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All Journal Heart Science Journal Narra J Cermin Dunia Kedokteran Jurnal Klinik dan Riset Kesehatan
Fajar, Jonny Karunia
Department Of Internal Medicine, Faculty Of Medicine, Universitas Brawijaya, Malang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Heart Science Journal

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The Effect of Garcinia Mangostana Linn Extract to The Levels of Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with High Framingham Score Aditha Satria Maulana; Djanggan Sargowo; Ardian Rizal; Heny Martini; Mohammad Saifur Rohman; Anna Fuji Rahimah; Jonny Karunia Fajar
Heart Science Journal Vol 1, No 2 (2020): The Assessment of Diagnostic and Treatment Modality in Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (32.966 KB) | DOI: 10.21776/ub.hsj.2020.001.02.6

Abstract

Background : Recently, studies have concerned on the use of xanthones for treating patients with cardiovascular diseases. In our country, xanthones were found in Garcinia Mangostana Linn.Objectives : To assess the effect of Garcinia Mangostana Linn Extract (GMLE) to the levels of Circulating Endothelial Cells (CEC) and Endothelial Progenitor Cells (EPC) in patients with high framingham score.Methods : A prospective cohort study was conducted from November 2018 to January 2019. The patients were divided into two groups. The first group was given 2520 mg/day of GMLE for 90 days and the second group was given placebo. In sub group analyses, patients were divided based on previous medication, including statin, statin and angiotensin-converting-enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB), statin and oral antidiabetic drugs (OAD), and statin and ACEI or ARB and OAD. The outcome measures were CEC and EPC levels, measured at baseline and after 90 days of treatment. We used multiple linear regression to analyze the correlation and effect estimates.Results: A total of 72 patients was included in our study. All of the patients baseline characteristics were distributed homogeneously (p>0.05). Our findings confirmed that GMLE administration was associated with decreased CEC level compared to placebo. On other hands, increased EPC level compared to placebo was observed after GMLE administration. In sub-group analyses, our study found that the combination of GMLE with statin and ACEI or ARB and the combination of GMLE with statin and ACEI or ARB and OAD were associated with decreased level of CEC compared to placebo, with the odd ratios were 0.12 and 0.18, respectively. Conversely, increased level of EPC was observed in subjects receiving the combination of GMLE with statin and ACEI or ARB and the combination of GMLE with statin.Conclusion: Administration of GMLE as adjuvant therapy is associated with the improvement of CEC and EPC levels in patients with high framingham scores.
Advancing scholarship: HSJ attains scopus indexing - embarking on a new scientific journey Fajar, Jonny Karunia
Heart Science Journal Vol. 5 No. 2 (2024): Challenges in the Management of Congenital Heart and Structural Heart Diseases
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub/hsj.2024.005.02.1

Abstract

Following the inclusion of Heart Science Journal (HSJ) in the Scopus index, we present this announcement outlining our forward trajectory and strategies aimed at elevating the quality of HSJ. Since the outset of 2024, HSJ has been formally indexed in Scopus, marking a significant milestone in our journey. We extend profound appreciation to our authors, editorial team, and reviewers for their diligent efforts and steadfast dedication, pivotal in realizing this accomplishment. In our ongoing pursuit of enhancing journal quality, we extend a global invitation to authors to contribute their research endeavors to HSJ. In essence, HSJ embarks on a new chapter within Scopus, and we extend a cordial invitation to scientists worldwide to partake in this collaborative endeavor.
Exploring the efficacy of al-hijamah (wet cupping) in managing hypertension and dyslipidemia among Indonesian population: a meta-analysis Aulya, Justika Usmadhani; Matondang, Asri Rizqi; Farahdina, Farahdina; Rizaliansyah, Ferdian; Samsu, Nur; Fajar, Jonny Karunia
Heart Science Journal Vol. 5 No. 4 (2024): The Current Perspective About Cardiometabolic Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2024.005.04.8

Abstract

BACKGROUND: In Indonesia, wet cupping therapy has been thoroughly investigated as a treatment for hypertension and dyslipidemia. Nevertheless, the outcomes across these studies are contradictory.OBJECTIVES: To appraise the effectiveness of wet cupping therapy in the management of hypertension and dyslipidemia among the Indonesian population.METHODS: We examined papers sourced from Google Scholar, the Indonesian Scientific Journal Database, and Garba Rujukan Digital until September 5, 2020. These papers investigated blood pressure and lipid profile levels both pre- and post-wet cupping treatment. The collective data underwent Z-test analysis to assess associations.RESULTS: In total, we included 26 papers examining the correlation between wet cupping therapy and blood pressure, as well as 16 papers assessing lipid profile levels. Our combined analysis revealed significantly reduced systolic blood pressure (MD: 13.86; 95% CI: 10.01, 17.71), diastolic blood pressure (MD: 6.31; 95% CI: 3.84, 8.79), and lower total cholesterol levels (MD: 21.56; 95% CI: 10.32, 32.80]) in the post-treatment group compared to the pre-treatment group. However, we were unable to elucidate the impact of wet cupping therapy on the concentrations of low-density lipoprotein and triglyceride.CONCLUSIONS: Wet cupping therapy exhibits potential efficacy in reducing blood pressure and total cholesterol levels among individuals in Indonesia.
Regulatory RNAs and coronary artery calcification: A systematic review of clinical associations and biological insights Tsuraya, Alfi; Raras, Tri Yudani Mardining; Lestari, Bayu; Ramadhani, Risa; Hose, Victor Alvianoes Guterez; Rohman, Mohammad Saifur; Waranugraha, Yoga; Fajar, Jonny Karunia
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.7

Abstract

BACKGROUND: Regulatory RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as key regulators of vascular remodelling and coronary heart disease. However, their specific roles in coronary artery calcification (CAC) remain fragmented across diverse clinical studies. OBJECTIVES: This review aims to systematically synthesize human observational evidence on differentially expressed regulatory RNAs associated with CAC and their underlying molecular mechanisms. METHODS: We included clinical observational studies (case-control, cross-sectional, or cohort designs) that compared regulatory RNA expression in patients with and without CAC. We searched PubMed, BioMed Central, Wiley, ScienceDirect, and Cochrane between January 2010 and June 2025. Risk of bias was assessed using the JBI Critical Appraisal Checklist for Observational Studies. Data were synthesized narratively with stratification by RNA type, direction of expression, and biological mechanism. RESULTS: A total of 10 eligible studies were included. Several regulatory RNAs demonstrated potential as biomarkers or modulators of CAC. However, the diversity of regulatory RNAs highlights the complex and multifactorial nature of CAC, while also revealing opportunities for future investigation. CONCLUSION: Notably, circSmad4 demonstrated a favourable trend with a high AUC and a reasonably balanced mix of sensitivity and specificity, despite with relatively larger sample sizes.
Co-Authors -, Jamhur Aditha Satria Maulana Anak Agung Dewi Megawati, Anak Agung Dewi Anna Fuji Rahimah Ardian Rizal Aulya, Justika Usmadhani Cut Intan Hidayah Dewi Megawati Djanggan Sargowo Farahdina, Farahdina Firzan Firzan Firzan, Firzan Garjito , Triwibowo Ambar Hendra Zufry Hendra Zufry, Hendra Heny Martini Hidayah, Cut Intan Hose, Victor Alvianoes Guterez Ilmawan, Muhammad Jamhur - Kurnia F. Jamil Kurnia F. Jamil Kurniawan, Jemmy Lestari, Bayu Lia Meuthia Zaini, Lia Meuthia Matondang, Asri Rizqi Mohammad Saifur Rohman Mudatsir Mudatsir Mudatsir Mudatsir Nur Samsu Pandji Wibawa Dhewantara Pandji Wibawa Dhewantara Panji Probo Saktianggi Putri, Frilya Rachma R. Tedjo Sasmono Ramadhani, Risa Rizaliansyah, Ferdian Roy Nusa Roy Nusa Saktianggi, Panji Probo Samsul Anwar Sasmono, R. Tedjo Tri Yudani MR Triwibowo Ambar Garjito Tsuraya, Alfi Yoga Waranugraha