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All Journal CHEMICA Jurnal Teknik Kimia GRADIEN PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Ideas: Jurnal Pendidikan, Sosial dan Budaya Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Molluca Journal of Chemistry Education (MJoCE) Indonesian Journal of Community Empowerment and Service Aceh International Journal of Science and Technology Andromeda: Jurnal Pengabdian Masyarakat Rafflesia Bencoolen Journal of Pharmacy Rafflesia Journal of Natural and Applied Sciences (RJNAS) Jurnal Abdimas Bencoolen
Devi Ratnawati
Department Of Chemistry Faculty Of Mathematics And Natural Sciences Universitas Bengkulu
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Bencoolen Journal of Pharmacy

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Effect of catalyst and solvent on the Claisen-Schmidt condensation reaction between benzaldehyde derivatives and 2-acetylpyridine Ratnawati, Devi
BENCOOLEN JOURNAL OF PHARMACY Vol. 4 No. 2 (2024): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v4i2.37449

Abstract

This study was conducted to observe the effect of catalyst and solvent on the Claisen-Schmidt condensation reaction between benzaldehyde derivatives (compound 1) and 2-acetylpyridine. Chalcones, as compounds with various biological activities, are the focus in the fields of medicine and pharmacology. Efficient and environmentally friendly synthesis methods are essential in the production of these compounds. In this study, the Claisen-Schmidt condensation reaction was used to synthesize the target chalcones. Variations of base catalysts (NaOH and KOH) and solvents (ethanol and methanol) were evaluated to optimize the yield and efficiency of the reaction. The results showed that the use of KOH as a catalyst produced compound 2 with an abundance of 60.47%, which was associated with the stronger nucleophilic nature of hydroxide ions in KOH. In addition, ethanol proved to be a more effective solvent than methanol in this reaction.
Co-Authors Abdul Rahman Afriana Mayang Sentani Agus Martono Agus Martono Agus Martono Hadi Putranto Agus Martono HP Asmiyenti Djaliasrin Djalil Charles Banon Cindy Wulandari Devi Rizanty Dwi Sutanto, Teja Dwita Oktiarni Dyah Fitriani Eni Widiyati Eni Widiyati Evi Maryanti Fadilah Sari Ghufira Ghufira Hadi Putranto Ibdal Satar Lesta Nurul Jayanti Lusiana . Martono Hadi Putranto, Agus Morina Adfa Nadia Arum Pangestu Nurhadi, Nurhadi Ria Nurwidiyani Sari, Yanci Novita Syalfinaf Manaf Teja Dwi Sutanto Totok Eka Suharto Triawan, Deni Agus Wahidah Fitriyanti Wiranti Sri Rahayu