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All Journal HAYATI Journal of Biosciences CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Veteriner Ecotrophic, Journal of Environmental Science Indonesian Journal of Cancer Jurnal Media Sains Journal of Health Sciences and Medicine INTERNATIONAL JOURNAL OF APPLIED CHEMISTRY RESEARCH Indonesian Journal of Cancer
WIWIK SUSANAH RITA
Chemistry Department, Faculty Of Mathematic And Natural Sciences Universitas Udayana Badung, Bali
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Journal : Indonesian Journal of Cancer

 1 
Aktivitas Antikanker Ekstrak Spons Hyrtios Erecta SWANTARA, I MADE DIRA; RITA, WIWIK SUSANAH
Indonesian Journal of Cancer Vol 9, No 4 (2015): Okt - Des 2015
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

ABSTRACTAnticancer activity test of the ethanol extract of sponge Hyrtios erecta from Pari Island beach (Jakarta) has been conducted. Extraction of the sponge was carried out by 70% ethanol at room temperature. Toxicity screening test was carried out based on Bhrine Shrimp Lethality Test (BSLT). Invitro anticancer activity test of the extract was carried out using HeLa cell line. Based on the results, it was found that ethanol extract of Hyrtios erecta sponges has anticancer activity with LC50 of 26.35 ppm.ABSTRAKTelah dilakukan uji antikanker ekstrak etanol spons Hyrtios erecta yang berasal dari perairan Pulau Pari Kepulauan Seribu, Jakarta. Ekstraksi dilakukan dengan cara maserasi menggunakan etanol 70% pada temperatur kamar. Skrining toksisitas dilakukan dengan metode Bhrine Shrimp Lethality Test (BSLT). Uji antikanker secara invitro ekstrak tersebut menggunakan sel HeLa. Berdasarkan hasil penelitian ini diperoleh bahwa ekstrak etanol spons Hyrtios erecta bersifat antikanker dengan harga LC50 sebesar 26,35 ppm.
Potensi Antikanker Isolat Toksik Tiga Spons Indonesia SWANTARA, MADE DIRA; RITA, WIWIK SUSANAH; SIBARANI, JAMES
Indonesian Journal of Cancer Vol 7, No 4 (2013): Oct - Dec 2013
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Telah dilakukan uji antikanker isolat toksik 3 (tiga) jenis spons yang berasal dari perairan Indonesia. Ketiga spons tersebut adalah Callyspongia aerizusa, Haliclona fascigera, dan Lanthella basta. Isolasi metabolit dalam spons dilakukan dengan cara maserasi, kemudian dilanjutkan dengan tahap pemisahan dan pemurnian menggunakan cara partisi serta kromatografi kolom. Skrining toksisitas dilakukan dengan metode Bhrine Shrimp Lethality Test (BSLT). Uji antikanker secara in vitro isolat yang paling toksik menggunakan sel HeLa. Berdasarkan hasil penelitian ini diperoleh bahwa spons Callyspongia aerizusa bersifat sebagai antikanker dengan LC50 sebesar 5,50 ppm. Spons Haliclona fascigera tidak bersifat antikanker terhadap sl HeLa, karena harga LC50 sebesar 44,67 ppm. Sedangkan spons Lanthella basta bersifat antikanker dengan harga LC50 sebesar 18,62 ppm.Kata Kunci: aktivitas antikanker; Callyspongia aerizusa; Haliclona fascigera; Lanthella basta
Identifikasi Isolat Antikanker Spons Hyrtios Erecta SWANTARA, I MADE DIRA; RITA, WIWIK SUSANAH; HERNINDYA, ANISA
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTIsolation, anticancer activity test, and identification of the toxic isolate from ethanol extract of the sponge Hyrtios erecta taken from Pari Island beach (Jakarta) has conducted. Extraction of the sponges was carried out by 70% ethanol at room temperature. Partition and purification of the compounds were done by column chromatography with the stationary phase of silica gel and the mobile phase of n-hexane-chloroform (2:8). Toxicity screening test was done based on Bhrine Shrimp Lethality Test (BSLT). In vitro anticancer activity test of the isolate was carried out using HeLa cell line. Identification of the compounds was performed by Gas chromatography-mass spectroscopy (GC-MS). Based on the results, it was found that the toxic isolate of H. erecta sponges has anticancer activity with IC50 of 30,497 ppm. Four compounds was detected from the anticancer isolate i.e: 4-nonylphenol; dibutyl phthalate; hexanedioic acid bis(2- ethylhexyl) ester; and cholesterol.ABSTRAKTelah dilakukan isolasi, uji aktivitas antikanker, dan identifikasi isolat toksik yang berasal dari ekstrak etanol spons Hyrtios erecta yang diambil dari perairan Pulau Pari (Jakarta). Ekstraksi dilakukan dengan cara maserasi menggunakan etanol 70% pada temperatur kamar. Pemisahan dan pemurnian komponen menggunakan kromatografi kolom denganfase diam silikagel dan fase gerak n-heksana-kloroform (2:8). Skrining toksisitas dilakukan dengan metode Bhrine Shrimp Lethality Test (BSLT). Uji antikanker secara in vitro isolat toksik tersebut menggunakan sel HeLa. Senyawanya diidentifikasi menggunakan Gas chromatography-mass spectroscopy (GC-MS). Berdasarkan hasil penelitian ini diperoleh bahwa isolat toksik spons H. erecta bersifat antikanker dengan IC50 sebesar 30,497 ppm. Pada isolat antikanker tersebut terdeteksi empat senyawa, yaitu 4-nonylphenol; dibutil phtalat; ester heksadioat bis(2-etilheksil); dankolesterol.
Identifikasi Isolat Antikanker Spons Hyrtios Erecta SWANTARA, I MADE DIRA; RITA, WIWIK SUSANAH; HERNINDYA, ANISA
Indonesian Journal of Cancer Vol 10, No 4 (2016): October - December 2016
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.135 KB)

Abstract

ABSTRACTIsolation, anticancer activity test, and identification of the toxic isolate from ethanol extract of the sponge Hyrtios erecta taken from Pari Island beach (Jakarta) has conducted. Extraction of the sponges was carried out by 70% ethanol at room temperature. Partition and purification of the compounds were done by column chromatography with the stationary phase of silica gel and the mobile phase of n-hexane-chloroform (2:8). Toxicity screening test was done based on BhrineShrimp Lethality Test (BSLT). In vitro anticancer activity test of the isolate was carried out using HeLa cell line. Identification of the compounds was performed by Gas chromatography-mass spectroscopy (GC-MS). Based on theresults, it was found that the toxic isolate of H. erecta sponges has anticancer activity with IC50 of 30,497 ppm. Four compounds was detected from the anticancer isolate i.e: 4-nonylphenol; dibutyl phthalate; hexanedioic acid bis(2-ethylhexyl) ester; and cholesterol. ABSTRAKTelah dilakukan isolasi, uji aktivitas antikanker, dan identifikasi isolat toksik yang berasal dari ekstrak etanol spons Hyrtios erecta yang diambil dari perairan Pulau Pari (Jakarta). Ekstraksi dilakukan dengan cara maserasi menggunakan etanol 70% pada temperatur kamar. Pemisahan dan pemurnian komponen menggunakan kromatografi kolom dengan fase diam silikagel dan fase gerak n-heksana-kloroform (2:8). Skrining toksisitas dilakukan dengan metode Bhrine Shrimp Lethality Test (BSLT). Uji antikanker secara in vitro isolat toksik tersebut menggunakan sel HeLa. Senyawanya diidentifikasi menggunakan Gas chromatography-mass spectroscopy (GC-MS). Berdasarkan hasil penelitian ini diperoleh bahwa isolat toksik spons H. erecta bersifat antikanker dengan IC50 sebesar 30,497 ppm. Pada isolat antikankertersebut terdeteksi empat senyawa, yaitu 4-nonylphenol; dibutil phtalat; ester heksadioat bis(2-etilheksil); dan kolesterol.
Co-Authors Abdul Rahim Adi Djona Silaen Ali Sabikin Frida R. Koreh Gede Widihati, Ida Ayu HERNINDYA, ANISA I Gusti Agung Gede Bawa I Gusti Ayu Kunti Sri Panca Dewi I Gusti Bagus Teguh Ananta I Kadek Pater Suteja I M, Sukadana I Made Adi Suardhyana I Made Dira Swantara I Made Oka Adi Parwata I Made Siaka I Nyoman Suarsana I Nyoman Suartha I W BUDIARSA SUYASA I Wayan Gede Gunawan I Wayan Suirta I. A. R. Astiti Asih Irdhawati Irdhawati Irvansyah Habibi Resaputra Iryanti Eka Suprihatin James Sibarani Kenanda, I Putu Bayu Mbatu, Rosanti Suryani Tince Ni Kadek Dyan Mustika Sri Wahyuni Ni Ketut Sinarsih Ni Ketut Sinarsih Ni Komang Ariati Ni Luh Putu Lilis Wirastiningsih Ni Luh Rustini Ni Luh Yuli Damayanti Ni Made Dwita Prasetyawati Ni Made Puspawati Ni Made Puspawati Ni Made Suaniti Ni Made Sukma Sanjiwani Ni Made Yuliari Ni Putu Eka Vinapriliani Ni Putu Widayanti Putu Prisanti Putri Utami Putu Puspita Sari Putu Sariningsih Raditya Yoga Rahayu, Riana Suastari Retno Kawuri Rr Anisa Hernindy Sinarsih, Ni Ketut Suharta, I Gede Yeyen Valent, Febryna Aurora WAHYU DWIDJANI S Wirajana, Nengah Yenni Ciawi Yohanes Armawan Sandi