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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Produksi Tanaman Herb-Medicine Journal JPBIO (Jurnal Pendidikan Biologi) BIHARI: JURNAL PENDIDIKAN SEJARAH DAN ILMU SEJARAH Didaktik : Jurnal Ilmiah PGSD STKIP Subang Jurnal Bahasa Inggris Terapan Jurnal PRIMED:Primary Education Journal atau Jurnal Ke-SD An JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal MedScientiae Jurnal Multidisiplin Indonesia Jurnal Kedokteran Meditek International Journal of Economics and Management Sciences
Ika Rahayu
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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PENGEMBANGAN MEDIA PEMBELAJARAN JAMBUHARI MATA PELAJARAN MATEMATIKA KELAS II MI BAHRUL ULUM Albar, Melani; Rahayu, Ika
Primary Education Journals (Jurnal Ke-SD-An) Vol 3 No 2 (2023): AGUSTUS
Publisher : Universitas Islam Raden Rahmat Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33379/primed.v3i2.2764

Abstract

Penelitian pengembangan ini dilatar belakangi oleh sulitnya memahamimateri satuan waktu kelas II MI BahrulUlum Pakisaji. Adapun beberapa faktor yang mempengaruhi permasalahan tersebut yaitu : 1) Metode pembelajaranguru yang hanya menggunakan ceramah dan penugasan saja, 2) Media pembelajaran yang masih belum begitu seringdigunakan, 3) Guru yang minim penguasaan teknologi. Prosedur penelitian dan pengembangannya yakni media ADDIEyang memuat 5tahapan sebagai berikut : 1) Analiysis, 2) Design, 3) Development, 4) Implementation 5) Evaluation.Hasil yang diperoleh pada pengkajian kevalidan ahli materi dan media dengan presentase sebagai berikut : validasi ahlimateri mencapai 80% dengan kategori “valid” dan validasiahli media mencapai 92% dengan kategori “sangat layak”.Kelayakan media juga dibuktikan dari unjuk kerja siswa dalam menggunakan media pembelajaran dengan baik dansesuai dengan arahan guru. Padauji tes siswa memperoleh peningkatan sebanyak 42% dengan kategori “efektif” Dapatdiambil kesimpulan dari penelitian ini yang menunjukkan bahwasannya pengembangan media pembelajaranJAMBUHARI jam bunga matahari dinyatakan efektif dan layak untuk digunakan.Kata kunci: Jam Bunga Matahari, Mata Pelajaran Matematika
An Analysis of Simple Past Tense Errors in the Soul Sense with Silkina Podcast by Using the Surface Strategy Taxonomy Nurmala, Ela; Rahayu, Ika; Sapari, Gingin Ginanjar; Rahayu, Rahmayanti
Jurnal Bahasa Inggris Terapan Vol. 9 No. 1 (2023): April 2023
Publisher : Jurusan Bahasa Inggris - Politeknik Negeri Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35313/jbit.v9i1.4698

Abstract

The purpose of this study is to investigate the simple past tense errors found in the Soul Sense with Silkina Podcast. The study employed qualitative method with descriptive analysis. The data were collected from a podcast entitled Soul Sense with Silkina Podcast which consists 10 episodes of Soul Sense with Silkina Podcast. The data were analysed by applying the Surface Strategy Taxonomy proposed by Dulay. The result shows that there were four types of errors committed by the podcasters in using Simple Past Tense. Those types were Omission, Addition, Mis-formation and Mis-ordering. The total numbers of errors were 120 divided into Omission (23 errors), Addition (11 error), Mis-formation (82 errors), and Mis-ordering (4 errors). In other words, the highest amount of errors was Mis-formation with the percentage of 68.34%, while the omission was in the second place with the percentage around 19.17%. The third place was addition with the percentage around 9.16%, and the last was mis-ordering with the percentage around 3.33%.
In silico study of the bioactive compounds in Peronema canescens Jack (Sungkai) leaf infusion targeting VEGFR-2: Insights into anticancer potential rahayu, Ika; Sudrajat, Susana Elya; Timotius, Kris Herawan
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 3, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss3.art6

Abstract

Background: Peronema canescens Jack, commonly known as sungkai, is a medicinal plant traditionally consumed as a herbal infusion. It has demonstrated potential anticancer properties attributed to its bioactive constituents, particularly clerodane-type diterpenoids known as peronemins. The anticancer potential of these compounds can be preliminarily explored using in silico approaches. Of particular interest are the reported the cytotoxic effects of sungkai leaves against cancer cell lines and their interactions with angiogenesis-related targets, including vascular endothelial growth factor receptor-2 (VEGFR-2). VEGFR-2 is a critical tyrosine kinase receptor that regulates angiogenesisa and Its aberrant activation contributes to tumor growth and metastasis. Consequently, VEGFR-2 represents a well-established target for anticancer therapy development. Objectives: This study aims to investigate the bioactive compounds present in sungkai leaf infusion using liquid chromatography-mass spectrometry (LC-MS), and to predict their interactions with VEGFR-2 through in silico molecular docking analysis. Methods: Phytochemical profiling of the leaf infusion was conducted using LC-MS. Molecular docking was performed using PyRx 0.8 integrated with AutoDock Vina to assess ligand-protein interactions between selected compounds and VEGFR-2 (PDB ID: 2QU5). The resulting interactions were visualized using Discovery Studio.Results: LC-MS analysis identified ten major compounds in the leaf infusion, consisting of one alkaloid (gentiatibetine) and nine flavonoids. Molecular docking analysis revealed that genkwanin and acacetin-7-galactoside exhibited strong binding affinities toward VEGFR-2 (−9.6 and −9.2 kcal/mol, respectively), approaching that of the referencesorafenib (−11.2 kcal/mol). Both compounds interacted with key catalytic residues, suggesting their potential to inhibit VEGFR-2 by stabilizing its inactive conformation.Conclusion: This study provides the first to report that sungkai leaf infusion is rich in flavonoid compounds two of which exhibit strong anti-VEGFR-2 activity. These findings suggest the potential of sungkai leaf infusion as a natural anticancer agent and support the needfor further in vitro and in vivo validation.
Co-Authors Agus Limanto Ahmad Hamim Sadewa Albar, Melani Anggraeni, Rustini Dewi Mahrani Rangkuty Farianti Wiranda Hemi Sinorita Hesa, Alfi Kahfi, M Kris Herawan Timotius Lita Soetopo Nurmala, Ela Puspasari, Monica Rahayu, Rahmayanti Safitri, Ratih Sancnia, Sancnia Sapari, Gingin Ginanjar Shavab, Oka Agus Kurniawan Sudrajat, Susana Elya Susana Elya Sudradjat Syahida, Fithrah Yulistiani, Irna