This study aims to determine the amount of water runoff and water depth in the Tabanio Watershed, Tanah Laut Regency. The study was conducted using the HEC-RAS software to generate a flood simulation model. Data analysis included Digital Elevation Model for National Scale (DEMNAS) data, flood discharge data, rainfall data, river bathymetry, and tidal data. DEMNAS data was obtained from the website of the National Geospatial Information Agency (BIG), rainfall data was obtained from the Center for Hydrometeorology and Remote Sensing (CHRS) website. Rainfall data analysis involves selecting the maximum daily rainfall value to determine the flood discharge. The hourly flood discharge is calculated using the Synthetic Unit Hydrograph method with the Nakayasu approach. River bathymetry data is processed as additional data for DEM, with interval recording done every 0.2 seconds. Tide data was obtained through prediction based on the location constant closest to the research area and analyzed using the Pasut.exe software for a period of 6 days. Based on the results of flood analysis research using the HEC-RAS model in the Tabanio Watershed, Tanah Laut Regency, South Kalimantan Province, it can be concluded that the model results show the water depth and area of water runoff at maximum discharge. as follows: less than 0.5 meters with a very low category covering an area of 4,168.86 hectares, 0.51 to 1.5 meters with a low category covering an area of 6,417.79 hectares, 1.51 to 2.5 meters with a medium category covering an area of 1,987, 25 hectares, 2.51 to 3.5 meters with a high category of 741.47 hectares, and above 3.51 meters with a very high category of 113.69 hectares. So that the total water runoff reaches 13,429.05 hectares.