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All Journal Jurnal Gizi dan Pangan Journal of Food and Pharmaceutical Science Jurnal Riset Kesehatan Pharmascience Jurnal Ilmu Pangan dan Hasil Pertanian Jurnal Surya Masyarakat JURNAL PENDIDIKAN TAMBUSAI Minda Baharu Pontianak Nutrition Journal (PNJ) Menara Perkebunan Journal Syifa Sciences and Clinical Research (JSSCR) J-KESMAS: Jurnal Kesehatan Masyarakat Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Journal of Pharmaceutical Care Anwar Medika Jurnal Surya Masyarakat Jurnal Ilmiah Gizi Kesehatan (JIGK) PROFESSIONAL HEALTH JOURNAL JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Indonesian Journal of Community Dedication in Health (IJCDH) Jurnal Sehat Indonesia (JUSINDO) Journal of Food and Pharmaceutical Sciences Jurnal Farmasi Galenika
Diah Ratnasari
Universitas Muhammadiyah Gresik
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Journal : PROFESSIONAL HEALTH JOURNAL

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Kajian Kajian In Silico Aktivitas Ekstrak Daun Mangga (Mangifera indica L.) Sebagai Antidiabetes Tipe 2 Janatun naimah; Anindi Lupita Nasyanka; Diah Ratnasari; Siti Nur Asiyah
PROFESSIONAL HEALTH JOURNAL Vol 5 No 1sp (2023): Special Issue Outcome PDP
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v5i1sp.500

Abstract

Type 2 diabetes mellitus is the most common type of diabetes in the world. Type 2 diabetes mellitus is caused by an increase in blood sugar due to a decrease in low insulin secretion by the pancreas gland. Pharmacological therapy for type 2 diabetes, namely oral antidiabetic drugs (OAD) or insulin such as acarbose, metformin, or voglibose has been reported to have side effects. Side effects that occur, such as gastrointestinal disturbances (diarrhea and flatulence), liver disorders, dizziness, nausea and vomiting. Thus, herbal ingredients are an alternative in the treatment of diabetes mellitus. In this study, mango leaf extract, namely mangiferin, was suspected as an antidiabetic compound. The purpose of this study was to determine the interaction of mangiferin which is an extract of mango leaves (Mangifera Indica L.) with -glucosidase in silico. The results showed that mangiferin as a type 2 antidiabetic compound by producing an G value between -glucosidase and mangiferin of -38.89 kcal/mol. The interaction that occurs is hydrogen bonding between mangiferin and amino acid residues Glu553, Asn551, Arg500 and Tyr460, Phe461. Keywords: α-glucosidase, in silico, mangiferin, mango leaf,
Co-Authors Amilia Putri, Sasti Anggraeni, Novi Anggray Duvita Wahyani Arry Wulan Zahiriyah Choti'ah, Faridhotul Nur Dalmayanti, Fanny Dini Kesuma Duvita, Anggray Dyah Kartika Wening Estu Varesya Maulina Faridhotul Nur Choti'ah Fatmawati, Fita Fitriyani, Nabila Nurul Fitriyatus Sholikhah Janatun Na’imah Jannatun Na'imah koidah Latifah, Fitri Istifarani Lutiana Mohammad Zen Rahfiludin Mudalifah, Efa Mustikaningrum, Mega Nasyanka, Anindi Lupita Na’imah, Janatun Noorainny Yunitasari Norainny Yunitasari Pemta Tiadeka Putra, Ade Seldiano Qomariyah, Zumrotul Rachman, Riska Novia Renny Novi Puspitasari Rifatul Masrikhiyah Riskha Aulia Riskha Aulia Setyaningsih, Sulasyi Siti Nur Asiyah Suhartono Yuniarti Dewi Rahmawati, Yuniarti Dewi Yunika Purwanti Yunitasari, Norainny Zumrotul Qomariyah