1 (2025): (Available online: 1 June 2025)
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v6i1.77

Background: The perinatal period involves significant physiological and metabolic transitions, particularly concerning hypertensive disorders, preeclampsia, hemorrhage, lactation challenges, and oxidative stress. Although pharmacological therapies are available, their safety and accessibility remain inconsistent, especially in resource-limited settings. Indonesia’s extensive biodiversity and deep-rooted ethnomedicinal traditions offer promising yet underutilized botanical alternatives. This study aimed to review the efficacy of Indonesian medicinal plants used in pregnancy, postpartum, and lactation. Methods: This systematic review investigates ten Indonesian medicinal plants traditionally used during pregnancy, postpartum recovery, and lactation: Sauropus androgynus, Curcuma longa, Moringa oleifera, Nigella sativa, Centella asiatica, Orthosiphon aristatus, Syzygium polyanthum, Andrographis paniculata, Solanum nigrum, and Zingiber officinale. Literature from 2000 to 2025 was reviewed using PRISMA guidelines across global and regional databases. Phytochemical composition, mechanisms of action, therapeutic effects (e.g., antihypertensive, antidiabetic, galactagogue, hemostatic, antioxidant), and clinical relevance were critically evaluated. Results: All ten plants demonstrated pharmacological potential relevant to perinatal health challenges. Notably, Zingiber officinale offers antiemetic and anti-inflammatory benefits during early pregnancy, complementing the lactogenic, antihypertensive, and wound-healing properties of other species. However, gaps persist in human trials, dosage standardization, and regulatory oversight. Conclusion: The review highlights the importance of integrating validated traditional botanicals into perinatal care through interdisciplinary research, targeted clinical trials, and culturally responsive health policies. Bridging ethnopharmacology with maternal health systems offers a scalable, sustainable pathway toward maternal wellness and equity in Indonesia and comparable global settings.

Co-Authors Adhi Pribadi Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Alicka Octorevia Witjaksono Anak Agung Gede Putra Wiradnyana Anak Agung Ngurah Jaya Kusuma Andonotopo, Wiku Andrieta Berliana Marzani Angel Yustina Ngongo Angela Mulyana Sugiaman Angelica Rosa Septiana Hartono Anita Deborah Anwar Apriani Lam Bachnas, Muhammad Adrianes Bambang Rahardjo Budi Handono Catharine Welanai Jemarut Catharine Welanai Jemarut Chandni P. Daryanani Chris Monalisa Cindy Thalia Putri Cut Meurah Yeni Cut Meurah Yeni Difati Cesar Marselino Djanas, Dovy Dudy Aldiansyah Ecclesia Tessalina Ecclesia Tessalina Efendi Lukas Elisabeth Mariska Natasha Herdiana Elisabeth Mariska Natasha Herdiana Eric Edwin Yuliantara Ernawati Darmawan Evert Solomon Pangkahila Evert Solomon Pangkahila Fabianus Ferdian Damario Gede Anggara Setya Dewa Brata Gede Anggara Setya Dewa Brata Harry Kurniawan Gondo Hendrik Andrianto Hendrik Andrianto I Made Putra Rena I Nyoman Hariyasa Sanjaya I Nyoman Hariyasa Sanjaya Indra Hapdijaya Indra Hapdijaya Indry Andy Ginting Janice Natalia Janice Natalia Jessica Natasya Johanes C. Mose Johanna Julian Dewantiningrum Julian Dewantiningrum Kellen Clementine Kevin Axel Khanisyah Erza Gumilar Kurjak, Asim Laksmana Adi Krista Nugraha Liana Alvitri Livia Devina Livia Devina Maxzillion Sky Kasnadi Milan Stanojevic Mochammad Besari Adi Pramono Monica Monica Muhammad Adrianes Bachnas Muhammad Ilham Aldika Akbar Nadya Ariella Nafisya Dhira Bella Novinka Iriane Nuswil Bernolian Nuswil Bernolian Pramono, Mochammad Besari Adi Ridwan Abdullah Putra Rizna Tyrani Rumanti Rizna Tyrani Rumanti Ryan Saktika Mulyana Ryan Saktika Mulyana Sharone Amabel Sheila Meriyani Sri Sulistyowati Stanojevic, Milan Stefanie Sumartono Steffi, Steffi Syifa Navisah Theresia Monica Rahardjo Theresia Monica Rahardjo Theresia Monica Rahardjo Tiara Margaretha Tabolong Trengginas Aji Suroso Waskita Ekamaheswara Kasumba Andanaputra Wibisana Andika Krista Dharma Winda Permata Sari Wiradnyana, Anak Agung Gede Putra Wisnu Prabowo Yoshua Adhi Nicholaus Yosua Kristian Setia Budi Yovita Hamdani Zarahnaya Putri

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