Article Per Year (5 Year)
p-Index From 2021 - 2026
1.503
P-Index
This Author published in this journals
All Journal SAINSMAT bionature BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Dedikasi Seminar Nasional Pengabdian Kepada Masyarakat SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam Indonesian Journal of Fundamental Sciences Seminar Nasional Hasil Penelitian LP2M UNM
Hartati, Hartati
Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Negeri Makassar
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
MICROALGAE METALLOTHIONEIN OPTIMIZATION THROUGH GENETIC ENGINEERING FOR BIOREMEDIATION AND BIOLOGY EDUCATION Nurul Magfirah; Hartati Hartati
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 12 No. 2 (2026): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v12i2.16729

Abstract

Heavy metal pollution (e.g., Cd, Pb, Hg) threatens aquatic ecosystems due to its persistence, toxicity, and bioaccumulation. Microalgae are promising agents for bioremediation via bioadsorption and intracellular bioaccumulation, but their intrinsic metal uptake is often inadequate under high contamination. This review aimed to synthesize current evidence on metallothionein (MT)-based enhancement of microalgae bioremediation and to map its relevance for project-based and STEM-oriented biology learning. A narrative (descriptive–analytical) literature review was conducted using recent publications (primarily within the last 10 years) on MT/PC mechanisms, microalgae genetic engineering and synthetic biology, genome editing, and biosafety. Content analysis was used to extract and integrate findings. The review indicates that MT functions as a metal buffer, detoxifier, and antioxidant, and that MT performance can be improved through (i) target-gene selection informed by omics and motif/phylogenetic analyses, (ii) construct design with strong/metal-inducible promoters and subcellular targeting, (iii) pathway-level co-engineering (transporters, glutathione/antioxidant systems), and (iv) genome editing (e.g., CRISPR-based knockout of inhibitory regulators). Biosafety-by-design strategies (biocontainment, auxotrophy, closed photobioreactor deployment) are critical for real-world use. Overall, MT-centered engineering offers a feasible route to strengthen microalgae bioremediation and provides an authentic context for integrating biotechnology with socio-scientific issues in biology education.
Co-Authors A. Irma Suryani A. Mu’nisa Abd Muis Ainun Chamila Alimuddin Ali Andi Asmawati Azis Andi Mifta Farid Darminto Darminto Fajar Harianto Fariani Madukubah Halifah Pagarra Halifah Paggarra Herlina Rante Idris, Irma Suryani Iwan Dini Muhammad Junda Muhiddin Palennari Mutahharah Hasyim, Mutahharah Nani Kurnia Nurul Magfirah Oslan Jumadi Pagarra, Halifah Sahribulan Sahribulan Siti Maulyda Ayu MZ Suriati Eka Putri Syamsiah, Syamsiah Taiyeb A. Mushawwir Yasser Abd. Djawad