Nurpudji A. Taslim
Bagian Ilmu Biomedik, Universitas Hasanuddin, Makassar

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PEMBERIAN L-ALANYL L-GLUTAMYL DENGAN ASUPAN TINGGI PROTEIN PADA PASIEN LUKA BAKAR LISTRIK 48% DERAJAT II-III Margherita Suppini Sumardi; Nurpudji A. Taslim; A. Yasmin Syauki
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 2 No 1 (2019): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v2i1.86

Abstract

Luka bakar merupakan masalah kesehatan masyarakat yang paling sering ditemukan pada usia produktif. Data unit luka bakar rumah sakit di Indonesia menunjukkan terjadinya peningkatan mortalitas. Pada luka bakar berat terjadi hipermetabolisme dan proteolisis yang tinggi sehingga diperlukan terapi nutrisi yang tepat dan dini. Dilaporkan kasus seorang laki-laki, 18 tahun dengan keluhan nafsu makan melalui oral menurun dengan diagnosis severe protein energy malnutrition, luka bakar listrik 48% grade II-III. Terapi nutrisi yang diberikan adalah diet energi 3350 kkal melalui oral dan parenteral dengan komposisi protein: karbohidrat: lemak = 14,3%: 50%: 35,7%. Diet dimulai dengan 40% lalu 80% dan 100% dari total energi (hari ke-III). Kebutuhan protein 2,0 g/kg/hari dengan suplementasi parenteral glutamin (13,46 g/hari). Suplementasi mikronutrien berupa zink 40 mg/24 jam, ekstrak ikan gabus 480 g/hari, vitamin B1 4 mg/8 jam, vitamin C 500 mg/12 jam, vitamin A 10.000 IU/24 jam. Perbaikan balans nitrogen dari -7,7 menjadi +5,36. Albumin dan protein total mengalami perbaikan dari 2, 4 g/dl menjadi 3,5 g/dl dan 6,8 g/dl menjadi 6,8 g/dl. Penyembuhan luka terjadi dengan baik (inflamasi-repair dan remodeling) selama tiga puluh tiga hari masa perawatan. Kesimpulan: suplementasi glutamin dengan asupan tinggi protein dapat mempercepat penyembuhan luka, dan mencegah mortalitas pada pasien luka bakar berat.
Is There A Way to Prevent Aging? A Study Using Metformin in Blood Sugar Levels and Serum Levels of IGF-1 Arlina Wiyata Gama; Arief Santoso; Ika Yustisia; Nurpudji Astuti Taslim; Irfan Idris; Isra Wahid
Al-Sihah : The Public Health Science Journal Volume 13, Nomor 1, January-June 2021
Publisher : Program Studi Kesehatan Masyarakat UIN Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-sihah.v13i1.21694

Abstract

Aging is influenced by lifestyle, which one is by consuming excessive calories. In recent years there have been many studies on aging and age-related diseases, calorie restriction mimetic is one of them. Metformin is a calorie restriction mimetic that is attractive to gerontologists. This research analyzed the effect of metformin as a calorie restriction mimetic on fasting blood glucose and IGF-1 serum levels in old white male Wistar rats. This study conducted with an experimental study with a pre and post-test pattern with controlled group design on male rats (Rattus novergicus) Wistar strain which was divided into 3 groups, control group (K), the calorie restriction group (P1), and the metformin group (P2), 6 rats each group. Blood glucose levels were measured by a glucometer and serum IGF-1 levels were measured with an ELISA kit, where blood samples were taken from the tail of the rats. In general, the provision of metformin and calorie restriction tended to reduce blood glucose levels, but increased serum IGF-1 levels. There is a significant relationship between blood glucose levels and serum IGF-1 levels. It’s necessary to conduct further research to determine the effective dose and maximum dose of metformin to reduce blood glucose level and serum IG-1 levels which can be slow down the aging process.
Pengaruh Edukasi Media Whatsapp Tentang Gizi Laktasi, Involusi Uteri, Dan Lochea Terhadap Pengetahuan, Sikap Dan Perilaku Ibu Nifas Ratnaeni; Agussalim Bukhari; Healthy Hidayanty; Nurpudji Astuti Daud; Burhanuddin Bahar; Ni Luh Puti Herli Mastuti
Oksitosin : Jurnal Ilmiah Kebidanan Vol. 8 No. 1 (2021): OKSITOSIN : Jurnal Ilmiah Kebidanan
Publisher : Prodi D III Kebidanan Fakultas Ilmu Kesehatan Universitas Ibrahimy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35316/oksitosin.v8i1.724

Abstract

The abnormal period of nifas causes problems such as the sub-involution of utero and bleeding, when it is not handled quickly can result in maternal mortality. Education is one of the upbringing to improve the knowledge, attitudes and behaviors of mother Nifas. The aim of this research is to know the effect of WhatsApp education on lactation, uteri, and Lochea on the knowledge, attitudes and behavior of puerperium in the working area of Sitti Khadijah I Muhammadiyah Makassar ". Research design that is quasi experiment with one group pre-Test and post-Test design. The research was conducted in Rsia Sitti Khadijah I Muhammadiyah Makassar in January S/d february year 2020. Sample of 39 respondents. Sampling technique using purposive sampling, intervention is given through WhatsApp media about lactation, utero and Lochea for 14 days with 2 times the provision of materials in a day and completed the division of the research material conducting group monitoring if the material is accessed then the name of the respondent is in the field "read by" but if it has not been accessed the name of the respondent is in the field Data was analyzed using Mc Nemar test. Result: Most of the respondents were 20-35 years old as much as 84.6%, the majority of the education of respondents was the college as much as 41.0%, respondents MOSTLY worked as IRT, which was 56.4%, most of the family income was 3-5 million per month as many as 69.2% and most respondents had a total of 2-4 children as much as 43.6%. There was a significant increase in the knowledge of 84.6% and an attitude of 79.5% after the intervention with P-value 0.000. While on the behavioral consumption of proteins, Vit A and vit C respectively at 35.9%, 41% and 59% after administration of the intervention with P value < 0.05. There is an increase in the knowledge, attitudes and behaviors of puerperium mothers in the work area of RSIA Sitti Khadijah I Muhammadiyah Branch of Makassar. And expected to be Pregnant and mother Nifas to make use of social media owned especially Whatsapp and Dipleaseto further researchers in order to develop this research using other social media. Keywords: Education, Social Media Whatsapp, Nutrition, Puerperium The abnormal period of nifas causes problems such as the sub-involution of utero and bleeding, when it is not handled quickly can result in maternal mortality. Education is one of the upbringing to improve the knowledge, attitudes and behaviors of mother Nifas. The aim of this research is to know the effect of WhatsApp education on lactation, uteri, and Lochea on the knowledge, attitudes and behavior of puerperium in the working area of Sitti Khadijah I Muhammadiyah Makassar ". Research design that is quasi experiment with one group pre-Test and post-Test design. The research was conducted in Rsia Sitti Khadijah I Muhammadiyah Makassar in January S/d february year 2020. Sample of 39 respondents. Sampling technique using purposive sampling, intervention is given through WhatsApp media about lactation, utero and Lochea for 14 days with 2 times the provision of materials in a day and completed the division of the research material conducting group monitoring if the material is accessed then the name of the respondent is in the field "read by" but if it has not been accessed the name of the respondent is in the field Data was analyzed using Mc Nemar test. Result: Most of the respondents were 20-35 years old as much as 84.6%, the majority of the education of respondents was the college as much as 41.0%, respondents MOSTLY worked as IRT, which was 56.4%, most of the family income was 3-5 million per month as many as 69.2% and most respondents had a total of 2-4 children as much as 43.6%. There was a significant increase in the knowledge of 84.6% and an attitude of 79.5% after the intervention with P-value 0.000. While on the behavioral consumption of proteins, Vit A and vit C respectively at 35.9%, 41% and 59% after administration of the intervention with P value < 0.05. There is an increase in the knowledge, attitudes and behaviors of puerperium mothers in the work area of RSIA Sitti Khadijah I Muhammadiyah Branch of Makassar. And expected to be Pregnant and mother Nifas to make use of social media owned especially Whatsapp and Dipleaseto further researchers in order to develop this research using other social media. Keywords: Education, Social Media Whatsapp, Nutrition, Puerperium ABSTRAK Masa nifas yang abnormal menyebabkan masalah seperti sub-involusi uteri dan perdarahan, apabila tidak tertangani dengan cepat dapat berakibat pada kematian ibu. Edukasi merupakan salah satu asuhan untuk meningkatkan pengetahuan, sikap dan perilaku ibu nifas. Tujuan penelitian ini adalah untuk Mengetahui efek edukasi whatsapp tentang gizi laktasi, involusi uteri, dan lochea terhadap pengetahuan, sikap dan perilaku ibu nifas di wilayah kerja RSIA Sitti Khadijah I Muhammadiyah Makassar”. Desain Penelitian yaitu quasi experiment dengan one group pre-test dan post-test design. Penelitian dilaksanakan di RSIA Sitti Khadijah I Muhammadiyah Makassar pada bulan Januari s/d Februari tahun 2020. Sampel sebanyak 39 responden. Tekhnik pengambilan sampel menggunakan purposive sampling, intervensi diberikan melalui media whatsapp tentang gizi laktasi, involusi uteri dan lochea selama 14 hari dengan 2 kali pemberian materi dalam sehari dan selesai pembagian materi peneliti melakukan pemantauan group jika materi telah diakses maka nama responden berada pada kolom “Dibaca Oleh” namun jika belum diakses nama responden berada pada kolom “Tersampaikan Ke”. Data dianalisis menggunakan uji Mc Nemar. Sebagian besar responden berumur 20-35 tahun yaitu sebanyak 84.6%, mayoritas pendidikan responden yaitu perguruan tinggi sebanyak 41.0%, responden sebagian besar bekerja sebagai IRT yaitu sebanyak 56.4%, Sebagian besar responden pendapatan keluarganya 3-5 juta perbulan sebanyak 69.2% dan sebagian besar responden memiliki jumlah anak 2-4 yaitu sebanyak 43.6%. Terjadi peningkatan yang signifikan terhadap pengetahuan sebesar 84.6% dan sikap sebesar 79.5% setelah pemberian intervensi dengan p-value 0.000. sedangkan pada perilaku konsumsi protein, VIT A dan VIT C masing-masing sebesar 35.9%, 41% dan 59% setelah pemberian intervensi dengan p value < 0.05. Terdapat peningkatan pengetahuan, sikap dan perilaku ibu nifas di wilayah kerja RSIA Sitti Khadijah I Cabang Muhammadiyah Makassar. Dan diharapkan ibu hamil maupun ibu nifas agar memanfaatkan media sosial yang dimiliki khususnya Whatsapp serta diharapkan peneliti selanjutnya agar bisa mengembangkan penelitian ini dengan menggunakan media sosial yang lainnya. Kata Kunci : Edukasi, Media Sosial Whatsapp, Gizi, Ibu Nifas
The Effect of Trehalose Supplementation on Macrovascular Inflammation Biomarker in Old Rats by Assessing NFκB-p65 Expression Inggrid -; Aminuddin -; Arif Santoso; Nurpudji A Taslim; Ika Yustisia; Irfan Idris
Amerta Nutrition Vol. 6 No. 2 (2022): AMERTA NUTRITION
Publisher : Universitas Airlangga, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v6i2.2022.183-190

Abstract

Background: Vascular inflammation is one of contributing factors to the pathogenesis of arterial aging. Age-related activation of the inflammatory process can lead to various macro-and microvascular pathologies. The pro-inflammatory microenvironment generated in the vascular wall can lead to the pathogenesis of vascular diseases due to an increase in vascular dysfunction. Trehalose is a disaccharide that has several functions, protecting against stressors (one of them is reactive oxygen species/ROS) and preventing the inflammatory responses induced by endotoxic shock. Objectives: To analyze the effect of trehalose supplementation on macrovascular inflammatory processes related to the aging process. Methods: The experimental study used 28 male Wistar rats (Rattus novergicus) which were divided into 4 groups, young control group (Group A), old control group (Group B), 2% sucrose group (Group C), and 2% trehalose group (Group D); were then observed for 8 weeks. Results: The results showed that there were no significant differences in aortic tissue NFκB-p65 expression between old and young subjects (p=0.247). The 2% trehalose group had 40% lower aortic tissue NFkB-p65 expression compared to the old control group (p=0.012); while the group given 2% sucrose solution had a 30% higher aortic tissue NFkB-p65 expression compared to the trehalose group (p=0.018). Conclusion: Trehalose has a good effect on aging-associated vascular inflammatory processes that can be seen from the low aortic tissue NFκB-p65 expression in old rats.
Perubahan Berat Badan Tikus Sprague Dawley Setelah Pemberian Ekstrak Kurma Ajwa Marzelina Karim; Nurpudji Astuti Taslim; Agussalim Bukhari; Firdaus Hamid; Irfan Idris; Himawan Dharmayani Sanusi
Indonesian Journal of Human Nutrition Vol. 9 No. 1 (2022)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2022.009.01.4

Abstract

Kelebihan lemak yang menyebabkan terjadinya obesitas dapat berpengaruh dalam proses penuaan dan menurunkan angka harapan hidup. Hal ini disebabkan oleh karena adanya peningkatan Reactive Oxygen Species (ROS) yang memicu terjadinya stres oksidatif dan proses inflamasi dari organisme yang memengaruhi telomer, yang berperan sebagai penanda usia biologis. Kandungan serat makanan dan antioksidan yang tinggi pada kurma Ajwa menjadikannya pilihan untuk pengobatan berbagai penyakit seperti diabetes, obesitas, kanker, dan penyakit jantung. Penelitian ini bertujuan untuk mengetahui perubahan berat badan tikus Sprague dawley setelah pemberian ekstrak kurma Ajwa (Phoenix dactylifera L.). Rancangan penelitian yaitu pre-post test with control group design. 15 ekor tikus jantan Sprague dawley dibagi dalam 5 tikus kelompok kontrol, 5 tikus kelompok perlakuan I yang diinduksi diet tinggi lemak dan 5 tikus kelompok perlakuan II yang diintervensi ekstrak kurma Ajwa. Induksi PTL diberikan selama 30 hari dan pemberian ekstrak kurma Ajwa selama 7 hari. Hasil penelitian menunjukkan kelompok tikus yang diberi PTL mengalami perubahan berat badan yang signifikan, diperoleh nilai p<0,011. Kesimpulannya, terjadi penurunan berat badan pada tikus Sprague dawley yang diberikan ekstrak kurma Ajwa.
The Influence Of Module-Based Education To Adolescent Women On Increasing Self Efficacy In Cases Premenstrual Syndrome Ika Rezky Burhan; Nasrudin Andi Mappaware; Nurpudji Astuti Daud; St. Nurasni St. Nurasni
JKM (Jurnal Kebidanan Malahayati) Vol 9, No 3 (2023): Volume 9 No. 3 Juli 2023
Publisher : Program Studi Kebidanan Fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkm.v9i3.8797

Abstract

Latar Belakang: Masalah kesehatan reproduksi remaja saat ini masih menjadi perhatian karena dapat membahayakan kesejahteraan wanita dan berdampak negatif pada kualitas hidup. Terdapat perubahan masalah fisik mental dan emosional inilah yang membentuk periode yang berbeda dari kehidupannya.Tujuan: mengetahui pengaruh pemberian edukasi berbasis modul pada remaja putri terhadap peningkatan self efficacy pada kasus premenstrual syndrome.Metode penelitian menggunakan quasi eksperimen yang dapat diartikan sebagai metode penelitian yang digunakan untuk mencari pengaruh perlakuan tertentu terhadap yang lain, kondisi yang terkendali dengan menggunakan total sampling.Hasil: Dari 60 responden dilakukan pretest yang rata-rata tingkat pengetahuan siswi berada pada kategori kurang sebanyak 93,3%. Pada posttest mengalami peningkatan dan rata-rata pengetahuan siswi pada kategori cukup sebanyak 81,7% dan kategori baik sebanyak 18,3%. Dari hasil uji Wilcoxon menunjukkan bahwa nilai p= Value sebesar 0,00 (p-value<0,05)Kesimpulan: terdapat pengaruh antara pemberian edukasi menggunakan modul terhadap peningkatan self efficacy siswi tentang premenstrual syndrome.Saran: Diharapkan siswi lebih seringa tau banyak membaca tentang edukasi premenstrual syndrome agar siap menghadapi masa menarche. Kata kunci : Efikasi Diri, Modul, Premenstrual Syndrome, Remaja Putri ABSTRACT Background: Adolescent reproductive health issues today are still a concern because they can endanger women's well-being and negatively impact quality of life. There are changes in these physical, mental, and emotional problems that shape different periods of his life.Objective: determine the effect of providing module-based education to adolescent girls on increasing self-efficacy  in cases of premenstrual syndrome.Methods: using quasi-experiments which can be interpreted as research methods used to look for the effect of certain treatments on other, controlled conditions using total sampling.Results: Of  the 60 respondents conducted a pretest whose average level of knowledge of female students was in the less category as much as 93.3%. In the posttest, there was an increase and the average knowledge of female students in the category was quite 81.7% and the good category was 18.3%. From the results of the Wilcoxon test shows that the value of p = Value is 0.00 (p-value<0.05).Conclusion: there is an influence between the provision of education using modules on increasing students' self-efficacy about premenstrual syndrome.Suggestion: It is hoped that students will read more often about premenstrual syndrome education to be ready for menarche. Keywords: Adolescent Women, Module-Based Education, Self Efficacy, Premenstrual Syndrome